المؤلفون: Slack, RJ, Russell, LJ, Hall, DA, Luttmann, MA, Ford, AJ, Saunders, KA, Hodgson, ST, Connor, HE, Browning, C, Clark, KL

مصطلحات موضوعية: Niacinamide, Rhinitis, Allergic, Perennial, Ovalbumin, Bronchoconstriction, Guinea Pigs, Bronchi, CHO Cells, In Vitro Techniques, Transfection, Binding, Competitive, Bronchial Provocation Tests, Cell Line, Cricetulus, Piperidines, Cricetinae, Animals, Humans, Receptors, Histamine H3, Receptors, Histamine H1, Pyrilamine, Allergens, Benzazepines, Research Papers, Recombinant Proteins, Histamine H1 Antagonists, Phthalazines, Carbachol, Female, Histamine, Histamine H3 Antagonists

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f844559eacdf71f69ee5c3b202156d2a
https://europepmc.org/articles/PMC3230810/

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المؤلفون: Slack, RJ, Hall, DA

المصدر: British Journal of Pharmacology; Jul2012, Vol. 166 Issue 6, p1774-1792, 19p

مصطلحات موضوعية: CHEMOKINE receptors, CELL membranes, F-actin, T cells, RADIOLIGAND assay, CELLULAR signal transduction, CD4 antigen

المؤلفون: Gasson R; Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK., Roper JA; Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK., Slack RJ; Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 19; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Erythrocytes*/metabolism , Erythrocytes*/drug effects , Hemagglutination*/drug effects , Galectins*/antagonists & inhibitors , Galectins*/metabolism , Galectin 1*/antagonists & inhibitors , Galectin 1*/metabolism, Humans ; Galectin 3/antagonists & inhibitors ; Galectin 3/metabolism ; Agglutination Tests/methods ; Hemagglutination Tests ; Agglutination/drug effects

المؤلفون: Kim H; NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France., Kretz L; NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France., Ronin C; NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France., Starck C; NovAliX, 16 Rue d'Ankara, 67000 Strasbourg, France., Roper JA; Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK., Kahl-Knutson B; Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden., Peterson K; Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden., Leffler H; Department of Laboratory Medicine, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden., Nilsson UJ; Department of Chemistry, Lund University, P.O. Box 124, SE-221 00 Lund, Sweden.; Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark., Pedersen A; Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark., Zetterberg FR; Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg, Sweden., Slack RJ; Galecto Biotech AB, Stevenage Bioscience Catalyst, Stevenage SG1 2FX, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jun 18; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Galectin 1*/metabolism , Galectin 1*/antagonists & inhibitors , Galectin 1*/chemistry , Surface Plasmon Resonance*/methods , Protein Binding*, Humans ; Animals ; Mice ; Kinetics ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/chemistry ; Fluorescence Polarization/methods

المؤلفون: Zetterberg FR; Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg,Sweden., Peterson K; Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg,Sweden., Nilsson UJ; Galecto Biotech AB, Sahlgrenska Science Park, Medicinaregatan 8 A, SE-413 46 Gothenburg,Sweden.; Department of Chemistry, Lund University, Box 124, SE-221 00 Lund, Sweden., Andréasson Dahlgren K; Red Glead Discovery AB, Medicon Village, SE-223 63 Lund, Sweden., Diehl C; SARomics Biostructures AB, Medicon Village, SE-223 63 Lund, Sweden., Holyer I; Nine Edinburgh Bioquarter, Galecto Biotech ApS, 9 Little France Road, Edinburgh EH16 4UX, U.K., Håkansson M; SARomics Biostructures AB, Medicon Village, SE-223 63 Lund, Sweden., Khabut A; Red Glead Discovery AB, Medicon Village, SE-223 63 Lund, Sweden., Kahl-Knutson B; Department of Laboratory Medicine, Lund University, Box 124, SE-221 00 Lund, Sweden., Leffler H; Department of Laboratory Medicine, Lund University, Box 124, SE-221 00 Lund, Sweden., MacKinnon AC; Nine Edinburgh Bioquarter, Galecto Biotech ApS, 9 Little France Road, Edinburgh EH16 4UX, U.K., Roper JA; Stevenage Bioscience Catalyst, Galecto Biotech ApS, Stevenage, Hertfordshire SG1 2FX, U.K., Slack RJ; Stevenage Bioscience Catalyst, Galecto Biotech ApS, Stevenage, Hertfordshire SG1 2FX, U.K., Zarrizi R; Red Glead Discovery AB, Medicon Village, SE-223 63 Lund, Sweden., Pedersen A; Galecto Biotech AB, Cobis Science Park, Ole Maaloes Vej 3, DK-2200 Copenhagen, Denmark.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 9374-9388. Date of Electronic Publication: 2024 May 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Galectin 1*/antagonists & inhibitors , Galectin 1*/metabolism , Lung Neoplasms*/drug therapy , Lung Neoplasms*/pathology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/pharmacokinetics , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/therapeutic use, Humans ; Animals ; Mice ; Administration, Oral ; Apoptosis/drug effects ; Structure-Activity Relationship ; Jurkat Cells ; Drug Discovery ; Crystallography, X-Ray ; Thiazoles/pharmacokinetics ; Thiazoles/pharmacology ; Thiazoles/chemistry

المؤلفون: Calver JF; School of Medicine, University of Nottingham, Nottingham, United Kingdom; Stevenage Bioscience Catalyst, Galecto Biotech AB, Stevenage, United Kingdom., Parmar NR; School of Medicine, University of Nottingham, Nottingham, United Kingdom; Roche Products Limited, Welwyn Garden City, Hertfordshire, United Kingdom., Harris G; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire, United Kingdom., Lithgo RM; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire, United Kingdom; School of Biosciences, University of Nottingham, Loughborough, Leicestershire, United Kingdom; Membrane Protein Laboratory, Diamond Light Source, Rutherford Appleton Laboratory, Didcot, Oxfordshire, United Kingdom; Diamond Light Source, Diamond House, Rutherford Appleton Laboratories, Didcot, Oxfordshire, United Kingdom., Stylianou P; Institute for Lung Health, NIHR Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom; Leicester Institute for Structural and Chemical Biology, Henry Wellcome Building, University of Leicester, Leicester, United Kingdom., Zetterberg FR; Galecto Biotech AB, Sahlgrenska Science Park, Gothenburg, Sweden., Gooptu B; Institute for Lung Health, NIHR Leicester Respiratory Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom; Leicester Institute for Structural and Chemical Biology, Henry Wellcome Building, University of Leicester, Leicester, United Kingdom., Mackinnon AC; Galecto Biotech AB, Nine Edinburgh BioQuarter, Edinburgh, United Kingdom., Carr SB; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire, United Kingdom; Department of Chemistry, University of Oxford, Oxford, Oxfordshire, United Kingdom., Borthwick LA; Fibrofind Ltd, Newcastle upon Tyne, United Kingdom; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Scott DJ; Research Complex at Harwell, Rutherford Appleton Laboratory, Didcot, Oxfordshire, United Kingdom; School of Biosciences, University of Nottingham, Loughborough, Leicestershire, United Kingdom., Stewart ID; National Heart and Lung Institute, Imperial College London, London, United Kingdom., Slack RJ; Stevenage Bioscience Catalyst, Galecto Biotech AB, Stevenage, United Kingdom., Jenkins RG; National Heart and Lung Institute, Imperial College London, London, United Kingdom., John AE; National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: a.john@imperial.ac.uk.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jun; Vol. 300 (6), pp. 107300. Date of Electronic Publication: 2024 Apr 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Transforming Growth Factor beta1*/metabolism , Galectin 3*/metabolism , Galectin 3*/genetics , Fibroblasts*/metabolism , Fibroblasts*/pathology , Idiopathic Pulmonary Fibrosis*/metabolism , Idiopathic Pulmonary Fibrosis*/pathology, Humans ; Lung/metabolism ; Lung/pathology ; Signal Transduction ; Receptor, Transforming Growth Factor-beta Type II/metabolism ; Receptor, Transforming Growth Factor-beta Type II/genetics ; Receptors, Transforming Growth Factor beta/metabolism ; Protein Binding ; Protein Serine-Threonine Kinases/metabolism ; Galectins/metabolism ; Collagen Type I/metabolism ; Cells, Cultured ; Blood Proteins

المؤلفون: Slack RJ; Intensive Care Unit Department, Western Health, Melbourne, Vic, Australia., McGain F; Intensive Care Unit Department, Western Health, Melbourne, Vic, Australia., Cox N; Department of Cardiology, Western Health, Melbourne, Vic, Australia., French C; Intensive Care Unit Department, Western Health, Melbourne, Vic, Australia., Cheng V; Department of Cardiology, Western Health, Melbourne, Vic, Australia., Stub D; Department of Cardiology, Western Health, Melbourne, Vic, Australia; Department of Cardiology, Alfred Hospital, Melbourne, Vic, Australia., Zakhem B; Department of Cardiology, Western Health, Melbourne, Vic, Australia., Dade F; Intensive Care Unit Department, Western Health, Melbourne, Vic, Australia., Bloom JE; Department of Cardiology, Western Health, Melbourne, Vic, Australia; Department of Cardiology, Alfred Hospital, Melbourne, Vic, Australia., Chan W; Department of Cardiology, Western Health, Melbourne, Vic, Australia; Department of Cardiology, Alfred Hospital, Melbourne, Vic, Australia., Yang Y; Intensive Care Unit Department, Western Health, Melbourne, Vic, Australia. Electronic address: Yang.Yang@wh.org.au.

المصدر: Heart, lung & circulation [Heart Lung Circ] 2024 Apr; Vol. 33 (4), pp. 460-469. Date of Electronic Publication: 2024 Feb 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Australia Country of Publication: Australia NLM ID: 100963739 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1444-2892 (Electronic) Linking ISSN: 14439506 NLM ISO Abbreviation: Heart Lung Circ Subsets: MEDLINE

مواضيع طبية MeSH: Shock, Cardiogenic*/therapy , Shock, Cardiogenic*/surgery , Heart-Assist Devices* , Percutaneous Coronary Intervention*/methods , Myocardial Infarction*/complications, Humans ; Male ; Female ; Middle Aged ; Aged ; Adult ; Ventricular Function, Left/physiology ; Retrospective Studies ; Echocardiography ; Follow-Up Studies