المؤلفون: Sison-Young, RL, Lauschke, VM, Johann, E, Alexandre, E, Antherieu, S, Aerts, H, Gerets, HHJ, Labbe, G, Hoet, D, Dorau, M, Schofield, CA, Lovatt, CA, Holder, JC, Stahl, SH, Richert, L, Kitteringham, NR, Jones, RP, Elmasry, M, Weaver, RJ, Hewitt, PG, Ingelman-Sundberg, M, Goldring, CE, Park, BK

المصدر: Archives of toxicology. 91(3):1385-1400

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:135388458

المؤلفون: Yang, K, Battista, C, Woodhead, JL, Stahl, SH, Mettetal, JT, Watkins, PB, Siler, SQ, Howell, BA

المصدر: Clinical Pharmacology & Therapeutics; Apr2017, Vol. 101 Issue 4, p501-509, 9p

مصطلحات موضوعية: HYPERBILIRUBINEMIA, HEPATOTOXICOLOGY, BILIRUBIN, LIVER diseases, GENETIC polymorphisms

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المؤلفون: Kikuchi R; Quantitative, Translational and ADME Sciences, AbbVie Inc., North Chicago, Illinois, USA., Chothe PP; Global Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc. (TDCA), Lexington, Massachusetts, USA., Chu X; ADME and Discovery Toxicology, Merck & Co., Inc., Rahway, New Jersey, USA., Huth F; PK Sciences, Novartis Pharma AG, Basel, Switzerland., Ishida K; Drug Metabolism, Gilead Sciences Inc., Foster City, California, USA., Ishiguro N; Pharmacokinetics and Non-Clinical Safety Department, Nippon Boehringer Ingelheim Co., Ltd., Kobe, Japan., Jiang R; Drug Metabolism and Pharmacokinetics, Eisai Inc., Cambridge, Massachusetts, USA., Shen H; Departments of Drug Metabolism and Pharmacokinetics, Bristol Myers Squibb Research and Development, Princeton, New Jersey, USA., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Varma MVS; Pharmacokinetics, Dynamics and Metabolism, Medicine Design, Pfizer Inc., Groton, Connecticut, USA., Willemin ME; Drug Metabolism and Pharmacokinetics, Janssen Research and Development, a Division of Janssen Pharmaceutica NV, Beerse, Belgium., Morse BL; Department of Drug Disposition, Eli Lilly, Indianapolis, Indiana, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2023 Dec; Vol. 114 (6), pp. 1170-1183. Date of Electronic Publication: 2023 Oct 11.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Coproporphyrins*/metabolism , Organic Anion Transporters*, Humans ; Liver-Specific Organic Anion Transporter 1 ; Drug Interactions ; Biomarkers ; Drug Industry

المؤلفون: Caetano-Pinto P; Department of Urology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße, 17475 Greifswald, Germany., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, 310 Darwin Building, Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 21; Vol. 24 (20). Date of Electronic Publication: 2023 Oct 21.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Organic Anion Transporters, Sodium-Independent*/genetics , Organic Anion Transporters*/metabolism, Animals ; Humans ; Organic Anion Transport Protein 1/genetics ; Organic Anion Transport Protein 1/metabolism ; Kidney/metabolism ; Kidney Tubules, Proximal/metabolism ; Epithelial Cells/metabolism

المؤلفون: Caetano-Pinto P; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.; Department of Urology, University Medicine Greifswald, Greifswald, Germany., Nordell P; DMPK, Research and Early Development Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Nieskens T; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden., Haughan K; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Fenner KS; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom., Stahl SH; ADME Sciences, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, United Kingdom.; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Gothenburg, Sweden.

المصدر: ALTEX [ALTEX] 2023; Vol. 40 (3), pp. 408-424. Date of Electronic Publication: 2022 Nov 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE

مواضيع طبية MeSH: Microphysiological Systems* , Metformin*/metabolism , Metformin*/pharmacology, Animals ; Humans ; Cidofovir/pharmacology ; Kidney/metabolism ; Drug Elimination Routes

المؤلفون: Brouwer KLR; Division of Pharmacotherapy and Experimental Therapeutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Evers R; Preclinical Sciences and Translational Safety, Johnson & Johnson, Janssen Pharmaceuticals, Spring House, Pennsylvania, USA., Hayden E; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA., Hu S; College of Pharmacy, The Ohio State University, Columbus, Ohio, USA., Li CY; PKDM, Amgen Inc., South San Francisco, California, USA., Meyer Zu Schwabedissen HE; Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland., Neuhoff S; Certara UK Ltd., Simcyp Division, Sheffield, UK., Oswald S; Institute of Pharmacology and Toxicology, Rostock University Medical Center, Rostock, Germany., Piquette-Miller M; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada., Saran C; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA., Sjöstedt N; Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland., Sprowl JA; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York, USA., Stahl SH; CVRM Safety, Clinical Pharmacology and Safety Sciences, R&D, AstraZeneca, Cambridge, UK., Yue W; College of Pharmacy, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 461-484. Date of Electronic Publication: 2022 May 24.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Carrier Proteins*/metabolism , Membrane Transport Proteins*/genetics , Membrane Transport Proteins*/metabolism, Biological Transport ; Gene Expression Regulation ; Humans ; Pharmaceutical Preparations ; Receptors, Cytoplasmic and Nuclear/genetics

المؤلفون: Krishnan S; Drug Metabolism and Pharmacokinetics, Oncology Research & Development, AstraZeneca, Boston, Massachusetts, USA., Ramsden D; Drug Metabolism and Pharmacokinetics, Oncology Research & Development, AstraZeneca, Boston, Massachusetts, USA., Ferguson D; Drug Metabolism and Pharmacokinetics, Oncology Research & Development, AstraZeneca, Boston, Massachusetts, USA., Stahl SH; Cardiovascular, Renal, and Metabolism Safety, Clinical Pharmacology and Safety Sciences, Research & Development, AstraZeneca, Cambridge, UK., Wang J; Department of Pharmaceutics, University of Washington, Seattle, Washington, USA., McGinnity DF; Drug Metabolism and Pharmacokinetics, Oncology Research & Development, AstraZeneca, Cambridge, UK., Hariparsad N; Drug Metabolism and Pharmacokinetics, Oncology Research & Development, AstraZeneca, Boston, Massachusetts, USA.

المصدر: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2022 Sep; Vol. 112 (3), pp. 562-572. Date of Electronic Publication: 2022 Jun 25.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

مواضيع طبية MeSH: Kidney*/metabolism , Organic Cation Transport Proteins*/metabolism, Drug Interactions ; HEK293 Cells ; Humans ; Organic Cation Transporter 2/metabolism ; Renal Elimination

المؤلفون: Ramsden D; Takeda Development Center Americas, Inc., Cambridge, MA, USA.; current affiliation: AstraZeneca, Waltham, MA. USA., Belair DG; AbbVie, N Chicago, IL, USA., Agarwal S; Alnylam Pharmaceuticals, Cambridge, MA, USA., Andersson P; AstraZeneca, Gothenburg, Sweden., Humphreys S; Amgen, S. San Francisco, CA, USA., Dalmas DA; GlaxoSmithKline, Collegeville, PA, USA., Stahl SH; AstraZeneca, Cambridge, UK., Maclauchlin C; Alnylam Pharmaceuticals, Cambridge, MA, USA., Cichocki JA; Vertex Pharmaceuticals, Boston, MA, USA.

المصدر: ALTEX [ALTEX] 2022; Vol. 39 (2), pp. 273–296. Date of Electronic Publication: 2021 Nov 11.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Spektrum Akademischer Verlag Country of Publication: Germany NLM ID: 100953980 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-8551 (Electronic) Linking ISSN: 1868596X NLM ISO Abbreviation: ALTEX Subsets: MEDLINE

مواضيع طبية MeSH: Oligonucleotides*/therapeutic use, Animals ; Pharmaceutical Preparations

المؤلفون: Dargue R; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Grant I; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Nye LC; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Nicholls A; GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire SG12 0DP, UK., Dare T; GlaxoSmithKline R&D, Park Road, Ware, Hertfordshire SG12 0DP, UK., Stahl SH; ADME Sciences, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Unit 310 Cambridge Science Park, Milton Road, Cambridge CB4 0WG, UK., Plumb RS; WatersCorporation, Milford, MA 01757, USA., Lee K; Department of Clinical Science & Services, Royal Veterinary College, University of London, Hertfordshire AL9 7TA, UK., Jalan R; UCL Institute for Liver & Digestive Health, Royal Free Hospital, London NW3 2PF, UK., Coen M; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK., Wilson ID; Division of Systems Medicine, Department of Metabolism, Digestion & Reproduction, Imperial College London, Exhibition Road, South Kensington, London SW7 2AZ, UK.

المصدر: Bioanalysis [Bioanalysis] 2020 Apr; Vol. 12 (7), pp. 485-500. Date of Electronic Publication: 2020 Apr 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101512484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-6199 (Electronic) Linking ISSN: 17576180 NLM ISO Abbreviation: Bioanalysis Subsets: MEDLINE

مواضيع طبية MeSH: Acetaminophen/*metabolism , Chromatography, High Pressure Liquid/*methods , Plasma/*metabolism , Tandem Mass Spectrometry/*methods, Animals ; Humans ; Rats ; Rats, Wistar ; Swine