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1
المؤلفون: Philip L. Ross, Gunther Kern, Stephania Livchak, Jason Thresher, Beth Andrews, Wei Yang, Adam B. Shapiro, Ning Gao
المصدر: SLAS Discovery. 18:341-347
مصطلحات موضوعية: High-throughput screening, Drug Evaluation, Preclinical, Fluorescence Polarization, Peptide binding, Peptide, Ligands, Binding, Competitive, Biochemistry, Analytical Chemistry, Lipid A, Inhibitory Concentration 50, Catalytic Domain, Acyl Carrier Protein, Escherichia coli, Enzyme Inhibitors, chemistry.chemical_classification, Uridine Diphosphate N-Acetylglucosamine, biology, Active site, Molecular biology, High-Throughput Screening Assays, Acyl carrier protein, chemistry, biology.protein, Molecular Medicine, Peptides, Bacterial outer membrane, Myristic Acids, Acyltransferases, Fluorescence anisotropy, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::414ddc9fd857be4a035ae45e30bb46b4
https://doi.org/10.1177/1087057112462062 -
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المؤلفون: Haris Jahic, David E. Ehmann, Stephania Livchak, Ce Feng Liu, Jason Thresher, Hongming Wang
المصدر: Biochemical Pharmacology. 84:654-660
مصطلحات موضوعية: Adenosine, DNA Ligases, Calorimetry, Biology, Biochemistry, chemistry.chemical_compound, Mutant protein, Drug Discovery, medicine, Enzyme Inhibitors, Mode of action, DNA Primers, Pharmacology, chemistry.chemical_classification, DNA ligase, Base Sequence, Isothermal titration calorimetry, Molecular biology, Anti-Bacterial Agents, Kinetics, Streptococcus pneumoniae, Enzyme, chemistry, Mutagenesis, Site-Directed, Antibacterial activity, DNA, medicine.drug
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3
المؤلفون: Nelson B. Olivier, D. Bryan Prince, Jian Huang, Ed T. Buurman, Andrew D. Ferguson, Matthew D. Miller, Jonas Noeske, Gregory S. Basarab, Ning Gao, Roger B. Altman, Manuel F. Juette, Erin Code, Scott C. Blanchard, Jamie H. D. Cate, Stephania Livchak
المصدر: Proceedings of the National Academy of Sciences of the United States of America. 111(46)
مصطلحات موضوعية: Models, Molecular, Protein subunit, Minocycline, GTPase, Biology, Bioinformatics, Crystallography, X-Ray, Ribosome, Binding, Competitive, Tigecycline, RNA, Transfer, Drug Resistance, Multiple, Bacterial, RNA, Ribosomal, 16S, Escherichia coli, Point Mutation, Binding site, Base Pairing, Multidisciplinary, Binding Sites, Tetracycline Resistance, Amino Acids, Diamino, Translation (biology), Cell biology, Anti-Bacterial Agents, A-site, RNA, Bacterial, Förster resonance energy transfer, Tetracyclines, Protein Biosynthesis, Transfer RNA, Physical Sciences, Nucleic Acid Conformation, Ribosomes
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b34b6de37be21fda65c290479370859
https://pubmed.ncbi.nlm.nih.gov/25368144 -
4
المؤلفون: Robert E. McLaughlin, Tiffany Palmer, Tory J. Nash, James D. Whiteaker, Grant K. Walkup, Kathy McCormack, Jason Thresher, Stephania Livchak, Sushmita D. Lahiri, Laurie Hajec, Michele Johnstone, M. Angela Tanudra, Richard A. Alm
المصدر: The Journal of antimicrobial chemotherapy. 70(6)
مصطلحات موضوعية: Microbiology (medical), medicine.drug_class, Avibactam, Mutant, Cephalosporin, Ceftazidime, Microbial Sensitivity Tests, Biology, medicine.disease_cause, beta-Lactam Resistance, beta-Lactamases, Microbiology, chemistry.chemical_compound, Bacterial Proteins, Mutation Rate, Mutant protein, medicine, Humans, Pharmacology (medical), Selection, Genetic, Pharmacology, chemistry.chemical_classification, Pseudomonas aeruginosa, Ceftazidime/avibactam, Anti-Bacterial Agents, Drug Combinations, Infectious Diseases, Enzyme, chemistry, Azabicyclo Compounds, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96182096509ee44a703fafe9a62e2dd0
https://pubmed.ncbi.nlm.nih.gov/25645206 -
5
المؤلفون: Ning Gao, Mark Sylvester, Jun Hu, Jason Thresher, Helen Plant, Jarrod Walsh, Sharon Tentarelli, Adam B. Shapiro, Stephania Livchak
المصدر: Journal of biomolecular screening. 19(8)
مصطلحات موضوعية: High-throughput screening, Fluorescence Polarization, Biology, Biochemistry, Binding, Competitive, Analytical Chemistry, Amino Acyl-tRNA Synthetases, chemistry.chemical_compound, Structure-Activity Relationship, Adenosine Triphosphate, Anticodon, Enzyme Inhibitors, chemistry.chemical_classification, Methionine, Escherichia coli Proteins, Lysine, Cytidine, Molecular biology, High-Throughput Screening Assays, Scintillation proximity assay, Enzyme, chemistry, Transfer RNA, Pseudomonas aeruginosa, Molecular Medicine, Lysidine, Adenosine triphosphate, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095058ca21555d9e1f444f56fa5ac174
https://pubmed.ncbi.nlm.nih.gov/24820111 -
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المؤلفون: Ed T. Buurman, Stephania Livchak, Laurel Hajec, Sushmita D. Lahiri, Robert Albert, Moriah M. Gagnon, Beth Andrews, David C. McKinney, Pamela Hill, Hongming Wang, Ayome Abibi, Nelson B. Olivier, Jason Thresher, Ning Gao, Jian Huang, Tyler Grebe
المصدر: Journal of medicinal chemistry. 56(18)
مصطلحات موضوعية: Models, Molecular, Methyltransferase, Adenosine, Stereochemistry, Drug Evaluation, Preclinical, Microbial Sensitivity Tests, Isozyme, Substrate Specificity, Structure-Activity Relationship, Protein structure, Methionine, RNA, Transfer, Drug Discovery, Structure–activity relationship, Humans, Amines, Enzyme Inhibitors, Gene, chemistry.chemical_classification, tRNA Methyltransferases, Chemistry, RNA, Haemophilus influenzae, Anti-Bacterial Agents, Protein Structure, Tertiary, Enzyme, Biochemistry, Transfer RNA, Molecular Medicine
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المؤلفون: Haris Jahic, Tiffany Palmer, Stewart L. Fisher, Ning Gao, David E. Ehmann, Stephania Livchak, Jun Hu, Sushmita D. Lahiri, Jason Thresher, Grant K. Walkup, Philip L. Ross, Thomas F. Durand-Reville, Rong-Fang Gu
المصدر: The Journal of biological chemistry. 288(39)
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Time Factors, Stereochemistry, Avibactam, Kinetics, Microbial Sensitivity Tests, medicine.disease_cause, Biochemistry, Mass Spectrometry, beta-Lactamases, Acylation, chemistry.chemical_compound, Hydrolysis, Drug Resistance, Bacterial, Enterobacter cloacae, polycyclic compounds, medicine, Escherichia coli, Enzyme kinetics, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Cell Biology, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, biology.organism_classification, Anti-Bacterial Agents, Enzyme, chemistry, Pseudomonas aeruginosa, Enzymology, Azabicyclo Compounds, Plasmids
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13c32d88d43e3856a04764b318c8d9f
https://pubmed.ncbi.nlm.nih.gov/23913691 -
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المؤلفون: James D. Whiteaker, Rong Fang Gu, Jian Huang, Ning Gao, Jason Thresher, Adam B. Shapiro, Stephania Livchak, Haris Jahic
المصدر: Journal of biomolecular screening. 17(3)
مصطلحات موضوعية: Peptidoglycan, Biology, Reductase, Biochemistry, Fluorescence, Analytical Chemistry, chemistry.chemical_compound, Non-competitive inhibition, Cell Wall, Drug Discovery, Escherichia coli, Polynucleotide phosphorylase, chemistry.chemical_classification, Polyribonucleotide Nucleotidyltransferase, Substrate (chemistry), Molecular biology, Anti-Bacterial Agents, High-Throughput Screening Assays, Adenosine Diphosphate, Adenosine diphosphate, Enzyme, chemistry, Molecular Medicine, Carbohydrate Dehydrogenases, Adenosine triphosphate, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f753ea805edee5c7d264d2841a9e02a
https://pubmed.ncbi.nlm.nih.gov/22068704