المؤلفون: Stuart B. Rosenblum, Stephen Gavalas, Francisco Velazquez, Pinto Patrick A, Oleg Selyutin, Neng-Yang Shih, Yuhua Huang, Wanli Wu, Sony Agrawal, Yueheng Jiang, Srikanth Venkatraman, Joseph A. Kozlowski, Chuan-kui Jiang, Hsueh-Cheng Huang, Jose S. Duca, Anilkumar G. Nair, Bancha Vibulbhan, Eric Ferrari, Kevin X. Chen, Cheng Li, Charles A. Lesburg, F. George Njoroge, Frank Bennett, Qingbei Zeng

المصدر: Bioorganic & Medicinal Chemistry. 21:2007-2017

مصطلحات موضوعية: Indoles, Hepatitis C virus, Clinical Biochemistry, Pharmaceutical Science, RNA-dependent RNA polymerase, Hepacivirus, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Humans, Replicon, Binding site, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, virus diseases, RNA-Dependent RNA Polymerase, Hepatitis C, Virology, digestive system diseases, Molecular Docking Simulation, Enzyme, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f016854d014a0a4d91a3500623598032
https://doi.org/10.1016/j.bmc.2013.01.024

المؤلفون: Ashok Arasappan, Seong-Heon Kim, Robert C. Reynolds, Cheng Li, Aneta Kosinski, Jeremy Clark, Joseph A. Kozlowski, Ling Tong, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, F. George Njoroge, Anita T. Fowler, Vishal Verma, Subramaniam Ananthan, Randall R. Rossman, Robert Chase, Neng-Yang Shih, Joseph A. Maddry, John A. Secrist, Cecil D. Kwong, Hollis S. Kezar, Abhijit Roychowdhury, Stephanie Curry, Malcolm MacCoss, Hsueh-Cheng Huang, Razia Rizvi, Frank Bennett, Stephen Gavalas, Yuhua Huang, Francisco Velazquez, Alvarez Carmen S, Feng Geng, Xiao Tong, John J. Piwinski, Regina Huelgas, Bandarpalle B. Shankar, Srikanth Venkatraman

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3229-3234

مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Substituent, Pharmaceutical Science, Rodentia, Hepacivirus, Virus Replication, Antiviral Agents, Methylation, Biochemistry, Residue (chemistry), chemistry.chemical_compound, Dogs, Species Specificity, In vivo, Drug Discovery, Animals, Potency, Moiety, Benzothiazoles, Replicon, Molecular Biology, Chemistry, Organic Chemistry, Haplorhini, Pyrimidines, Benzothiazole, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e593455015b9cae754dc9b1385747b
https://doi.org/10.1016/j.bmcl.2012.03.036

المؤلفون: Oleg Selyutin, F. George Njoroge, Qingbei Zeng, Stuart B. Rosenblum, Joseph A. Kozlowski, Mousumi Sannigrahi, Yueheng Jiang, Frank Bennett, Neng-Yang Shih, Eric Ferrari, Gopinadhan N. Anilkumar, Bancha Vibulbhan, Hsueh-Cheng Huang, Jose S. Duca, Li Wang, Pinto Patrick A, Stephen Gavalas, Haiyan Pu, Sony Agrawal, Kevin X. Chen, Charles A. Lesburg, Yuhua Huang, Tin-Yau Chan, Chuan-kui Jiang, Francisco Velazquez, Srikanth Venkatraman

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:713-717

مصطلحات موضوعية: Models, Molecular, Indoles, Isostere, Chemistry, Pharmaceutical, viruses, Carboxylic acid, Clinical Biochemistry, Molecular Conformation, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Biochemistry, Ns5b polymerase, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Moiety, Replicon, Molecular Biology, NS5B, chemistry.chemical_classification, Indole test, Sulfonamides, Organic Chemistry, virus diseases, Hydrogen Bonding, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Sulfonamide, Models, Chemical, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f74a4343432a940d8f437e79028a4cd
https://doi.org/10.1016/j.bmcl.2011.10.041

المؤلفون: Tin-Yau Chan, Frank Bennett, David Hesk, Qingbei Zeng, Li Wang, Pinto Patrick A, Jennifer J. Gesell, Jose S. Duca, Neng-Yang Shih, Kevin X. Chen, Yuhua Huang, Bancha Vibulbhan, Yueheng Jiang, Sony Agrawal, Oleg Selyutin, Steve Sorota, Haiyan Pu, Hsueh-Cheng Huang, Joseph A. Kozlowski, Charles A. Lesburg, Francisco Velazquez, Stephen Gavalas, Cheng Li, Anilkumar G. Nair, Eric Ferrari, F. George Njoroge, Srikanth Venkatraman, Chuan-kui Jiang, Mousumi Sannigrahi, Stuart B. Rosenblum

المصدر: Bioorganicmedicinal chemistry letters. 23(24)

مصطلحات موضوعية: Male, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Hepacivirus, Molecular Dynamics Simulation, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, Dogs, Pharmacokinetics, In vivo, Drug Discovery, Distribution (pharmacology), Animals, Humans, Replicon, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Organic Chemistry, Metabolism, Haplorhini, Molecular biology, In vitro, Protein Structure, Tertiary, Rats, Enzyme Activation, Enzyme, chemistry, Quinolines, Molecular Medicine, Lead compound, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04eb82ee6ce4c43fa35b72c72cd7bb9
https://pubmed.ncbi.nlm.nih.gov/24252545

المؤلفون: Yueheng Jiang, Frank Bennett, Eric Ferrari, Jose S. Duca, Yuhua Huang, Bancha Vibulbhan, Hsueh-Cheng Huang, Oleg Selyutin, Kevin X. Chen, F. George Njoroge, Francisco Velazquez, Stuart B. Rosenblum, Cheng Li, Neng-Yang Shih, Joseph A. Kozlowski, Charles A. Lesburg, Pinto Patrick A, Wanli Wu, Anilkumar G. Nair, Sony Agrawal, Chuan-kui Jiang, Larry Heimark, Srikanth Venkatraman, Stephen Gavalas, Qingbei Zeng

المصدر: Bioorganicmedicinal chemistry. 22(1)

مصطلحات موضوعية: Indoles, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, Biochemistry, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, Structure–activity relationship, Potency, Animals, Humans, Prodrugs, Molecular Biology, Polymerase, Indole test, chemistry.chemical_classification, biology, Chemistry, Drug discovery, Organic Chemistry, Esters, Haplorhini, Prodrug, Rats, biology.protein, Molecular Medicine, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8528b5ecd0188d3d6346727d7e5565
https://pubmed.ncbi.nlm.nih.gov/24275348

المؤلفون: Cecil D. Kwong, Stephanie Curry, John A. Secrist, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, Hsueh-Cheng Huang, Aneta Kosinski, Razia Rizvi, Robert C. Reynolds, Ling Tong, Ashok Arasappan, F. George Njoroge, Subramaniam Ananthan, Frank Bennett, Joseph A. Kozlowski, Vishal Verma, Joseph A. Maddry, Hollis S. Kezar, Malcolm MacCoss, Yuhua Huang, Namita Bansal, Francisco Velazquez, Randall R. Rossman, Xiao Tong, Stephen Gavalas, Seong-Heon Kim, Cheng Li, Robert Chase, Bandarpalle B. Shankar, Srikanth Venkatraman

المصدر: Bioorganicmedicinal chemistry letters. 22(22)

مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, High selectivity, Carbohydrates, Pharmaceutical Science, Biological Availability, Hepacivirus, Virus Replication, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Animals, Molecular Biology, Geminal, Organic Chemistry, Haplorhini, Rats, Pyrimidines, chemistry, Plasma exposure, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a6f48b123a123044b72874916a54d0
https://pubmed.ncbi.nlm.nih.gov/23036957

المؤلفون: Jacob Valiyaveettil, Vinay Girijavallabhan, Pinto Patrick A, Lei Chen, Seong-Heon Kim, Anita T. Fowler, Cecil D. Kwong, Neng-Yang Shih, Xiao Tong, Cheng Li, Frank Bennett, Namita Bansal, Joseph A. Maddry, Hsueh-Cheng Huang, Subramaniam Ananthan, Ling Tong, Stephanie Curry, Joseph A. Kozlowski, Malcolm MacCoss, Srikanth Venkatraman, Francisco Velazquez, Hollis S. Kezar, Bandarpalle B. Shankar, Alvarez Carmen S, Vishal Verma, Randall R. Rossman, John J. Piwinski, Yuhua Huang, Robert C. Reynolds, Stephen Gavalas, Razia Rizvi, Robert Chase, Aneta Kosinski, Ashok Arasappan, John A. Secrist, Jeremy Clark, F. George Njoroge

المصدر: Bioorganicmedicinal chemistry letters. 22(17)

مصطلحات موضوعية: Pyrimidine, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, RNA-dependent RNA polymerase, Hepacivirus, Ring (chemistry), Virus Replication, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Potency, Molecule, Animals, Humans, Molecular Biology, Glyceraldehyde 3-phosphate dehydrogenase, biology, Organic Chemistry, Hepatitis C, Rats, Thiazoles, Pyrimidines, chemistry, Benzothiazole, biology.protein, Molecular Medicine, Selectivity

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b8f85f4ca4fda22394ea622aca8cb0
https://pubmed.ncbi.nlm.nih.gov/22858143

المؤلفون: Stephen Gavalas, Boris Feld, K.-C. Cheng, Weiying Yang, Frank Bennett, Cheng Li, Gopinadhan N. Anilkumar, Qingbei Zeng, Jose S. Duca, Oleg Selyutin, Bancha Vibulbhan, Neng-Yang Shih, Yuhua Huang, Li Wang, Pinto Patrick A, Kevin X. Chen, Joseph A. Kozlowski, F. George Njoroge, Srikanth Venkatraman, Charles A. Lesburg, Hsueh-Cheng Huang, Stuart B. Rosenblum, Haiyan Pu, Francisco Velazquez, Tin-Yau Chan, Sony Agrawal, Yueheng Jiang

المصدر: Journal of medicinal chemistry. 55(5)

مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Pyridones, Carboxylic acid, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Moiety, Structure–activity relationship, Animals, Sulfones, Indole test, chemistry.chemical_classification, Molecular Structure, Mutagenicity Tests, Haplorhini, Nitro Compounds, In vitro, Rats, chemistry, Covalent bond, Thiol, Molecular Medicine, Derivative (chemistry)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf86bc03c5325879522fa91b8c41fa0c
https://pubmed.ncbi.nlm.nih.gov/22247956

المؤلفون: Jose S. Duca, F. George Njoroge, Mousumi Sannigrahi, Sony Agrawal, Boris Feld, Bancha Vibulbhan, Neng-Yang Shih, Hsueh-Cheng Huang, Frank Bennet, Yuhua Huang, Pinto Patrick A, Qingbei Zeng, Srikanth Venkatraman, Gopinadhan N. Anilkumar, Joseph A. Kozlowski, Francisco Velazquez, Tin-Yau Chan, Wanli Wu, Charles A. Lesburg, Kevin X. Chen, Stephen Gavalas, Weiying Yang, Cheng Li, Yueheng Jiang, K.-C. Cheng, Oleg Selyutin, Stuart B. Rosenblum

المصدر: Journal of medicinal chemistry. 55(2)

مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, Substituent, Administration, Oral, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Antiviral Agents, Permeability, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Drug Discovery, Potency, Structure–activity relationship, Animals, Humans, NS5B, IC50, Indole test, chemistry.chemical_classification, Sulfonamides, Molecular Structure, Rats, Enzyme, chemistry, Benzyl group, Molecular Medicine, Replicon, Caco-2 Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb17080a988d48f773efe84a18fc615c
https://pubmed.ncbi.nlm.nih.gov/22148957

المؤلفون: Neng Yang Shih, Hsueh-Cheng Huang, Jose S. Duca, Bancha Vibulbhan, Frank Bennett, Kevin X. Chen, Stephen Gavalas, Yueheng Jiang, Robert E. Palermo, Charles A. Lesburg, Srikanth Venkatraman, Zhiqing He, Francisco Velazquez, Nancy Butkiewicz, Li Wang, Boris Feld, Pinto Patrick A, Gopinadhan N. Anilkumar, Yuhua Huang, Stuart B. Rosenblum, Chuan Kui Jiang, Haiyan Pu, Tin Yau Chan, Eric Ferrari, George F Njoroge, Joseph A. Kozlowski, Sony Agrawal, Henry M. Vaccaro, Mousumi Sannigrahi, Qingbei Zeng, Patricia McMonagle, Oleg Selyutin

المصدر: Bioorganicmedicinal chemistry letters. 21(18)

مصطلحات موضوعية: Models, Molecular, Indoles, Stereochemistry, viruses, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Viral Nonstructural Proteins, Crystallography, X-Ray, Biochemistry, Ns5b polymerase, chemistry.chemical_compound, Structure-Activity Relationship, Heterocyclic Compounds, Catalytic Domain, Drug Discovery, Peptide bond, Replicon, Enzyme Inhibitors, Molecular Biology, NS5B, Polymerase, Indole test, chemistry.chemical_classification, biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, virus diseases, Stereoisomerism, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Enzyme, chemistry, biology.protein, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bbcde4c34dd48082f61c28f48aee1b2
https://pubmed.ncbi.nlm.nih.gov/21840715