-
1
المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
-
2
المؤلفون: Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Oxamyl, Apoptosis, Peptide, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Caspase, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Neurodegenerative Diseases, Dipeptides, Caspase Inhibitors, In vitro, Stroke, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
-
3
المؤلفون: Robert Smidt, Jose-Luis Diaz, Lalitha Kodandapani, Joe C. Wu, Brian Pham, Donald S. Karanewsky, Kevin J. Tomaselli, Robert J. Ternansky, Lawrence C. Fritz, Steven D. Linton
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:2969-2971
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Peptidomimetic, Acylation, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, medicine, Enzyme Inhibitors, Molecular Biology, Caspase, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, Dipeptides, Caspase Inhibitors, In vitro, Isoenzymes, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Indicators and Reagents, Oligopeptides, Lactone
-
4
المؤلفون: Gang Liu, Tohru Fukuyama, Steven D. Linton, Hiroshi Nishino, Shao Cheng Lin
المصدر: Tetrahedron Letters. 34:2577-2580
مصطلحات موضوعية: Benzodiazepine, medicine.drug_class, Stereochemistry, Chemistry, Organic Chemistry, Antibiotics, food and beverages, Total synthesis, Glutamic acid, Biochemistry, chemistry.chemical_compound, Drug Discovery, Porothramycin B, medicine, Lactam, Organic chemistry, Enantiomer
-
5
المؤلفون: Gang Liu, Tohru Fukuyama, Shao Cheng Lin, H. Nishino, Steven D. Linton
المصدر: ChemInform. 24
مصطلحات موضوعية: medicine.drug_class, Chemistry, Stereochemistry, Antibiotics, Porothramycin B, medicine, Total synthesis, General Medicine
-
6
المؤلفون: Donald S. Karanewsky, Kevin J. Tomaselli, Bryan Pham, Joseph F. Krebs, Steven D. Linton, Xu Bai, Joe Wu
المصدر: ChemInform. 30
مصطلحات موضوعية: chemistry.chemical_classification, chemistry.chemical_compound, Dipeptide, Enzyme, Biochemistry, chemistry, parasitic diseases, Substituent, Caspase 1, Interleukin 1β converting enzyme, Caspase 3, General Medicine, Highly selective
-
7
المؤلفون: Steven D. Linton, Tom O'Brien
المصدر: Design of Caspase Inhibitors as Potential Clinical Agents
مصطلحات موضوعية: chemistry.chemical_classification, Caspase inhibitors, Protease, Enzyme, Chemistry, Mechanism (biology), medicine.medical_treatment, medicine, Abnormal cell, Cysteine proteinases, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8c83c69bc3e29c13b5c8d573f2c6bdcd
https://doi.org/10.1201/9781420045413 -
8
المؤلفون: Steven D. Linton, Tohru Fukuyama, Min Min Tun
المصدر: Tetrahedron Letters. 31:5989-5992
مصطلحات موضوعية: Diketone, chemistry.chemical_classification, Chemistry, Stereochemistry, Organic Chemistry, Diol, Total synthesis, Biochemistry, chemistry.chemical_compound, Drug Discovery, X-ray crystallography, Enol ether, Side chain, Stereoselectivity, Selectivity
-
9
المؤلفون: Steven D. Linton
المصدر: Current topics in medicinal chemistry. 5(16)
مصطلحات موضوعية: Programmed cell death, Caspase inhibitors, biology, Pralnacasan, Drug Industry, business.industry, General Medicine, Disease, Pharmacology, Cysteine Proteinase Inhibitors, Caspase Inhibitors, Clinical trial, Cellular mechanism, Structure-Activity Relationship, Drug Discovery, biology.protein, Medicine, Animals, Humans, business, Caspase, Pharmaceutical industry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3efe82d3f403e0001020d0060451620
https://pubmed.ncbi.nlm.nih.gov/16375749 -
10
المؤلفون: Teresa Aja, Kevin J. Tomaselli, Edward D. Robinson, Joe C. Wu, Steven D. Linton, Xin Gu, Robert O. Sayers, Steven P. Meduna, Kip Nalley, Lalitha Kodandapani, Silvio Roggo, Vincent J. Kalish, Jose-Luis Diaz, Donald S. Karanewsky, Ning Chen, Albert Schmitz, Julia Herrmann, Brett R. Ullman, Joseph J. Krebs, Robert J. Ternansky
المصدر: Bioorganicmedicinal chemistry letters. 15(15)
مصطلحات موضوعية: Programmed cell death, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Naphthols, Cysteine Proteinase Inhibitors, Biochemistry, Chemical synthesis, Models, Biological, Mice, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Animals, Molecular Biology, Caspase, Cells, Cultured, chemistry.chemical_classification, Aspartic Acid, biology, Bicyclic molecule, Cell Death, Organic Chemistry, Valine, Ketones, Caspase Inhibitors, In vitro, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Cellular model