نتائج البحث - "Soren K. Thomsen"

1

A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk

المؤلفون: Daniel Ebner, Romina J. Bevacqua, Agata Wesolowska-Andersen, Sameena Nawaz, Anna L. Gloyn, Seokho Kim, Baronio R, Elena Navarro-Guerrero, Rajesh, Antje Grotz, Soren K. Thomsen

مصطلحات موضوعية: Effector, CRISPR, Genome-wide association study, Computational biology, Biology, Gene, Genome, Phenotype, Function (biology), Genetic association

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::50361baae7089b419cb765f677471d1d
https://doi.org/10.1101/2021.05.28.445984

2

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

المصدر: Nature genetics.

مصطلحات موضوعية: Genetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a07fe363cc8affb6271b941a65af3d70
https://pubmed.ncbi.nlm.nih.gov/36543916

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3

Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation

المؤلفون: Wieland Kiess, Josée Dupuis, Yingchang Lu, Yii-Der Ida Chen, Sara M. Willems, George Dedoussis, Frida Renström, Carolina Medina-Gomez, Tamara B. Harris, Cramer Christensen, Audrey Y. Chu, Nicola L. Beer, Emil V. R. Appel, Niels Grarup, Fredrik Karpe, Mark I. McCarthy, Yuning Chen, Veikko Salomaa, Sylvain Sebert, Richard A. Jensen, Joel N. Hirschhorn, Lars Lind, Jocelyn E. Manning Fox, Caroline Hayward, Patrick E. MacDonald, Matti Uusitupa, Stavroula Kanoni, Carola Marzi, Kenneth Rice, Leslie A. Lange, Ken Sin Lo, Jennifer L. Asimit, Nisa M. Maruthur, Leonard Lipovich, James S. Floyd, Rona J. Strawbridge, Magdalena Zoledziewska, Anne Raimondo, Robert Sladek, Alexandra I. F. Blakemore, Hugoline G. de Haan, Danish Saleheen, Ji Chen, Neil Robertson, Ching-Yu Cheng, Heiner Boeing, Min A. Jhun, Marjo-Riitta Järvelin, Anubha Mahajan, Rainer Rauramaa, Satu Männistö, Paul M. Ridker, Ivan Brandslund, Hester M. den Ruijter, Tien Yin Wong, Alison D. Murray, Jaakko Tuomilehto, Xueling Sim, Igor Rudan, Martijn van de Bunt, Jin Li, Marit E. Jørgensen, Marie-France Hivert, Archie Campbell, Salman M. Tajuddin, Pekka Jousilahti, Lawrence F. Bielak, Juan P. Fernandez, Eleanor Wheeler, Alan B. Zonderman, Anne Clark, Lori L. Bonnycastle, Kurt Lohman, Peter Kovacs, Jung-Jin Lee, Jennifer Wessel, Wesam A Alhejily, Gerard Pasterkamp, John M. Starr, Ping An, Matthias Blüher, Jian'an Luan, Hanieh Yeghootkar, Jakob Stokholm, Michael Roden, Blair H. Smith, Johanna Jakobsdottir, Franco Giulianini, Andrianos M. Yiorkas, Hidetoshi Kitajima, Michael A. Province, Aliki-Eleni Farmaki, Kerrin S. Small, Juha Saltevo, Robert A. Scott, Alena Stančáková, Gaëlle Marenne, Asif Rasheed, Ruth J. F. Loos, David J. Porteous, Cecilia M. Lindgren, Inês Barroso, Gail Davies, Anna L. Gloyn, Shuai Wang, Paul Redmond, Xiuqing Guo, Ele Ferrannini, Mariaelisa Graff, Cornelia M. van Duijn, Juha Auvinen, David R. Weir, Kay-Tee Kaw, Tarunveer S. Ahluwalia, Olov Rolandsson, Wei Zhao, Paul Elliott, Torben Hansen, Abbas Dehghan, Bram P. Prins, Michiel L. Bots, Alison Pattie, Jun Liu, Gonçalo R. Abecasis, Maria Karaleftheri, Claudia Langenberg, Jan-Håkan Jansson, Marja Vääräsmäki, James S. Pankow, Rebecca S. Fine, Jaana Lindström, Ozren Polasek, Vinicius Tragante, Soren K. Thomsen, Jana K. Rundle, Najaf Amin, Saima Afaq, Jennifer A. Smith, Anne U. Jackson, Eirini Marouli, Weihua Zhang, Tim D. Spector, Paul W. Franks, Serena Sanna, Mark J. Caulfield, Heikki A. Koistinen, Jaspal S. Kooner, Tea Skaaby, Francis S. Collins, Eva Rabing Brix Petersen, Arfan Ikram, Sander W. van der Laan, Johanna Kuusisto, Jette Bork-Jensen, Daniel I. Chasman, Michele K. Evans, Emmanouil Tsafantakis, A. I. Tarasov, Ian J. Deary, Hans Bisgaard, Dennis O. Mook-Kanamori, Helen R. Warren, Kent D. Taylor, Andrew D. Morris, Eleftheria Zeggini, Sharon L.R. Kardia, Emma Ahlqvist, Gert J. de Borst, Torben Jørgensen, Antonella Mulas, Man Li, Betina H. Thuesen, Yuan Shi, Timo A. Lakka, Jie Yao, Tapani Ebeling, Natasha H. J. Ng, Sai Chen, Leena Kinnunen, Antje Körner, Klaus Bønnelykke, Lorraine Southam, Anette P. Gjesing, Ilonca Vaartjes, Heather M. Highland, Göran Hallmans, Anke Tönjes, Markku Laakso, Lenore J. Launer, Josef Coresh, Oscar H. Franco, Yongmei Liu, Beverley Balkau, Leena Moilanen, Karl-Heinz Herzig, James G. Wilson, Jennifer A. Brody, Renée de Mutsert, Alisa K. Manning, Anne E. Justice, Matthias B. Schulze, Sandosh Padmanabhan, Jose C. Florez, Shuang Feng, Heather M. Stringham, Bruce M. Psaty, Erwin P. Bottinger, Hannu Puolijoki, Vilmundur Gudnason, Leif Groop, Nicholas J. Wareham, Karina Meidtner, Andrew P. Morris, Taulant Muka, Benoit Hastoy, Panos Deloukas, Pirjo Komulainen, Ayse Demirkan, Francesco Cucca, Stefan Gustafsson, Eric Boerwinkle, Patrik Rorsman, Mike A. Nalls, Erik Ingelsson, Colin N. A. Palmer, Allan Linneberg, Tiinamaija Tuomi, Dan E. Arking, Steve Franks, Jonathan Marten, Mark Walker, Ruifang Li-Gao, Kai Savonen, Michael Stumvoll, Andreas Fritsche, E-Shyong Tai, Mark O. Goodarzi, Matt J. Neville, Oluf Pedersen, Eero Kajantie, Ching-Ti Liu, Michael Boehnke, Aaron Leong, Patricia B. Munroe, Patricia A. Peyser, Jessica D. Faul, John C. Chambers, John Danesh, Sirkka Keinänen-Kiukaanniemi, Giorgio Pistis, Karen L. Mohlke, Folkert W. Asselbergs, James B. Meigs, Tibor V. Varga, Erica L. Kleinbrink, Andrew T. Hattersley, Nathan A. Bihlmeyer, Harald Grallert, Albert V. Smith, Konstantin Strauch, Jerome I. Rotter, Frits R. Rosendaal

المصدر: SSRN Electronic Journal.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785079dbcb50e1abe846740e443e2f2a
https://doi.org/10.2139/ssrn.3469835

4

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

المؤلفون: Maddalena Trombetta, Fernando Abaitua, Isabella Artner, Nicola L. Beer, Ulrika Krus, Reshma Ramracheya, Jesper Gromada, Jason Flannick, Philipp Kramer, Martijn van de Bunt, Mark I. McCarthy, Deepak Jain, Patrik Rorsman, Enzo Bonora, Rebecca Cheung, Julia Brosnan, Ioannis Spiliotis, Anu Suoranta, Pauline Chabosseau, Antje Grotz, Ann Marie Richard, Claes B. Wolheim, Ola Hansson, Riccardo C. Bonadonna, Anna L. Gloyn, Leif Groop, Om Prakash Dwivedi, Mikko Lehtovirta, Anthony Payne, Timo Otonkoski, Vikash Chandra, L Sarelin, Nicole A.J. Krentz, Sandra Kleiner, Benjamin Davies, Soren K. Thomsen, Benoit Hastoy, Guy A. Rutter, Tiinamaija Tuomi, Daniel Gomez, Benoite Champon, Jens O. Lagerstedt, Emma Ahlqvist, Aris Baras, Daniela Moralli, Rashmi B. Prasad, Andria Theodoulou

المصدر: Nature Genetics
Nature genetics

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, endocrine system, endocrine system diseases, Adolescent, Genotype, Induced Pluripotent Stem Cells, Type 2 diabetes, Zinc Transporter 8, Biology, Article, Aged, Diabetes Mellitus, Type 2, Female, Glucose, Humans, Islets of Langerhans, Middle Aged, Young Adult, Insulin Secretion, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Internal medicine, Diabetes Mellitus, Genetics, medicine, Glucose homeostasis, Allele, 11 Medical and Health Sciences, 030304 developmental biology, Proinsulin, 0303 health sciences, SLC30A8, Glucagon secretion, 06 Biological Sciences, medicine.disease, Endocrinology, biology.protein, Type 2, 030217 neurology & neurosurgery, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf3d7f6ed23ebde66f74d680abc44a6

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5

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic β-cells

المصدر: Nature Genetics

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, endocrine system diseases, medicine.medical_treatment, Genome-wide association study, Type 2 diabetes, Biology, Polymorphism, Single Nucleotide, Article, Cell Line, Mixed Function Oxygenases, Mice, 03 medical and health sciences, Insulin-Secreting Cells, Internal medicine, Diabetes mellitus, Insulin Secretion, parasitic diseases, Genetics, medicine, Animals, Humans, Insulin, Genetic Predisposition to Disease, Allele, Alleles, geography, geography.geographical_feature_category, HEK 293 cells, nutritional and metabolic diseases, medicine.disease, Islet, HEK293 Cells, 030104 developmental biology, Endocrinology, Diabetes Mellitus, Type 2, Cell culture, Amidine-Lyases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b615f2323fe2cadbea8c8cc5ba3c7977

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6

Keys to the kingdom

المؤلفون: Jernej Godec, Sophia X. Pfister, Laurynas Pliuskys, Aryaman Shalizi, Katie Richardson, Laura S. Sasportas, Madura K P Jayatunga, Charvi Shetty, Hila Bahar, Soren K. Thomsen, Daniel A Perez, Simcha Jong, Akhil Mehra, Erika Geihe Stanzl, Cecilia Chui, Brian R Gordon, Melina Mathur, Sybil C.K. Wong

المصدر: Bioentrepreneur. :1-5

مصطلحات موضوعية: Universities, Conflict of Interest, Biomedical Engineering, Legislation as Topic, Bioengineering, Guidelines as Topic, General Medicine, Applied Microbiology and Biotechnology, Genealogy, United Kingdom, United States, Kingdom, Technology Transfer, Financial Statements, Molecular Medicine, Sociology, Licensure, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e78f0732a27ba1a3f5031eb1e2d43efa
https://doi.org/10.1038/bioe.2015.2

7

Type 2 Diabetes Risk Alleles Reveal a Role for Peptidylglycine Alpha-amidating Monooxygenase in Beta Cell Function

المؤلفون: A Clark, Austin Bautista, Nicola L. Beer, Anne Raimondo, Amy Barrett, M Umapathysivam, J. E. Manning Fox, Anna L. Gloyn, P Rorsman, Christopher J. Groves, B Hastoy, Patrick E. MacDonald, Dai X-Q., Soren K. Thomsen

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c57e350a9913128a8f2ce5ad4e66ae

8

Prioritising Causal Genes at Type 2 Diabetes Risk Loci

المؤلفون: Antje Grotz, Anna L. Gloyn, Soren K. Thomsen

المصدر: Current Diabetes Reports

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013ce1a7962237b2698da83091f05805
http://europepmc.org/articles/PMC5534459

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9

Human genetics as a model for target validation: finding new therapies for diabetes

المؤلفون: Soren K. Thomsen, Anna L. Gloyn

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Genome-wide association study, Human genetic variation, Computational biology, Type 2 diabetes, Disease, Review, Bioinformatics, Genome-wide association studies, Target validation, 03 medical and health sciences, 0302 clinical medicine, Quality of life (healthcare), Monogenic diabetes, Diabetes mellitus, Internal Medicine, medicine, Animals, Humans, Therapeutic mechanisms, business.industry, Adverse effects, Precision medicine, Genetic Variation, Human Genetics, medicine.disease, Human genetics, 3. Good health, 030104 developmental biology, Diabetes Mellitus, Type 2, Target discovery, business, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e95f9460b54ad81940d5c5d2ef79f8
http://ora.ox.ac.uk/objects/uuid:

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10

The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes

المؤلفون: Mark I. McCarthy, Anna L. Gloyn, Soren K. Thomsen

المصدر: Frontiers in Endocrinology, Vol 7 (2016)
Frontiers in Endocrinology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3234587d089c362528549b5ef1f58af2
http://journal.frontiersin.org/Journal/10.3389/fendo.2016.00112/full

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