المؤلفون: Rees, MG, Seashore-Ludlow, B, Cheah, JH, Adams, DJ, Price, EV, Gill, S, Javaid, S, Coletti, ME, Jones, VL, Bodycombe, NE, Soule, CK, Alexander, B, Li, A, Montgomery, P, Kotz, JD, Hon, CSY, Munoz, B, Liefeld, T, Dancik, V, Haber, DA, Clish, CB, Bittker, JA, Palmer, M, Wagner, BK, Clemons, PA, Shamji, AF, Schreiber, SL

المصدر: Nature chemical biology. 12(2):109

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:132916551

المؤلفون: Liu GW; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Pickett MJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Chemistry, Yale University, New Haven, CT, USA., Kuosmanen JLP; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Ishida K; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Fractyl Health, Inc., Lexington, MA, USA., Madani WAM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Weill Cornell Medical College, New York City, NY, USA., White GN; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jenkins J; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Ross University School of Veterinary Medicine, Basseterre, St. Kitts and Nevis., Park S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Feig VR; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Stanford University, Stanford, CA, USA., Jimenez M; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Boston University, Boston, MA, USA., Karavasili C; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lal NB; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; MIT Media Lab, Cambridge, MA, USA., Murphy M; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Lopes A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Morimoto J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Fitzgerald N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Tufts University, Medford, MA, USA., Cheah JH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Soule CK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fabian N; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Hayward A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA., Langer R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Traverso G; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.; Division of Gastroenterology, Hepatology, and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu.

المصدر: Nature materials [Nat Mater] 2024 Feb 27. Date of Electronic Publication: 2024 Feb 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101155473 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4660 (Electronic) Linking ISSN: 14761122 NLM ISO Abbreviation: Nat Mater Subsets: MEDLINE

المؤلفون: Abbott KL; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ali A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Casalena D; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Do BT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Harvard-MIT Health Sciences and Technology, Cambridge, MA 02139, USA., Ferreira R; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Deik A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kunchok T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Schmidt DR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Renner S; Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland., Honeder SE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Diagnostic and Research Institute of Pathology, Medical University of Graz, Graz, Austria., Wu M; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chan SH; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Tseyang T; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Stoltzfus AT; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Michel SLJ; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA., Greaves D; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Hsu PP; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02113, USA., Ng CW; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Zhang CJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Farsidjani A; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Kent JR; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Madariaga MLL; Department of Surgery, University of Chicago Medicine, Chicago, IL 60637, USA., Gramatikov IMT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA., Matheson NJ; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Cambridge Institute of Therapeutic Immunology & Infectious Disease, University of Cambridge, Cambridge CB2 0AW, UK; Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02139, USA., Clish CB; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Griner LM; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Muir A; Ben May Department of Cancer Research, University of Chicago, Chicago, IL 60637, USA., Auld DS; Novartis Institute for BioMedical Research, Cambridge, MA 02139, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Dana-Farber Cancer Institute, Boston, MA 02115, USA. Electronic address: mvh@mit.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2023 Sep 21; Vol. 30 (9), pp. 1156-1168.e7. Date of Electronic Publication: 2023 Sep 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Culture Techniques* , High-Throughput Screening Assays*, Humans ; Cell Line ; Small Molecule Libraries/pharmacology

المؤلفون: Mead BE; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA., Kummerlowe C; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA., Liu N; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA., Kattan WE; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA., Cheng T; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA., Peters J; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA.; Harvard Medical School; Boston, MA, 02115, USA., Lowder KE; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Dana Farber Cancer Institute, Boston, MA, 02215, USA., Blainey PC; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Department of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA., Hahn WC; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Dana Farber Cancer Institute, Boston, MA, 02215, USA.; Harvard Medical School; Boston, MA, 02115, USA., Cleary B; Faculty of Computing and Data Sciences, Department of Biomedical Engineering, Department of Biology, Boston University; Boston, MA, 02215, USA., Bryson B; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA.; Department of Biological Engineering, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA., Winter PS; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Dana Farber Cancer Institute, Boston, MA, 02215, USA., Raghavan S; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Dana Farber Cancer Institute, Boston, MA, 02215, USA.; Harvard Medical School; Boston, MA, 02115, USA., Shalek AK; Institute for Medical Engineering and Science (IMES), Department of Chemistry, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Broad Institute of MIT and Harvard; Cambridge, MA, 02142, USA.; Ragon Institute of MGH, MIT, and Harvard; Cambridge, MA, 02139, USA.; Program in Computational and Systems Biology, Massachusetts Institute of Technology; Cambridge, MA, 02139, USA.; Program in Immunology, Harvard Medical School; Boston, MA, 02115, USA.; Harvard Stem Cell Institute; Cambridge, MA, 02138, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 23. Date of Electronic Publication: 2023 Jan 23.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Reker D; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, USA., Rybakova Y; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Kirtane AR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Cao R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Engineering Science, University of Toronto, Toronto, Ontario, Canada., Yang JW; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.; Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY, USA., Navamajiti N; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Biomedical Engineering Program, Faculty of Engineering, Chulalongkorn University, Bangkok, Thailand., Gardner A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhang RM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA., Esfandiary T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., L'Heureux J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., von Erlach T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Smekalova EM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Leboeuf D; Skolkovo Institute of Science and Technology, Moscow, Russia., Hess K; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Lopes A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Rogner J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Collins J; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Tamang SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Ishida K; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Chamberlain P; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Yun D; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Lytton-Jean A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Soule CK; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cheah JH; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Hayward AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Langer R; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA., Traverso G; Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. cgt20@mit.edu.; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. cgt20@mit.edu.

المصدر: Nature nanotechnology [Nat Nanotechnol] 2021 Jun; Vol. 16 (6), pp. 725-733. Date of Electronic Publication: 2021 Mar 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101283273 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1748-3395 (Electronic) Linking ISSN: 17483387 NLM ISO Abbreviation: Nat Nanotechnol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Carriers/*chemistry , High-Throughput Screening Assays/*methods , Nanoparticles/*chemistry , Sorafenib/*pharmacology , Terbinafine/*pharmacology, Animals ; Candida albicans/drug effects ; Computer Simulation ; Drug Carriers/chemical synthesis ; Drug Design ; Drug Evaluation, Preclinical/methods ; Dynamic Light Scattering ; Excipients/chemistry ; Female ; Glycyrrhizic Acid/chemistry ; Humans ; Machine Learning ; Mice, Inbred Strains ; Skin Absorption ; Sorafenib/chemistry ; Sorafenib/pharmacokinetics ; Taurocholic Acid/chemistry ; Terbinafine/chemistry ; Tissue Distribution ; Xenograft Model Antitumor Assays ; Mice

المؤلفون: Lee CX; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cheah JH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Soule CK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Ding H; The Barbara K. Ostrom (1978) Bioinformatics and Computing Facility in the Swanson Biotechnology Center, Massachusetts Institute of Technology, Cambridge, MA, USA., Whittaker CA; The Barbara K. Ostrom (1978) Bioinformatics and Computing Facility in the Swanson Biotechnology Center, Massachusetts Institute of Technology, Cambridge, MA, USA., Karhohs K; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Burds AA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Subramanyam KS; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Carpenter AE; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA., Eisner BH; Department of Urology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Cima MJ; Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA. mjcima@mit.edu.; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. mjcima@mit.edu.; Department of Material Science Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA. mjcima@mit.edu.

المصدر: Nature biomedical engineering [Nat Biomed Eng] 2020 Jan; Vol. 4 (1), pp. 28-39. Date of Electronic Publication: 2019 Dec 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: England NLM ID: 101696896 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2157-846X (Electronic) Linking ISSN: 2157846X NLM ISO Abbreviation: Nat Biomed Eng Subsets: MEDLINE

مواضيع طبية MeSH: Muscle Contraction/*drug effects , Myocytes, Smooth Muscle/*drug effects , Ureter/*drug effects , Vasodilator Agents/*administration & dosage, Animals ; Cells, Cultured ; Drug Evaluation, Preclinical ; Humans ; Nifedipine/administration & dosage ; Protein Kinase Inhibitors/administration & dosage ; Sus scrofa

المؤلفون: Wong MY; Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., Doan ND; Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., DiChiara AS; Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., Papa LJ 3rd; Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., Cheah JH; High-Throughput Sciences Facility, Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., Soule CK; High-Throughput Sciences Facility, Koch Institute for Integrative Cancer Research , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States., Watson N; W. M. Keck Microscopy Facility , The Whitehead Institute , Cambridge , Massachusetts 02142 , United States., Hulleman JD; Departments of Ophthalmology and Pharmacology , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Shoulders MD; Department of Chemistry , Massachusetts Institute of Technology , Cambridge , Massachusetts 02139 , United States.

المصدر: Biochemistry [Biochemistry] 2018 May 15; Vol. 57 (19), pp. 2814-2827. Date of Electronic Publication: 2018 May 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays*, Collagen Type I/*chemistry , HSP90 Heat-Shock Proteins/*chemistry , Membrane Glycoproteins/*chemistry, Benzoquinones/pharmacology ; Cell Line ; Collagen Type I/biosynthesis ; Collagen Type I/metabolism ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; Humans ; Lactams, Macrocyclic/pharmacology ; Membrane Glycoproteins/antagonists & inhibitors ; Protein Isoforms/chemistry

المؤلفون: Seashore-Ludlow B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Rees MG; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cheah JH; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cokol M; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Price EV; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Coletti ME; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Jones V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bodycombe NE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Soule CK; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Gould J; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Alexander B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Li A; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Montgomery P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Wawer MJ; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Kuru N; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Hon CS; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Munoz B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Liefeld T; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Dančík V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bittker JA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Palmer M; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bradner JE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. Cancer Biology and Medical Oncology, Harvard Medical School, Boston, Massachusetts., Shamji AF; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Clemons PA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2015 Nov; Vol. 5 (11), pp. 1210-23. Date of Electronic Publication: 2015 Oct 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Drug Screening Assays, Antitumor* , Small Molecule Libraries*, Computational Biology/*methods , Drug Resistance, Neoplasm/*genetics , Gene Expression Regulation, Neoplastic/*drug effects , Neoplasms/*genetics, Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cluster Analysis ; Datasets as Topic ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans ; Mutation ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology