المؤلفون: Edwige Lorthiois, Marc Gerspacher, Kim S. Beyer, Andrea Vaupel, Catherine Leblanc, Rowan Stringer, Andreas Weiss, Rainer Wilcken, Daniel A. Guthy, Andreas Lingel, Claudio Bomio-Confaglia, Rainer Machauer, Pascal Rigollier, Johannes Ottl, Dorothee Arz, Pascal Bernet, Gaëlle Desjonqueres, Solene Dussauge, Malika Kazic-Legueux, Marie-Anne Lozac’h, Christophe Mura, Mickaël Sorge, Milen Todorov, Nicolas Warin, Florence Zink, Hans Voshol, Frederic J. Zecri, Richard C. Sedrani, Nils Ostermann, Saskia M. Brachmann, Simona Cotesta

المصدر: Journal of Medicinal Chemistry. 65:16173-16203

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ad7ccf3634960d3fbc0cb2fa59a10551
https://doi.org/10.1021/acs.jmedchem.2c01438

المؤلفون: Erika Tassano, Charles Moore, Solene Dussauge, Alexandra Vargas, Radka Snajdrova

المصدر: Organic Process Research & Development. 26:1996-2003

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::33e06f518c788f2bb5b3114c040a6043
https://doi.org/10.1021/acs.oprd.1c00405

المؤلفون: Edwige, Lorthiois, Marc, Gerspacher, Kim S, Beyer, Andrea, Vaupel, Catherine, Leblanc, Rowan, Stringer, Andreas, Weiss, Rainer, Wilcken, Daniel A, Guthy, Andreas, Lingel, Claudio, Bomio-Confaglia, Rainer, Machauer, Pascal, Rigollier, Johannes, Ottl, Dorothee, Arz, Pascal, Bernet, Gaëlle, Desjonqueres, Solene, Dussauge, Malika, Kazic-Legueux, Marie-Anne, Lozac'h, Christophe, Mura, Mickaël, Sorge, Milen, Todorov, Nicolas, Warin, Florence, Zink, Hans, Voshol, Frederic J, Zecri, Richard C, Sedrani, Nils, Ostermann, Saskia M, Brachmann, Simona, Cotesta

المصدر: Journal of medicinal chemistry.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::f23204123ca46f243137471f372b4f1d
https://pubmed.ncbi.nlm.nih.gov/36399068

المؤلفون: Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein

المصدر: Journal of medicinal chemistry. 63(15)

مصطلحات موضوعية: Drug, Male, Proteases, Peptidomimetic, medicine.medical_treatment, media_common.quotation_subject, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Pharmacology, 01 natural sciences, Factor XIa, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Structure-Activity Relationship, Dogs, Complement Factor D, Drug Discovery, medicine, Animals, Humans, Amino Acid Sequence, 030304 developmental biology, ADME, media_common, Serine protease, 0303 health sciences, Protease, biology, Chemistry, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Coagulation, biology.protein, Molecular Medicine, Factor Xa Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603

المؤلفون: Stefanie Flohr, Simon Rüdisser, Anna Vulpetti, Andrea De Erkenez, Stefan Steinbacher, Olivier Rogel, Laurence Kieffer, Solene Dussauge, Louis Yang, Frederic Cumin, Karen Anderson, Aengus Mac Sweeney, Edwige Lorthiois, Nils Ostermann, Ronald Newton, Viral Kansara, Sha-Mei Liao, Ulrich Hommel, Constanze Hartwieg, Upendra A. Argikar, Stefan Andreas Randl, Laura R. La Bonte, Omar Delgado, Kamal Fettis, Jürgen Maibaum, Bruce D Jaffee

المصدر: Journal of Medicinal Chemistry. 60:5717-5735

مصطلحات موضوعية: Male, 0301 basic medicine, Proline, Complement Pathway, Alternative, Administration, Oral, Complement Membrane Attack Complex, Pharmacology, Macular Degeneration, Mice, 03 medical and health sciences, In vivo, Drug Discovery, Atypical hemolytic uremic syndrome, medicine, Animals, Humans, Atypical Hemolytic Uremic Syndrome, biology, Chemistry, Haplorhini, medicine.disease, Complement system, Macaca fascicularis, 030104 developmental biology, Biochemistry, biology.protein, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, Molecular Medicine, Complement Factor D, Female, Factor D, Complement membrane attack complex, Ex vivo

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242e3d44a96036addb2cb8f7ea9cefc
https://doi.org/10.1021/acs.jmedchem.7b00425

المؤلفون: Frederic Cumin, Bernd Kinzel, Anna Vulpetti, Antonio M. Risitano, Richard A. Harrison, Kamal Fettis, Aengus Mac Sweeney, Stefan Andreas Randl, Edwige Lorthiois, Fabrice A. Kolb, Nils Ostermann, Solene Dussauge, Corinne Durand, Nicola Hughes, Bernd Gerhartz, Karen Anderson, Samuel Barbieri, Paul Erbel, Omar Delgado, Jörg Eder, Ulrich Hommel, Stefanie Flohr, Simon Rüdisser, Anna Schubart, Ty Gould, Bruce D Jaffee, Jürgen Maibaum, Julia Wagner, Sha-Mei Liao

المساهمون: Maibaum, Jürgen, Liao, Sha Mei, Vulpetti, Anna, Ostermann, Nil, Randl, Stefan, Rüdisser, Simon, Lorthiois, Edwige, Erbel, Paul, Kinzel, Bernd, Kolb, Fabrice A, Barbieri, Samuel, Wagner, Julia, Durand, Corinne, Fettis, Kamal, Dussauge, Solene, Hughes, Nicola, Delgado, Omar, Hommel, Ulrich, Gould, Ty, Sweeney, Aengus Mac, Gerhartz, Bernd, Cumin, Frederic, Flohr, Stefanie, Schubart, Anna, Jaffee, Bruce, Harrison, Richard, Risitano, ANTONIO MARIA, Eder, Jörg, Anderson, Karen

المصدر: Nature chemical biology. 12(12)

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Models, Molecular, medicine.medical_treatment, Complement Pathway, Alternative, Biology, Small Molecule Libraries, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Protease, Innate immune system, Complement component 3, Dose-Response Relationship, Drug, Molecular Structure, Cell Biology, medicine.disease, Small molecule, Complement system, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, 030220 oncology & carcinogenesis, Alternative complement pathway, Paroxysmal nocturnal hemoglobinuria, biology.protein, Factor D, Complement Factor D

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2c3a47759beca17b7b3f2b775e9551
https://pubmed.ncbi.nlm.nih.gov/27857140