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المؤلفون: Peter R. Butchers, Claire E. Smith, Iain M. McLay, Rosemary Sasse, Keith Biggadike, Peter J. Mutch, Panayiotis A. Procopiou, Stephen A. Richards, Richard Conroy, Diane M. Coe, Edney Dean David, Stephen Barry Guntrip, Alison J. Ford, Rita Field, Brian Edgar Looker, Nicola Bevan, Michael John Monteith, Victoria J. Barrett, Valerie S. Morrison
المصدر: Journal of Medicinal Chemistry. 52:2280-2288
مصطلحات موضوعية: Models, Molecular, Agonist, Stereochemistry, medicine.drug_class, Guinea Pigs, Administration, Oral, Biological Availability, Bronchi, CHO Cells, In Vitro Techniques, Chemical synthesis, Guinea pig, Structure-Activity Relationship, Cricetulus, Dogs, In vivo, Oral administration, Cricetinae, Microsomes, Drug Discovery, Cyclic AMP, medicine, Animals, Humans, Structure–activity relationship, Albuterol, Adrenergic beta-2 Receptor Agonists, Salmeterol Xinafoate, chemistry.chemical_classification, 2-Hydroxyphenethylamine, Sulfonamides, Chemistry, Muscle, Smooth, Stereoisomerism, In vitro, Rats, Sulfonamide, Trachea, Molecular Medicine, Muscle Contraction
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2
المؤلفون: Fiona S. Lucas, Anthony William James Cooper, Ed Robinson, Ian Robert Baldwin, Charlotte J. Hardy, Giovanni Vitulli, Suzanne Elaine Keeling, Daniel Thomas, Joelle Le, Christopher James Lunniss, Sarah Smith, Zoe Alicia Harrison, Angela M. Deakin, Augustin Amour, Stefano Livia, Stephen Barry Guntrip, Yoshiaki Washio, Leigh M. Felton, Katherine Louise Jones, Nigel J. Parr, Kenneth David Down, Paul Jones, J. Nicole Hamblin, Paul Rowland
المصدر: Journal of medicinal chemistry. 58(18)
مصطلحات موضوعية: Gene isoform, Male, Indazoles, Indoles, Ovalbumin, Respiratory Tract Diseases, Pharmacology, Isozyme, Piperazines, Rats, Sprague-Dawley, chemistry.chemical_compound, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, Th2 Cells, Microsomes, Drug Discovery, Administration, Inhalation, medicine, Structure–activity relationship, Potency, Animals, Humans, Respiratory system, Oxazoles, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Phosphoinositide 3-kinase, biology, Chemistry, Respiratory disease, Stereoisomerism, Pneumonia, medicine.disease, Asthma, Rats, Isoenzymes, Molecular Docking Simulation, biology.protein, Molecular Medicine, Female, Rabbits, Lead compound
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المؤلفون: Peter R. Butchers, Victoria J. Barrett, Peter J. Mutch, Andrew P. Craven, Sara C Hughes, Mark Ruston, Duncan S. Holmes, Alison J. Ford, Keith Biggadike, Brian Edgar Looker, Stephen Barry Guntrip, Anne Jones, Deborah Needham, Panayiotis A. Procopiou, Claire E. Smith
المصدر: Journal of medicinal chemistry. 57(1)
مصطلحات موضوعية: Agonist, Adrenergic receptor, medicine.drug_class, Guinea Pigs, CHO Cells, Pharmacology, Drug Administration Schedule, Sulfone, Hydroxylation, chemistry.chemical_compound, Cricetulus, Dogs, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Sulfones, Adrenergic beta-2 Receptor Agonists, respiratory system, Bioavailability, Rats, Trachea, chemistry, Toxicity, Hepatocytes, Molecular Medicine, Salmeterol, medicine.drug
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المؤلفون: Armour Duncan Robert, B. Evans, T. Hubbard, Corinne Kay, Stephen Barry Guntrip, P. Ward, K. M. L. Chung, J.E. Mordaunt, Stephen P. Watson, M. V. Vinader, David Middlemiss, Miles Congreve, Neil Anthony Pegg
المصدر: Bioorganic & Medicinal Chemistry Letters. 6:1015-1020
مصطلحات موضوعية: Antiemetic Agent, medicine.drug_class, Chemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Receptor antagonist, Biochemistry, Combinatorial chemistry, chemistry.chemical_compound, Orally active, Drug Discovery, medicine, Molecular Medicine, Antiemetic, Identification (biology), Tetrazole, Receptor, Molecular Biology
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المؤلفون: M. V. Vinader, B. Evans, Neil Anthony Pegg, T. Hubbard, Stephen Barry Guntrip, Armour Duncan Robert, P. Ward, David Middlemiss, Corinne Kay, Stephen P. Watson, K. M. L. Chung, J.E. Mordaunt, Miles Congreve
المصدر: ChemInform. 27
مصطلحات موضوعية: chemistry.chemical_compound, Antiemetic Agent, Orally active, chemistry, medicine.drug_class, medicine, Antiemetic, Identification (biology), Tetrazole, General Medicine, Pharmacology, Receptor, Receptor antagonist
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المؤلفون: Hazel Player, John Andrew Corfield, Iain P. Chessell, Helen Susanne Price, Sharon C Stratton, Stephen Barry Guntrip, Neil Anthony Pegg, Elizabeth Pickup, Sue D. Collins, Terry Brown, Paul F. Lambeth, Kerry Browning, Sharon Bingham, Paul John Beswick, Alan Naylor, C. Bountra, Claudine Haslam, Ian B. Campbell, Nick M. Clayton, Alexander J. Stevens, Graham Murkit, Fiona S. Lucas, Joanne O. Wiseman, Neil Mathews
المصدر: Bioorganic and medicinal chemistry letters. 14(21)
مصطلحات موضوعية: Male, Clinical Biochemistry, Analgesic, Freund's Adjuvant, Pharmaceutical Science, Administration, Oral, Biological Availability, Pharmacology, Biochemistry, Chemical synthesis, Pyridazine, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclooxygenase Inhibitors, Infusions, Intravenous, Molecular Biology, biology, Bicyclic molecule, Cyclooxygenase 2 Inhibitors, Organic Chemistry, Brain, Membrane Proteins, Arthritis, Experimental, Rats, Pyridazines, chemistry, Enzyme inhibitor, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, biology.protein, Molecular Medicine, Pyrazoles, Cyclooxygenase
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المؤلفون: David Spalding, Stuart Cockerill, Malcolm Clive Carter, Peter Topley, Lindy L. Thomsen, D. J. Hayes, Patrick M. Woollard, Jeremy N. Stables, Karen Affleck, Malcolm Willson, Colin Stubberfield, Robert D. Shaw, Amanda Jowett, Steve McKeown, Kathryn Jane Smith, Stephen Barry Guntrip
المصدر: Bioorganicmedicinal chemistry letters. 11(11)
مصطلحات موضوعية: Receptor, ErbB-2, Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Mice, SCID, Biochemistry, Receptor tyrosine kinase, Mice, Epidermal growth factor, Drug Discovery, Tumor Cells, Cultured, Animals, Receptor, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Kinase, Organic Chemistry, Xenograft Model Antitumor Assays, ErbB Receptors, Disease Models, Animal, Enzyme, Pyrimidines, Enzyme inhibitor, Cell culture, Cancer research, biology.protein, Quinazolines, Molecular Medicine, Signal transduction, Cell Division
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