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1دورية أكاديمية
المؤلفون: Fernando A. Batista, Soraya S. Bosch, Sabine Butzloff, Sergey Lunev, Kamila A. Meissner, Marleen Linzke, Atilio R. Romero, Chao Wang, Ingrid B. Müller, Alexander S. S. Dömling, Matthew R. Groves, Carsten Wrenger
المصدر: MicrobiologyOpen, Vol 8, Iss 7, Pp n/a-n/a (2019)
مصطلحات موضوعية: drug target validation, oligomeric state, phenotypic mapping, Plasmodium falciparum, structural biology, Microbiology, QR1-502
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-8827
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المؤلفون: Soraya S Bosch, Fernando de Assis Batista, Alexander Dömling, Sergey Lunev, Thales Kronenberger, Matthew Groves, Marleen Linzke, Carsten Wrenger
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: ACS Infectious Diseases, 6(5), 986-999. TAYLOR & FRANCIS LTD
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USPمصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, biology, ANIMAIS PARASITOS, Transgene, 030106 microbiology, Mutant, Plasmodium falciparum, biology.organism_classification, In vitro, 3. Good health, 03 medical and health sciences, Aspartate carbamoyltransferase, 030104 developmental biology, Infectious Diseases, Enzyme, chemistry, Biochemistry, Cell culture, Pyrimidine metabolism
وصف الملف: application/vnd.openxmlformats-officedocument.wordprocessingml.document
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المؤلفون: Juliana F Vilacha, Fernando de Assis Batista, Carsten Wrenger, Sergey Lunev, Soraya S Bosch, Benjamin Gyau, Matthew Groves
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USPمصطلحات موضوعية: BLOOD STAGES, Plasmodium, PLASMODIUM-VIVAX DHFR, Computer science, Population, Drug target, Druggability, Aspartate metabolism, Computational biology, Validation Studies as Topic, LEAD OPTIMIZATION, TRANSGENE EXPRESSION, Antimalarials, 03 medical and health sciences, 0302 clinical medicine, Drug Development, MALARIA PARASITES, Drug Discovery, medicine, Animals, Humans, education, PIPERAQUINE RESISTANCE, NEGATIVE SELECTION, GENE-EXPRESSION, 030304 developmental biology, 0303 health sciences, education.field_of_study, Drug discovery, Protein oligomerisation, DRUG TARGET, POLIPEPTÍDEOS, medicine.disease, Malaria, Drug development, phenotypic mapping, FALCIPARUM DIHYDROOROTATE DEHYDROGENASE, Proof of concept, 030220 oncology & carcinogenesis, drug target validation
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa441dc06eb1da8d3efd735dafa160e
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المؤلفون: Alexander Dömling, Fernando de Assis Batista, Matthew Groves, George Chamoun, Carsten Wrenger, Soraya S Bosch, Chao Wang, Paul D Kruithof, Jingyao Li, Sergey Lunev, Marleen Linzke
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Biochemical and Biophysical Research Communications, 497(3), 835-842. ACADEMIC PRESS INC ELSEVIER SCIENCE
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USPمصطلحات موضوعية: 0301 basic medicine, Plasmodium falciparum, Allosteric regulation, Biophysics, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Non-competitive inhibition, Catalytic Domain, Drug Discovery, Aspartate Carbamoyltransferase, Journal Article, Humans, Enzyme Inhibitors, Malaria, Falciparum, MALÁRIA, Molecular Biology, Antiparasitic Agents, 030102 biochemistry & molecular biology, biology, Drug discovery, Chemistry, Active site, Cell Biology, biology.organism_classification, Antiparasitic agent, Molecular Docking Simulation, Aspartate carbamoyltransferase, 030104 developmental biology, Pyrimidine metabolism, biology.protein
وصف الملف: application/pdf
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المؤلفون: Atilio Reyes Romero, Carsten Wrenger, Sergey Lunev, Chao Wang, Marleen Linzke, Soraya S Bosch, Sabine Butzloff, Kamila Anna Meissner, Alexander Dömling, Fernando de Assis Batista, Matthew Groves, Ingrid B. Müller
المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: MicrobiologyOpen
MicrobiologyOpen, 8(7):e779. Wiley
MicrobiologyOpen, Vol 8, Iss 7, Pp n/a-n/a (2019)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USPمصطلحات موضوعية: AMINOTRANSFERASE, Plasmodium falciparum, Mutant, lcsh:QR1-502, Druggability, PURINE, Computational biology, Biology, METABOLISM, Microbiology, lcsh:Microbiology, MECHANISMS, 03 medical and health sciences, 0302 clinical medicine, In vivo, structural biology, Gene, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, oligomeric state, Original Articles, ANTIMALÁRICOS, biology.organism_classification, GENE, 3. Good health, Enzyme, chemistry, Structural biology, phenotypic mapping, Original Article, drug target validation, 030217 neurology & neurosurgery, Function (biology), INTERFACES
وصف الملف: application/pdf
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المساهمون: Drug Design, Medicinal Chemistry and Bioanalysis (MCB)
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Acta Crystallographica Section F: Structural Biology Communications, 72(7), 523-533. INT UNION CRYSTALLOGRAPHYمصطلحات موضوعية: Models, Molecular, 0301 basic medicine, endocrine system diseases, MUTAGÊNESE, Protozoan Proteins, Gene Expression, Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Substrate Specificity, Research Communications, chemistry.chemical_compound, Structural Biology, Catalytic Domain, Carbamoyl phosphate, Aspartate Carbamoyltransferase, Transferase, Cloning, Molecular, biology, Condensed Matter Physics, Recombinant Proteins, Aspartate carbamoyltransferase, Pyrimidine metabolism, hormones, hormone substitutes, and hormone antagonists, Plasmids, Protein Binding, Carbamyl Phosphate, Stereochemistry, Plasmodium falciparum, Biophysics, 03 medical and health sciences, parasitic diseases, Escherichia coli, Genetics, Protein Interaction Domains and Motifs, Amino Acid Sequence, Aspartic Acid, Binding Sites, Sequence Homology, Amino Acid, 030102 biochemistry & molecular biology, Mutagenesis, nutritional and metabolic diseases, Active site, biology.organism_classification, Kinetics, 030104 developmental biology, chemistry, Mutation, biology.protein, Dihydroorotate dehydrogenase, Protein Multimerization, Sequence Alignment
وصف الملف: application/pdf
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المؤلفون: Isolmar T. Schettert, Soraya S Bosch, Carsten Wrenger, Dirk Stegehake, Flávia Menezes Zimbres, Natália M. Izui, Eva Liebau, Kamila Anna Meissner, Thales Kronenberger
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
BioMed Research International, Vol 2015 (2015)
BioMed Research Internationalمصطلحات موضوعية: medicine.medical_specialty, Babesia, Cryptosporidium, lcsh:Medicine, Review Article, medicine.disease_cause, General Biochemistry, Genetics and Molecular Biology, Host-Parasite Interactions, Babesiosis, medicine, Animals, Humans, General Immunology and Microbiology, biology, ESTRESSE OXIDATIVO, business.industry, Coccidiosis, Public health, fungi, lcsh:R, General Medicine, biology.organism_classification, medicine.disease, Virology, Toxoplasmosis, Oxidative Stress, Immunology, business, Toxoplasma, Oxidative stress
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae060f1184b0d1436f175c46382ff317
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