المؤلفون: Inoue A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Gastroenterological Surgery, Osaka General Medical Center, Osaka, Japan. Electronic address: inoue_akira@gh.opho.jp., Robinson FS; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Minelli R; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Tomihara H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rizi BS; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Rose JL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kodama T; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Osaka University, Osaka, Japan., Srinivasan S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Harris AL; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Zuniga AM; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Mullinax RA; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Ma X; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Seth S; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Daniele JR; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Peoples MD; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Loponte S; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Akdemir KC; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Khor TO; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Feng N; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Roszik J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Sobieski MM; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Brunell D; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Stephan C; Center for Translational Cancer Research, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas., Giuliani V; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deem AK; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Shingu T; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Deribe YL; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Menter DG; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Heffernan TP; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Viale A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Bristow CA; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas., Kopetz S; Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Draetta GF; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas., Genovese G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: ggenovese@mdanderson.org., Carugo A; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas; Translational Research to Advance Therapeutics and Innovation in Oncology (TRACTION) platform, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: acarugo@mdanderson.org.

المصدر: Gastroenterology [Gastroenterology] 2021 Jul; Vol. 161 (1), pp. 196-210. Date of Electronic Publication: 2021 Mar 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: W.B. Saunders Country of Publication: United States NLM ID: 0374630 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-0012 (Electronic) Linking ISSN: 00165085 NLM ISO Abbreviation: Gastroenterology Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Antineoplastic Combined Chemotherapy Protocols/*administration & dosage , Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors , Biomarkers, Tumor/*genetics , Colorectal Neoplasms/*drug therapy , Karyopherins/*antagonists & inhibitors , Protein Kinase Inhibitors/*administration & dosage , Receptors, Cytoplasmic and Nuclear/*antagonists & inhibitors , Tumor Suppressor Protein p53/*genetics, Animals ; Ataxia Telangiectasia Mutated Proteins/metabolism ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Databases, Genetic ; HCT116 Cells ; HT29 Cells ; Humans ; Indoles/administration & dosage ; Karyopherins/metabolism ; Mice ; Morpholines/administration & dosage ; Piperazines/administration & dosage ; Pyridines/administration & dosage ; Pyrimidines/administration & dosage ; Receptors, Cytoplasmic and Nuclear/metabolism ; Sulfonamides/administration & dosage ; Xenograft Model Antitumor Assays ; Exportin 1 Protein

المؤلفون: Ding Z; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E

المصدر: Journal of biomolecular screening [J Biomol Screen] 2012 Jun; Vol. 17 (5), pp. 572-80. Date of Electronic Publication: 2012 Feb 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*/methods , High-Throughput Screening Assays*, Von Hippel-Lindau Tumor Suppressor Protein/*metabolism, Cell Line ; Cysteine Proteinase Inhibitors/pharmacology ; Humans ; Leupeptins/pharmacology ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Proteasome Endopeptidase Complex/metabolism ; Proteasome Inhibitors ; Protein Stability/drug effects ; Reproducibility of Results ; Small Molecule Libraries/pharmacology ; Von Hippel-Lindau Tumor Suppressor Protein/genetics