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المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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2
المؤلفون: Qing Zhang, William J. Zavadoski, Robert J. Aiello, M.C. Holt, Nicole Barucci, Jim Valentine, A.J. Stein, Vishwas M. Paralkar, Stéphane De Lombaert, Daniel R. Goldberg, Patricia Bourassa
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:413-419
مصطلحات موضوعية: 0301 basic medicine, Serotonin, Proline, Clinical Biochemistry, Pharmaceutical Science, Tryptophan Hydroxylase, Pharmacology, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 03 medical and health sciences, Dogs, 0302 clinical medicine, Oral administration, In vivo, Drug Discovery, Animals, Humans, Prodrugs, Spiro Compounds, Intestinal Mucosa, Molecular Biology, Binding Sites, TPH1, Chemistry, Organic Chemistry, Prodrug, Tryptophan hydroxylase, Oxidoreductase inhibitor, Protein Structure, Tertiary, Rats, Intestines, Molecular Docking Simulation, Pyrimidines, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, Half-Life
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3
المؤلفون: Nicole Barucci, Stéphane De Lombaert, Vishwas M. Paralkar, Jim Valentine, William J. Zavadoski, Patricia Bourassa, Robert J. Aiello, A.J. Stein, Daniel R. Goldberg, Qing Zhang
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:2855-2860
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Tryptophan Hydroxylase, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Biosynthesis, Drug Discovery, Humans, Structure–activity relationship, Enzyme Inhibitors, Guanidine, Molecular Biology, 5-HT receptor, TPH1, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Tryptophan hydroxylase, Oxidoreductase inhibitor, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Molecular Medicine, Serotonin
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المؤلفون: Patricia Bourassa, Nicole Barucci, Stéphane De Lombaert, William J. Zavadoski, Daniel R. Goldberg, Qing Zhang, Robert J. Aiello, James J. Valentine, Vishwas M. Paralkar
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:1124-1129
مصطلحات موضوعية: 0301 basic medicine, Serotonin, Proline, Clinical Biochemistry, Pharmaceutical Science, Tryptophan Hydroxylase, Inhibitory postsynaptic potential, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Spiro Compounds, Neurotransmitter, Molecular Biology, chemistry.chemical_classification, Binding Sites, TPH1, Aryl, Organic Chemistry, Brain, Protein Structure, Tertiary, Rats, Amino acid, Molecular Docking Simulation, 030104 developmental biology, Monoamine neurotransmitter, chemistry, Drug Design, Molecular Medicine, Half-Life, Protein Binding
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5
المؤلفون: Adam Flegg, Tina Morwick, Ho Yin Lo, Todd Bosanac, Weimin Liu, Valentina Berger, Steven Kerr, Stéphane De Lombaert, Paige Erin Mahaney, Ralph Binetti, John Broadwater, Spencer Napier, Alessandra Bartolozzi, Lifen Wu, Hidenori Takahashi, Asitha Abeywardane, Heather Tye, Tazmeen Fadra-Khan, John D. Huber, Adrian Kotey, Ming-Hong Hao, Dines Jonathon Alan, Anil Kumar Padyana, Alan Olague, Michael Garrigou, David S. Thomson, J. Matthew Hutzler, Pui Leng Loke, Renee Zindell, Edward Pack, Zhidong Chen, Rebecca Crux, Thomas Simpson, Rajvee Dave, Doris Riether
المصدر: Journal of Medicinal Chemistry. 58:1669-1690
مصطلحات موضوعية: Models, Molecular, Oxadiazoles, Arachidonate 5-Lipoxygenase, Dose-Response Relationship, Drug, CYP3A4, Stereochemistry, Chemistry, Molecular Conformation, Oxadiazole, 5-Lipoxygenase-Activating Protein Inhibitors, Crystallography, X-Ray, Structure-Activity Relationship, chemistry.chemical_compound, Pharmacokinetics, Acetamides, Drug Discovery, Humans, Molecular Medicine, Lipoxygenase Inhibitors, IC50, Ex vivo, Drug metabolism, Whole blood
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المؤلفون: Jeffrey Dubins, Marc Humbert, Christophe Guignabert, Vishwas Paralkar, Stéphane De Lombaert, Qing Zhang, Maria A. Cavasin, Robert J. Aiello, Timothy A. McKinsey, Daniel R. Goldberg, Patricia-Ann Bourassa
المصدر: The Journal of pharmacology and experimental therapeutics. 360(2)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Serotonin, Ambrisentan, Hypertension, Pulmonary, Myocytes, Smooth Muscle, Vasodilation, 030204 cardiovascular system & hematology, Biology, Pulmonary Artery, Tryptophan Hydroxylase, Vascular Remodeling, Gene Expression Regulation, Enzymologic, Rats, Sprague-Dawley, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Animals, Humans, Enzyme Inhibitors, Lung, Semaxanib, Cell Proliferation, Pharmacology, TPH1, Mast cell, medicine.disease, Pulmonary hypertension, Tadalafil, Rats, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, HEK293 Cells, Molecular Medicine, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336cec7de4fd3c39c5c8d3e11f228815
https://pubmed.ncbi.nlm.nih.gov/27927914 -
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المؤلفون: Xiang Li, Hidenori Takahashi, Steven S. Pullen, Stéphane De Lombaert, Asitha Abeywardane, Ming-Hong Hao, John R. Proudfoot, Anil Kumar Padyana, Brandon Collins, Leslie Martin, Daniel R. Albaugh, Steven John Taylor, Shuang Liang, Bennett Sandy Farmer, Melissa Hill-Drzewi
المصدر: Journal of Medicinal Chemistry. 56:4465-4481
مصطلحات موضوعية: Models, Molecular, Serine Proteinase Inhibitors, Molecular Structure, Chymase, Cardiovascular Agents, In Vitro Techniques, Cathepsin G, Crystallography, X-Ray, Structure-Activity Relationship, chemistry.chemical_compound, Chymases, chemistry, Biochemistry, Fragment (logic), Catalytic Domain, Drug Discovery, Microsomes, Liver, Screening method, Humans, Molecular Medicine, Benzimidazoles, Oxindole, Protein Binding
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المؤلفون: Raymond A. Kemper, Jennifer Burke, James V. Haist, Nelamangara Nagaraja, Charles A. Kennedy, Christian Eickmeier, Stephen J. Boyer, Stéphane De Lombaert, Xin Guo, John D. Huber, Alan David Swinamer, Jeffrey B. Madwed, Anne B. Eldrup, Kirrane Thomas M, Morris Karmazyn, Fariba Soleymanzadeh, Paul Kaplita, Eugene R. Hickey, Jörg Bentzien, Elizabeth Mainolfi
المصدر: Journal of Medicinal Chemistry. 55:7114-7140
مصطلحات موضوعية: Blood Platelets, Male, Models, Molecular, ERG1 Potassium Channel, Cell Membrane Permeability, Sodium-Hydrogen Exchangers, Intracellular pH, Myocardial Infarction, Ischemia, Biological Availability, Myocardial Reperfusion Injury, Pharmacology, Guanidines, Permeability, Calcium in biology, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Drug Discovery, medicine, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Protein Isoforms, Cell damage, Cell Size, Myocardial stunning, Sodium-Hydrogen Exchanger 1, Chemistry, Membranes, Artificial, medicine.disease, Ether-A-Go-Go Potassium Channels, Rats, Sodium–hydrogen antiporter, Benzamides, Microsomes, Liver, Molecular Medicine, Reperfusion injury, Ex vivo
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المؤلفون: William J. Zavadoski, Daniel R. Goldberg, Patricia-Ann Bourassa, Nicole Barucci, Stéphane De Lombaert, Qing Zhang, Robert J. Aiello, Jeffrey Dubins, Vishwas Paralkar
المصدر: 4.3 Pulmonary Circulation and Pulmonary Vascular Disease.
مصطلحات موضوعية: medicine.medical_specialty, Lung, TPH1, business.industry, Tryptophan hydroxylase, Mast cell, In vitro, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, chemistry, Internal medicine, medicine, Serotonin, business, Perfusion, Histamine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fb928e7ba61ce63c065b799da12796f4
https://doi.org/10.1183/13993003.congress-2015.pa4909 -
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المؤلفون: Ming-Hong Hao, E. Michael August, Danielle M. Fowler, Jin Mi Kim, Neil A. Farrow, Stéphane De Lombaert, Peter Allen Nemoto, Hidenori Takahashi, Leslie Martin, Daniel R. Albaugh, Steven S. Pullen, Kevin Chungeng Qian, Ho Yin Lo, Melissa Hill-Drzewi, Richard D. Schneiderman
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:4533-4539
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Chymases, Drug Discovery, Side chain, Humans, Moiety, Protease Inhibitors, Molecular Biology, Indole test, Binding Sites, Organic Chemistry, Chymase, Benzothiophene, Glutathione, Protein Structure, Tertiary, chemistry, Molecular Medicine, Benzimidazoles, Hydrophobic and Hydrophilic Interactions, Oxidation-Reduction, Lead compound, Conjugate
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