لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Crawford JJ; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States. Electronic address: crawford.james@gene.com., Feng J; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Brightbill HD; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Johnson AR; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wright M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Kolesnikov A; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Lee W; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Castanedo GM; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Do S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Blaquiere N; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Staben ST; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Chiang PC; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Fan PW; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Baumgardner M; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Wong S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Godemann R; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Grabbe A; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Wiegel C; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Sujatha-Bhaskar S; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hymowitz SG; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Liau N; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Hsu PL; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., McEwan PA; Evotec SE., Manfred Eigen Campus, Essener Bogen 7, Hamburg 22419, Germany., Ismaili MHA; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States., Landry ML; Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Jun 01; Vol. 89, pp. 129277. Date of Electronic Publication: 2023 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: NF-kappa B*/metabolism , Signal Transduction*, Humans ; Half-Life ; Drug Design

المؤلفون: Rosenberg SC; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Shanahan F; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yamazoe S; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Kschonsak M; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Zeng YJ; Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Lee J; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Plise E; Department of Drug Metabolism and Pharmacokinetics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Yen I; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Rose CM; Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Quinn JG; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Gazzard LJ; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Walters BT; Department of Biochemical and Cellular Pharmacology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Kirkpatrick DS; Department of Microchemistry, Proteomics and Lipidomics, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Staben ST; Department of Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA., Foster SA; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: foster.scott@gene.com., Malek S; Department of Discovery Oncology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. Electronic address: shiva.malek@novartis.com.

المصدر: Cell chemical biology [Cell Chem Biol] 2023 Feb 08. Date of Electronic Publication: 2023 Feb 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

المؤلفون: Steffek M; Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Helgason E; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Popovych N; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Rougé L; Structure Biology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Bruning JM; Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Li KS; Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Burdick DJ; Chemistry Departments, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Cai J; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Crawford T; Chemistry Departments, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Xue J; Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Decurtins W; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Fang C; WuXi AppTec (Wuhan) Company, Ltd., No. 666 GaoXin Road, WuHan East Lake High-tech Development Zone, Hubei 430075, China., Grubers F; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Holliday MJ; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Langley A; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Petersen A; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Satz AL; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Song A; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Stoffler D; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Strebel Q; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Tom JYK; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Skelton N; Chemistry Departments, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Staben ST; Chemistry Departments, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Wichert M; Roche Pharma Research and Early Development, Roche Innovation Center, Grenzacherstrasse 124, 4070 Basel, Switzerland., Mulvihill MM; Biochemical and Cellular Pharmacology, Genentech, 1 DNA Way, South San Francisco, California 94080, United States., Dueber EC; Early Discovery Biochemistry, Genentech, 1 DNA Way, South San Francisco, California 94080, United States.

المصدر: Biochemistry [Biochemistry] 2023 Feb 07; Vol. 62 (3), pp. 633-644. Date of Electronic Publication: 2022 Jan 05.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Microtubule-Associated Proteins*/metabolism , Autophagy*, Humans ; Animals ; Ligands ; Autophagy-Related Protein 8 Family/chemistry ; Autophagosomes/metabolism ; Mammals/metabolism