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المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106516d185208367e68bb96ffc0bed07
https://doi.org/10.1158/1535-7163.22500843.v1 -
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المؤلفون: Heather K. Raymon, Sabita Sankar, Peter Worland, Stacie S. Canan, Mehran F. Moghaddam, Brian E. Cathers, Zeen Tong, Wen Qing Yang, Tao Shi, Tam Tran, Sophie Perrin-Ninkovic, Sophie X. Peng, Samantha Richardson, Rene Bissonette, Rama Krishna Narla, Matt Hickman, Kamran Ghoreishi, Julius Apuy, Jingjing Zhao, Jim Leisten, James C. Gamez, Godrej Khambatta, Garrick Packard, Weiming Xu, Shuichan Xu, Kimberly E. Fultz, Deborah S. Mortensen
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4ce3c68a5bf01dbc4b5578e36679e558
https://doi.org/10.1158/1535-7163.c.6536589.v1 -
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المؤلفون: Mark A. Nagy, Robert Hilgraf, Deborah S. Mortensen, Jan Elsner, Stephen Norris, Jayashree Tikhe, Won Yoon, David Paisner, Mercedes Delgado, Paul Erdman, Jason Haelewyn, Godrej Khambatta, Li Xu, William J. Romanow, Kevin Condroski, Sogole Bahmanyar, Meg McCarrick, Brent Benish, Kate Blease, Laurie LeBrun, Mehran F. Moghaddam, Julius Apuy, Stacie S. Canan, Brydon L. Bennett, Yoshitaka Satoh
المصدر: Journal of Medicinal Chemistry. 64:18193-18208
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Charles E. Mowbray, Kazuya Nagaoka, Sachiko Itono, Rina Kaki, Yafeng Cao, Hiromi Nakai, Kevin Ronald Condroski, Constantin Radu, Naoaki Watanabe, Garry Pairaudeau, Ieuan Roberts, Benjamin Ian Perry, Ola Engkvist, Yuichiro Akao, Chiaki Kimura, Osamu Yoshida, Ryu Yoshida, Thierry Kogej, Mitsuyuki Shimada, Akira Naito, David Shum, Huanxu Xie, Stacie S. Canan, Shuji Yonezawa
مصطلحات موضوعية: Pharmacology, Virtual screening, Rapid expansion, Computer science, Organic Chemistry, Pharmaceutical Science, Computational biology, medicine.disease, Biochemistry, Visceral leishmaniasis, Drug Discovery, medicine, Molecular Medicine, Pharmacophore
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2eab07a33951ad2b661f896dbd891f48
https://doi.org/10.26434/chemrxiv.13134785.v1 -
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المؤلفون: Tamara Kreiss, Sreedhar R. Tummalapalli, Agnieszka Nawrocka Chojnowski, Vikram Khetani, David P. Rotella, Stacie S. Canan, Jerome B. Zeldis, Deborah Mortensen, Rohit Bhat, John J. Siekierka, Monika Prorok, Natalie Anne Hawryluk, Ronald Goldberg
المصدر: ACS Medicinal Chemistry Letters. 9:210-214
مصطلحات موضوعية: 0301 basic medicine, 010405 organic chemistry, business.industry, Kinase, Organic Chemistry, Disease, medicine.disease, 01 natural sciences, Biochemistry, Stress activated protein kinase, 0104 chemical sciences, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, medicine, Cancer research, business, Lymphatic filariasis
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المؤلفون: Xiuju Jiang, Madeleine R. Wood, Véronique Dartois, Shashirekha Mundhra, Matthew C. Zimmerman, Natalie Anne Hawryluk, Renier van der Westhuyzen, Kelly Chibale, Leslie J. Street, Colin R. Wilson, Suna Park, Andrea Ballabio, Elaina Weber, Vikram Khetani, Nunzia Pastore, Stacie S. Canan, Joseph Camardo, Carl Nathan, Ruslana Bryk, Li Zhang, Daniel Pfau
المساهمون: Bryk, R., Mundhra, S., Jiang, X., Wood, M., Pfau, D., Weber, E., Park, S., Zhang, L., Wilson, C., Van der Westhuyzen, R., Street, L., Chibale, K., Zimmerman, M., Dartois, V., Pastore, N., Ballabio, A., Hawryluk, N., Canan, S., Khetani, V., Camardo, J., Nathan, C.
المصدر: PLoS Pathogens
PLoS Pathogens, Vol 16, Iss 6, p e1008567 (2020)مصطلحات موضوعية: Bacterial Diseases, Kinase Inhibitors, Antitubercular Agents, Pathology and Laboratory Medicine, Biochemistry, White Blood Cells, Mice, PIKFYVE, Animal Cells, Drug Discovery, Medicine and Health Sciences, Biology (General), Enzyme Inhibitors, Immune Response, 0303 health sciences, Cell Death, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Kinase, 030302 biochemistry & molecular biology, Tuberculosis Drug Discovery, Cell biology, Actinobacteria, Infectious Diseases, Cell Processes, Female, Cellular Types, Cellular Structures and Organelles, Rifampin, medicine.symptom, Research Article, Drug Research and Development, QH301-705.5, Immune Cells, Autophagic Cell Death, Immunology, Inflammation, Biology, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, Signs and Symptoms, Diagnostic Medicine, In vivo, Virology, Genetics, medicine, Tuberculosis, Animals, Molecular Biology, Transcription factor, 030304 developmental biology, Pharmacology, Blood Cells, Bacteria, Macrophages, Autophagy, Organisms, Biology and Life Sciences, Cell Biology, RC581-607, Tropical Diseases, biology.organism_classification, Disease Models, Animal, Enzymology, TFEB, Parasitology, Immunologic diseases. Allergy, Lysosomes
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المؤلفون: Sogole Bahmanyar, Brian E. Cathers, Mehran F. Moghaddam, Peter Worland, Lida Tehrani, Brandon Wade Whitefield, Heather Raymon, James C. Gamez, Godrej Khambatta, Julius Apuy, Samantha J. Richardson, Rene R. Bisonette, Jingjing Zhao, Graziella I. Shevlin, Deborah Mortensen, Matt Hickman, Jan Elsner, Correa Matthew D, Roy L. Harris, Sophie Perrin-Ninkovic, Rama K. Narla, Jennifer Riggs, Kimberly Elizabeth Fultz, Sabita Sankar, Patrick Papa, John Sapienza, Stacie S. Canan, Sophie X. Peng, Jason Simon Parnes, Garrick Packard, Jim Leisten, Branden Lee
المصدر: Journal of Medicinal Chemistry. 58:5599-5608
مصطلحات موضوعية: Protein Conformation, Triazole, mTORC1, Pharmacology, mTORC2, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Chemistry, Kinase, TOR Serine-Threonine Kinases, Triazoles, Xenograft Model Antitumor Assays, Rats, Molecular Docking Simulation, Biochemistry, Drug Design, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jason Simon Parnes, Rene R. Bisonette, Sophie Perrin-Ninkovic, Deborah Mortensen, Branden Lee, Peter Worland, James C. Gamez, Graziella I. Shevlin, Matt Hickman, Stacie S. Canan, Julius Apuy, Samantha J. Richardson, Jingjing Zhao, Godrej Khambatta, Sophie X. Peng, Jim Leisten, Garrick Packard, Correa Matthew D, Rama K. Narla, Lida Tehrani, Jennifer Riggs, Heather Raymon, Jan Elsner, Roy L. Harris, Kimberly Elizabeth Fultz, Patrick Papa, Sogole Bahmanyar, Brandon Wade Whitefield, Sabita Sankar, John Sapienza, Mehran F. Moghaddam, Brian E. Cathers
المصدر: Journal of Medicinal Chemistry. 58:5323-5333
مصطلحات موضوعية: Male, Models, Molecular, Antineoplastic Agents, Pharmacology, MTOR Kinase Inhibitor CC-223, Structure-Activity Relationship, In vivo, Drug Discovery, Tumor Cells, Cultured, Animals, Humans, Structure–activity relationship, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Molecular Structure, Drug discovery, Chemistry, Kinase, TOR Serine-Threonine Kinases, RPTOR, Prostatic Neoplasms, Rats, Inhibitory potency, Pyrazines, Molecular Medicine, Signal Transduction
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المؤلفون: Jingjing Zhao, Sophie X. Peng, Brian E. Cathers, Sabita Sankar, Garrick Packard, Stacie S. Canan, Shuichan Xu, Heather Raymon, Godrej Khambatta, Rama K. Narla, Kimberly Elizabeth Fultz, Sophie Perrin-Ninkovic, Matt Hickman, Tam Tran, Samantha J. Richardson, Jim Leisten, Kamran Ghoreishi, Rene Bissonette, Mehran F. Moghaddam, Julius Apuy, Tao Shi, Deborah Mortensen, Wen Qing Yang, Weiming Xu, James C. Gamez, Peter Worland, Zeen Tong
المصدر: Molecular Cancer Therapeutics. 14:1295-1305
مصطلحات موضوعية: Cancer Research, Blotting, Western, Apoptosis, P70-S6 Kinase 1, Mechanistic Target of Rapamycin Complex 2, Mice, SCID, mTORC1, Mechanistic Target of Rapamycin Complex 1, Biology, mTORC2, In vivo, Cell Line, Tumor, Neoplasms, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Neovascularization, Pathologic, Cell growth, Kinase, TOR Serine-Threonine Kinases, RPTOR, HCT116 Cells, Xenograft Model Antitumor Assays, Tumor Burden, HEK293 Cells, Oncology, Multiprotein Complexes, Pyrazines, Cancer research, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50876b20cd6236c0e871976f53e0b444
https://doi.org/10.1158/1535-7163.mct-14-1052 -
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المؤلفون: Stacie S. Canan
المصدر: Cancer Drug Discovery and Development ISBN: 9783319141503
مصطلحات موضوعية: chemistry.chemical_compound, Nicotinamide, Stereochemistry, medicine.drug_class, Chemistry, Poly ADP ribose polymerase, PARP inhibitor, medicine, Carboxamide, NAD+ kinase, Tyrosine, Tankyrase-1, Binding site
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fe03c37f26eabb2476085b1c5f15f937
https://doi.org/10.1007/978-3-319-14151-0_8
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