المؤلفون: Queathem ED, Moazzami Z, Stagg DB, Nelson AB, Fulghum K, Hayir A, Seay A, Gillingham JR, d'Avignon DA, Han X, Ruan HB, Crawford PA, Puchalska P

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Jul 11. Date of Electronic Publication: 2024 Jul 11.

نوع المنشور: Journal Article; Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Rome FI; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota., Shobert GL; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota., Voigt WC; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota., Stagg DB; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota., Puchalska P; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota., Burgess SC; Center for Human Nutrition, The University of Texas Southwestern Medical Center, Dallas, Texas.; Department of Pharmacology, The University of Texas Southwestern Medical Center, Dallas, Texas., Crawford PA; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota., Hughey CC; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, Minnesota.

المصدر: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Jan 01; Vol. 324 (1), pp. E9-E23. Date of Electronic Publication: 2022 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1555 (Electronic) Linking ISSN: 01931849 NLM ISO Abbreviation: Am J Physiol Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Glucose*/metabolism , Liver*/metabolism, Mice ; Animals ; Phosphoenolpyruvate/metabolism ; Gluconeogenesis ; 3-Hydroxybutyric Acid/metabolism

المؤلفون: Nelson AB; Division of Molecular Medicine, Department of Medicine.; Bioinformatics and Computational Biology Program., Chow LS; Division of Diabetes, Endocrinology and Metabolism, Department of Medicine., Stagg DB; Division of Molecular Medicine, Department of Medicine.; Department of Biochemistry, Molecular Biology, and Biophysics, and., Gillingham JR; Division of Molecular Medicine, Department of Medicine., Evans MD; Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, Minnesota, USA., Pan M; Barshop Institute for Longevity and Aging Studies and.; Department of Medicine - Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Hughey CC; Division of Molecular Medicine, Department of Medicine.; Department of Integrative Biology and Physiology and., Myers CL; Bioinformatics and Computational Biology Program.; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA., Han X; Barshop Institute for Longevity and Aging Studies and.; Department of Medicine - Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA., Crawford PA; Division of Molecular Medicine, Department of Medicine.; Bioinformatics and Computational Biology Program.; Department of Biochemistry, Molecular Biology, and Biophysics, and., Puchalska P; Division of Molecular Medicine, Department of Medicine.

المصدر: JCI insight [JCI Insight] 2022 Apr 08; Vol. 7 (7). Date of Electronic Publication: 2022 Apr 08.

نوع المنشور: Clinical Study; Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Esters*/analysis , Esters*/chemistry , Esters*/metabolism , Overweight*, Adenine ; Cross-Sectional Studies ; Exercise ; Fatty Acids/metabolism ; Humans ; Metabolome ; Obesity

المؤلفون: Stagg DB; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Gillingham JR; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Nelson AB; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA., Lengfeld JE; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., d'Avignon DA; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Puchalska P; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA., Crawford PA; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA. Electronic address: crawforp@umn.edu.

المصدر: Molecular metabolism [Mol Metab] 2021 Nov; Vol. 53, pp. 101269. Date of Electronic Publication: 2021 Jun 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Glucose/*biosynthesis , Hepatocytes/*metabolism , Hydroxybutyrate Dehydrogenase/*metabolism , Ketones/*metabolism, Animals ; Citric Acid Cycle ; Female ; Hydroxybutyrate Dehydrogenase/deficiency ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout

المؤلفون: Puchalska P; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA. Electronic address: ppuchals@umn.edu., Nelson AB; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA., Stagg DB; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA., Crawford PA; Division of Molecular Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA; Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN, USA; Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN, USA.

المصدر: Talanta [Talanta] 2021 Apr 01; Vol. 225, pp. 122048. Date of Electronic Publication: 2020 Dec 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE

مواضيع طبية MeSH: Ketone Bodies* , Tandem Mass Spectrometry*, 3-Hydroxybutyric Acid ; Animals ; Chromatography, High Pressure Liquid ; Chromatography, Liquid

المؤلفون: Stagg DB; Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA., Whittlesey RL; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Li X; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Lozovatsky L; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA., Gardenghi S; Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA., Rivella S; Department of Pediatrics, Division of Hematology-Oncology, Weill Cornell Medical College, New York, NY, USA.; Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, NY, USA.; Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA., Finberg KE; Department of Pathology, Duke University School of Medicine, Durham, North Carolina, USA karin.finberg@yale.edu.; Department of Pathology, Yale School of Medicine, New Haven, Connecticut, USA.

المصدر: Haematologica [Haematologica] 2019 Oct; Vol. 104 (10), pp. e442-e446. Date of Electronic Publication: 2019 Feb 28.

نوع المنشور: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Ferrata Storti Foundation Country of Publication: Italy NLM ID: 0417435 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1592-8721 (Electronic) Linking ISSN: 03906078 NLM ISO Abbreviation: Haematologica Subsets: MEDLINE

مواضيع طبية MeSH: Cell Differentiation*, Erythroid Cells/*metabolism , Membrane Proteins/*deficiency , Serine Endopeptidases/*deficiency , beta-Thalassemia/*metabolism, Animals ; Disease Models, Animal ; Erythroid Cells/pathology ; Membrane Proteins/metabolism ; Mice ; Mice, Knockout ; Serine Endopeptidases/metabolism ; beta-Thalassemia/genetics ; beta-Thalassemia/pathology

المؤلفون: Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Ellison SJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Baker JG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Stagg DB; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Park S; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Alley HM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Baldi RM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Yllanes A; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Andreano KJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Stice JP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Lawrence SA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Eisner JR; Innocrin Pharmaceuticals Inc., Durham, North Carolina, USA., Price DK; Genitourinary Malignancies Branch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA., Moore WR; Innocrin Pharmaceuticals Inc., Durham, North Carolina, USA., Figg WD; Genitourinary Malignancies Branch, National Cancer Institute (NCI), NIH, Bethesda, Maryland, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.

المصدر: The Journal of clinical investigation [J Clin Invest] 2017 Jun 01; Vol. 127 (6), pp. 2326-2338. Date of Electronic Publication: 2017 May 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists/*pharmacology , Antineoplastic Agents, Hormonal/*pharmacology , Prostatic Neoplasms, Castration-Resistant/*drug therapy , Steroid 17-alpha-Hydroxylase/*antagonists & inhibitors, Active Transport, Cell Nucleus ; Animals ; Benzamides ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Drug Synergism ; HEK293 Cells ; Humans ; Inhibitory Concentration 50 ; Male ; Metribolone/pharmacology ; Mice, Inbred NOD ; Mice, SCID ; Nitriles ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/pharmacology ; Protein Binding ; Receptors, Androgen/metabolism ; Steroid 17-alpha-Hydroxylase/metabolism ; Testosterone/pharmacology ; Transcriptional Activation/drug effects ; Xenograft Model Antitumor Assays

المؤلفون: Pollock JA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Parent AA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Stagg DB; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Ellison SJ; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Alley HM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Chao CA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Lawrence SA; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Stice JP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Spasojevic I; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.; Duke Cancer Institute, Pharmaceutical Research-PK/PD Core Laboratory, Durham, North Carolina, USA., Baker JG; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Kim SH; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA., Katzenellenbogen JA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina, USA.

المصدر: Nature chemical biology [Nat Chem Biol] 2016 Oct; Vol. 12 (10), pp. 795-801. Date of Electronic Publication: 2016 Aug 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists/*pharmacology , Antineoplastic Agents/*pharmacology , Cell Nucleus/*drug effects , Cell Nucleus/*metabolism , Prostatic Neoplasms, Castration-Resistant/*drug therapy , Prostatic Neoplasms, Castration-Resistant/*metabolism , Receptors, Androgen/*metabolism, Androgen Receptor Antagonists/chemistry ; Antineoplastic Agents/chemistry ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Male ; Prostatic Neoplasms, Castration-Resistant/pathology ; Structure-Activity Relationship

المؤلفون: Gustafson JL; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Neklesa TK; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Cox CS; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Roth AG; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Buckley DL; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Tae HS; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Sundberg TB; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., Stagg DB; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 (USA)., Hines J; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA)., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 (USA)., Norris JD; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710 (USA)., Crews CM; Departments of Molecular, Cellular, and Developmental Biology, Chemistry, and Pharmacology, Yale University, New Haven, CT 065111 (USA). craig.crews@yale.edu.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2015 Aug 10; Vol. 54 (33), pp. 9659-62. Date of Electronic Publication: 2015 Jun 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists/*chemistry , Androgen Receptor Antagonists/*pharmacology , Proteolysis/*drug effects , Receptors, Androgen/*metabolism , Small Molecule Libraries/*chemistry , Small Molecule Libraries/*pharmacology, Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Benzamides ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Drug Resistance, Neoplasm ; Humans ; Hydrophobic and Hydrophilic Interactions ; Male ; Nitriles ; Phenylthiohydantoin/analogs & derivatives ; Phenylthiohydantoin/chemistry ; Phenylthiohydantoin/pharmacology ; Point Mutation ; Prostate/drug effects ; Prostate/metabolism ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/metabolism ; Receptors, Androgen/genetics