المؤلفون: Yue Cheng, George K.C. Wong, Yuen Shan Fan, Philip C.W. Lui, Ho Keung Ng, Steve S. Wong, Gary Tse, Tony K.F. Chau, Alice N.H. Chan, Wai Sang Poon

المصدر: Human Pathology. 40:1611-1617

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Pathology, Activin Receptors, Type II, Plasma Cells, H&E stain, Brain tumor, Granuloma, Plasma Cell, Pathology and Forensic Medicine, Central nervous system disease, Lymphoplasmacytic Infiltrate, medicine, Humans, Brain Diseases, business.industry, Anatomical pathology, Middle Aged, medicine.disease, Immunohistochemistry, stomatognathic diseases, Immunoglobulin G, Granuloma, Inflammatory pseudotumor, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ce877d65679cceff9393094cbb0795
https://doi.org/10.1016/j.humpath.2009.04.016

المؤلفون: Raymond H.Y. Li, Steve S Wong, Alfreda Stadlin

المصدر: Brain Research. 836:237-244

مصطلحات موضوعية: chemistry.chemical_classification, medicine.medical_specialty, Reactive oxygen species, General Neuroscience, MPTP, 1-Methyl-4-phenylpyridinium, Biology, medicine.disease_cause, Superoxide dismutase, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, nervous system, chemistry, Internal medicine, medicine, biology.protein, Neurotoxin, Neuroglia, Neurology (clinical), Molecular Biology, Neuroscience, Oxidative stress, Developmental Biology, Astrocyte

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::fd4e71222eda166c81b785c454a9b5df
https://doi.org/10.1016/s0006-8993(99)01661-3

المؤلفون: Teresa M. M. Thomas, Tony K.F. Chau, Philip C.W. Lui, Gary Tse, Ho Keung Ng, Steve S. Wong, Patrick P. L. Lau

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Choroid Plexus Neoplasms, Necrosis, Psammoma body, Intranuclear Inclusion Bodies, Biology, Pathology and Forensic Medicine, Meningioma, Diagnosis, Differential, Cytology, medicine, Meningeal Neoplasms, Humans, Aged, Cell Nucleus, Intraoperative Care, Neurooncology, Anatomical pathology, General Medicine, Anatomy, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Vacuoles, Mitotic Figure, Original Article, Female, medicine.symptom, Cytoplasmic Vacuolation

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b0bd2a84b6c79d1a6c8f29dee65938
https://europepmc.org/articles/PMC1972413/

المؤلفون: Noel MS; Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia, USA., Kim S; TYME Technologies Inc., Bedminster, New Jersey, USA., Hartley ML; The Ruesch Center for the Cure of Gastrointestinal Cancers, Washington, District of Columbia, USA., Wong S; Sarcoma Oncology Research Center, Santa Monica, California, USA., Picozzi VJ; Virginia Mason Hospital and Medical Center, Seattle, Washington, USA., Staszewski H; Mather Hospital, Port Jefferson, New York, USA., Kim DW; The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Van Tornout JM; TYME Technologies Inc., Bedminster, New Jersey, USA., Philip PA; Karmanos Cancer Center, Wayne State University, Michigan, Detroit, USA.; SWOG, Farmington Hills, Michigan, USA., Chung V; City of Hope, Duarte, California, USA., Ocean AJ; Weill Cornell Medicine, New York-Presbyterian Hospital, New York, New York, USA., Wang-Gillam A; Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.

المصدر: Cancer medicine [Cancer Med] 2022 Nov; Vol. 11 (22), pp. 4169-4181. Date of Electronic Publication: 2022 May 02.

نوع المنشور: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/pathology , Adenocarcinoma*/pathology, Humans ; Methoxsalen/therapeutic use ; Phenytoin/therapeutic use ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Sirolimus/adverse effects ; Quality of Life ; Pancreatic Neoplasms

المؤلفون: Leger PR; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Hu DX; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Biannic B; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Bui M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Han X; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Karbarz E; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Maung J; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Okano A; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Osipov M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Shibuya GM; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Young K; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Higgs C; Schrödinger, 120 West 45th Street, New York, New York 10036, United States., Abraham B; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Bradford D; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Cho C; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Colas C; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Jacobson S; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Ohol YM; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Pookot D; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Rana P; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Sanchez J; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Shah N; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Sun M; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Wong S; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Brockstedt DG; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Kassner PD; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Schwarz JB; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States., Wustrow DJ; RAPT Therapeutics, Inc., 561 Eccles Avenue, South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5398-5420. Date of Electronic Publication: 2020 May 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*administration & dosage , Antineoplastic Agents/*chemistry , Drug Discovery/*methods , Ubiquitin-Specific Peptidase 7/*antagonists & inhibitors , Ubiquitin-Specific Peptidase 7/*chemistry, Administration, Oral ; Animals ; Cell Line, Tumor ; Crystallography, X-Ray/methods ; Humans ; Mice ; Mice, Inbred NOD ; Mice, Nude ; Mice, SCID ; Protein Structure, Tertiary ; Ubiquitin-Specific Peptidase 7/metabolism ; Xenograft Model Antitumor Assays/methods

المؤلفون: Zazoulina J; Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Cheung CC; Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Hurlburt A; Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Chahal D; Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Wong S; Division of General Internal Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

المصدر: CJC open [CJC Open] 2019 Apr 10; Vol. 1 (4), pp. 206-208. Date of Electronic Publication: 2019 Apr 10 (Print Publication: 2019).

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Elsevier Inc Country of Publication: United States NLM ID: 101763635 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-790X (Electronic) Linking ISSN: 2589790X NLM ISO Abbreviation: CJC Open Subsets: PubMed not MEDLINE

المؤلفون: Zhu Q; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Lu B; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., McTamney P; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Palaszynski S; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Diallo S; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Ren K; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Ulbrandt ND; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Kallewaard N; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Wang W; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Fernandes F; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Wong S; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Svabek C; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Moldt B; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Esser MT; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Jing H; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland., Suzich JA; Department of Infectious Diseases-Vaccines, MedImmune, LLC, Gaithersburg, Maryland.

المصدر: The Journal of infectious diseases [J Infect Dis] 2018 Jul 13; Vol. 218 (4), pp. 572-580.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Amino Acid Substitution*, Antibodies, Neutralizing/*immunology , Antibodies, Viral/*immunology , Immunologic Factors/*pharmacology , Respiratory Syncytial Virus Infections/*virology , Respiratory Syncytial Virus, Human/*immunology , Viral Fusion Proteins/*immunology, Binding Sites ; Biological Products/pharmacology ; Crystallography, X-Ray ; Drug Resistance, Viral ; Gene Frequency ; Humans ; Immune Evasion ; Mutant Proteins/chemistry ; Mutant Proteins/genetics ; Mutant Proteins/immunology ; Neutralization Tests ; Prevalence ; Protein Conformation ; Respiratory Syncytial Virus Infections/epidemiology ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/isolation & purification ; United States/epidemiology ; Viral Fusion Proteins/chemistry ; Viral Fusion Proteins/genetics ; Virus Attachment/drug effects ; Virus Replication/drug effects

المؤلفون: Zhou HJ; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Wang J; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Yao B; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Wong S; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Djakovic S; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Kumar B; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Rice J; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Valle E; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Soriano F; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Menon MK; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Madriaga A; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Kiss von Soly S; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Kumar A; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Parlati F; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Yakes FM; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Shawver L; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Le Moigne R; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Anderson DJ; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Rolfe M; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States., Wustrow D; Cleave Biosciences Inc. , 866 Malcom Road, Burlingame, California 94010, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2015 Dec 24; Vol. 58 (24), pp. 9480-97. Date of Electronic Publication: 2015 Dec 04.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Adenosine Triphosphatases/*antagonists & inhibitors , Antineoplastic Agents/*chemistry , Indoles/*chemistry , Nuclear Proteins/*antagonists & inhibitors , Pyrimidines/*chemistry, Administration, Oral ; Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/pharmacology ; Apoptosis ; Biological Availability ; Cell Line, Tumor ; Drug Screening Assays, Antitumor ; Female ; Heterografts ; Humans ; Indoles/pharmacokinetics ; Indoles/pharmacology ; Mice, Nude ; Molecular Docking Simulation ; Neoplasm Transplantation ; Proteasome Endopeptidase Complex/metabolism ; Pyrimidines/pharmacokinetics ; Pyrimidines/pharmacology ; Structure-Activity Relationship ; Ubiquitin/metabolism ; Unfolded Protein Response

المؤلفون: Anderson DJ; Cleave Biosciences, Inc., Burlingame, CA 94010, USA. Electronic address: danderson@cleavebio.com., Le Moigne R; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Djakovic S; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Kumar B; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Rice J; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Wong S; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Wang J; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Yao B; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Valle E; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Kiss von Soly S; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Madriaga A; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Soriano F; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Menon MK; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Wu ZY; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Kampmann M; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Chen Y; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Weissman JS; Department of Cellular and Molecular Pharmacology and Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., Aftab BT; Division of Hematology & Oncology, Department of Medicine, Helen Diller Family Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA., Yakes FM; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Shawver L; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Zhou HJ; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Wustrow D; Cleave Biosciences, Inc., Burlingame, CA 94010, USA., Rolfe M; Cleave Biosciences, Inc., Burlingame, CA 94010, USA.

المصدر: Cancer cell [Cancer Cell] 2015 Nov 09; Vol. 28 (5), pp. 653-665.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101130617 Publication Model: Print Cited Medium: Internet ISSN: 1878-3686 (Electronic) Linking ISSN: 15356108 NLM ISO Abbreviation: Cancer Cell Subsets: MEDLINE

مواضيع طبية MeSH: Adenosine Triphosphatases/*antagonists & inhibitors , Enzyme Inhibitors/*pharmacology , Homeostasis/*drug effects , Neoplasms/*drug therapy , Nuclear Proteins/*antagonists & inhibitors, Adenosine Triphosphatases/genetics ; Adenosine Triphosphatases/metabolism ; Animals ; Apoptosis/drug effects ; Blotting, Western ; CRISPR-Cas Systems ; Cell Line, Tumor ; Endoplasmic Reticulum-Associated Degradation/drug effects ; Enzyme Inhibitors/chemistry ; Gene Expression Regulation, Neoplastic/drug effects ; HCT116 Cells ; HEK293 Cells ; Humans ; Indoles/chemistry ; Indoles/pharmacology ; K562 Cells ; Mice, Nude ; Mice, SCID ; Molecular Structure ; Molecular Targeted Therapy/methods ; Neoplasms/genetics ; Neoplasms/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Pyrimidines/chemistry ; Pyrimidines/pharmacology ; RNA Interference ; Reverse Transcriptase Polymerase Chain Reaction ; Ubiquitinated Proteins/metabolism ; Xenograft Model Antitumor Assays

المؤلفون: Corbin JA; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Bhaskar V; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Goldfine ID; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America., Bedinger DH; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lau A; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Michelson K; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Gross LM; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Maddux BA; Department of Medicine, University of California San Francisco, San Francisco, California, United States of America., Kuan HF; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Tran C; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lao L; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Handa M; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Watson SR; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Narasimha AJ; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Zhu S; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Levy R; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Webster L; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wijesuriya SD; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Liu N; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wu X; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Chemla-Vogel D; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Lee SR; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wong S; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., Wilcock D; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America., White ML; Department of Preclinical Research, XOMA Corporation, Berkeley, California, United States of America.

المصدر: PloS one [PLoS One] 2014 Feb 12; Vol. 9 (2), pp. e88684. Date of Electronic Publication: 2014 Feb 12 (Print Publication: 2014).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*chemistry , Antigens, CD/*metabolism , Glucose/*metabolism , Receptor, Insulin/*metabolism, Allosteric Site ; Animals ; C-Peptide/chemistry ; CHO Cells ; Cell Separation ; Cricetinae ; Cricetulus ; Diabetes Mellitus, Type 2/metabolism ; Flow Cytometry ; Humans ; Hyperglycemia/metabolism ; Hyperinsulinism/metabolism ; Insulin/chemistry ; Insulin Resistance ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Peptide Library ; Phosphorylation ; Protein Structure, Tertiary ; Signal Transduction