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المؤلفون: Zhen Chen, Jiahui Chen, Laigao Chen, Chi-Hyeon Yoo, Jian Rong, Hualong Fu, Tuo Shao, Karen Coffman, Stefanus J. Steyn, April T. Davenport, James B. Daunais, Ahmed Haider, Lee Collier, Lee Josephson, Hsiao-Ying Wey, Lei Zhang, Steven H. Liang
المصدر: Journal of Medicinal Chemistry. 66:1712-1724
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المؤلفون: Manthena V.S. Varma, Stefanus J. Steyn
المصدر: Molecular Pharmaceutics. 17:3024-3032
مصطلحات موضوعية: Drug, biology, business.industry, media_common.quotation_subject, CYP1A2, Pharmaceutical Science, Cytochrome P450, 02 engineering and technology, Pharmacology, 021001 nanoscience & nanotechnology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Plasma exposure, Drug Discovery, Lipophilicity, biology.protein, Molecular Medicine, Medicine, 0210 nano-technology, CYP2C8, business, Clinical risk factor, CYP2C9, media_common
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المؤلفون: Christopher R Butter, Joshua Moon, John F. Harms, Stefanus J. Steyn, John T. Lazzaro, Rebecca E. O’Connor, Catherine A. Thorn, Clinton A Bourbonais, Eda Stark, Jeremy R. Edgerton, Michael Popiolek
المصدر: ACS Chemical Neuroscience. 10:1753-1764
مصطلحات موضوعية: Pyridines, Physiology, Cognitive Neuroscience, Prefrontal Cortex, Hippocampus, Striatum, Muscarinic Agonists, Hippocampal formation, CREB, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Thiadiazoles, Muscarinic acetylcholine receptor, Animals, Prefrontal cortex, CA1 Region, Hippocampal, 030304 developmental biology, 0303 health sciences, biology, Chemistry, Receptor, Muscarinic M1, Cell Biology, General Medicine, Acetylcholine, Corpus Striatum, biology.protein, Xanomeline, Neuroscience, 030217 neurology & neurosurgery
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المؤلفون: Brendan Tierney, Stefanus J. Steyn, Michael Popiolek, Michael DeVivo
المصدر: ACS Chemical Neuroscience. 9:2832-2837
مصطلحات موضوعية: D-Amino-Acid Oxidase, Psychosis, Physiology, Cognitive Neuroscience, D-amino acid oxidase, Pharmacology, Receptors, N-Methyl-D-Aspartate, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Alzheimer Disease, Sodium Benzoate, medicine, Animals, Humans, Cognitive Dysfunction, Cognitive decline, Receptor, Oxidase test, Alanine, business.industry, Cell Biology, General Medicine, Benzoic Acid, medicine.disease, 030227 psychiatry, Treatment Outcome, chemistry, Glycine, Schizophrenia, Sodium benzoate, NMDA receptor, business, 030217 neurology & neurosurgery
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المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
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المؤلفون: Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
المصدر: Biochemistry. 55:7073-7085
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M1, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, Inositol, Inositol phosphate, 030217 neurology & neurosurgery
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المؤلفون: Anthony A. Estrada, Brian K. Fiske, Karin Rudolph, Paul Galatsis, Stephen A. Ploch, Ellis M, Yu H, Zhizhang Yin, Dianne K. Bryce, Matthew L. Maddess, Antonia F. Stepan, Stefanus J. Steyn, Alok K. Sharma, Christopher Houle, Trost C, Carrie G. Markgraf, Warren D. Hirst, Xiang Wang, Ted Barrett, Marco A. S. Baptista, Todd Sherer, Susan E. Hill, Kalpana M. Merchant, William A. Meier, Matthew E. Kennedy, Hong Mei, Xingrong Liu, Christopher Royer, Reina N. Fuji, Matthew J. Fell, Anastasia G. Henry
مصطلحات موضوعية: Lung, business.industry, Kinase, Pharmacology, LRRK2, Pulmonary function testing, nervous system diseases, medicine.anatomical_structure, Toxicity, Medicine, Toxicokinetics, Dosing, Kinase activity, business
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4465f413546427102589d503f22b2061
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المؤلفون: João Paulo Lima Daher, Andrew B. West, Warren D. Hirst, Stefanus J. Steyn, Mark S. Moehle, Hisham Abdelmotilib, Laura A. Volpicelli-Daley, Elie Needle, Xianzhen Hu, Paul Galatsis, Yi Chen, Kyle B. Fraser
المصدر: Journal of Biological Chemistry. 290:19433-19444
مصطلحات موضوعية: Male, Genetic Vectors, Substantia nigra, Protein Serine-Threonine Kinases, Pharmacology, Biology, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Neuroprotection, Antiparkinson Agents, Rats, Sprague-Dawley, Neurobiology, medicine, Animals, Humans, Pyrroles, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Neuroinflammation, Injections, Intraventricular, Kinase, Neurodegeneration, Parkinson Disease, Cell Biology, Dependovirus, medicine.disease, LRRK2, Rats, nervous system diseases, Substantia Nigra, Disease Models, Animal, Pyrimidines, Gene Expression Regulation, alpha-Synuclein, Female, Signal transduction, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33003aa29a17b64485ee9ab6c36fa2bd
https://doi.org/10.1074/jbc.m115.660001 -
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المصدر: Pharmaceutical Research. 32:3785-3802
مصطلحات موضوعية: Drug, Membrane permeability, Metabolic Clearance Rate, media_common.quotation_subject, Pharmaceutical Science, Pharmacology, Kidney, Models, Biological, Permeability, Cell Line, Dogs, Pharmacokinetics, Drug Discovery, Animals, Humans, Pharmacology (medical), media_common, Drug discovery, Chemistry, Biopharmaceutics, Organic Chemistry, Transporter, Biopharmaceutics Classification System, Renal Elimination, Liver, Pharmaceutical Preparations, Molecular Medicine, Efflux, Biotechnology
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المؤلفون: Chakrapani Subramanyam, Gregory W. Kauffman, Patrick B. Mullins, Longfei Xie, Stefanus J. Steyn, John M. Humphrey, Eddie Yang, Patrick Robert Verhoest, Beth C. Vetelino, Tuan P. Tran, Butler Todd W, Benjamin Adam Fish, Martin Pettersson, Kelly R. Bales, Antonia F. Stepan, Christopher J. O’Donnell, Cory Michael Stiff, Kathleen M. Wood, Michael Eric Green, Douglas S. Johnson, Leslie R. Pustilnik, Christopher W. am Ende
المصدر: ACS Medicinal Chemistry Letters. 6:596-601
مصطلحات موضوعية: chemistry.chemical_compound, Pharmacokinetics, Biochemistry, Chemistry, Organic Chemistry, Drug Discovery, Potency, γ secretase, Efflux, Metabolic stability, Pharmacology, Lead compound