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المؤلفون: Van Espen B; University of California, San Diego, La Jolla., Prideaux EB; University of California, San Diego, La Jolla., Wilson AR; University of California, San Diego, La Jolla., Machado CRL; University of California, San Diego, La Jolla., Sendo S; University of California, San Diego, La Jolla., Parker J; Eli Lilly and Company, Indianapolis, Indiana., Seumois G; La Jolla Institute for Immunology, La Jolla, California., Sacchetti C; University of California, San Diego, La Jolla., Belongia AC; University of California, San Diego, La Jolla., Perumal NB; Eli Lilly and Company, Indianapolis, Indiana., Vijayanand P; University of California, San Diego, and La Jolla Institute for Immunology, La Jolla, California., Linnik MD; Eli Lilly and Company, Indianapolis, Indiana., Benschop RJ; Eli Lilly and Company, Indianapolis, Indiana., Wang W; University of California, San Diego, La Jolla., Bottini N; University of California, San Diego, La Jolla, and Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California., Firestein GS; University of California, San Diego, La Jolla., Stanford SM; University of California, San Diego, La Jolla.

المصدر: Arthritis & rheumatology (Hoboken, N.J.) [Arthritis Rheumatol] 2024 Aug; Vol. 76 (8), pp. 1243-1251. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101623795 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2326-5205 (Electronic) Linking ISSN: 23265191 NLM ISO Abbreviation: Arthritis Rheumatol Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Rheumatoid*/genetics , Arthritis, Rheumatoid*/pathology , Synovial Membrane*/pathology , Synovial Membrane*/metabolism , Sequence Analysis, RNA* , Laser Capture Microdissection*, Humans ; Female ; Male ; Middle Aged ; Transcriptome ; Aged ; Osteoarthritis/genetics ; Osteoarthritis/pathology ; Principal Component Analysis ; Gene Expression Profiling

المؤلفون: Zhuang C; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA., Yang S; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA; Department of Medicine, Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Gonzalez CG; Department of Pharmacology, University of California, San Diego, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, USA., Ainsworth RI; Department of Medicine, Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Li S; Department of Medicine, University of California, San Diego, California, USA., Kobayashi MT; Department of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, Connecticut, USA., Wierzbicki I; Department of Pharmacology, University of California, San Diego, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, USA., Rossitto LM; Department of Pharmacology, University of California, San Diego, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, USA., Wen Y; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA., Peti W; Department of Molecular Biology and Biophysics, University of Connecticut Health, Farmington, Connecticut, USA., Stanford SM; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA., Gonzalez DJ; Department of Pharmacology, University of California, San Diego, California, USA; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, California, USA., Murali R; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA; Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Santelli E; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA; Department of Medicine, Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA., Bottini N; Department of Medicine, Altman Clinical and Translational Research Institute, University of California, San Diego, California, USA; Department of Medicine, Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA. Electronic address: Nunzio.Bottini@cshs.org.

المصدر: The Journal of biological chemistry [J Biol Chem] 2024 Jun; Vol. 300 (6), pp. 107393. Date of Electronic Publication: 2024 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Antigen, T-Cell*/metabolism , Receptors, Antigen, T-Cell*/immunology , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 22*/metabolism , Signal Transduction*, Humans ; Phosphorylation ; Gain of Function Mutation ; T-Lymphocytes/metabolism ; T-Lymphocytes/immunology ; Jurkat Cells ; HEK293 Cells

المؤلفون: Stanford SM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Nguyen TP; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Chang J; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Zhao Z; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Hackman GL; Department of Nutritional Sciences, College of Natural Sciences and Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Santelli E; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Sanders CM; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Katiki M; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Dondossola E; Department of Genitourinary Medical Oncology and David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Brauer BL; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Diaz MA; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Zhan Y; Department of Pediatrics and Department of Oncology, Dell Medical School, Livestrong Cancer Institutes, College of Natural Sciences, The University of Texas at Austin, Austin, TX USA., Ramsey SH; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Watson PA; Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sankaran B; Department of Molecular Biophysics and Integrated Bioimaging, Berkeley Center for Structural Biology, Lawrence Berkeley National Laboratory, Berkeley, CA, USA., Paindelli C; Department of Genitourinary Medical Oncology and David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Parietti V; Department of Genitourinary Medical Oncology and David H. Koch Center for Applied Research of Genitourinary Cancers, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mikos AG; Department of Bioengineering, Rice University, Houston, TX, USA., Lodi A; Department of Nutritional Sciences, College of Natural Sciences and Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, USA., Bagrodia A; Department of Urology, University of California, San Diego, La Jolla, CA, USA., Elliott A; Department of Clinical and Translational Research, Caris Life Sciences, Phoenix, AZ, USA., McKay RR; Department of Medicine, University of California, San Diego, La Jolla, CA, USA., Murali R; Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA., Tiziani S; Department of Nutritional Sciences, College of Natural Sciences and Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, USA.; Department of Pediatrics and Department of Oncology, Dell Medical School, Livestrong Cancer Institutes, College of Natural Sciences, The University of Texas at Austin, Austin, TX USA., Kettenbach AN; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA., Bottini N; Department of Medicine, University of California, San Diego, La Jolla, CA, USA.; Kao Autoimmunity Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

المصدر: Science advances [Sci Adv] 2024 Feb 02; Vol. 10 (5), pp. eadg7887. Date of Electronic Publication: 2024 Jan 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Prostatic Neoplasms*/drug therapy , Prostatic Neoplasms*/genetics, Male ; Humans ; Mice ; Animals ; Molecular Weight ; Tyrosine ; Protein Tyrosine Phosphatases/metabolism

المؤلفون: Stanford SM; Department of Medicine, University of California, San Diego, CA, USA. ststanford@health.ucsd.edu., Bottini N; Department of Medicine, University of California, San Diego, CA, USA. nbottini@health.ucsd.edu.

المصدر: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2023 Apr; Vol. 22 (4), pp. 273-294. Date of Electronic Publication: 2023 Jan 24.

نوع المنشور: Journal Article; Review; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-1784 (Electronic) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

مواضيع طبية MeSH: Autoimmune Diseases*/drug therapy , Neoplasms*/drug therapy, Humans ; Protein Tyrosine Phosphatases/metabolism ; Phosphoprotein Phosphatases ; Immunotherapy

المؤلفون: Imbery JF; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Heinzelbecker J; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Jebsen JK; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., McGowan M; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Myklebust C; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bottini N; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Stanford SM; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, San Diego, La Jolla, California, USA., Skånland SS; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Cancer Immunology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Tveita A; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Tjønnfjord GE; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Haematology, Oslo University Hospital, Oslo, Norway., Munthe LA; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Szodoray P; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Nakken B; Department of Immunology, Oslo University Hospital, Oslo, Norway.; Faculty of Medicine, KG Jebsen Centre for B Cell Malignances, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

المصدر: British journal of haematology [Br J Haematol] 2022 Aug; Vol. 198 (3), pp. 556-573. Date of Electronic Publication: 2022 Jun 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

مواضيع طبية MeSH: Leukemia, Lymphocytic, Chronic, B-Cell*/pathology, CD40 Ligand ; Cell Proliferation ; Galectin 1 ; Humans ; T-Lymphocytes, Helper-Inducer

المؤلفون: Stanford SM; Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA., Collins M; Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, USA.; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA., Diaz MA; Department of Medicine, University of California, San Diego, La Jolla, California, USA., Holmes ZJ; Department of Medicine, University of California, San Diego, La Jolla, California, USA., Gries P; Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, USA.; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA., Bliss MR; Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA., Lodi A; Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, USA.; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA., Zhang V; Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA., Tiziani S; Department of Nutritional Sciences, The University of Texas at Austin, Austin, Texas, USA.; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA.; Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA., Bottini N; Department of Medicine, University of California, San Diego, La Jolla, California, USA.; Division of Cellular Biology, La Jolla Institute for Allergy and Immunology, La Jolla, California, USA.

المصدر: Journal of cellular physiology [J Cell Physiol] 2021 Sep; Vol. 236 (9), pp. 6630-6642. Date of Electronic Publication: 2021 Feb 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0050222 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4652 (Electronic) Linking ISSN: 00219541 NLM ISO Abbreviation: J Cell Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Adipogenesis*/genetics, Adipocytes/*metabolism , Adipocytes/*pathology , Protein Tyrosine Phosphatases/*metabolism , Proto-Oncogene Proteins/*metabolism , Subcutaneous Fat/*pathology, 3T3-L1 Cells ; Animals ; Cell Differentiation/genetics ; Cell Respiration ; Cell Size ; Electron Transport ; Gene Deletion ; Gene Expression Regulation ; Glucose/metabolism ; Glycolysis ; Hypertrophy ; JNK Mitogen-Activated Protein Kinases/metabolism ; Metabolome ; Mice ; Mice, Knockout ; Mitochondria/metabolism ; Models, Biological ; PPAR gamma/metabolism ; Phosphorylation ; Phosphoserine/metabolism ; Protein Tyrosine Phosphatases/antagonists & inhibitors ; Proto-Oncogene Proteins/antagonists & inhibitors ; Receptor, Platelet-Derived Growth Factor alpha/metabolism ; Signal Transduction ; p38 Mitogen-Activated Protein Kinases/metabolism

المؤلفون: Szodoray P; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: peter.szodoray@medisin.uio.no., Andersen TK; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for Influenza Vaccine Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Heinzelbecker J; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Imbery JF; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Huszthy PC; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway., Stanford SM; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive MC #0656, La Jolla, CA 92093, USA., Bogen B; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for Influenza Vaccine Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Landsverk OB; Department of Pathology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway., Bottini N; Division of Rheumatology, Allergy and Immunology, Department of Medicine, University of California, San Diego, 9500 Gilman Drive MC #0656, La Jolla, CA 92093, USA., Tveita A; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Munthe LA; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway., Nakken B; Department of Immunology, University of Oslo and Oslo University Hospital-Rikshospitalet, 0372 Oslo, Norway; K.G. Jebsen Center for B Cell Malignancies, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

المصدر: Cell reports [Cell Rep] 2021 Aug 10; Vol. 36 (6), pp. 109525.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Immunologic Memory*, B-Lymphocytes/*cytology , Cell Differentiation/*immunology , Leukocyte Common Antigens/*metabolism , Plasma Cells/*cytology , Receptors, Antigen, B-Cell/*metabolism , T-Lymphocytes, Helper-Inducer/*metabolism, Animals ; Antibody Formation ; CD40 Ligand/metabolism ; Female ; Galectin 1/metabolism ; Germinal Center/cytology ; Humans ; Lymphocyte Subsets/metabolism ; Mice, Inbred BALB C ; Up-Regulation ; Mice

المؤلفون: Stanford SM; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Diaz MA; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Ardecky RJ; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Zou J; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Roosild T; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Holmes ZJ; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Nguyen TP; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Hedrick MP; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Rodiles S; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Guan A; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Grotegut S; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Santelli E; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Chung TDY; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Jackson MR; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States., Bottini N; Department of Medicine, University of California, San Diego, La Jolla, California 92037, United States., Pinkerton AB; Conrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 5645-5653. Date of Electronic Publication: 2021 Apr 29.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors/*chemistry , Protein Tyrosine Phosphatases/*antagonists & inhibitors , Purines/*chemistry, Administration, Oral ; Animals ; Binding Sites ; Crystallography, X-Ray ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/etiology ; Disease Models, Animal ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/metabolism ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Half-Life ; Humans ; Insulin Resistance ; Kinetics ; Molecular Dynamics Simulation ; Obesity/complications ; Obesity/pathology ; Phosphorylation/drug effects ; Protein Tyrosine Phosphatases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Purines/metabolism ; Purines/pharmacology ; Purines/therapeutic use ; Signal Transduction/drug effects ; Structure-Activity Relationship

المؤلفون: Hsieh WC; Department of Medicine, UCSD School of Medicine, La Jolla, California, USA., Svensson MN; Department of Medicine, UCSD School of Medicine, La Jolla, California, USA.; Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Zoccheddu M; Department of Medicine, UCSD School of Medicine, La Jolla, California, USA., Tremblay ML; Rosalind and Morris Goodman Cancer Research Centre.; Department of Biochemistry, and.; Division of Experimental Medicine, Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montréal, Québec, Canada., Sakaguchi S; Laboratory of Experimental Immunology, Immunology Frontier Research Center, Osaka University, Suita, Japan.; Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan., Stanford SM; Department of Medicine, UCSD School of Medicine, La Jolla, California, USA., Bottini N; Department of Medicine, UCSD School of Medicine, La Jolla, California, USA.

المصدر: JCI insight [JCI Insight] 2020 Oct 15; Vol. 5 (20). Date of Electronic Publication: 2020 Oct 15.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis/*genetics , Autoimmune Diseases/*genetics , DNA-Binding Proteins/*genetics , Protein Tyrosine Phosphatase, Non-Receptor Type 2/*genetics , Receptors, G-Protein-Coupled/*genetics , Receptors, Peptide/*genetics, Animals ; Arthritis/chemically induced ; Arthritis/pathology ; Autoimmune Diseases/chemically induced ; Autoimmune Diseases/pathology ; Colitis/chemically induced ; Colitis/genetics ; Colitis/pathology ; Colon/drug effects ; Colon/metabolism ; Forkhead Transcription Factors/genetics ; Gene Expression Regulation ; Haploinsufficiency/genetics ; Humans ; Inflammation/chemically induced ; Inflammation/genetics ; Inflammation/pathology ; Interleukin-17/genetics ; Intestines/pathology ; Joints/metabolism ; Joints/pathology ; Mannans/toxicity ; Mice ; Mice, Knockout ; Sodium Dodecyl Sulfate/toxicity ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/pathology