المؤلفون: Hagerstrand, D, Tong, A, Schumacher, SE, Ilic, N, Shen, RR, Cheung, HW, Vazquez, F, Shrestha, Y, Kim, SY, Giacomelli, AO, Rosenbluh, J, Schinzel, AC, Spardy, NA, Barbie, DA, Mermel, CH, Weir, BA, Garraway, LA, Tamayo, P, Mesirov, JP, Beroukhim, R, Hahn, WC

المصدر: Cancer discovery. 3(9):1044-1057

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Cancer och onkologi, Medicinska och farmaceutiska grundvetenskaper, Medicinsk genetik

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:127372168

المؤلفون: Ilic N; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Birsoy K; Laboratory of Metabolic Regulation and Genetics, The Rockefeller University, New York, NY 10065., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Kory N; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Pacold ME; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Singh S; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Moody SE; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., DeAngelo JD; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Spardy NA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Freinkman E; Whitehead Institute for Biomedical Research, Cambridge, MA 02142., Weir BA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Tsherniak A; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Cowley GS; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Root DE; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Asara JM; Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115., Vazquez F; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142., Widlund HR; Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115., Sabatini DM; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.; Whitehead Institute for Biomedical Research, Cambridge, MA 02142.; David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215; william_hahn@dfci.harvard.edu.; Broad Institute of MIT and Harvard University, Cambridge, MA 02142.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Apr 25; Vol. 114 (17), pp. E3434-E3443. Date of Electronic Publication: 2017 Apr 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Class I Phosphatidylinositol 3-Kinases*/genetics , Class I Phosphatidylinositol 3-Kinases*/metabolism , Ketoglutarate Dehydrogenase Complex*/biosynthesis , Ketoglutarate Dehydrogenase Complex*/genetics , Mutation* , Neoplasm Proteins*/genetics , Neoplasm Proteins*/metabolism , Neoplasms*/enzymology , Neoplasms*/genetics , Neoplasms*/pathology, Animals ; Cell Line, Tumor ; Citric Acid Cycle/genetics ; Glycolysis/genetics ; Humans ; Mice ; Mice, Nude