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المؤلفون: Isabella Pallavicini, Greta Bagnolini, Andrea Balboni, Marinella Roberti, Janet Robertson, Giuseppina Di Stefano, Fulvia Farabegoli, Sebastiano Peri, Jose Antonio Ortega, Saverio Minucci, D. Gioia, Federico Falchi, Domenico Milano, Francesca De Franco, Fabrizio Schipani, Roberto Pellicciari, Andrea Cavalli, Marcella Manerba, Stefania Girotto
المساهمون: Bagnolini G., Milano D., Manerba M., Schipani F., Ortega J.A., Gioia D., Falchi F., Balboni A., Farabegoli F., De Franco F., Robertson J., Pellicciari R., Pallavicini I., Peri S., Minucci S., Girotto S., Di Stefano G., Roberti M., Cavalli A.
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Models, Molecular, RAD51, Antineoplastic Agents, Synthetic lethality, Adenocarcinoma, Poly(ADP-ribose) Polymerase Inhibitors, 01 natural sciences, Poly (ADP-Ribose) Polymerase Inhibitor, Piperazines, Article, Poly(ADP-ribose) Polymerase Inhibitor, Olaparib, Antineoplastic Agent, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Small Molecule Librarie, Cell Line, Tumor, Pancreatic cancer, Drug Discovery, medicine, Humans, Protein Interaction Maps, Homologous Recombination, Piperazine, Phthalazine, 030304 developmental biology, BRCA2 Protein, 0303 health sciences, Drug discovery, Pancreatic Neoplasm, Drug Synergism, medicine.disease, 0104 chemical sciences, Pancreatic Neoplasms, 010404 medicinal & biomolecular chemistry, chemistry, Cancer research, Phthalazines, Molecular Medicine, Rad51 Recombinase, Synthetic Lethal Mutations, Homologous recombination, Protein Interaction Map, Human, DNA Damage
وصف الملف: STAMPA
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المؤلفون: Patrizia Diana, Girolamo Cirrincione, Domenico Schillaci, Elisa Giovannetti, Stella Cascioferro, Barbara Parrino, Ilaria Carnevale
المساهمون: Parrino, Barbara, Schillaci, Domenico, Carnevale, Ilaria, Giovannetti, Elisa, Diana, Patrizia, Cirrincione, Girolamo, Cascioferro, Stella
المصدر: Parrino, B, Schillaci, D, Carnevale, I, Giovannetti, E, Diana, P, Cirrincione, G & Cascioferro, S 2019, ' Synthetic small molecules as anti-biofilm agents in the struggle against antibiotic resistance ', European Journal of Medicinal Chemistry, vol. 161, pp. 154-178 . https://doi.org/10.1016/j.ejmech.2018.10.036
مصطلحات موضوعية: Antibiotic resistance, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Bacterial growth, Dispersal agent, 01 natural sciences, Virulence factor, Microbiology, Small Molecule Libraries, Structure-Activity Relationship, 03 medical and health sciences, Small Molecule Librarie, Anti-Bacterial Agent, Drug Discovery, medicine, 030304 developmental biology, Pharmacology, 0303 health sciences, Bacteria, Dose-Response Relationship, Drug, Molecular Structure, Microbial Sensitivity Test, 010405 organic chemistry, Chemistry, Biofilm, Organic Chemistry, Drug Resistance, Microbial, General Medicine, biochemical phenomena, metabolism, and nutrition, Anti-biofilm agent, Settore CHIM/08 - Chimica Farmaceutica, Small molecule, Anti-Bacterial Agents, 0104 chemical sciences, Anti-adhesion agent, Biofilms, Anti-virulence compound, Anti biofilm
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المؤلفون: Linda Cerofolini, Gerolama Condorelli, Giovanna Polcaro, Daniela Arosio, Vincenzo Maria D'Amore, Stefano Pepe, Riccardo Scaglia, Marco Fragai, E. Novellino, Giulia Assoni, Luciana Marinelli, Pasquale Russomanno, Stefano Giuntini, Jussara Amato, Diego Brancaccio, Francesco Sabbatino, Marianna Falzoni, Valeria La Pietra, Greta Donati, Paolo Orlando, Pierfausto Seneci, Cristina Quintavalle, Martina Pedrini, Bruno Pagano
المساهمون: Russomanno, P., Assoni, G., Amato, J., D'Amore, V. M., Scaglia, R., Brancaccio, D., Pedrini, M., Polcaro, G., La Pietra, V., Orlando, P., Falzoni, M., Cerofolini, L., Giuntini, S., Fragai, M., Pagano, B., Donati, G., Novellino, E., Quintavalle, C., Condorelli, G., Sabbatino, F., Seneci, P., Arosio, D., Pepe, S., Marinelli, L.
المصدر: Journal of medicinal chemistry 64 (2021): 16020–16045. doi:10.1021/acs.jmedchem.1c01409
info:cnr-pdr/source/autori:Russomanno, Pasquale; Assoni, Giulia; Amato, Jussara; D'Amore, Vincenzo Maria; Scaglia, Riccardo; Brancaccio, Diego; Pedrini, Martina; Polcaro, Giovanna; La Pietra, Valeria; Orlando, Paolo; Falzoni, Marianna; Cerofolini, Linda; Giuntini, Stefano; Fragai, Marco; Pagano, Bruno; Donati, Greta; Novellino, Ettore; Quintavalle, Cristina; Condorelli, Gerolama; Sabbatino, Francesco; Seneci, Pierfausto; Arosio, Daniela; Pepe, Stefano; Marinelli, Luciana/titolo:Interfering with the Tumor-Immune Interface: Making Way for Triazine-Based Small Molecules as Novel PD-L1 Inhibitors/doi:10.1021%2Facs.jmedchem.1c01409/rivista:Journal of medicinal chemistry/anno:2021/pagina_da:16020/pagina_a:16045/intervallo_pagine:16020–16045/volume:64مصطلحات موضوعية: Models, Molecular, medicine.drug_class, Immune Checkpoint Inhibitor, B7-H1 Antigen, Calorimetry, Differential Scanning, Cell Line, Tumor, Coculture Techniques, Humans, Immune Checkpoint Inhibitors, Neoplasms, Small Molecule Libraries, Structure-Activity Relationship, Triazines, Calorimetry, Monoclonal antibody, Differential Scanning, Peripheral blood mononuclear cell, PD-1/PD-L1, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Immune system, Small Molecule Librarie, Models, PD-L1, Drug Discovery, medicine, Cytotoxicity, Coculture Technique, immune checkpoint, 030304 developmental biology, 0303 health sciences, Tumor, biology, Chemistry, Molecular, Small molecule, 3. Good health, Triazine, Apoptosis, 030220 oncology & carcinogenesis, Cancer cell, Cancer research, biology.protein, Molecular Medicine, Neoplasm, Human
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1f62ede8b1113fad08327fc34d5b33
http://hdl.handle.net/11588/878222 -
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المؤلفون: Emiliano Manzo, Angelo Fontana, Giusi Barra, Giuliana d'Ippolito, Laura Fioretto, Genoveffa Nuzzo, Carmela Gallo, Raffaele De Palma, Marcello Ziaco, Marisa Saponaro
المساهمون: Gallo, Carmela, Barra, Giusi, Saponaro, Marisa, Manzo, Emiliano, Fioretto, Laura, Ziaco, Marcello, Nuzzo, Genoveffa, D'Ippolito, Giuliana, De Palma, Raffaele, Fontana, Angelo
المصدر: Marine Drugs, Vol 18, Iss 604, p 604 (2020)
Marine drugs (2020). doi:10.3390/md18120604
info:cnr-pdr/source/autori:Carmela Gallo, Giusi Barra, Marisa Saponaro, Emiliano Manzo, Laura Fioretto, Marcello Ziaco, Genoveffa Nuzzo, Giuliana d'Ippolito, Raffaele De Palma, Angelo Fontana/titolo:A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity/doi:10.3390%2Fmd18120604/rivista:Marine drugs/anno:2020/pagina_da:/pagina_a:/intervallo_pagine:/volume
Marine Drugs
Volume 18
Issue 12مصطلحات موضوعية: High-Throughput Screening Assay, Cytotoxicity, Immunologic, medicine.medical_treatment, Cytotoxicity, T-Lymphocytes, screening guidelines, Pharmaceutical Science, Lymphocyte Activation, Antineoplastic Agent, bioassay platform, Mice, 0302 clinical medicine, chemical immunology, immunotherapy, dendritic cell, drug discovery, anticancer, high throughput, Immunologic, Neoplasms, Bioassay, Innate, Pharmacology, Toxicology and Pharmaceutics (miscellaneous), lcsh:QH301-705.5, 0303 health sciences, Tumor, Drug discovery, Primary adaptive immune response, Small molecule, screening guideline, Phenotype, 030220 oncology & carcinogenesis, Biological Assay, Animals, Antineoplastic Agents, Cell Line, Tumor, Dendritic Cells, High-Throughput Screening Assays, Immunity, Innate, Small Molecule Libraries, Drug Discovery, Immunotherapy, Biology, Article, Cell Line, 03 medical and health sciences, Immune system, Small Molecule Librarie, medicine, 030304 developmental biology, Animal, Immunity, Dendritic cell, In vitro, T-Lymphocyte, lcsh:Biology (General), Cancer research, Neoplasm
وصف الملف: application/pdf
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المؤلفون: Federica Belluti, Angela Rampa, Concettina Cappadone, Giovanna Farruggia, Silvia Gobbi, Giovanna Picone, Emil Malucelli, Alessandra Bisi, Dario Valenti, Ottavia Spiga, Jessica Caciolla, Alfonso Trezza, Stefano Iotti
المساهمون: Caciolla J., Picone G., Farruggia G., Valenti D., Rampa A., Malucelli E., Belluti F., Trezza A., Spiga O., Iotti S., Gobbi S., Cappadone C., Bisi A.
المصدر: Bioorganic chemistry. 106
مصطلحات موضوعية: Bridged-Ring Compounds, MDR modulator, Revertant, Triazole, Succinimides, Antineoplastic Agents, Apoptosis, Drug resistance, P-glycoprotein, 01 natural sciences, Biochemistry, Antineoplastic Agent, Small Molecule Libraries, chemistry.chemical_compound, Structure-Activity Relationship, Small Molecule Librarie, Cell Line, Tumor, Drug Discovery, Potency, Moiety, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, Cell Proliferation, Anthracenes, biology, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Collateral sensitivity, Apoptosi, HL60 cell, In vitro, Drug Resistance, Multiple, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Bridged-Ring Compound, Anticancer, Docking (molecular), Drug Resistance, Neoplasm, Anthracene, biology.protein, Drug Screening Assays, Antitumor, Human, Protein Binding
وصف الملف: ELETTRONICO
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6Discovery of epi-enprioline as a novel drug for the treatment of vincristine resistant neuroblastoma
المؤلفون: Sime W., Jemaa M., Abassi Y., Lasorsa V. A., Kohler J. B., Hansson K., Bexell D., Michaelis M., Cinatl J., Strand D., Capasso M., Massoumi R.
المساهمون: Sime, W., Jemaa, M., Abassi, Y., Lasorsa, V. A., Kohler, J. B., Hansson, K., Bexell, D., Michaelis, M., Cinatl, J., Strand, D., Capasso, M., Massoumi, R.
مصطلحات موضوعية: High-Throughput Screening Assay, Animal, Cell Survival, Pyridine, Apoptosi, Mice, Nude, Xenograft Model Antitumor Assays, Antineoplastic Agent, Neuroblastoma, Mice, Small Molecule Librarie, Vincristine, Doxorubicin, Drug Resistance, Neoplasm, Cell Line, Tumor, Female, Drug Screening Assays, Antitumor, Chemoresistance, Epi-enprioline, Human
URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3730::74482308ed0d6a3226a55a777ff0a141
http://hdl.handle.net/11588/875768 -
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المؤلفون: Nirmal Robinson, Melanie Schwerdtfeger, Luigi Mele, Gianpaolo Papaccio, Vitale Del Vecchio, Vincenzo Desiderio, Marcella La Noce, Claudia Prisco, Davide Liccardo, V. Tirino
المساهمون: Mele, Luigi, del Vecchio, Vitale, Liccardo, Davide, Prisco, Claudia, Schwerdtfeger, Melanie, Robinson, Nirmal, Desiderio, Vincenzo, Tirino, Virginia, Papaccio, Gianpaolo, La Noce, Marcella, Del Vecchio, Vitale, Mele, L., del Vecchio, V., Liccardo, D., Prisco, C., Schwerdtfeger, M., Robinson, N., Desiderio, V., Tirino, V., Papaccio, G., La Noce, M.
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Cell, Tyrosine kinase inhibitor, Drug resistance, medicine.disease_cause, Targeted therapy, Fight-or-flight response, 0302 clinical medicine, Antineoplastic Agents, Immunological, Neoplasms, tyrosine kinase inhibitors, Molecular Targeted Therapy, Monoclonal antibodie, Immunotoxins, Antibodies, Monoclonal, General Medicine, targeted therapy, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, monoclonal antibodies, medicine.symptom, Human, autophagy, Protein Kinase Inhibitor, Small Molecule Libraries, 03 medical and health sciences, Small Molecule Librarie, medicine, Autophagy, Animals, Humans, Radiology, Nuclear Medicine and imaging, Protein Kinase Inhibitors, Tyrosine kinase inhibitors, Immunotoxin, drug resistance, business.industry, Animal, Hypoxia (medical), 030104 developmental biology, Drug Resistance, Neoplasm, Cancer research, Neoplasm, business, Homeostasis, Oxidative stress
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af801393b36c762e1cc82e95e5131a6a
https://hdl.handle.net/11541.2/142862 -
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المؤلفون: Susanna Cogoi, Andrey E. Shchekotikhin, Alexander S. Tikhomirov, Jessica Marinello, Giulia Miglietta, Giovanni Capranico, Luigi E. Xodo
المساهمون: Miglietta, Giulia, Cogoi, Susanna, Marinello, Jessica, Capranico, Giovanni, Tikhomirov, Alexander S., Shchekotikhin, Andrey, Xodo, Luigi E.
المصدر: Journal of medicinal chemistry. 60(23)
مصطلحات موضوعية: 0301 basic medicine, Antineoplastic Agents, Thiophenes, medicine.disease_cause, Antineoplastic Agent, Proto-Oncogene Proteins p21(ras), Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, 5' Untranslated Region, Small Molecule Librarie, Thiophene, Cell Line, Tumor, Drug Discovery, medicine, Protein biosynthesis, G-Quadruplexe, Humans, Messenger RNA, Oncogene, Protein Biosynthesi, Cell growth, Chemistry, Drug Discovery3003 Pharmaceutical Science, Pancreatic Neoplasm, RNA, Molecular biology, G-Quadruplexes, Pancreatic Neoplasms, 030104 developmental biology, Molecular Medicine, 030220 oncology & carcinogenesis, Protein Biosynthesis, Cancer cell, KRAS, 5' Untranslated Regions, Human
وصف الملف: STAMPA
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المؤلفون: Tamara Tchkonia, Jing Zhao, Priscilla Tang, Xuesen Li, Laura J. Niedernhofer, Yuan Yuan Ling, Lana Corbo, Siobhán Q. Gregg, Paul D. Robbins, James L. Kirkland, Sara J. McGowan, Diego Grassi, Christina Bukata, Jennifer L. Stripay, Heike Fuhrmann-Stroissnigg, Nadja Ring, Mauro Giacca, Akaitz Dorronsoro, Yi Zhu, Robert W. Brooks
المساهمون: Fuhrmann-Stroissnigg, Heike, Ling, Yuan Yuan, Zhao, Jing, Mcgowan, Sara J., Zhu, Yi, Brooks, Robert W., Grassi, Diego, Gregg, Siobhan Q., Stripay, Jennifer L., Dorronsoro, Akaitz, Corbo, Lana, Tang, Priscilla, Bukata, Christina, Ring, Nadja, Giacca, Mauro, Li, Xuesen, Tchkonia, Tamara, Kirkland, James L., Niedernhofer, Laura J., Robbins, Paul D.
المصدر: NATURE COMMUNICATIONS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Nature Communicationsمصطلحات موضوعية: Genetics and Molecular Biology (all), 0301 basic medicine, Aging, CLEARANCE, STRESS, Drug Evaluation, Preclinical, General Physics and Astronomy, Apoptosis, Benzoquinone, Biochemistry, Hsp90 inhibitor, Macrocyclic, Mice, Phosphatidylinositol 3-Kinases, Benzoquinones, lcsh:Science, Cellular Senescence, LIFE-SPAN, Multidisciplinary, biology, Chemistry (all), CELLULAR SENESCENCE, Hsp90, Preclinical, APOPTOSIS, 3. Good health, DNA-Binding Proteins, Fibroblast, Biological Assay, Female, Stem cell, Human, Signal Transduction, Senescence, Lactams, STRATEGIES, DNA repair, DNA-Binding Protein, Science, Lactams, Macrocyclic, Human Umbilical Vein Endothelial Cell, SENESCENT SECRETORY PHENOTYPE, Down-Regulation, Article, General Biochemistry, Genetics and Molecular Biology, Small Molecule Libraries, Physics and Astronomy (all), 03 medical and health sciences, Small Molecule Librarie, Animals, Autophagy, Biomarkers, Endonucleases, Fibroblasts, HSP90 Heat-Shock Proteins, Human Umbilical Vein Endothelial Cells, Humans, Proto-Oncogene Proteins c-akt, Biochemistry, Genetics and Molecular Biology (all), Endonuclease, AGENTS, Senolytic, Animal, HUMAN-CELLS, Apoptosi, Biomarker, General Chemistry, Embryonic stem cell, HSP90 Heat-Shock Protein, COMBINATION THERAPY, 030104 developmental biology, Immunology, Cancer research, biology.protein, Drug Evaluation, lcsh:Q, Phosphatidylinositol 3-Kinase
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المساهمون: Homan, Kristoff T., Wu, Emily, Cannavo, Alessandro, Koch, Walter J., Tesmer, John J. G.
المصدر: Molecules (Basel, Switzerland)
Molecules, Vol 19, Iss 10, Pp 16937-16949 (2014)
Molecules
Volume 19
Issue 10
Pages 16937-16949مصطلحات موضوعية: High-Throughput Screening Assay, G-Protein-Coupled Receptor Kinase 5, Models, Molecular, G-Protein-Coupled Receptor Kinase 1, Pharmaceutical Science, Aminopyridines, IκB kinase, Pharmacology, Crystallography, X-Ray, Analytical Chemistry, chemistry.chemical_compound, 0302 clinical medicine, Anti-Allergic Agents, Drug Discovery, Cells, Cultured, 0303 health sciences, biology, Kinase, Anti-Allergic Agent, 3. Good health, inhibitor, Biochemistry, Amlexanox, Chemistry (miscellaneous), 030220 oncology & carcinogenesis, Molecular Medicine, medicine.symptom, medicine.drug, Human, Protein Kinase Inhibitor, Article, Balanol, lcsh:QD241-441, Small Molecule Libraries, 03 medical and health sciences, Structure-Activity Relationship, Small Molecule Librarie, lcsh:Organic chemistry, medicine, Animals, Humans, drug screening, structure, Physical and Theoretical Chemistry, Protein Kinase Inhibitors, 030304 developmental biology, Kinetic, G protein-coupled receptor kinase, Animal, amlexanox, Beta adrenergic receptor kinase, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, differential scanning fluorometry, High-Throughput Screening Assays, Rats, Kinetics, Aminopyridine, Mechanism of action, chemistry, Animals, Newborn, biology.protein, Rat, Cattle
وصف الملف: application/pdf
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