المؤلفون: Gareri C; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Pfeiffer CT; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Jiang X; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Pham U; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Chundi A; Department of Biomedical Engineering, Duke University, Durham, NC 27710, USA., Wingler LM; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Staus DP; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Stepniewski TM; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM)-Pompeu Fabra University (UPF), 08003 Barcelona, Spain.; Faculty of Chemistry, Biological and Chemical Research Center, University of Warsaw, Warsaw, Poland.; InterAx Biotech AG, PARK InnovAARE, 5234 Villigen, Switzerland., Selent J; Research Programme on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM)-Pompeu Fabra University (UPF), 08003 Barcelona, Spain., Lucero EY; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Grogan A; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Rajagopal S; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA., Rockman HA; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.

المصدر: Science signaling [Sci Signal] 2024 Aug 13; Vol. 17 (849), pp. eadk5736. Date of Electronic Publication: 2024 Aug 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Angiotensin, Type 1*/metabolism , Receptor, Angiotensin, Type 1*/chemistry , Receptor, Angiotensin, Type 1*/genetics , Signal Transduction* , beta-Arrestins*/metabolism , beta-Arrestins*/genetics, Phosphorylation ; Humans ; HEK293 Cells ; Molecular Dynamics Simulation ; Angiotensin II/metabolism

المؤلفون: Skiba MA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Sterling SM; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Cryo-EM Facility at MIT.nano, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Rawson S; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Zhang S; Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland., Xu H; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Jiang H; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Nemeth GR; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Gilman MSA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Hurley JD; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA., Shen P; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA., Staus DP; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.; Septerna, South San Francisco, CA, USA., Kim J; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., McMahon C; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.; Sanofi, Large Molecule Research, Cambridge, MA, USA., Lehtinen MK; Department of Pathology, Boston Children's Hospital, Boston, MA, USA., Rockman HA; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA., Barth P; Interfaculty Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.; Ludwig Institute for Cancer Research Lausanne, Epalinges, Switzerland., Wingler LM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, USA., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. Andrew_Kruse@hms.harvard.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2024 May 14. Date of Electronic Publication: 2024 May 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

المؤلفون: Skiba MA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Sterling SM; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Rawson S; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Gilman MSA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Xu H; Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA., Nemeth GR; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Hurley JD; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Shen P; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA., Staus DP; Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA., Kim J; Department of Medicine and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA., McMahon C; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lehtinen MK; Department of Pathology, Boston Children's Hospital, Boston, MA, 02115, USA., Wingler LM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Aug 24. Date of Electronic Publication: 2023 Aug 24.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Pani B; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Ahn S; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Rambarat PK; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Vege S; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Kahsai AW; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Liu A; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Valan BN; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Staus DP; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Costa T; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.)., Lefkowitz RJ; Department of Medicine (B.P., S.A., S.V., A.W.K., A.L., B.N.V., D.P.S., R.J.L.), Department of Biochemistry (R.J.L.), and Howard Hughes Medical Institute (R.J.L.), Duke University Medical Center, Durham, North Carolina, USA; Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA (P.K.R.); and Viale America 111, Rome, Italy (T.C.) lefko001@receptor-biol.duke.edu.

المصدر: Molecular pharmacology [Mol Pharmacol] 2021 Nov; Vol. 100 (5), pp. 513-525. Date of Electronic Publication: 2021 Sep 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Adrenergic, beta-2*/metabolism, Adrenergic beta-Antagonists/*pharmacology , Carvedilol/*pharmacology , beta-Arrestins/*pharmacology, Adrenergic beta-Antagonists/chemistry ; Adrenergic beta-Antagonists/metabolism ; Allosteric Regulation/drug effects ; Allosteric Regulation/physiology ; Animals ; Carvedilol/chemistry ; Carvedilol/metabolism ; Dose-Response Relationship, Drug ; HEK293 Cells ; Humans ; Sf9 Cells ; beta-Arrestins/chemistry ; beta-Arrestins/metabolism

المؤلفون: Smith JS; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Pack TF; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710, USA., Inoue A; Department of Pharmaceutical Sciences, Tohoku University, Japan., Lee C; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Zheng K; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Choi I; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Eiger DS; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Warman A; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Xiong X; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Ma Z; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Viswanathan G; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Levitan IM; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA., Rochelle LK; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA., Staus DP; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Snyder JC; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA., Kahsai AW; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Caron MG; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.; Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA., Rajagopal S; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA. sudarshan.rajagopal@duke.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.

المصدر: Science (New York, N.Y.) [Science] 2021 Mar 12; Vol. 371 (6534). Date of Electronic Publication: 2021 Jan 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: GTP-Binding Protein alpha Subunits, Gi-Go/*metabolism , Receptors, G-Protein-Coupled/*metabolism , beta-Arrestins/*metabolism, Bioluminescence Resonance Energy Transfer Techniques ; Cell Movement ; Extracellular Signal-Regulated MAP Kinases/metabolism ; HEK293 Cells ; Humans ; Signal Transduction

المؤلفون: Pakharukova N; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Masoudi A; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Pani B; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Staus DP; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Department of Biochemistry, Duke University Medical Center, Durham, North Carolina, USA; Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA. Electronic address: lefko001@receptor-biol.duke.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Dec 04; Vol. 295 (49), pp. 16773-16784. Date of Electronic Publication: 2020 Sep 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Receptor, Muscarinic M2/*metabolism , Receptors, Adrenergic, beta-2/*metabolism , Receptors, Vasopressin/*metabolism , beta-Arrestin 1/*metabolism , src-Family Kinases/*metabolism, Allosteric Regulation ; Enzyme Activation ; Humans ; Kinetics ; Mutagenesis, Site-Directed ; Nanostructures/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Phosphorylation ; Protein Binding ; Proto-Oncogene Mas ; Receptor, Muscarinic M2/chemistry ; Receptors, Adrenergic, beta-2/chemistry ; Receptors, Vasopressin/chemistry ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry ; Recombinant Proteins/isolation & purification ; Substrate Specificity ; beta-Arrestin 1/chemistry ; beta-Arrestin 1/genetics ; src Homology Domains ; src-Family Kinases/chemistry

المؤلفون: McMahon C; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Staus DP; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.; Department of Medicine, Duke University Medical Center, Durham, NC 27710., Wingler LM; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710.; Department of Medicine, Duke University Medical Center, Durham, NC 27710., Wang J; Department of Medicine, Duke University Medical Center, Durham, NC 27710., Skiba MA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115., Elgeti M; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095., Hubbell WL; Jules Stein Eye Institute, University of California, Los Angeles, CA 90095.; Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095., Rockman HA; Department of Medicine, Duke University Medical Center, Durham, NC 27710.; Department of Cell Biology, Duke University Medical Center, Durham, NC 27710., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115; andrew_kruse@hms.harvard.edu lefko001@receptor-biol.duke.edu., Lefkowitz RJ; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710; andrew_kruse@hms.harvard.edu lefko001@receptor-biol.duke.edu.; Department of Medicine, Duke University Medical Center, Durham, NC 27710.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 18; Vol. 117 (33), pp. 20284-20291. Date of Electronic Publication: 2020 Aug 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin Receptor Antagonists* , Single-Domain Antibodies*, Receptors, Angiotensin/*immunology, Animals ; Antibody Affinity ; Blood Pressure ; Cell Line ; Humans ; Mice

المؤلفون: Staus DP; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Hu H; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; School of Life and Health Sciences, Kobilka Institute of Innovative Drug Discovery, The Chinese University of Hong Kong, Shenzhen, China., Robertson MJ; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Kleinhenz ALW; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA.; School of Medicine, University of Michigan, Ann Arbor, MI, USA., Wingler LM; Department of Medicine, Duke University Medical Center, Durham, NC, USA.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA., Capel WD; Department of Medicine, Duke University Medical Center, Durham, NC, USA., Latorraca NR; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Computer Science, Stanford University, Stanford, CA, USA.; Biophysics Program, Stanford University, Stanford, CA, USA., Lefkowitz RJ; Department of Medicine, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu.; Department of Biochemistry, Duke University Medical Center, Durham, NC, USA. lefko001@receptor-biol.duke.edu., Skiniotis G; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA. yiorgo@stanford.edu.

المصدر: Nature [Nature] 2020 Mar; Vol. 579 (7798), pp. 297-302. Date of Electronic Publication: 2020 Jan 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Models, Molecular*, Lipids/*chemistry , beta-Arrestins/*chemistry, Cell Line ; Computer Simulation ; Cryoelectron Microscopy ; Humans ; Nanostructures/chemistry ; Protein Structure, Tertiary

المؤلفون: Wingler LM; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Skiba MA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., McMahon C; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Staus DP; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Kleinhenz ALW; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Suomivuori CM; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA., Latorraca NR; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.; Biophysics Program, Stanford University, Stanford, CA 94305, USA., Dror RO; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Departments of Molecular and Cellular Physiology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.; Biophysics Program, Stanford University, Stanford, CA 94305, USA., Lefkowitz RJ; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA. lefko001@receptor-biol.duke.edu andrew_kruse@hms.harvard.edu.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA. lefko001@receptor-biol.duke.edu andrew_kruse@hms.harvard.edu.

المصدر: Science (New York, N.Y.) [Science] 2020 Feb 21; Vol. 367 (6480), pp. 888-892.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Angiotensin II/*chemistry , Receptor, Angiotensin, Type 1/*chemistry, Humans ; Ligands ; Protein Conformation ; Signal Transduction ; beta-Arrestins/chemistry

المؤلفون: Suomivuori CM; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA., Latorraca NR; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.; Biophysics Program, Stanford University, Stanford, CA 94305, USA., Wingler LM; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Eismann S; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.; Department of Applied Physics, Stanford University, Stanford, CA 94305, USA., King MC; Department of Computer Science, Stanford University, Stanford, CA 94305, USA.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA., Kleinhenz ALW; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Skiba MA; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Staus DP; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA., Kruse AC; Department of Biological Chemistry and Molecular Pharmacology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA., Lefkowitz RJ; Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710, USA.; Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.; Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA., Dror RO; Department of Computer Science, Stanford University, Stanford, CA 94305, USA. ron.dror@stanford.edu.; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA 94305, USA.; Biophysics Program, Stanford University, Stanford, CA 94305, USA.

المصدر: Science (New York, N.Y.) [Science] 2020 Feb 21; Vol. 367 (6480), pp. 881-887.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*, Arrestins/*chemistry , GTP-Binding Proteins/*chemistry , Receptor, Angiotensin, Type 1/*chemistry, Allosteric Regulation ; Humans ; Molecular Dynamics Simulation ; Protein Conformation