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المؤلفون: Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso
المصدر: ChemMedChem.
مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry
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المؤلفون: Ninfa L. Straubinger, Stephen Caddick, Daniel B. Longley, James F Burrows, Darren K.W. Chan, Charlene Minx, Michelle K. Greene, Jun Wang, Robert M. Straubinger, Sandra Van Schaeybroeck, James R. Baker, Vijay Chudasama, Eifion Robinson, Ting Chen, Christopher J. Scott, Donald E. Mager
المصدر: Greene, M K, Chen, T, Robinson, E, Straubinger, N L, Minx, C, Chan, D K W, Wang, J, Burrows, J F, Van Schaeybroeck, S, Baker, J R, Caddick, S, Longley, D B, Mager, D E, Straubinger, R M, Chudasama, V & Scott, C J 2020, ' Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01046-6
British Journal of Cancerمصطلحات موضوعية: Male, Cancer Research, Antibody-drug conjugate, Immunoconjugates, medicine.medical_treatment, Cetuximab, Mice, Transgenic, Mice, SCID, medicine.disease_cause, Article, Targeted therapy, Proto-Oncogene Proteins p21(ras), Mice, 03 medical and health sciences, Targeted therapies, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Growth factor receptor, Antigen, In vivo, Cell Line, Tumor, Pancreatic cancer, Animals, Humans, Medicine, Aminobenzoates, Molecular Targeted Therapy, business.industry, Drugs, Investigational, medicine.disease, Xenograft Model Antitumor Assays, ErbB Receptors, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Pancreatic Neoplasms, body regions, Cell Transformation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, KRAS, business, Oligopeptides, Chemical modification, medicine.drug
وصف الملف: application/pdf
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المؤلفون: Peter A. Szijj, Vijay Chudasama, James R. Baker, Stephen Caddick, Antoine Maruani, João C. F. Nogueira, Calise Bahou
المصدر: Bioconjugate Chemistry. 31:520-529
مصطلحات موضوعية: Pharmacology, Bispecific antibody, 010405 organic chemistry, Plug and play, Chemistry, Organic Chemistry, Biomedical Engineering, Pharmaceutical Science, Bioengineering, 02 engineering and technology, Computational biology, Limiting, 021001 nanoscience & nanotechnology, 01 natural sciences, Antibody fragments, Epitope, 0104 chemical sciences, 3. Good health, Click chemistry, 0210 nano-technology, Biotechnology
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المؤلفون: Antoine, Maruani, Peter A, Szijj, Calise, Bahou, João C F, Nogueira, Stephen, Caddick, James R, Baker, Vijay, Chudasama
المصدر: Bioconjugate chemistry. 31(3)
مصطلحات موضوعية: Epitopes, Antibodies, Bispecific, Antibodies, Monoclonal, Click Chemistry
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المؤلفون: Antoine Maruani, Stephen Caddick, Eifion Robinson, Mark E. B. Smith, João P. Nunes, Vessela Vassileva, James R. Baker, R. Barbara Pedley, João C. F. Nogueira, Vijay Chudasama
المصدر: RSC Advances. 7:9073-9077
مصطلحات موضوعية: Drug, Chemistry, Multidisciplinary, TRASTUZUMAB, BIOCONJUGATION, General Chemical Engineering, media_common.quotation_subject, THERAPEUTIC INDEX, Pharmacology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Therapeutic index, Trastuzumab, In vivo, LINKER STABILITY, medicine, BREAST-CANCER, TECHNOLOGY, REAGENTS, STRATEGY, media_common, Science & Technology, Bioconjugation, 010405 organic chemistry, SITE-SPECIFIC CONJUGATION, General Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, ATTACHMENT, body regions, Chemistry, Monomethyl auristatin E, chemistry, Physical Sciences, medicine.drug, Conjugate
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f284be16884546ad478e386f9a1e0e5
https://doi.org/10.1039/c7ra00788d -
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المؤلفون: Maurício Morais, João P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama, James R. Baker
المصدر: Organic & Biomolecular Chemistry. 19:3024-3024
مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae235c812945331eb2686689513a69
https://doi.org/10.1039/d1ob90035h -
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المؤلفون: Vanessa D’Antongiovanni, Manuela Platé, Rachel C. Chambers, Eifion Robinson, Alejandro Ortiz Stern, Vijay Chudasama, Chris J. Scotton, Gabor Jarai, Stephen Caddick, Natalia Smoktunowicz
المصدر: Oncotarget
مصطلحات موضوعية: 0301 basic medicine, Integrin beta Chains, Lung Neoplasms, Cancer, PAR-1, TGFβ, Thrombin, A549 Cells, Adenocarcinoma, Blood Coagulation, Cell Movement, Gene Expression Regulation, Neoplastic, Humans, Integrin alpha5, MAP Kinase Signaling System, Protein Kinases, Receptor, PAR-1, Smad3 Protein, Transforming Growth Factor beta, Up-Regulation, Oncology, medicine.medical_treatment, 03 medical and health sciences, Downregulation and upregulation, Thrombin receptor, medicine, cancer, A549 cell, Neoplastic, biology, business.industry, Transforming growth factor beta, medicine.disease, 3. Good health, 030104 developmental biology, Cytokine, Gene Expression Regulation, Immunology, biology.protein, Cancer research, business, medicine.drug, Receptor, Research Paper
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e9e683b1a4843fc06f379d33f2bde0
http://europepmc.org/articles/PMC5323169 -
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المؤلفون: Stephen Caddick, Vijay Chudasama, Antoine Maruani
المصدر: Nature Chemistry. 8:114-119
مصطلحات موضوعية: Drug, Immunoconjugates, General Chemical Engineering, medicine.medical_treatment, media_common.quotation_subject, Nanotechnology, Computational biology, 010402 general chemistry, 01 natural sciences, Targeted therapy, Food and drug administration, Antibody Specificity, Antibodies monoclonal, medicine, Humans, media_common, Therapeutic window, 010405 organic chemistry, Chemistry, Antibodies, Monoclonal, General Chemistry, 0104 chemical sciences, body regions, Pharmaceutical Preparations, Drug Design, Drug delivery, Clinical evaluation
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المؤلفون: Vijay Chudasama, Natalia Smoktunowicz, Graham G. Inglis, Eifion Robinson, Stephen Caddick, Emily Knight, Rachel C. Chambers
المصدر: Organic & Biomolecular Chemistry. 14:3198-3201
مصطلحات موضوعية: 0301 basic medicine, Indazoles, Metabolite, Molecular Conformation, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Humans, Urea, Structure–activity relationship, Receptor, PAR-1, Physical and Theoretical Chemistry, Active metabolite, Dose-Response Relationship, Drug, Organic Chemistry, Antagonist, Biological activity, Metabolic stability, 030104 developmental biology, Par 1 antagonist, chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af35dd5509eef3e9ac97676bda2beb7b
https://doi.org/10.1039/c6ob00332j