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1
المؤلفون: M. Zhang, Richard Walter Schevitz, David K. Clawson, Gerald F. Smith, Nickolay Y. Chirgadze, Daniel Jon Sall, Stephen L. Briggs
المصدر: Protein Science. 9:29-36
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Thiophenes, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, Side chain, Thiophene, medicine, Humans, Structure–activity relationship, Enzyme Inhibitors, Binding site, Molecular Biology, Indole test, Binding Sites, biology, Chemistry, Active site, biology.protein, Research Article, Discovery and development of direct thrombin inhibitors, medicine.drug
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2دورية أكاديمية
المؤلفون: John D. Carpten, Andrew L. Faber, Candice Horn, Gregory P. Donoho, Stephen L. Briggs, Christiane M. Robbins, Galen Hostetter, Sophie Boguslawski, Tracy Y. Moses, Stephanie Savage, Mark Uhlik
المصدر: Nature, Nature. 448(7152):439-444
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3
المؤلفون: Elwood V. Jensen, Thomas P. Burris, Nickolay Y. Chirgadze, Yong Wang, Sohaib Z. Khan, Stephen L. Briggs
المصدر: Proceedings of the National Academy of Sciences. 103:9908-9911
مصطلحات موضوعية: Binding Sites, Crystallography, Multidisciplinary, Antineoplastic Agents, Hormonal, Protein Conformation, Stereochemistry, Chemistry, Estrogen receptor, Biological Sciences, Small molecule, Protein Structure, Tertiary, Tamoxifen, A-site, Protein structure, Nuclear receptor coactivator 3, Coactivator, Estrogen Receptor beta, Humans, Binding site, Estrogen receptor beta
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f68612ec972603f741cc6202039e76
https://doi.org/10.1073/pnas.0510596103 -
4
المؤلفون: John O. Trent, Anne-Marie Leduc, Thomas P. Burris, Yong Wang, Nikolay Y. Chirgadze, Stephen L. Briggs, James L. Wittliff, Arno F. Spatola, Kelli S. Bramlett
المصدر: Proceedings of the National Academy of Sciences. 100:11273-11278
مصطلحات موضوعية: Models, Molecular, Receptors, Steroid, Multidisciplinary, Peptide analog, Protein Conformation, Chemistry, Stereochemistry, Peptidomimetic, Circular Dichroism, Molecular Sequence Data, Estrogen receptor, Biological Sciences, Crystallography, X-Ray, Ligand (biochemistry), Peptides, Cyclic, Pentapeptide repeat, Protein structure, Nuclear receptor, Amino Acid Sequence, Receptor, Nuclear Magnetic Resonance, Biomolecular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0412613e3684f98910895442869e2c3f
https://doi.org/10.1073/pnas.1934759100 -
5
المؤلفون: Lei Jin, Stephen L. Briggs, Srinivasan Chandrasekhar, Nickolay Y. Chirgadze, David K. Clawson, Richard W. Schevitz, David L. Smiley, Armen H. Tashjian, Faming Zhang
المصدر: Journal of Biological Chemistry. 275:27238-27244
مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::92a9f6509db7302ffce875d94406f1b6
https://doi.org/10.1016/s0021-9258(19)61502-4 -
6
المؤلفون: Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:775-780
مصطلحات موضوعية: Models, Molecular, Tertiary amine, Molecular model, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Thrombin, In vivo, Drug Discovery, medicine, Thiophene, Animals, Humans, Binding site, Molecular Biology, Binding Sites, biology, Organic Chemistry, Anticoagulants, Active site, Thrombosis, Rats, Disease Models, Animal, chemistry, biology.protein, Molecular Medicine, medicine.drug, Discovery and development of direct thrombin inhibitors
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7
المؤلفون: Brigitte Elisabeth Schoner, Richard D. DiMarchi, Stephen L. Briggs, Thomas Charles Furman, Lisa M. Churgay, Richard Walter Schevitz, John E. Hale, Dennis P. Smith, Jean-Pierre Wery, Xing Y. Zhang, David K. Clawson, Margret Barbara Basinski, Hansen M. Hsiung, Faming Zhang, John Michael Beals
المصدر: Nature. 387:206-209
مصطلحات موضوعية: Leptin, Models, Molecular, medicine.medical_specialty, Protein Conformation, medicine.medical_treatment, Molecular Sequence Data, Mutant, Biology, Crystallography, X-Ray, medicine.disease_cause, Protein Structure, Secondary, Internal medicine, medicine, Animals, Humans, Amino Acid Sequence, Conserved Sequence, Mutation, Multidisciplinary, Leptin receptor, Wild type, Proteins, Biological activity, Endocrinology, Cytokine, Cytokines, Crystallization, Sequence Alignment, Hormone
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8دورية أكاديمية
المؤلفون: Faming Zhang, Margret B. Basinski, John M. Beals, Stephen L. Briggs, Lisa M. Churgay, David K. Clawson, Richard D. DiMarchi, Thomas C. Furman, John E. Hale, Hansen M. Hsiung, Brigitte E. Sch
المصدر: Nature, Nature. 387(6629):206-209
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9
المؤلفون: Valentine J. Klimkowski, David K. Clawson, Jefferson Ray Mccowan, Daniel Jon Sall, James H. Wikel, Smith Gf, Nickolay Y. Chirgadze, Donetta S. Gifford-Moore, Stephen L. Briggs
المصدر: ChemInform. 30
مصطلحات موضوعية: Dibasic acid, biology, Chemistry, Stereochemistry, biology.protein, Active site, General Medicine, Binding site, Thiophene derivatives, Discovery and development of direct thrombin inhibitors
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10
المؤلفون: Christiane M. Robbins, Mark Uhlik, Jeffrey W. Touchman, Andrew L. Faber, Mei-Huei T. Lai, Stephanie Savage, Aimin Lin, Galen Hostetter, Jian Du, Yue-Wei Qian, Gregory P. Donoho, Tracy Moses, Michael L. Bittner, Kerry L. Blanchard, Spyro Mousses, Stephen L. Briggs, Douglas J. Zeckner, Sophie Boguslawski, Candice Horn, Greg Tucker-Kellogg, Ketan J. Patel, James E. Thomas, Richard W. Schevitz, John D. Carpten
المصدر: Nature. 448(7152)
مصطلحات موضوعية: Models, Molecular, medicine.medical_specialty, DNA Mutational Analysis, AKT1, Breast Neoplasms, Biology, medicine.disease_cause, Mice, Germline mutation, Protein structure, Mutant protein, Internal medicine, Neoplasms, medicine, Animals, Humans, Ovarian Neoplasms, Mutation, Multidisciplinary, Leukemia, Oncogene, Sequence Homology, Amino Acid, Blood Proteins, Phosphoproteins, Molecular biology, humanities, Transport protein, Protein Structure, Tertiary, Pleckstrin homology domain, Enzyme Activation, Protein Transport, Endocrinology, Cell Transformation, Neoplastic, Female, Colorectal Neoplasms, Proto-Oncogene Proteins c-akt