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1
المؤلفون: Stephen John Atkinson, Patricia F Medeiros, Paola Grandi, Simon Taylor, Chun-wa Chung, James Gray, Robert J. Watson, Ian D. Wall, Alexander L. Satz, Rab K. Prinjha, Francesco Rianjongdee, Alex Preston, Emmanuel Hubert Demont, Gang Yao, Alex Phillipou, Inmaculada Rioja, Cassie Messenger, Laura J. Kaushansky
المصدر: Journal of Medicinal Chemistry. 64:10806-10833
مصطلحات موضوعية: Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug Evaluation, Preclinical, Proteins, chemical and pharmacologic phenomena, hemic and immune systems, Chemical probe, Clinical settings, DNA, Computational biology, Highly selective, Bromodomain, Small Molecule Libraries, Structure-Activity Relationship, Safety profile, Protein Domains, Drug Discovery, Humans, Molecular Medicine, A-DNA
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2
المؤلفون: Antonia J. Lewis, Anna K. Bassil, Lee Andrew Harrison, Darren Jason Mitchell, Dave Lugo, Robert J. Watson, James Gray, Rab K. Prinjha, Alex Preston, Anne-Marie Michon, Ian D. Wall, Simon Taylor, Chun-wa Chung, Jonathan Thomas Seal, Stephen John Atkinson, Etienne Levernier, Paola Grandi, Emmanuel Hubert Demont, Inmaculada Rioja, James Michael Woolven, Cassie Messenger
المصدر: Journal of Medicinal Chemistry. 64:10742-10771
مصطلحات موضوعية: BRD4, Drug discovery, Chemistry, In vivo, Drug Discovery, Aqueous solubility, Molecular Medicine, Molecule, Solubility, Selectivity, Combinatorial chemistry, Bromodomain
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3
المؤلفون: Emmanuel Hubert Demont, Jonathan Thomas Seal, Stephen John Atkinson, Anna K. Bassil, Paola Grandi, Robert J. Watson, Thomas George Christopher Hayhow, James Gray, Chun-wa Chung, Aylott Helen Elizabeth, Alexander N Phillipou, Darren Jason Mitchell, James Michael Woolven, Inmaculada Rioja, Laurie J. Gordon, Francesco Rianjongdee, Paul Bamborough, Ian D. Wall, Rab K. Prinjha, Alex Preston, Lee Andrew Harrison, Cassie Messenger
المصدر: Journal of Medicinal Chemistry. 64:3249-3281
مصطلحات موضوعية: 0303 health sciences, Drug discovery, Cell Cycle Proteins, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Bromodomain, Small Molecule Libraries, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, chemistry.chemical_compound, Protein Domains, chemistry, Drug Design, Amide, Drug Discovery, Humans, Molecular Medicine, Acetamide, Transcription Factors, 030304 developmental biology
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4
المؤلفون: Stephen John Atkinson, Royston C. B. Copley, Matthew J Lindon, Rab K. Prinjha, Alex Preston, James Michael Woolven, Jonathan Thomas Seal, Chun-wa Chung, James Gray, Thomas George Christopher Hayhow, Laurie J. Gordon, Emmanuel Hubert Demont, Aylott Helen Elizabeth, Paola Grandi, Lee Andrew Harrison, Inmaculada Rioja, Robert J. Watson, Simon Taylor, Cassie Messenger, Ian D. Wall, Anne-Marie Michon, Darren Jason Mitchell, Paul Bamborough
المصدر: 'Journal of Medicinal Chemistry ', vol: 63, pages: 9093-9126 (2020)
مصطلحات موضوعية: Male, Stereochemistry, Protein domain, Anti-Inflammatory Agents, Administration, Oral, Cell Cycle Proteins, Molecular Dynamics Simulation, Crystallography, X-Ray, Ligands, Structure-Activity Relationship, Dogs, Protein Domains, In vivo, Drug Discovery, Animals, Humans, Structure–activity relationship, Rats, Wistar, Binding site, Binding Sites, Chemistry, Ligand, Hydrogen Bonding, Amides, Phenotype, Rats, Bromodomain, Molecular Medicine, Selectivity, Half-Life, Transcription Factors
وصف الملف: application/pdf
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5
المؤلفون: Peter D. Craggs, Darren Jason Mitchell, Rab K. Prinjha, Alex Preston, James Michael Woolven, Laurie J. Gordon, Simon Taylor, Paul Bamborough, Chun-wa Chung, Paola Grandi, James Gray, Francesco Rianjongdee, Matthew J Lindon, Anne-Marie Michon, Emma J. Jones, Inmaculada Rioja, Robert J. Watson, Ian D. Wall, Stephen John Atkinson, Emmanuel Hubert Demont, Jonathan Thomas Seal
المصدر: Journal of Medicinal Chemistry. 63:9070-9092
مصطلحات موضوعية: 0303 health sciences, Chemistry, Protein domain, Highly selective, 01 natural sciences, Phenotype, In vitro, 0104 chemical sciences, Cell biology, Bromodomain, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, In vivo, Drug Discovery, Molecular Medicine, Structure–activity relationship, Binding site, 030304 developmental biology
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6
المؤلفون: Anne-Marie Michon, Rab K. Prinjha, Alex Preston, Laurie J. Gordon, Inmaculada Rioja, Pierre Thesmar, Emmanuel Hubert Demont, James Michael Woolven, Stephen John Atkinson, Jon T. Seal, Cassie Messenger, Lee Andrew Harrison, Paola Grandi, Darren Jason Mitchell, Robert J. Watson, Simon Taylor, Chun-wa Chung, James Gray, Antonia J. Lewis, Ian D. Wall, Dave Lugo, Paul Bamborough
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, business.industry, Organic Chemistry, chemical and pharmacologic phenomena, hemic and immune systems, Pharmacology, Highly selective, 01 natural sciences, Biochemistry, In vitro, 0104 chemical sciences, Bromodomain, 010404 medicinal & biomolecular chemistry, Safety profile, In vivo, Drug Discovery, Medicine, business
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7
المؤلفون: Ian D. Wall, Thomas Grimes, Laurie J. Gordon, James Michael Woolven, Simon Taylor, Robert P. Davis, Simon C. C. Lucas, Chun-wa Chung, James J R Gray, Paola Grandi, Nicholas C. O. Tomkinson, Rab K. Prinjha, Robert J. Watson, Inmaculada Rioja, Alex Preston, Alexander N Phillipou, Stephen John Atkinson, Emmanuel Hubert Demont
مصطلحات موضوعية: RM, QL, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Proteins, Combinatorial chemistry, In vitro, Bromodomain, RS, Structure-Activity Relationship, Solubility, Pharmacokinetics, In vivo, Drug Discovery, Humans, Molecular Medicine, Selectivity, Benzofurans
وصف الملف: application/pdf
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8
المؤلفون: Alex Phillipou, Ryan G. Kruger, Simon Taylor, Chun-wa Chung, Rab K. Prinjha, Laurie J. Gordon, Robert J. Watson, James Gray, Alex Preston, James J. Foley, Cassie Messenger, Anna K. Bassil, Inmaculada Rioja, James Michael Woolven, Xi-Ping Zhang, Francesco Rianjongdee, Paola Grandi, Jeanne J. Matteo, Anastasia Wyce, Ian D. Wall, Paul Bamborough, Darren Jason Mitchell, Lee Andrew Harrison, Michael T. McCabe, Stephen John Atkinson, Jonathan Thomas Seal, Emmanuel Hubert Demont
المصدر: Journal of medicinal chemistry. 64(15)
مصطلحات موضوعية: Improved solubility, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Stereochemistry, Proteins, Pyrazole, Scaffold hopping, Bromodomain, chemistry.chemical_compound, Safety profile, Structure-Activity Relationship, Drug Discovery, Molecular Medicine, Humans, Pyrazoles, Furans, Pyrrole
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9
المؤلفون: Chun-wa Chung, Rab K. Prinjha, Simon C. C. Lucas, Nicholas C. O. Tomkinson, Alexander N Phillipou, Stephen John Atkinson, Darren Jason Mitchell, Paul Bamborough, Robert J. Sheppard, Emmanuel Hubert Demont, Robert J. Watson, Laurie J. Gordon, Heather A. Barnett
مصطلحات موضوعية: Stereochemistry, Lysine, 01 natural sciences, Protein Structure, Secondary, 03 medical and health sciences, Protein structure, Protein Domains, Drug Discovery, Humans, QD, Asparagine, Tyrosine, 030304 developmental biology, Sulfonamides, 0303 health sciences, biology, Chemistry, HEK 293 cells, 0104 chemical sciences, Bromodomain, DNA-Binding Proteins, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Histone, Acetylation, biology.protein, ATPases Associated with Diverse Cellular Activities, Molecular Medicine, Protein Binding, Transcription Factors
وصف الملف: application/pdf
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10
المؤلفون: Peter Ernest Soden, Emma J. Roberts, Danette L. Daniels, Chun-wa Chung, Stephen John Atkinson, Paul Bamborough, Anne Marie Michon, Johanna Vappiani, Andrea C. Haynes, Massimo Petretich, Marcus Bantscheff, Miriam M. Yeung, Matthew J Bell, Sarah-Jane Dawson, Paola Grandi, Dane Vassiliadis, Simon Taylor, James Gray, Omer Gilan, Kathy Knezevic, Marjeta Urh, Matthew J Lindon, Marian L. Burr, Rab K. Prinjha, Alex Preston, Inmaculada Rioja, Mark A. Dawson, Gerard Drewes, Thilo Werner, Christopher Roland Wellaway, Emmanuel Hubert Demont, Anna K. Bassil, Nicola Harker, Thomas Gobbetti, Enid Y.N. Lam, David F. Tough, Vinod Kumar
المصدر: Science
مصطلحات موضوعية: Regulation of gene expression, Male, BRD4, Multidisciplinary, Chromatin binding, HEK 293 cells, Prostatic Neoplasms, Proteins, Biology, Article, Chromatin, Bromodomain, Protein Domains, Gene expression, Cancer research, Humans, Transcription factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58f230e3011891f1a84ffe803aee2fab
https://europepmc.org/articles/PMC7610820/