نتائج البحث - "Stephane Nave"

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دورية أكاديمية

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2045-2322

URL الوصول: https://doaj.org/article/1cc826ca236941e185deaad9d64c993b

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Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-20 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Science, Allosteric regulation, Morris water navigation task, Basmisanil, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Radioligand Assay, Xenopus laevis, 0302 clinical medicine, Medical research, Allosteric Regulation, Medicine, Animals, Humans, Learning, GABA-A Receptor Agonists, Receptor, Multidisciplinary, GABAA receptor, business.industry, Drug discovery, Brain, Human brain, Receptors, GABA-A, Healthy Volunteers, Rats, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, HEK293 Cells, Anxiogenic, Positron-Emission Tomography, Female, business, Neuroscience, 030217 neurology & neurosurgery, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c3b0913085fae374eb6efde4d99400
https://doaj.org/article/1cc826ca236941e185deaad9d64c993b

Find this article in full text from Springer Verlag.

Find this article in full text from ProQuest

3

General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy

المؤلفون: Adam P. Hill, Zhen Song, Haibo Ni, Norman Stockbridge, David G. Strauss, Jamie I. Vandenberg, Todd Wisialowski, Mikiko Nakamura, Takashi Yoshinaga, Godfrey L. Smith, Jill Steidl‐Nichols, Mark Holbrook, Stefano Severi, Pierre Morissette, Derek J. Leishman, Colleen E. Clancy, Gary R. Mirams, Andrea Greiter-Wilke, Andrew G. Edwards, Xiaomei Han, Zhihua Li, Flora Musuamba Tshinanu, Stefano Morotti, Stephane Nave, Aaron Fullerton, Bradley J. Ridder, Zhilin Qu, Michelangelo Paci, Alfonso Bueno-Orovio, Janell E. Chen, Thomas Singer, Peter R. Kowey, Liudmila Polonchuk, Eric A. Sobie, Blanca Rodriguez, Randall L. Rasmusson, Elisa Passini, Eleonora Grandi, Ken Wang, Michael Liu, Bruce P. Damiano, Xin Zhou

المساهمون: Li Z., Mirams G.R., Yoshinaga T., Ridder B.J., Han X., Chen J.E., Stockbridge N.L., Wisialowski T.A., Damiano B., Severi S., Morissette P., Kowey P.R., Holbrook M., Smith G., Rasmusson R.L., Liu M., Song Z., Qu Z., Leishman D.J., Steidl-Nichols J., Rodriguez B., Bueno-Orovio A., Zhou X., Passini E., Edwards A.G., Morotti S., Ni H., Grandi E., Clancy C.E., Vandenberg J., Hill A., Nakamura M., Singer T., Polonchuk L., Greiter-Wilke A., Wang K., Nave S., Fullerton A., Sobie E.A., Paci M., Musuamba Tshinanu F., Strauss D.G., Tampere University, BioMediTech, Research group: Computational Biophysics and Imaging Group

المصدر: Clinical pharmacology and therapeutics, vol 107, iss 1
Clinical Pharmacology and Therapeutics

وصف الملف: application/pdf; ELETTRONICO; fulltext

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc2ff4e1c2fbbbeb607662c3df93ed0e
https://doi.org/10.1002/cpt.1647

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Risdiplam treatment has not led to retinal toxicity in patients with spinal muscular atrophy

المساهمون: Wills Eye Hospital, Jefferson (Philadelphia University + Thomas Jefferson University), Fondazione Policlinico Universitario Agostino Gemelli IRCCS, NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Institut de Myologie, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Association française contre les myopathies (AFM-Téléthon)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Stanford University, Columbia University Medical Center (CUMC), Columbia University [New York], Istituto Clinico Humanitas [Milan] (IRCCS Milan), Humanitas University [Milan] (Hunimed), Medical University of Gdańsk, National Center for Global Health and Medicine [Japan] (NCGM), F. Hoffmann-La Roche [Basel], Pagès, Nathalie

المصدر: Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, 2021, 8 (1), pp.54-65. ⟨10.1002/acn3.51239⟩

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Visual acuity, Adolescent, genetic structures, [SDV]Life Sciences [q-bio], RG7916 TREATMENT, Retina, Muscular Atrophy, Spinal, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Ophthalmology, EXPLORATORY OUTCOMES, Humans, Medicine, Child, Adverse effect, Research Articles, Clinical Trials as Topic, medicine.diagnostic_test, business.industry, General Neuroscience, Fundus photography, Infant, Retinal, Spinal muscular atrophy, Middle Aged, medicine.disease, SMA, [SDV] Life Sciences [q-bio], Clinical trial, Pyrimidines, 030104 developmental biology, Neuromuscular Agents, chemistry, Child, Preschool, SAFETY, Eye disorder, Female, Neurology (clinical), medicine.symptom, business, Azo Compounds, 030217 neurology & neurosurgery, Research Article