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المؤلفون: Stefan Peukert, Hatice Belgin Gulgeze Efthymiou, Ruowei Mo, Yunshan Peng, Fupeng Ma, Guillaume Barbe, Gregory Bebernitz, Cary Fridrich, Chiara Buono, Eric T. Williams, Thomas Daniels, Lisha Li, Xia Zhang, Yuichiro Adachi, Mie Abe, Andrew K.P. Taggart
المصدر: Bioorganic & Medicinal Chemistry Letters. 85:129237
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Molecular Biology, Biochemistry
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2
المؤلفون: Noel Marie-France Thomsen, Simone Bonazzi, Stephanie M. McTighe, Guiqing Liang, Danuta Lubicka, Sarah Salas, Jill Nunez, Franco Lombardo, Rajeshri Ganesh Karki, Audrey Gray, Stefan Peukert, Doug Burdette, Jean-Cosme Dodart, Leon Murphy, Grazia Piizzi, Carleton Goold, Labbe-Giguere Nancy, Erin P. Keaney, Jonathan D. Biag, Christine D. Wilson, Aakruti Gorde, Lawrence G. Hamann, Yingchuan Sun, Lin Deng, Hasnain A. Malik, Daniel Curtis, Shanming Liu
المصدر: Journal of medicinal chemistry. 63(3)
مصطلحات موضوعية: Purine, Male, Cell, Central nervous system, 01 natural sciences, Tuberous Sclerosis Complex 1 Protein, 03 medical and health sciences, chemistry.chemical_compound, Seizures, Drug Discovery, medicine, Animals, Humans, Mechanistic target of rapamycin, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, 030304 developmental biology, Mice, Knockout, Neurons, 0303 health sciences, Everolimus, Binding Sites, biology, Drug discovery, TOR Serine-Threonine Kinases, Brain, 0104 chemical sciences, Rats, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Thiazoles, medicine.anatomical_structure, Pyrimidines, chemistry, Cancer research, biology.protein, Molecular Medicine, Anticonvulsants, TSC1, medicine.drug, Protein Binding
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3
المؤلفون: Yuji Mishina, Jianling Wang, Choi-Lai Tiong-Yip, He Guo, Noel Marie-France Thomsen, Jill Nunez, Franco Lombardo, Clayton Springer, Jason Baird, L. Alex Gaither, John D. Norris, Sunkyu Kim, Brant Firestone, Stefan Peukert, Kaitlin J. Macchi, Donald P. McDonnell, Tinya Abrams, Chunrong Wang, Bing Yu, Lawrence G. Hamann, Yingchuan Sun, Burks Heather Elizabeth, Christina A. Kirby, George Scott Tria
المصدر: Journal of Medicinal Chemistry. 61:2837-2864
مصطلحات موضوعية: Selective Estrogen Receptor Modulators, 0301 basic medicine, Biological Availability, Mice, Nude, Estrogen receptor, Antineoplastic Agents, Breast Neoplasms, Thiophenes, Rats, Sprague-Dawley, Mice, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Drug Discovery, medicine, Animals, Humans, Endocrine system, Rats, Wistar, Aromatase, biology, Fulvestrant, Chemistry, Estrogen Receptor alpha, Cancer, medicine.disease, Xenograft Model Antitumor Assays, Rats, 030104 developmental biology, Selective estrogen receptor modulator, Drug Design, 030220 oncology & carcinogenesis, MCF-7 Cells, biology.protein, Cancer research, Molecular Medicine, Female, Estrogen receptor alpha, medicine.drug
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المؤلفون: Luis R. Camacho, Srinivasa P. S. Rao, Christian G. Noble, Ravinder Reddy Kondreddi, Thierry T. Diagana, Ujjini H. Manjunatha, Anne Goh, Maxime Herve, Paul W. Smith, Stefan Peukert, Pearly Shuyi Ng, Ngai Ling Ma
المصدر: European Journal of Medicinal Chemistry. 106:144-156
مصطلحات موضوعية: Models, Molecular, Drug, Pyridones, Phenotypic screening, media_common.quotation_subject, Antitubercular Agents, Biological Availability, Microbial Sensitivity Tests, Pharmacology, Mycobacterium tuberculosis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Stability, In vivo, Tuberculosis, Multidrug-Resistant, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, media_common, Dose-Response Relationship, Drug, Molecular Structure, biology, Organic Chemistry, General Medicine, biology.organism_classification, In vitro, Rats, chemistry, Microsomes, Liver, Lead compound
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5
المؤلفون: Burks Heather Elizabeth, Noel Marie-France Thomsen, Alexander Fekete, Alice Loo, Christina A. Kirby, Lawrence G. Hamann, Yingchuan Sun, Chunrong Wang, Jianling Wang, Chitra Saran, Danuta Lubicka, Donald P. McDonnell, Yuji Mishina, Franco Lombardo, Jason Baird, Tinya Abrams, Kaitlin J. Macchi, Stefan Peukert, Jill Nunez, John D. Norris, Sunkyu Kim
المصدر: Journal of medicinal chemistry. 60(7)
مصطلحات موضوعية: Estrogen receptor, Administration, Oral, Antineoplastic Agents, Breast Neoplasms, Pharmacology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dogs, In vivo, Tetrahydroisoquinolines, Drug Discovery, medicine, Animals, Humans, Breast, 010405 organic chemistry, Tetrahydroisoquinoline, Drug discovery, Estrogen Receptor alpha, Cancer, medicine.disease, 0104 chemical sciences, Mice, Inbred C57BL, Molecular Docking Simulation, chemistry, Acrylates, Hormone receptor, 030220 oncology & carcinogenesis, THIQ, Proteolysis, MCF-7 Cells, Molecular Medicine, Female, Estrogen receptor alpha, medicine.drug
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المؤلفون: Richard Hughes, Guiqing Liang, Jeffrey Shapiro, Zhao Yan, Rishi K. Jain, Sarah J. Luchansky, Luis Llamas, Vidya Kunjathoor, Jill Nunez, Stefan Peukert, Michael Pietropaolo, Avirup Bose, Xiaoping Wu, Adam Carlson, Anja Castellana, Guo He
المصدر: ACS Medicinal Chemistry Letters. 5:1114-1118
مصطلحات موضوعية: Agonist, Oral treatment, medicine.medical_specialty, Ligand efficiency, business.industry, medicine.drug_class, Phenotypic screening, Organic Chemistry, Antidiabetic treatment, Pharmacology, Biochemistry, Bioavailability, Endocrinology, Pharmacokinetics, Internal medicine, Drug Discovery, Medicine, business, Receptor
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المؤلفون: Jinyun Chen, Sarat Chandarlapaty, Qing Sheng, Choi Lai Tiong Yip, Alice Loo, Tinya Abrams, Stefan Peukert, Weiyi Toy, Adam S. Crystal, L. Alex Gaither, Rita Das, Yuji Mishina, Chunrong Wang
المصدر: Cancer Research. 79:922-922
مصطلحات موضوعية: Cancer Research, Fulvestrant, Cell growth, Chemistry, Mutant, Wild type, Estrogen receptor, In vitro, Oncology, In vivo, Cancer research, medicine, PI3K/AKT/mTOR pathway, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::07fff1068288a98f665ba82fe00d498e
https://doi.org/10.1158/1538-7445.am2019-922 -
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المؤلفون: Miao Dai, Feng He, Michael A Mcewan, Karen Miller-Moslin, Stefan Peukert, Adam Amaral, Rajesh Karki, Rui Zhang, Lei Huangshu, Rishi K. Jain, Luis Llamas, Tao Sheng, Yanhong Li, Jing Yuan, Melissa Matsumoto, Aaron Bourret, Joseph Kelleher, Walter Michael, Arun Ramamurthy, Marion Dorsch, Ribo Guo, Juliet Williams, Anthony Vattay, Yingchuan Sun, Lawrence Blas Perez, Wieslawa Maniara, Naeem Yusuff
المصدر: Journal of Medicinal Chemistry. 52:3954-3968
مصطلحات موضوعية: Cell, Administration, Oral, Antineoplastic Agents, Pharmacology, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, Hedgehog Proteins, Hedgehog, G protein-coupled receptor, Chemistry, Neoplasms, Experimental, Smoothened Receptor, Hedgehog signaling pathway, medicine.anatomical_structure, Phthalazines, Molecular Medicine, Signal transduction, Smoothened, Medulloblastoma, Signal Transduction
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المؤلفون: Arun Ramamurthy, Yingchuan Sun, Rishi K. Jain, Adrian Geisser, Rui Zhang, Adam Carlson, Aaron Bourret, Jennifer A. DaSilva, Joseph Kelleher, Stefan Peukert
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:328-331
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Inhibitory postsynaptic potential, Biochemistry, Microsomal triglyceride transfer protein, Receptors, G-Protein-Coupled, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Hedgehog Proteins, Receptor, Molecular Biology, Hedgehog, biology, Chemistry, Organic Chemistry, Amides, Smoothened Receptor, Hedgehog signaling pathway, biology.protein, Molecular Medicine, Carrier Proteins, Smoothened, Signal Transduction
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المؤلفون: Rui Zhang, Xiaoyu Shen, JoAnn Dzink-Fox, Brian Hurley, Sompong Wattanasin, Regina E. Cebula, Stefan Peukert, Michael Sabio, Christen Gray, Yingchuan Sun, Jianshi Tao
المصدر: Bioorganic & Medicinal Chemistry Letters. 18:1840-1844
مصطلحات موضوعية: Protein Conformation, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Microbial Sensitivity Tests, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Polyisoprenyl Phosphates, Drug Discovery, Escherichia coli, Enzyme Inhibitors, Furans, Molecular Biology, Antibacterial agent, chemistry.chemical_classification, Alkyl and Aryl Transferases, Molecular Structure, ATP synthase, biology, Chemistry, Organic Chemistry, Antimicrobial, Amides, Pyrrolidinones, Streptococcus pneumoniae, Enzyme, Cyclization, Drug Design, biology.protein, Molecular Medicine, Pharmacophore, Tetronic acid, Selectivity, Sesquiterpenes
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