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المؤلفون: Niani Tiaye Bailey, Bilon Khambu, Gang Liu, Sophia Blessinger, Katherine Byrnes, Russell Scaife
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 33-49 (2022)مصطلحات موضوعية: MCOLN1, mucolipin 1, Review, OPTN, optineurin, UPR, unfolded protein response, LIMP1, lysosomal integral membrane protein-1, General Pharmacology, Toxicology and Pharmaceutics, BNIP3L, BCL2 interacting protein 3 like, STBD1, starch-binding domain-containing protein 1, PLIN3, perilipin 3, LIR, LC3 interacting region, PPARα, peroxisomal proliferator-activated receptor-alpha, mTORC1, mammalian target of rapamycin complex 1, Translation (biology), WIPI1, WD repeat domain phosphoinositide-interacting protein 1, TBK1, serine/threonine-protein kinase, Cell biology, GIM, GABARAP-interacting motif, CREB, cAMP response element binding protein, PP2A, protein phosphatase 2a, Liver metabolism, CLN3, lysosomal/endosomal transmembrane protein, LALP70, lysosomal apyrase-like protein of 70 kDa, LD, lipid droplet, RETREG1, reticulophagy regulator 1, PINK1, phosphatase and tensin homolog (PTEN)-induced kinase 1, RM1-950, ATL3, Atlastin GTPase 3, RTNL3, a long isoform of RTN3, LAMP2, lysosomal-associated membrane protein-2, FXR, farnesoid X receptor, Farnesoid X receptor, Cryptochrome 1, FFA, free fatty acid, TFEB/TFE3, transcription factor EB, ULK1, Unc-51 like autophagy activating kinase 1, TRAC-1, thyroid-hormone-and retinoic acid-receptor associated co-repressor 1, RTN3, reticulon 3, S6K, P70-S6 kinase, SEC62, SEC62 homolog, preprotein translocation factor, GABARAPL1, GABA type A receptor associated protein like 1, TEX264, testis expressed 264, ER-phagy receptor, DFCP1, double FYVE-containing protein 1, LXRa, liver X receptor a, SLC36A1, solute carrier family 36 member 1, V-ATPase, vacuolar-ATPase, Regeneration (biology), Quality control, AIM, Atf8 interacting motif, VLDL, very-low-density lipoprotein, CYP7A1, cholesterol 7α-hydroxylase, NBR1, BRCA1 gene 1 protein, BCL2L13, BCL2 like 13, TGR5, takeda G protein receptor 5, NCoR1, nuclear receptor co-repressor 1, PKA, protein kinase A, Function (biology), CRY1, cryptochrome 1, LAMP1, lysosomal-associated membrane protein-1, Anabolism, S6RP, S6 ribosomal protein, LIMP3, lysosomal integral membrane protein-3, FAM134B, family with sequence similarity 134, member B, Nutrient regeneration, SPIN, spindling, FOXO1, Forkhead box O1, SCARB2, scavenger receptor class B member 2, PQLC2, PQ-loop protein, SQSTM1, sequestosome 1, CMA, chaperonin mediated autophagy, PLIN2, perilipin 2, PXR, pregnane X receptor, NPC-1, Niemann-Pick disease, type C1, SLC38A9, sodium-coupled neutral amino acid transporter 9, Lysosome, TRPML1, transient receptor potential mucolipin 1, BNIP3, BCL2 interacting protein 3, BA, bile acid, ATM, ATM serine/threonine kinase, CAR, constitutive androstane receptor, MFSD1, major facilitator superfamily domain containing 1, NAFLD, non-alcoholic fatty liver disease, PKB, protein kinase B, VDR, vitamin D3 receptor, SIRT1, sirtuin 1, LYAAT-1, lysosomal amino acid transporter 1, SNAT7, sodium-coupled neutral amino acid transporter 7, Biology, S1PR2, sphingosine-1-phosphate receptor 2, ROS, reactive oxygen species, CYP27A1, sterol 27-hydroxylase, Autophagy, NDP52, calcium-binding and coiled-coil domain-containing protein 2, ATGL, adipose triglyceride lipase, Signaling proteins, Catabolism, FUNDC1, FUN14 domain containing 1, CCPG1, cell cycle progression 1, LAAT-1, lysosomal amino acid transporter 1 homologue, PEX5, peroxisomal biogenesis factor 5, PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase, SLC38A7, solute carrier family 38 member 7, Therapeutics. Pharmacology, Homeostasis, Drug metabolism
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المؤلفون: Liang Ouyang, Yao Liu, Jie Liu, Lu Feng, Guan Wang, Yi Chen, Meng Wang, Tingting Jiang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 2, Pp 355-372 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: NTRK, neurotrophic receptor tyrosine kinase, FISH, fluorescence in situ hybridization, Review, Tropomyosin receptor kinase B, HNSCC, head and neck squamous cell carcinoma, Tropomyosin receptor kinase A, HTS, high-throughput screening, ring finger and WD repeat domain 2, E3 ubiquitin protein ligase, Tropomyosin receptor kinase C, LMNA, lamin A/C, Receptor tyrosine kinase, TPM3, tropomyosin 3, 0302 clinical medicine, MASC, mammary analogue secretory carcinoma, PROTAC proteolysis targeting chimera, QKI, SQSTM1, sequestosome 1, TPR, translocated promoter region, General Pharmacology, Toxicology and Pharmaceutics, RABGTPase activating protein 1-like, RFWD2, AML, acute myeloid leukemia, 0303 health sciences, ICC, intrahepatic cholangiocarcinoma, TRK, tropomyosin receptor kinase, Neurotrophic receptor tyrosine kinase fusions, PPL, periplakin, TP53, tumor protein P53, SBC, secretory breast carcinoma, OAK, osteoarthritis of the knee, TFG, TRK-fused gene, ARHGEF2, Rho/Rac guanine nucleotide exchange factor 2, NT3, neurotrophin-3, quaking I protein, RABGAP1L, ETV6, ETS translocation variant 6, 030220 oncology & carcinogenesis, CR, complete response, CRC, colorectal cancer, BCAN, brevican, BDNF, brain-derived neurotrophic factor, BTBD1, BTB (POZ) domain containing 1, RTK, receptor tyrosine kinase, DOR, durable objective responses, CDK-2, cyclin-dependent kinase 2, Tyrosine kinase, EWG, electron-withdrawing group, ORR, overall response rate, Neurotrophin, NCCN, National Comprehensive Cancer Network, VCL, vinculin, NGF, nerve growth factor, MPRIP, myosin phosphatase Rho interacting protein, Biology, PAN3, poly(A) nuclease 3, TRIM24, tripartite motif containing 24, Small-molecule inhibitor, NTRK fusion cancer, SCYL3, SCY1 like pseudokinase 3, 03 medical and health sciences, NACC2, NACC family member 2, NSCLC, non-small cell lung cancer, SAR, structure–activity relationship, Protein kinase B, VEGFR2, vascular endothelial growth factor receptor 2, 030304 developmental biology, DFG, Asp-Phe-Gly, CTCs, sequencing of circulating tumor cells, lcsh:RM1-950, GBM, glioblastoma multiforme, NFASC, neurofascin, NGS, next-generation sequencing of tumor tissue, FDA, U.S. Food and Drug Administration, lcsh:Therapeutics. Pharmacology, nervous system, Trk receptor, IG-C2, Ig-like C2 type I, Cancer research, biology.protein, Tropomyosin receptor kinase, AFAP1, actin filament-associated protein 1
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المؤلفون: Ruoxi Zhang, Rui Kang, Daolin Tang
المصدر: Chinese Journal of Traumatology
Chinese Journal of Traumatology, Vol 25, Iss 1, Pp 1-10 (2022)مصطلحات موضوعية: Medicine (General), type I IFNs, type I interferons, Review Article, PLCG1, phospholipase C gamma 1, CGAS, cyclic GMP-AMP synthase, Orthopedics and Sports Medicine, MLKL, mixed-lineage kinase domain-like pseudokinase, SQSTM1, sequestosome 1, ALK, ALK receptor tyrosine kinase, caspase, CASP, Shock, Septic, AKT, serine-threonine kinase, DMXAA, 5,6-dimethylxanthenone-4-acetic acid, TNFα, tumor necrosis factor α, CLP, cecal ligation and puncture, GPX4, glutathione peroxidase 4, medicine.symptom, HMGB1, high-mobility group box 1, Cell death, Programmed cell death, AIM2, absent in melanoma 2, Multiple Organ Failure, NF-κB, nuclear factor-κB, RIPK, receptor interacting serine/threonine-protein kinase, Inflammation, CDNs, cyclic dinucleotides, CXCL10, C-X-C motif chemokine ligand 10, CCL2, C-C motif chemokine ligand 2, Sepsis, ER, endoplasmic reticulum, R5-920, Immune system, Immunity, PAMPs, pathogen-associated molecular patterns, medicine, Autophagy, Humans, GSDMD, gasdermin D, PRRs, pattern-recognizing receptors, TLR9, toll-like receptor 9, Innate immune system, STING1, Septic shock, business.industry, IRF3, interferon regulatory factor 3, cfDNA, cell-free DNA, STING1, stimulator of interferon response cGAMP interactor 1, medicine.disease, Immunity, Innate, mtDNA, mitochondrial DNA, EGFR, epidermal growth factor receptor, IFNAR1, interferon alpha and beta receptor subunit 1, IL, interleukin, Immunology, DAMPs, damage-associated molecular patterns, TBK1, TANK-binding kinase 1, LPS, lipopolysaccharides, Surgery, GSDMD-N, N-terminal fragment of GSDMD, cGAMP, cyclic guanosine monophosphate-adenosine monophosphate, nDNA, nuclear DNA, business
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المؤلفون: Mengru Liu, Shijia Ma, Yue Li, Anil Ahsan, Wenping Yan, Yanrong Zheng, Zhong Chen, Zhanxun Wu, Ming Cao, Xingxian Zhang, Weiwei Hu, Ling Pan, Xiangnan Zhang
المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 7, Pp 1708-1720 (2021)مصطلحات موضوعية: Review, Mitochondrion, PD, Parkinson's disease, 0302 clinical medicine, FOXO, forkhead box O, Mitophagy, HD, Huntington's disease, TFEB, transcription factor EB, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, TIGAR, TP53-induced glycolysis and apoptosis regulator, Stroke, 0303 health sciences, AMPK, 5′-adenosine monophosphate-activated protein kinase, mTOR, mechanistic target of rapamycin, eIF2a, eukaryotic translation-initiation factor 2, PI3K, phosphatidylinositol 3-kinase, OGD/R, oxygen and glucose deprivation-reperfusion, Cerebral ischemia, ALS, amyotrophic lateral sclerosis, PERK, protein kinase R (PKR)-like endoplasmic reticulum kinase, Neuroprotection, Mitochondria, 030220 oncology & carcinogenesis, JNK, c-Jun N-terminal kinase, ULK, Unc-51- like kinase, AD, Alzheimer's disease, Intracellular, Programmed cell death, ATF6, activating transcription factor 6, IRE1, inositol-requiring enzyme 1, RM1-950, Natural compounds, IPC, ischemic preconditioning, ER, endoplasmic reticulum, 03 medical and health sciences, COPII, coat protein complex II, LKB1, liver kinase B1, ROS, reactive oxygen species, ΔΨm, mitochondrial membrane potential, medicine, Autophagy, Lysosomal activation, ATG, autophagy related genes, 030304 developmental biology, Uro-A, urolithin A, business.industry, FUNDC1, FUN14 domain containing 1, medicine.disease, LC3, light chain 3, GPCR, G-protein coupled receptor, BNIP3L, BCL2/adenovirus, Therapeutics. Pharmacology, LAMP, lysosomal-associated membrane protein, business, Neuroscience, Homeostasis, Neurological disorders, BCL-2, B-cell lymphoma 2
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المؤلفون: Keke Wang, Yaxin Chen, Yang Zhou, Rui Wang, Tao Li, Rong Hu, Mengran Cao, Mengdi Yang, Yunjiang Zhou
المصدر: Redox Biology, Vol 29, Iss, Pp-(2020)
Redox Biologyمصطلحات موضوعية: 0301 basic medicine, PDAC, pancreatic ductal adenocarcinoma, Clinical Biochemistry, HEATR1, Gemcitabine resistance, Nrf2, nuclear factor erythroid 2-related factor 2, Deoxycytidine, Biochemistry, 0302 clinical medicine, Cytotoxic T cell, SQSTM1, sequestosome 1, lcsh:QH301-705.5, HO-1, heme oxygenase-1, chemistry.chemical_classification, education.field_of_study, Gene knockdown, lcsh:R5-920, Kelch-Like ECH-Associated Protein 1, RNA-Binding Proteins, mRNA, messenger RNA, Amino acid, Keap1, Kelch-like ECH-associated protein 1, shRNA, short hairpin RNA, HEATR1, human HEAT repeat-containing protein 1, lcsh:Medicine (General), Research Paper, NF-E2-Related Factor 2, qRT-PCR, quantitative reverse transcription-PCR, Biology, Nrf2, Minor Histocompatibility Antigens, 03 medical and health sciences, Sequestosome 1, Cell Line, Tumor, Pancreatic cancer, NQO1, NAD(P)H quinone oxidoreductase 1, medicine, Humans, education, Cell Proliferation, Organic Chemistry, medicine.disease, Gemcitabine, KEAP1, Pancreatic Neoplasms, 030104 developmental biology, chemistry, lcsh:Biology (General), Cancer research, 030217 neurology & neurosurgery, Nrf2 signaling
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المؤلفون: Simon Wilkinson
المصدر: Wilkinson, S 2019, ' Emerging Principles of Selective ER Autophagy ', Journal of Molecular Biology . https://doi.org/10.1016/j.jmb.2019.05.012
Journal of Molecular Biologyمصطلحات موضوعية: AIM, Atg8-interacting motif, ERLAD, ER-to-lysosome associated degradation, sER, smooth ER, RTN3L, RHD, reticulon homology domain, FAM134B, family with sequence similarity 134, member B, LIR, LC3-interacting region, Endoplasmic Reticulum, ULK, Unc51-like autophagy activating kinase, ERAD, ER-associated degradation, UPR, unfolded protein response, 0302 clinical medicine, Structural Biology, SQSTM1, sequestosome 1, 0303 health sciences, HP1/2, hydrophobic pocket ½, GABARAP, gamma aminobutyric acid receptor-associated protein, Cell biology, PC, procollagen, medicine.anatomical_structure, Signal transduction, FAM134B, Signal Transduction, FIR, FIP200-interacting region, RETREG1, reticulophagy regulator 1, RTN3L, reticulon 3 long isoform, ATZ, alpha-1-antitrypsin, HSAN, hereditary sensory and autonomic neuropathy, NDP52, nuclear dot 52 kDa protein, CCPG1, cell cycle progression gene 1, Atg11BR, Atg11-binding region, Biology, Cell fate determination, Article, PI, phosphatidylinositol, MAP1LC3, microtubule associated protein 1 light chain 3, ER, endoplasmic reticulum, TEX264, testis-expressed protein 264 precursor, 03 medical and health sciences, SEC62, ATG, autophagy-related gene, Lysosome, Macroautophagy, Autophagy, medicine, Humans, Microautophagy, rER, rough ER, Molecular Biology, LDS, LIR docking site, 030304 developmental biology, Mechanism (biology), Endoplasmic reticulum, FIP200, FAK-family kinase interacting protein of 200 kDa, CCPG1, SEC62, translocation protein SEC62, GIMs, GABARAP-interacting motifs, ATL, atlastin, TEX264, Metabolism, Lysosomes, 030217 neurology & neurosurgery, NPC1, Niemann-Pick C1 protein
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246a9d79f96cd380e5927a63fe262605
https://hdl.handle.net/20.500.11820/5820d1dc-24f7-48aa-abb5-a702fa981686 -
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المؤلفون: Xingxiang Chen, Kehe Huang, Dandan Liu, Jiarui Su, Lei Ge, Chunfeng Wang, Qing Wang
المصدر: Environment International, Vol 143, Iss, Pp 105949-(2020)
Environment Internationalمصطلحات موضوعية: STING, Stimulator of interferon genes, 010504 meteorology & atmospheric sciences, Swine, MAPK, Mitogen-activated protein kinase, 010501 environmental sciences, MTORC1, Mammalian target of rapamycin complex 1, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, PI3K, Phosphoinositide 3 kinase, Environmental Toxins, CQ, Chloroquine, LSCM, Laser scanning confocal microscope, lcsh:Environmental sciences, General Environmental Science, Coronavirus, Swine Diseases, lcsh:GE1-350, ADG, Average daily gain, biology, PEDV, PEDV, Porcine epidemic diarrhea virus, IFN, Interferon, Diarrhea, ATP, Adenosine triphosphate, medicine.symptom, Coronavirus Infections, SQSTM1, Sequestosome 1, p38 mitogen-activated protein kinases, Trichothecene, IPEC-J2, Porcine small intestinal epithelial cell line, TGEV, Transmissible gastroenteritis virus, Article, Microbiology, LC3B, Light chain 3 β, In vivo, DON, Deoxynivalenol, Autophagy, medicine, Animals, Humans, Mycotoxin, MAPK p38 signaling, ComputingMethodologies_COMPUTERGRAPHICS, 0105 earth and related environmental sciences, TEM, Transmission electron microscopy, TCID50, Tissue culture infective dose, Porcine epidemic diarrhea virus, biology.organism_classification, Deoxynivalenol, ADFI, Average daily feed intake, chemistry, siRNA, small interfering RNA, Trichothecenes, LDH, Lactatedehydrogenase
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المؤلفون: Li Chen, Ming Zhang, Fan Yao
المصدر: Acta Pharmaceutica Sinica B, Vol 6, Iss 1, Pp 20-25 (2016)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: 0301 basic medicine, CaMKK, Ca2+ calmodulin-dependent protein kinase kinase, FoxO, forkhead box class O, mTORC1, IκB kinase, Review, DEPTOR, DEP domain-containing mTOR-interacting protein, AMP-activated protein kinase, ERK, extracellular signal-regulated kinase, AMPK, 5′-monophosphate-activated protein kinase, SQSTM1, sequestosome 1, General Pharmacology, Toxicology and Pharmaceutics, IKK, IκB kinase, SOGA, suppressor of glucose form autophagy, biology, Diabetes, JLDG, Jinlida granule, mTORC1, mammalian target of rapamycin (mTOR) complex 1, VPS34, vacuolar protein-sorting 34, AdipoR, adiponectin receptors, medicine.medical_specialty, ATP, adenosine triphosphate, ACC, carboxylase, PRAS40, proline-rich Akt substrate 40 kDa, mTOR, mammalian target of rapamycin, STZ, streptozotocin, JNK, janus kinase, Diabetic complications, 03 medical and health sciences, LKB1, liver kinase B1, Diabetes mellitus, Internal medicine, PKC, protein kinase C, medicine, Autophagy, PI3K/AKT/mTOR pathway, GFRs, glomerular filtration rates, business.industry, AMP-activated protein kinases, lcsh:RM1-950, AMPK, DM, Diabetes mellitus, DN, Diabetic nephropathy, ULK1, medicine.disease, ADP, adenosine diphosphate, ULK1, Unc-51-like kinase 1, LC3, light chain 3, 030104 developmental biology, Endocrinology, lcsh:Therapeutics. Pharmacology, AMP, adenosine monophosphate, Cancer research, biology.protein, business, TSC, tuberous sclerosis complex, RAPTOR, regulator associated protein of mTOR
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المؤلفون: Yi Jiang, Ming Shen, Honglin Liu, Yinghui Wei, Yan Cao
المصدر: Redox Biology
Redox Biology, Vol 18, Iss, Pp 138-157 (2018)مصطلحات موضوعية: 0301 basic medicine, Granulosa cells, PMSG, pregnant mare serum gonadotropin, Clinical Biochemistry, FOXO1, Vacuole, CCK-8, Cell Counting Kit-8, T-AOC, total antioxidation capability, medicine.disease_cause, Biochemistry, Antioxidants, Ac, acetylated, Mice, AOI, antioxidant inhibitors, MAP1LC3B, microtubule associated protein 1 light chain 3 beta, ATG, autophagy-related, GSH, glutathione, GR, glutathione reductase, PCD, programmed cell death, SQSTM1, sequestosome 1, lcsh:QH301-705.5, Cells, Cultured, Melatonin, lcsh:R5-920, Mice, Inbred ICR, GPx, glutathione peroxidase, Chemistry, Forkhead Box Protein O1, 3-NP, 3-nitropropionic acid, Follicular atresia, AVOs, acidic vesicular organelles, Cell biology, BECN1, beclin 1, Mel, melatonin, WCL, whole-cell lysates, Female, lcsh:Medicine (General), hormones, hormone substitutes, and hormone antagonists, NPC, non-plasmid control, POF, premature ovarian failure, medicine.drug, Research Paper, endocrine system, BP, blank plasmid, ADA, the 3 AKT phosphorylation sites of FOXO1 are mutated, Antioxidation-independent, Autophagic death, Oxidative phosphorylation, GCs, granulosa cell, P.E, pepstatin A and E64, FOXO1, forkhead box O1, 03 medical and health sciences, ROS, reactive oxygen species, AKT, thymoma viral proto-oncogene, SOD, superoxide dismutase, Oxidative damage, medicine, Autophagy, Animals, PIK3C3, phosphoinositide-3-kinase, class 3, TEM, transmission electron microscopy, PI3K/AKT/mTOR pathway, PI3K, class I phosphoinositide 3-kinase, Organic Chemistry, DBD, a FOXO1 mutant without DNA-binding activity, FOXO1N208A,H212R, MTOR, mechanistic target of rapamycin (serine/threonine kinase), Oxidative Stress, EP300, E1A binding protein p300, 030104 developmental biology, lcsh:Biology (General), CAT, catalase, PCOS, polycystic ovary syndrome, Oxidative stress, 3-MA, 3-methyladenine
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المؤلفون: Wenya, Ma, Fengzhi, Ding, Xiuxiu, Wang, Qi, Huang, Lai, Zhang, Chongwei, Bi, Bingjie, Hua, Ye, Yuan, Zhenbo, Han, Mengyu, Jin, Tianyi, Liu, Ying, Yu, Benzhi, Cai, Zhimin, Du
المصدر: EBioMedicine
مصطلحات موضوعية: LVIDd, left ventricular internal diastolic diameter, mRFP, monomeric red fluorescent protein, Myocardial Infarction, Mice, Transgenic, Autophagy-Related Protein 7, Mice, Cardiac progenitor cells, Autophagy, Animals, Humans, EF, ejection fraction, Cell Lineage, SQSTM1, sequestosome 1, LV, left ventricular, GFP, green fluorescent protein, MI, CPCs, cardiac progenitor cells, FS, fractional shortening, Adenine, Myocardium, Stem Cells, HE, hematoxylin and eosin, Atg7, autophagy-related gene 7, IHD, ischemic heart disease, Hydrogen Peroxide, Disease Models, Animal, MicroRNAs, Oxidative Stress, Proto-Oncogene Proteins c-kit, LVIDs, left ventricular internal dimension at end-systole, LV vol s, left ventricular end-systolic volume, MI, myocardial infarction, Atg7, 3-MA, 3-methyladenine, LV vol d, left ventricular end diastolic volume, Stem Cell Transplantation, Research Paper
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