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المؤلفون: Pettersson M; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Johnson DS; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Humphrey JM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Am Ende CW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Butler TW; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Dorff PH; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Efremov IV; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Evrard E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Green ME; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Helal CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Kauffman GW; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Mullins PB; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Navaratnam T; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Donnell CJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., O'Sullivan TJ; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Patel NC; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stepan AF; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Stiff CM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Subramanyam C; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Trapa P; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Tran TP; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Vetelino BC; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Yang E; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Xie L; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Pustilnik LR; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Steyn SJ; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Wood KM; Pfizer Worldwide Research and Development, Groton, Connecticut 06340, United States., Bales KR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Hajos-Korcsok E; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States., Verhoest PR; Pfizer Worldwide Research and Development, Cambridge, Massachusetts 02139, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. Date of Electronic Publication: 2024 Jun 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid Precursor Protein Secretases*/antagonists & inhibitors , Amyloid Precursor Protein Secretases*/metabolism , Alzheimer Disease*/drug therapy , Amyloid beta-Peptides*/metabolism, Humans ; Animals ; Rats ; Structure-Activity Relationship ; Mice ; Male ; Drug Discovery ; Furans/pharmacology ; Furans/pharmacokinetics ; Furans/chemical synthesis ; Furans/chemistry ; Furans/therapeutic use ; Rats, Sprague-Dawley ; Brain/metabolism

المؤلفون: Nippa DF; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland.; Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany., Atz K; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Hohler R; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Müller AT; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Marx A; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Bartelmus C; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Wuitschik G; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Marzuoli I; Process Chemistry and Catalysis (PCC), F. Hoffmann-La Roche Ltd., Basel, Switzerland., Jost V; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Wolfard J; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Binder M; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Stepan AF; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland., Konrad DB; Department of Pharmacy, Ludwig-Maximilians-Universität München, Munich, Germany. david.konrad@cup.lmu.de., Grether U; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. uwe.grether@roche.com., Martin RE; Roche Pharma Research and Early Development (pRED), Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, Switzerland. rainer_e.martin@roche.com., Schneider G; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. gisbert@ethz.ch.; ETH Singapore SEC Ltd, Singapore, Singapore. gisbert@ethz.ch.

المصدر: Nature chemistry [Nat Chem] 2024 Feb; Vol. 16 (2), pp. 239-248. Date of Electronic Publication: 2023 Nov 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Deep Learning*, High-Throughput Screening Assays

المؤلفون: Cecere G; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Guasch L; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Olivares-Morales AM; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Umehara K; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Stepan AF; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Aug 23; Vol. 13 (9), pp. 1444-1451. Date of Electronic Publication: 2022 Aug 23 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Dragovich PS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Haap W; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Mulvihill MM; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Plancher JM; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland., Stepan AF; Roche Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche AG, 4070 Basel, Switzerland.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Feb 24; Vol. 65 (4), pp. 3606-3615. Date of Electronic Publication: 2022 Feb 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Small Molecule Libraries*, Drug Discovery/*trends , Drug Industry/*trends , Pharmacology/*trends, DNA/chemistry ; DNA/genetics ; High-Throughput Screening Assays ; Humans ; Research Design

المؤلفون: Ciulli A; Biological Chemistry & Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK., Hamann L; Drug Discovery Sciences, Takeda Pharmaceuticals, 30 Landsdowne Street, Cambridge, MA 02139, USA., Jahnke W; Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland., Kalgutkar AS; Medicine Design, Pfizer, Inc., 1 Portland Street, Cambridge, MA 02139, USA., Magauer T; Department of Chemistry and Pharmacy, Institute of Organic Chemistry, Leopold-Franzens-University Innsbruck, Innrain 80-82, L02.012, 6020, Innsbruck, Austria., Ritter T; Max-Planck Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Muelheim an der Ruhr, Germany., Steadman V; Sai Life Sciences Ltd., Alderley Park, Manchester, UK., Williams SD; Wiley-VCH, Boschstrasse 12, 69469, Weinheim, Germany., Winter G; Research Center for Molecular Medicine (CeMM), Austrian Academy of Sciences, 1090, Vienna, Austria., Hoegenauer K; Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland., Krawinkler KH; Novartis Institutes for BioMedical Research, 4002, Basel, Switzerland., Stepan AF; F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland.

المصدر: ChemMedChem [ChemMedChem] 2021 Aug 05; Vol. 16 (15), pp. 2417-2423. Date of Electronic Publication: 2021 Jun 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Chemistry, Pharmaceutical* , Research Personnel*, Austria ; Humans

المؤلفون: Ratni H; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Baumann K; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Bellotti P; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Cook XA; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Green LG; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Luebbers T; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Reutlinger M; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Stepan AF; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748., Vifian W; pRED, Pharma Research & Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd. Grenzacherstrasse 124 4070 Basel Switzerland hasane.ratni@roche.com (+41) 61 688 2748.

المصدر: RSC medicinal chemistry [RSC Med Chem] 2021 Apr 12; Vol. 12 (5), pp. 758-766. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

المؤلفون: Di Maio R; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Ri.MED Foundation, Palermo, Italy., Hoffman EK; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Rocha EM; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Keeney MT; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Sanders LH; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, Duke University, Durham, NC 27710, USA., De Miranda BR; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Zharikov A; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Van Laar A; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Stepan AF; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA., Lanz TA; Worldwide Medicinal Chemistry, Pfizer Worldwide Research and Development, Cambridge, MA 02139, USA., Kofler JK; Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Burton EA; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA., Alessi DR; MRC Protein Phosphorylation and Ubiquitylation Units, University of Dundee, Dundee, Scotland., Hastings TG; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA., Greenamyre JT; Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15213, USA. jgreena@pitt.edu.; Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Geriatric Research, Education and Clinical Center, VA Pittsburgh Healthcare System, Pittsburgh, PA 15240, USA.

المصدر: Science translational medicine [Sci Transl Med] 2018 Jul 25; Vol. 10 (451).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/*metabolism , Parkinson Disease/*metabolism, 14-3-3 Proteins/genetics ; 14-3-3 Proteins/metabolism ; HEK293 Cells ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics ; Mutation/genetics ; Protein Binding ; alpha-Synuclein/genetics ; alpha-Synuclein/metabolism