يعرض 1 - 10 نتائج من 234 نتيجة بحث عن '"Stephen Caddick"', وقت الاستعلام: 1.11s تنقيح النتائج
  1. 1
    Functionalized Cyclopentenones with Low Electrophilic Character as Anticancer Agents

    المؤلفون: Késsia H. S. Andrade, Jaime A. S. Coelho, Raquel Frade, Ana M. Madureira, João P. M. Nunes, Stephen Caddick, Rafael F. A. Gomes, Carlos A. M. Afonso

    المصدر: ChemMedChem.

    مصطلحات موضوعية: Pharmacology, Organic Chemistry, Drug Discovery, Molecular Medicine, General Pharmacology, Toxicology and Pharmaceutics, Biochemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::689b9eae72655b30d86146a002904fa7
    https://doi.org/10.1002/cmdc.202300104

    View record at Wiley
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  2. 2
    Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer

    المؤلفون: Ninfa L. Straubinger, Stephen Caddick, Daniel B. Longley, James F Burrows, Darren K.W. Chan, Charlene Minx, Michelle K. Greene, Jun Wang, Robert M. Straubinger, Sandra Van Schaeybroeck, James R. Baker, Vijay Chudasama, Eifion Robinson, Ting Chen, Christopher J. Scott, Donald E. Mager

    المصدر: Greene, M K, Chen, T, Robinson, E, Straubinger, N L, Minx, C, Chan, D K W, Wang, J, Burrows, J F, Van Schaeybroeck, S, Baker, J R, Caddick, S, Longley, D B, Mager, D E, Straubinger, R M, Chudasama, V & Scott, C J 2020, ' Controlled coupling of an ultrapotent auristatin warhead to cetuximab yields a next-generation antibody-drug conjugate for EGFR-targeted therapy of KRAS mutant pancreatic cancer ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-01046-6
    British Journal of Cancer

    مصطلحات موضوعية: Male, Cancer Research, Antibody-drug conjugate, Immunoconjugates, medicine.medical_treatment, Cetuximab, Mice, Transgenic, Mice, SCID, medicine.disease_cause, Article, Targeted therapy, Proto-Oncogene Proteins p21(ras), Mice, 03 medical and health sciences, Targeted therapies, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Growth factor receptor, Antigen, In vivo, Cell Line, Tumor, Pancreatic cancer, Animals, Humans, Medicine, Aminobenzoates, Molecular Targeted Therapy, business.industry, Drugs, Investigational, medicine.disease, Xenograft Model Antitumor Assays, ErbB Receptors, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Pancreatic Neoplasms, body regions, Cell Transformation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Mutation, Cancer research, KRAS, business, Oligopeptides, Chemical modification, medicine.drug

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f864d8c2451371f563e79c98bb78d6bc
    https://doi.org/10.1038/s41416-020-01046-6

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  3. 3
    A Plug-and-Play Approach for the De Novo Generation of Dually Functionalized Bispecifics

    المؤلفون: Peter A. Szijj, Vijay Chudasama, James R. Baker, Stephen Caddick, Antoine Maruani, João C. F. Nogueira, Calise Bahou

    المصدر: Bioconjugate Chemistry. 31:520-529

    مصطلحات موضوعية: Pharmacology, Bispecific antibody, 010405 organic chemistry, Plug and play, Chemistry, Organic Chemistry, Biomedical Engineering, Pharmaceutical Science, Bioengineering, 02 engineering and technology, Computational biology, Limiting, 021001 nanoscience & nanotechnology, 01 natural sciences, Antibody fragments, Epitope, 0104 chemical sciences, 3. Good health, Click chemistry, 0210 nano-technology, Biotechnology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b41013f9a581d2dd0de367e70dc7fe06
    https://doi.org/10.1021/acs.bioconjchem.0c00002

    Find this issue from the American Chemical Society
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  4. 4
    A Plug-and-Play Approach for the

    المؤلفون: Antoine, Maruani, Peter A, Szijj, Calise, Bahou, João C F, Nogueira, Stephen, Caddick, James R, Baker, Vijay, Chudasama

    المصدر: Bioconjugate chemistry. 31(3)

    مصطلحات موضوعية: Epitopes, Antibodies, Bispecific, Antibodies, Monoclonal, Click Chemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::ee0feabd70122db66adce772f14864f5
    https://pubmed.ncbi.nlm.nih.gov/32093465

    Find this issue from the American Chemical Society
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  5. 5
    Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody

    المؤلفون: Antoine Maruani, Stephen Caddick, Eifion Robinson, Mark E. B. Smith, João P. Nunes, Vessela Vassileva, James R. Baker, R. Barbara Pedley, João C. F. Nogueira, Vijay Chudasama

    المصدر: RSC Advances. 7:9073-9077

    مصطلحات موضوعية: Drug, Chemistry, Multidisciplinary, TRASTUZUMAB, BIOCONJUGATION, General Chemical Engineering, media_common.quotation_subject, THERAPEUTIC INDEX, Pharmacology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Therapeutic index, Trastuzumab, In vivo, LINKER STABILITY, medicine, BREAST-CANCER, TECHNOLOGY, REAGENTS, STRATEGY, media_common, Science & Technology, Bioconjugation, 010405 organic chemistry, SITE-SPECIFIC CONJUGATION, General Chemistry, Combinatorial chemistry, In vitro, 0104 chemical sciences, ATTACHMENT, body regions, Chemistry, Monomethyl auristatin E, chemistry, Physical Sciences, medicine.drug, Conjugate

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f284be16884546ad478e386f9a1e0e5
    https://doi.org/10.1039/c7ra00788d

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  6. 6
    A Plug-and-Play Approach for the De Novo Generation of Dually Functionalised Bispecifics

    المؤلفون: Antoine Maruani, Peter A. Szijj, Calise Bahou, João C. F. Nogueira, Stephen Caddick, James R. Baker, Vijay Chudasama

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de0949899ca70dd94042ccb23164ed9
    https://doi.org/10.26434/chemrxiv.8068184

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  7. 7
    Correction: Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

    المؤلفون: Maurício Morais, João P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama, James R. Baker

    المصدر: Organic & Biomolecular Chemistry. 19:3024-3024

    مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ae235c812945331eb2686689513a69
    https://doi.org/10.1039/d1ob90035h

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  8. 8
    TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

    المؤلفون: Vanessa D’Antongiovanni, Manuela Platé, Rachel C. Chambers, Eifion Robinson, Alejandro Ortiz Stern, Vijay Chudasama, Chris J. Scotton, Gabor Jarai, Stephen Caddick, Natalia Smoktunowicz

    المصدر: Oncotarget

    مصطلحات موضوعية: 0301 basic medicine, Integrin beta Chains, Lung Neoplasms, Cancer, PAR-1, TGFβ, Thrombin, A549 Cells, Adenocarcinoma, Blood Coagulation, Cell Movement, Gene Expression Regulation, Neoplastic, Humans, Integrin alpha5, MAP Kinase Signaling System, Protein Kinases, Receptor, PAR-1, Smad3 Protein, Transforming Growth Factor beta, Up-Regulation, Oncology, medicine.medical_treatment, 03 medical and health sciences, Downregulation and upregulation, Thrombin receptor, medicine, cancer, A549 cell, Neoplastic, biology, business.industry, Transforming growth factor beta, medicine.disease, 3. Good health, 030104 developmental biology, Cytokine, Gene Expression Regulation, Immunology, biology.protein, Cancer research, business, medicine.drug, Receptor, Research Paper

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e9e683b1a4843fc06f379d33f2bde0
    http://europepmc.org/articles/PMC5323169

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  9. 9
    Recent advances in the construction of antibody–drug conjugates

    المؤلفون: Stephen Caddick, Vijay Chudasama, Antoine Maruani

    المصدر: Nature Chemistry. 8:114-119

    مصطلحات موضوعية: Drug, Immunoconjugates, General Chemical Engineering, medicine.medical_treatment, media_common.quotation_subject, Nanotechnology, Computational biology, 010402 general chemistry, 01 natural sciences, Targeted therapy, Food and drug administration, Antibody Specificity, Antibodies monoclonal, medicine, Humans, media_common, Therapeutic window, 010405 organic chemistry, Chemistry, Antibodies, Monoclonal, General Chemistry, 0104 chemical sciences, body regions, Pharmaceutical Preparations, Drug Design, Drug delivery, Clinical evaluation

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390da3d0aa966f834dbe668eed399869
    https://doi.org/10.1038/nchem.2415

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  10. 10
    Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

    المؤلفون: Vijay Chudasama, Natalia Smoktunowicz, Graham G. Inglis, Eifion Robinson, Stephen Caddick, Emily Knight, Rachel C. Chambers

    المصدر: Organic & Biomolecular Chemistry. 14:3198-3201

    مصطلحات موضوعية: 0301 basic medicine, Indazoles, Metabolite, Molecular Conformation, 030204 cardiovascular system & hematology, Pharmacology, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Humans, Urea, Structure–activity relationship, Receptor, PAR-1, Physical and Theoretical Chemistry, Active metabolite, Dose-Response Relationship, Drug, Organic Chemistry, Antagonist, Biological activity, Metabolic stability, 030104 developmental biology, Par 1 antagonist, chemistry

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af35dd5509eef3e9ac97676bda2beb7b
    https://doi.org/10.1039/c6ob00332j

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