المؤلفون: Jade Lyons Rimmer, Emanuela Ercolano, Daniele Baiz, Mahindra Makhija, Allison Berger, Todd Sells, Steve Stroud, David Hilton, Claire L. Adams, C Oliver Hanemann

المصدر: Cancers, Vol 12, Iss 7, p 1744 (2020)

مصطلحات موضوعية: Merlin, meningioma, CRL4-DCAF1, KSR1, Raf/MEK/ERK, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: https://www.mdpi.com/2072-6694/12/7/1744; https://doaj.org/toc/2072-6694

URL الوصول: https://doaj.org/article/4bb45e00a41042db92d0bda5dec613db

المؤلفون: Alexandra E. Gould, Courtney Cullis, Lee Hong Myung, David Lok, Rachel E. Gershman, Scott R. Rowland, Miho Mizutani, Dave Janowick, Gipson Krista E, Vihren Kolev, Robert J. Griffin, Joe Conlon, Steve Stroud, Akito Hata, Jeffrey Ciavarri, Dylan Bradley England, Cardin David P, Sandeep Pusalkar, Paul D. Greenspan, Adnan O Abu-Yousif, Jenna Malley, Doanh Mai, Michael Shaw, Ji Zhang, Robert J. Skene, Hu Zhigen, Matthew A. Jones, Atsushi Matsuda, Shih-Chung Huang, Nina Molchanova, Xu Tianlin, Jian Huang, He Xu, Stepan Vyskocil, Nanda Gulavita, Francois Soucy, Gang Li, Yongbo Hu, Liting Ma, Steven P. Langston, Zhan Shi, Christelle C. Renou, Luhua Shen, Sean Harrison, Elise Nunes, Kenneth M. Gigstad, Yosuke Sato, Hirotake Mizutani

المصدر: Journal of Medicinal Chemistry. 64:6902-6923

مصطلحات موضوعية: Transplantation, Heterologous, Inflammation, 01 natural sciences, Phosphates, Mice, Structure-Activity Relationship, 03 medical and health sciences, Cell Line, Tumor, Neoplasms, Drug Discovery, medicine, Animals, Humans, 030304 developmental biology, 0303 health sciences, Tumor microenvironment, Binding Sites, Innate immune system, Chemistry, Membrane Proteins, Type I interferon production, Acquired immune system, eye diseases, Rats, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Sting, Pyrimidines, Stimulator of interferon genes, Cancer research, Molecular Medicine, Administration, Intravenous, Cytokine secretion, Immunotherapy, Nucleotides, Cyclic, medicine.symptom, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f642868da1ca20f638998dc8a616442f
https://doi.org/10.1021/acs.jmedchem.1c00374

المؤلفون: Steve Stroud, Jade Lyons Rimmer, Emanuela Ercolano, David A Hilton, Claire L. Adams, Allison Berger, C. Oliver Hanemann, Mahindra Makhija, Daniele Baiz, Sells Todd B

المصدر: Cancers
Volume 12
Issue 7
Cancers, Vol 12, Iss 1744, p 1744 (2020)

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Cancer Research, CRL4-DCAF1, KSR1, lcsh:RC254-282, meningioma, Article, 03 medical and health sciences, 0302 clinical medicine, Medicine, Merlin, biology, Kinase, business.industry, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Ubiquitin ligase, Merlin (protein), 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Selumetinib, Neddylation, business, Raf/MEK/ERK, Cullin

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7980ab8cd9ac09755ed4833108fd2cfa
https://doi.org/10.3390/cancers12071744

المؤلفون: Kurt Eng, Mike Kuranda, Steve Stroud, Masanori Okaniwa, Robyn Fabrey, Kazuhide Nakamura, Saurabh Menon, Patrick Vincent, Elizabeth Grace Carideo Cunniff, Teena Vagrhese, Katherine M. Galvin, Julie Zhang, Takeo Arita, Khristofer Garcia, Jerome T. Mettetal, Deanna Borelli, Akito Nakamura, Sei Yoshida, Tomoyasu Ishikawa, Jouhara Chouitar

المصدر: Molecular Cancer Therapeutics. 12:C146-C146

مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Kinase, business.industry, Colorectal cancer, Melanoma, MEK inhibitor, Mutant, Cancer, Raf Kinase Inhibitor, Pharmacology, medicine.disease, Oncology, Cancer research, medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::be505a4c2cf4f834fafa067112f1bdf5
https://doi.org/10.1158/1535-7163.targ-13-c146

المؤلفون: Masanori Okaniwa, Robyn Fabrey, Patrick Vincent, Takeo Arita, Mike Kuranda, Deanna Borrelli, Akito Nakamura, Kurt Eng, Saurabh Menon, Kazuhide Nakamura, Julie Zhang, Steve Stroud, Khristofer Garcia, Jerome T. Mettetal, Katherine M. Galvin, Teena Vagrhese, Jouhara Chouitar, Tomoyasu Ishikawa, Elizabeth Grace Carideo Cunniff, Sei Yoshida

المصدر: Journal of Clinical Oncology. 31:e13529-e13529

مصطلحات موضوعية: Cancer Research, Kinase, business.industry, Colorectal cancer, Melanoma, Mutant, Raf Kinase Inhibitor, medicine.disease, Combined treatment, Oncology, Cancer research, Medicine, business, neoplasms

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5d11e592ed0690892241938bbe3ceba0
https://doi.org/10.1200/jco.2013.31.15_suppl.e13529