المؤلفون: Hernandez-Benitez R; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Altos Labs, Inc., San Diego, CA 92121, USA., Wang C; Altos Labs, Inc., San Diego, CA 92121, USA., Shi L; Key Laboratory of Genetic Evolution & Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China., Ouchi Y; Altos Labs, Inc., San Diego, CA 92121, USA; Department of Regenerative Medicine, Chiba University Graduate School of Medicine, Chiba, Japan., Zhong C; Altos Labs, Inc., San Diego, CA 92121, USA., Hishida T; Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Wakayama Medical University, 25-1 Shichibancho, Wakayama 640-8156, Japan., Liao HK; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Magill EA; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Memczak S; Altos Labs, Inc., San Diego, CA 92121, USA., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Fresia C; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA., Hatanaka F; Altos Labs, Inc., San Diego, CA 92121, USA., Lamas V; Altos Labs, Inc., San Diego, CA 92121, USA., Guillen I; Altos Labs, Inc., San Diego, CA 92121, USA., Sahu S; Altos Labs, Inc., San Diego, CA 92121, USA., Yamamoto M; Altos Labs, Inc., San Diego, CA 92121, USA., Shao Y; Altos Labs, Inc., San Diego, CA 92121, USA., Aguirre-Vazquez A; Altos Labs, Inc., San Diego, CA 92121, USA., Nuñez Delicado E; Universidad Católica San Antonio de Murcia (UCAM), Campus de los Jerónimos, Nº 135 12, 30107 Guadalupe, Spain., Guillen P; Clinica CEMTRO, 28035 Madrid, Spain., Rodriguez Esteban C; Altos Labs, Inc., San Diego, CA 92121, USA., Qu J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China., Reddy P; Altos Labs, Inc., San Diego, CA 92121, USA., Horvath S; Altos Labs, Inc., San Diego, CA 92121, USA., Liu GH; Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China; State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Magistretti P; King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia. Electronic address: pierre.magistretti@kaust.edu.sa., Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Altos Labs, Inc., San Diego, CA 92121, USA. Electronic address: jcbelmonte@altoslabs.com.

المصدر: Cell reports. Medicine [Cell Rep Med] 2024 Mar 19; Vol. 5 (3), pp. 101449.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

مواضيع طبية MeSH: Myoblasts*/metabolism , Muscles*, Mice ; Animals ; Cell Differentiation

المؤلفون: Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. ksuzuki@chem.es.osaka-u.ac.jp.; Institute for Advanced Co-Creation Studies, Osaka University, Osaka, 560-8531, Japan. ksuzuki@chem.es.osaka-u.ac.jp.; Graduate School of Engineering Science, Osaka University, Osaka, 560-8531, Japan. ksuzuki@chem.es.osaka-u.ac.jp., Yamamoto M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Hernandez-Benitez R; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Li Z; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, CA, 92093-0412, USA., Wei C; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, CA, 92093-0412, USA., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Universidad Catolica, San Antonio de Murcia, Campus de los Jeronimos, 135, Guadalupe, 30107, Spain., Aizawa E; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Graduate School of Engineering Science, Osaka University, Osaka, 560-8531, Japan., Hatanaka F; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Kurita M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Universidad Catolica, San Antonio de Murcia, Campus de los Jeronimos, 135, Guadalupe, 30107, Spain., Reddy P; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Ocampo A; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Hishida T; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Sakurai M; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA.; Universidad Catolica, San Antonio de Murcia, Campus de los Jeronimos, 135, Guadalupe, 30107, Spain., Nemeth AN; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Nuñez Delicado E; Universidad Catolica, San Antonio de Murcia, Campus de los Jeronimos, 135, Guadalupe, 30107, Spain., Campistol JM; Hospital Clinic of Barcelona, Carrer Villarroel, 170, 08036, Barcelona, Spain., Magistretti P; King Abdullah University of Science and Technology (KAUST), Thuwal, 23955-6900, Saudi Arabia., Guillen P; Fundacion Dr. Pedro Guillen, Clinica CEMTRO, Avenida Ventisquero de la Condesa, 4228035, Madrid, Spain., Rodriguez Esteban C; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA., Gong J; BGI-Shenzhen, Shenzhen, 518083, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, 518120, China.; Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Guangdong, China.; Shenzhen Engineering Laboratory for Innovative Molecular Diagnostics, Shenzhen, 518120, China., Yuan Y; BGI-Shenzhen, Shenzhen, 518083, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, 518120, China.; Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Guangdong, China., Gu Y; BGI-Shenzhen, Shenzhen, 518083, China.; Guangdong Provincial Key Laboratory of Genome Read and Write, Shenzhen, 518120, China.; Guangdong Provincial Academician Workstation of BGI Synthetic Genomics, BGI-Shenzhen, Guangdong, China., Liu GH; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China., López-Otín C; Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain., Wu J; Universidad Catolica, San Antonio de Murcia, Campus de los Jeronimos, 135, Guadalupe, 30107, Spain.; Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Zhang K; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, CA, 92093-0412, USA., Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, 92037, USA. belmonte@salk.edu.

المصدر: Cell research [Cell Res] 2019 Oct; Vol. 29 (10), pp. 804-819. Date of Electronic Publication: 2019 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9425763 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-7838 (Electronic) Linking ISSN: 10010602 NLM ISO Abbreviation: Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Gene Editing/*methods, Animals ; CRISPR-Cas Systems/genetics ; DNA Repair ; Dependovirus/genetics ; GATA3 Transcription Factor/genetics ; Gene Knock-In Techniques ; Genetic Therapy/methods ; Genetic Vectors/metabolism ; Human Embryonic Stem Cells ; Humans ; Introns ; Mice ; Mice, Inbred C57BL ; Mice, Inbred ICR ; Neurons/cytology ; Neurons/metabolism ; Rats ; Tubulin/genetics

المؤلفون: Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Tsunekawa Y; Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan., Hernandez-Benitez R; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA.; 4700 King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900, Saudi Arabia., Wu J; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA.; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe 30107, Murcia, Spain., Zhu J; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.; Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, California 92023, USA., Kim EJ; Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, California 92037, USA., Hatanaka F; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Yamamoto M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Araoka T; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA.; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe 30107, Murcia, Spain., Li Z; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, California 92093-0412, USA., Kurita M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Hishida T; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Li M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Aizawa E; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Guo S; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, California 92093-0412, USA., Chen S; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, California 92093-0412, USA., Goebl A; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Qu J; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Jiang T; Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, California 92023, USA.; Guangzhou EliteHealth Biological Pharmaceutical Technology Company Ltd, Guangzhou 510005, China., Fu X; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.; Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, California 92023, USA., Jafari M; Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, California 92023, USA., Esteban CR; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Berggren WT; Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA., Lajara J; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe 30107, Murcia, Spain., Nuñez-Delicado E; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe 30107, Murcia, Spain., Guillen P; Universidad Católica San Antonio de Murcia (UCAM) Campus de los Jerónimos, no. 135 Guadalupe 30107, Murcia, Spain.; Fundación Dr. Pedro Guillen, Investigación Biomedica de Clinica CEMTRO, Avenida Ventisquero de la Condesa, 42, 28035 Madrid, Spain., Campistol JM; Hospital Clinic, University of Barcelona, IDIBAPS, 08036 Barcelona, Spain., Matsuzaki F; Laboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, 2-2-3 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan., Liu GH; University of Chinese Academy of Sciences, Beijing 100049, China.; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou 510632, China.; Beijing Institute for Brain Disorders, Beijing 100069, China., Magistretti P; 4700 King Abdullah University of Science and Technology (KAUST) Thuwal 23955-6900, Saudi Arabia., Zhang K; Bioengineering, University of California, San Diego, 9500 Gilman Drive, MC0412, La Jolla, California 92093-0412, USA., Callaway EM; Systems Neurobiology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd., La Jolla, California 92037, USA., Zhang K; Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, China.; Shiley Eye Institute, Institute for Genomic Medicine, Institute of Engineering in Medicine, University of California, San Diego, 9500 Gilman Drive #0946, La Jolla, California 92023, USA.; Molecular Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China.; Veterans Administration Healthcare System, San Diego, California 92093, USA., Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Rd, La Jolla, California 92037, USA.

المصدر: Nature [Nature] 2016 Dec 01; Vol. 540 (7631), pp. 144-149. Date of Electronic Publication: 2016 Nov 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems/*genetics , Gene Editing/*methods , Gene Targeting/*methods , Genome/*genetics , Retinitis Pigmentosa/*genetics , Retinitis Pigmentosa/*therapy, Animals ; Cell Division ; Disease Models, Animal ; Gene Knock-In Techniques ; Genetic Therapy/methods ; Neurons/cytology ; Neurons/metabolism ; Rats ; Sequence Homology

المؤلفون: Zhang W; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li J; Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China., Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Qu J; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Wang P; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Zhou J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Liu X; Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China., Ren R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Xu X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Ocampo A; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Yuan T; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Yang J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li Y; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Shi L; Diagnosis and Treatment Center for Oral Disease, the 306th Hospital of the PLA, Beijing, China., Guan D; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Pan H; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Duan S; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Ding Z; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Yi F; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA., Bai R; State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China., Wang Y; Diagnosis and Treatment Center for Oral Disease, the 306th Hospital of the PLA, Beijing, China., Chen C; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Yang F; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li X; College of Life Sciences, Peking University, Beijing 100871, China., Wang Z; The Center for Anti-aging and Regenerative Medicine, Shenzhen University, Shenzhen 518060, China., Aizawa E; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Goebl A; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Universidad Católica San Antonio de Murcia, Campus de los Jerónimos s/n, 30107 Guadalupe, Murcia, Spain., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Reddy P; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Esteban CR; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Tang F; Biodynamic Optical Imaging Center, College of Life Sciences, Peking University, Beijing 100871, China. Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing 100871, China. Center for Molecular and Translational Medicine (CMTM), Beijing 100101, China. Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China. ghliu@ibp.ac.cn tangfuchou@pku.edu.cn belmonte@salk.edu., Liu GH; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. The Center for Anti-aging and Regenerative Medicine, Shenzhen University, Shenzhen 518060, China. Center for Molecular and Translational Medicine (CMTM), Beijing 100101, China. Beijing Institute for Brain Disorders, Beijing 100069, China. ghliu@ibp.ac.cn tangfuchou@pku.edu.cn belmonte@salk.edu., Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. ghliu@ibp.ac.cn tangfuchou@pku.edu.cn belmonte@salk.edu.

المصدر: Science (New York, N.Y.) [Science] 2015 Jun 05; Vol. 348 (6239), pp. 1160-3. Date of Electronic Publication: 2015 Apr 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Cellular Senescence*, Aging/*metabolism , Exodeoxyribonucleases/*metabolism , Heterochromatin/*metabolism , Mesenchymal Stem Cells/*metabolism , RecQ Helicases/*metabolism , Werner Syndrome/*metabolism, Aging/genetics ; Animals ; Cell Differentiation ; Centromere/metabolism ; Chromobox Protein Homolog 5 ; Chromosomal Proteins, Non-Histone/metabolism ; DNA-Binding Proteins/metabolism ; Epigenesis, Genetic ; Exodeoxyribonucleases/genetics ; Gene Knockout Techniques ; HEK293 Cells ; Heterochromatin/chemistry ; Humans ; Membrane Proteins/metabolism ; Methyltransferases/genetics ; Methyltransferases/metabolism ; Mice ; Models, Biological ; RecQ Helicases/genetics ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Werner Syndrome/genetics ; Werner Syndrome Helicase

المؤلفون: Liu GH; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.; Beijing Institute for Brain Disorders, Beijing 100069, China., Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Li M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Qu J; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.; Key Laboratory of Non-coding RNA, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Montserrat N; Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain., Tarantino C; Center for Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003 Barcelona, Spain., Gu Y; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Yi F; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Xu X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Zhang W; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Ruiz S; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Plongthongkum N; Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA., Zhang K; Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA., Masuda S; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Nivet E; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Tsunekawa Y; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Goebl A; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Aizawa E; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Kim NY; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Kim J; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Dubova I; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Li Y; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Ren R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Benner C; Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Del Sol A; Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, L-1511, Luxembourg, Luxembourg., Bueren J; Hematopoiesis and Gene Therapy Division. Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT)/Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Madrid 28040, Spain.; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBER-ER), Madrid 28040, Spain.; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD, UAM), Madrid 28040, Spain., Trujillo JP; Department of Genetics and Microbiology and Center for Biomedical Network Research on Rare Diseases (CIBERER), Universitat Autonoma de Barcelona, Campus de Bellaterra s/n 08193 Bellaterra, Spain., Surralles J; Department of Genetics and Microbiology and Center for Biomedical Network Research on Rare Diseases (CIBERER), Universitat Autonoma de Barcelona, Campus de Bellaterra s/n 08193 Bellaterra, Spain., Cappelli E; G. Gaslini Children's Hospital, Largo G. Gaslini 5, 16147 Genova Quarto, Italy., Dufour C; G. Gaslini Children's Hospital, Largo G. Gaslini 5, 16147 Genova Quarto, Italy., Esteban CR; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA., Belmonte JCI; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.

المصدر: Nature communications [Nat Commun] 2014 Jul 07; Vol. 5, pp. 4330. Date of Electronic Publication: 2014 Jul 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Validation Study

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Models, Biological*, Drug Evaluation, Preclinical/*methods , Fanconi Anemia/*etiology , Fanconi Anemia/*pathology , Stem Cells/*pathology, Cell Differentiation ; Epigenesis, Genetic ; Fanconi Anemia/drug therapy ; Fanconi Anemia Complementation Group A Protein/genetics ; Humans ; Induced Pluripotent Stem Cells ; Male ; Young Adult

المؤلفون: Suzuki K; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Yu C; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China., Qu J; Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Li M; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Yao X; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China., Yuan T; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Goebl A; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Tang S; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China; Institute of Digestive Disease and the Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong., Ren R; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Aizawa E; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Zhang F; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China; Department of Computational Medicine and Bioinformatics, Medical School, University of Michigan, 500 South State Street, Ann Arbor, MI 48109, USA., Xu X; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China., Soligalla RD; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Chen F; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China., Kim J; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Kim NY; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Liao HK; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Benner C; Integrative Genomics and Bioinformatics Core, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Esteban CR; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Jin Y; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China., Liu GH; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Center for Age-related Diseases (CAD), Beijing, China; Beijing Institute for Brain Disorders, Beijing 100069, China. Electronic address: ghliu@ibp.ac.cn., Li Y; BGI, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China. Electronic address: liyr@genomics.cn., Izpisua Belmonte JC; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: belmonte@salk.edu.

المصدر: Cell stem cell [Cell Stem Cell] 2014 Jul 03; Vol. 15 (1), pp. 31-6.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Therapy*, Adenoviridae/*genetics , Endonucleases/*metabolism , Genetic Vectors/*metabolism , Induced Pluripotent Stem Cells/*physiology, CRISPR-Cas Systems/genetics ; Clone Cells ; DNA Repair/genetics ; Endonucleases/genetics ; Genetic Vectors/genetics ; Genome/genetics ; HEK293 Cells ; Humans ; Mutation/genetics ; Regenerative Medicine ; Sequence Analysis, DNA

المؤلفون: Liu GH; National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ghliu@ibp.ac.cn, Qu J, Suzuki K, Nivet E, Li M, Montserrat N, Yi F, Xu X, Ruiz S, Zhang W, Wagner U, Kim A, Ren B, Li Y, Goebl A, Kim J, Soligalla RD, Dubova I, Thompson J, Yates J 3rd, Esteban CR, Sancho-Martinez I, Izpisua Belmonte JC

المصدر: Nature [Nature] 2012 Nov 22; Vol. 491 (7425), pp. 603-7. Date of Electronic Publication: 2012 Oct 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Mutant Proteins/*metabolism , Neural Stem Cells/*pathology , Parkinson Disease/*pathology , Protein Serine-Threonine Kinases/*genetics , Protein Serine-Threonine Kinases/*metabolism, Apoptosis ; Cell Differentiation ; Cell Division ; Cell Line ; Clone Cells/metabolism ; Clone Cells/pathology ; Embryonic Stem Cells/metabolism ; Embryonic Stem Cells/pathology ; Gene Knock-In Techniques ; Humans ; Induced Pluripotent Stem Cells/metabolism ; Induced Pluripotent Stem Cells/pathology ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 ; Mutant Proteins/genetics ; Mutation ; Neural Stem Cells/metabolism ; Nuclear Envelope/genetics ; Nuclear Envelope/pathology ; Proteasome Endopeptidase Complex/metabolism ; Stress, Physiological

المؤلفون: Liu GH; Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Suzuki K, Qu J, Sancho-Martinez I, Yi F, Li M, Kumar S, Nivet E, Kim J, Soligalla RD, Dubova I, Goebl A, Plongthongkum N, Fung HL, Zhang K, Loring JF, Laurent LC, Izpisua Belmonte JC

المصدر: Cell stem cell [Cell Stem Cell] 2011 Jun 03; Vol. 8 (6), pp. 688-94. Date of Electronic Publication: 2011 May 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101311472 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1875-9777 (Electronic) Linking ISSN: 18759777 NLM ISO Abbreviation: Cell Stem Cell Subsets: MEDLINE

مواضيع طبية MeSH: Mutation*, Induced Pluripotent Stem Cells/*metabolism , Lamin Type A/*genetics, Cell Line ; Genotype ; Humans ; Induced Pluripotent Stem Cells/pathology