نتائج البحث - "Sp1, specificity protein 1"

1

Tumor necrosis factor α upregulates the bile acid efflux transporter OATP3A1 via multiple signaling pathways in cholestasis

المؤلفون: Mingqiao Li, Weihua Wang, Ying Cheng, Xiaoxun Zhang, Nan Zhao, Ya Tan, Qiaoling Xie, Jin Chai, Qiong Pan

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: SP1, specificity protein 1, OATP3A1, Organic Anion Transporters, ERK, extracellular signal–regulated kinase, Biochemistry, NF-κB, Bile Acids and Salts, cDNA, complementary DNA, TNFα, Humans, RNA, Messenger, Extracellular Signal-Regulated MAP Kinases, Molecular Biology, Cholestasis, OATP3A1, organic anion–transporting polypeptide 3A1, Tumor Necrosis Factor-alpha, NF-kappa B, Cell Biology, FGF19, fibroblast growth factor 19, Up-Regulation, SP1, MRP3, multidrug resistance–associated protein 3, ChIP, chromatin immunoprecipitation, TNFα, tumor necrosis factor α, BA, bile acid, RT–qPCR, RT–quantitative real-time PCR, PLC, peritoneal lavage cell, Signal Transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87568537078818c628c5dc973f5fcc6f
https://pubmed.ncbi.nlm.nih.gov/34971708

2

LLGL1 Regulates Gemcitabine Resistance by Modulating the ERK-SP1-OSMR Pathway in Pancreatic Ductal AdenocarcinomaSummary

المؤلفون: Yangchao Chen, Tian Xia, Guolin Li, Frederic Khe Cheong Fung, Ka Fai To, Joanna H.M. Tong, Chi Han Li, Yin-Xin Zhu, Chi Hin Wong, Huiyi Feng, Rufu Chen

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 4, Pp 811-828 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, MAPK/ERK pathway, OSMR, oncostatin M receptor, ERK2, extracellular signal-regulated kinase 2, PDAC, pancreatic ductal adenocarcinoma, IC50, median inhibitory concentration, Deoxycytidine, MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, 0302 clinical medicine, RNA interference, Medicine, SP1 Signaling, Extracellular Signal-Regulated MAP Kinases, TGF, transforming growth factor, Original Research, Aged, 80 and over, Oncostatin M Receptor beta Subunit, Gene knockdown, Kinase, Gastroenterology, Oncostatin M receptor, Middle Aged, Sp1, specificity protein 1, Oncostatin M Receptor, ChIP, chromatin immunoprecipitation, HPDE, human pancreatic ductal epithelial, RNAi, RNA interference, hENT1, human equilibrative nucleoside transporter 1, Female, 030211 gastroenterology & hepatology, siLLGL1, small interfering lethal giant larvae homolog 1, EMT, epithelial-mesenchymal transition, IHC, immunohistochemistry, Carcinoma, Pancreatic Ductal, medicine.drug, Adult, Sp1 Transcription Factor, Young Adult, cDNA, complementary DNA, 03 medical and health sciences, Pancreatic Cancer, Cell Line, Tumor, SWH, Salvador/Warts/Hippo, Pancreatic cancer, Humans, Gene silencing, LLGL1, lethal giant larvae homolog 1, lcsh:RC799-869, Aged, Pol II, RNA polymerase II, Hepatology, business.industry, Lgl, lethal giant larvae, medicine.disease, CSC, cancer stem cell, Gemcitabine, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, Pancreatic Neoplasms, Cytoskeletal Proteins, 030104 developmental biology, OSM, oncostatin M, Drug Resistance, Neoplasm, siRNA, small interfering RNA, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, Dlg, discs large protein, Transcriptome, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::522e00f260ff434833ed2e958f307cb5
http://www.sciencedirect.com/science/article/pii/S2352345X20300989

3

Sp1 is a substrate of Keap1 and regulates the activity of CRL4AWDR23 ubiquitin ligase toward Nrf2

المؤلفون: Ferbian Milas Siswanto, Ami Oguro, Susumu Imaoka

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, DNA damage-binding protein 1, CUL4A, Cullin 4A, Cullin4A, RBX1, Ring-box 1, Biochemistry, Nrf2, nuclear factor erythroid 2-related factor 2, nuclear factor 2 (erythroid-derived 2-like factor), Ubiquitin, oxidative stress, Post-translational regulation, HO-1, heme oxygenase-1, biology, Chemistry, DDB1, DNA damage-binding protein 1, Sp1, specificity protein 1, Ubiquitin ligase, Cell biology, Keap1, Kelch-like ECH-associated protein 1, Kelch-Like ECH-Associated Protein 1, Ubiquitin ligase complex, shRNA, short hairpin RNA, Cullin, Research Article, NF-E2-Related Factor 2, Sp1 Transcription Factor, Ubiquitin-Protein Ligases, posttranslational regulation, ARE, antioxidant response elements, Kelch-like ECH-associated protein 1, CRL4, Cullin 4-RING ligase, 03 medical and health sciences, DDB1, WD40 repeat protein 23, Cell Line, Tumor, Cullin 4A-RING ligase, Humans, specificity protein 1, Molecular Biology, KD, knockdown, 030102 biochemistry & molecular biology, Cell Biology, Ring-box 1, Kinetics, 030104 developmental biology, Gene Expression Regulation, biology.protein, CUL4A, gene regulation, NQO1, NAD(P)H quinone dehydrogenase 1, WDR23, WD40 repeat protein 23

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::707cf01346d6f8bd9189f7ef3b137d58
http://europepmc.org/articles/PMC8141886

4

Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5′flanking region

المؤلفون: Sylvie Bortoli, Bernard Desbuquois, Martine Collinet

المصدر: Biochimie Open, Vol 7, Iss, Pp 26-32 (2018)
Biochimie Open

مصطلحات موضوعية: HNF4, hepatocyte nuclear factor 4, 0301 basic medicine, Research paper, Hepatoma cells, C/EBPβ, C/CAAT/enhancer binding protein β, 5' flanking region, FOXO1, STZ, streptozotocin, Biochemistry, HMGA1, high mobility group A1 protein, lcsh:Biochemistry, 03 medical and health sciences, IGFBP-1, insulin-like growth factor binding protein 1, Transcription (biology), Gene expression, lcsh:QD415-436, Transcription factor, Gene, biology, Chemistry, Sp1, specificity protein 1, HMGA1, Molecular biology, PI3K, phosphatidyl inositol 3-kinase, SINE, short interspersed nuclear element, TCF7L2, T-cell specific transcription factor 7-like 2, Insulin receptor, FoxO1, Forkhead box protein O1, 030104 developmental biology, Gene transcription, Liver, IR, insulin receptor, biology.protein, Vanadate, Rat, PEPCK, phosphoenolpyruvate carboxykinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f28a98099c18d8f778c71445315c4d
https://doi.org/10.1016/j.biopen.2018.09.001

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5

Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA

المؤلفون: Spiros Vlahopoulos, Zsolt Radak, Attila Bacsi, Bing Zhu, Leopoldo Aguilera-Aguirre, Allan R. Brasier, Xueqing Ba, Ruoxi Wang, Wenjing Hao, Tapas K. Hazra, Lang Pan, Istvan Boldogh, Tianyang Qi

المصدر: Redox Biology, Vol 18, Iss, Pp 43-53 (2018)
Redox Biology

مصطلحات موضوعية: GOrilla, Gene Ontology enRIchment anaLysis and visuaLizAtion tool, 0301 basic medicine, OGG1, 8-oxoguanine DNA glycosylase-1 protein, Clinical Biochemistry, 8-oxoG, 8-oxo-7, 8-dihydroguanine, Biochemistry, DNA Glycosylases, chemistry.chemical_compound, 0302 clinical medicine, Gene expression, Gene Regulatory Networks, CXCL-1, CXC-motif chemokine ligand-1 (protein), GEO, Gene Expression Omnibus, BER, base excision repair, lcsh:QH301-705.5, lcsh:R5-920, CCL, CC chemokine ligand, Epigenetic, Sp1, specificity protein 1, Chromatin, 3. Good health, Cell biology, Regulatory sequence, 030220 oncology & carcinogenesis, lcsh:Medicine (General), CCL, gene or mRNA encoding CC chemokine ligand, Research Paper, CXCL, human gene or mRNA encoding CXCL-1, IIR, innate immune response, ChIP, chromatin immunoprecipitation assays, TNFα, tumor necrosis factor alpha, TFIID, transcription initiation factor II-D, Biology, NF-κB, Nuclear Factor kappa B, 03 medical and health sciences, ROS, reactive oxygen species, AP, apurinic/apyrimidinic site in DNA, Humans, Epigenetics, Gene, GO, gene ontology, OGG1-BER, OGG1-initiated DNA base excision repair, APE1, apurinic/apyrimidinic endonuclease 1, Tumor Necrosis Factor-alpha, Organic Chemistry, ChIP-seq, chromatin immunoprecipitation assays followed by DNA sequencing, RNA Pol II, RNA polymerase II, DNA, 8-Oxoguanine, Oxidative Stress, HEK293 Cells, 030104 developmental biology, chemistry, lcsh:Biology (General), Oxidative DNA damage, DNA glycosylase, TSS, transcription start site, 8-oxoguanine, Reactive Oxygen Species, Chromatin immunoprecipitation, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa78aa331af47be4e5a92c2e745491dc
http://www.sciencedirect.com/science/article/pii/S2213231718303562

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6

Developing the next generation of graphene-based platforms for cancer therapeutics: The potential role of reactive oxygen species

المؤلفون: Tanveer A. Tabish, Shaowei Zhang, Paul G. Winyard

المصدر: Redox Biology
Redox Biology, Vol 15, Iss C, Pp 34-40 (2018)

مصطلحات موضوعية: STAT3, signal transducer and activator of transcription 3, HIF-1ɑ, hypoxia-inducible factor-1 alpha, Review Article, Photodynamic therapy, ROS, reactive oxygen species, Drug Delivery Systems, Neoplasms, Humans, mAb, monoclonal antibody, Rb, retinoblastoma, lcsh:QH301-705.5, GO, graphene oxide, lcsh:R5-920, PTEN, phosphatase and tensin homolog deleted on chromosome 10, Singlet oxygen, Gene Transfer Techniques, Sp1, specificity protein 1, Theranostics, Bioimaging, PPa, Pyropheophorbide-a, Oxidative Stress, lcsh:Biology (General), PDT, photodynamic therapy, Hh, hedgehog, Nrf2, nuclear factor erythroid-derived 2-like 2, Nanoparticles, Graphite, NF-ϰB-NF kappa B, nuclear factor kappa-light-chain-enhancer of activated B cells, Graphene, lcsh:Medicine (General), Reactive Oxygen Species, AP-1, activator protein-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b3b12c807fdcf7ce46e0475c4ee8c8d3
http://europepmc.org/articles/PMC5723279

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7

Targeting Epigenetic Mechanisms to Alleviate Alcoholic Steatosis

المؤلفون: Pranoti Mandrekar

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 9, Iss 4, Pp 713-714 (2020)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: Ct, Cycle of threshold, ALD, alcoholic liver disease, H3K9Ac, histone 3 lysine 9 acetylation, Alcoholic Liver Disease, Pol II, polymerase II, HDAC, histone deacetylase, Epigenetic Repression, Bioinformatics, EF, ethanol-fed, PCR, polymerase chain reaction, TRE, T3 response elements, Medicine, Humans, Gene Regulation, Epigenetics, lcsh:RC799-869, Triglycerides, Epigenetic Promoter Modification, Original Research, Tb, tributyrin, Hepatology, Ethanol, business.industry, Extramural, Gastroenterology, CPT-1A, carnitine palmitoyltransferase-1A, medicine.disease, DR, Direct Repeat, mRNA, messenger RNA, Fatty Liver, ChIP, chromatin immunoprecipitation, PGC-1α, Peroxisomal proliferator-activated receptor-γ coactivator-1α, SP1, Specificity Protein 1, Hepatocytes, HAT, histone acetyltransferase, lcsh:Diseases of the digestive system. Gastroenterology, Steatosis, business