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1
المؤلفون: Yanlei Zhang, Jeffrey Tredup, Mertzman Michael E, Nelly Aranibar, Kim W. McIntyre, Kathleen M. Gillooly, Jodi K. Muckelbauer, James R. Burke, Lihong Cheng, Joann Strnad, Celia D’Arienzo, Dawn Mulligan, Stephen T. Wrobleski, Charu Chaudhry, Adriana Zupa-Fernandez, Percy H. Carter, Dianlin Xie, Manoj Chiney, Elizabeth M. Heimrich, Moslin Ryan M, Christine Huang, Xiaoxia Yang, Shuqun Lin, David S. Weinstein, Tokarski John S, Chiehying Chang, Louis J. Lombardo, Huadong Sun, Steven H. Spergel
المصدر: Journal of Medicinal Chemistry. 62:8953-8972
مصطلحات موضوعية: Nicotinamide, medicine.drug_class, Allosteric regulation, Carboxamide, Pyridazine, chemistry.chemical_compound, chemistry, Biochemistry, Tyrosine kinase 2, Drug Discovery, medicine, Molecular Medicine, Structure–activity relationship, Transferase, Tyrosine kinase
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المؤلفون: Max Ruzanov, David J. Shuster, Manoj Chiney, Kim W. McIntyre, James R. Burke, Celia D’Arienzo, Nelly Aranibar, Elizabeth M. Heimrich, Louis J. Lombardo, Dianlin Xie, Moslin Ryan M, Joann Strnad, Anjaneya Chimalakonda, Lihong Cheng, James Kempson, Adriana Zupa-Fernandez, Javed Khan, Charu Chaudhry, Huadong Sun, Shuqun Lin, Percy H. Carter, Steven H. Spergel, Christine Huang, Dawn Mulligan, Stephen T. Wrobleski, Kathleen M. Gillooly, Yanlei Zhang, Jeffrey Tredup, David S. Weinstein, Tokarski John S, William J. Pitts, Xiaoxia Yang
المصدر: Journal of medicinal chemistry. 62(20)
مصطلحات موضوعية: Gene isoform, Allosteric regulation, Crystallography, X-Ray, 01 natural sciences, Autoimmune Diseases, 03 medical and health sciences, Mice, Allosteric Regulation, Heterocyclic Compounds, Drug Discovery, medicine, Animals, Humans, Kinome, Protein Kinase Inhibitors, 030304 developmental biology, Autoimmune disease, TYK2 Kinase, 0303 health sciences, Kinase Family, Chemistry, medicine.disease, Highly selective, Small molecule, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Tyrosine kinase 2, Cancer research, Molecular Medicine
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المؤلفون: Sidney Pitt, John S. Sack, Vicky Tang, William J. Pitts, Steven H. Spergel, Jonathan Lippy, Junqing Guo, Michael Galella, Mertzman Michael E, Sylwia Stachura, Steven G. Nadler, Aberra Fura, Percy H. Carter, Gary L. Schieven, Luisa Salter-Cid, Kim W. McIntyre, James Kempson, Javed Khan, Lauren Haque, Rosemary Zhang, John S. Tokarski, Guoxiang Shen, Kathleen M. Gillooly, Stephen T. Wrobleski, Joel C. Barrish
مصطلحات موضوعية: Tofacitinib, Kinase, business.industry, Organic Chemistry, Prodrug, Pharmacology, medicine.disease, Biochemistry, Immune system, Tyrosine kinase 2, Rheumatoid arthritis, Drug Discovery, Functional selectivity, Medicine, business, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee1a959ab8edd802fd477e946d59e0fb
https://europepmc.org/articles/PMC6421541/ -
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المؤلفون: Janet Dell-John, John D. Dimarco, Cheryl A. Rizzo, Mark E. Salvati, Steven H. Spergel, Gregory Scott Martin, Weifang Shan, Aaron Balog, Georgia Cornelius, Richard Rampulla, Marco M. Gottardis, Andrew Nation, Christian L. Holst, Liang Schweizer, Gregory D. Vite, Lana M. Rossiter, Ricardo M. Attar, David J. Fairfax, Thomas E. Spires, Stanley R. Krystek, George L. Trainor, Jack Z. Gougoutas
المصدر: ACS Medicinal Chemistry Letters. 6:908-912
مصطلحات موضوعية: Nonsteroidal, Bicalutamide, business.industry, digestive, oral, and skin physiology, Organic Chemistry, Antagonist, Cancer, Pharmacology, medicine.disease, Biochemistry, In vitro, Androgen receptor, stomatognathic diseases, Prostate cancer, chemistry.chemical_compound, chemistry, Drug Discovery, Medicine, Androgen receptor antagonist, business, medicine.drug
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المؤلفون: Jinghan Gui, Mertzman Michael E, Thomas E. La Cruz, Tian Qin, Nitin Darvatkar, Julian C. Lo, Ying Jin, Chung-Mao Pan, Steven H. Spergel, Phil S. Baran, William J. Pitts, Bryan J. Lee, Swaminathan Natarajan, Michael A. Schmidt
المصدر: Science. 348:886-891
مصطلحات موضوعية: Olefin fiber, chemistry.chemical_compound, Multidisciplinary, chemistry, Aryl, Nitro, Organic chemistry, Substrate (chemistry), Halide, Amine gas treating, Amine synthesis, Hydroamination
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::7937b6e747a390d8a9b94c903b4f1726
https://doi.org/10.1126/science.aab0245 -
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المؤلفون: Jingwu Duan, Stephen T. Wrobleski, Joel C. Barrish, Jagabandhu Das, Gary L. Schieven, Steven H. Spergel, Charu Chaudhry, Percy H. Carter, John S. Tokarski, Damaso Ovalle, John S. Sack, Aberra Fura, Zhonghui Lu, James Kempson, Luisa Salter-Cid, William J. Pitts, Junqing Guo, Yuval Blatt, John Hynes, Shuqun Lin, Hong Wu, Bin Jiang, Bingwei V. Yang, Javed Khan
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Cell Survival, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystal structure, Biochemistry, Active site cysteine, Cell Line, 03 medical and health sciences, Residue (chemistry), Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Drug Discovery, Molecule, Humans, Molecular Biology, Protein Kinase Inhibitors, Binding Sites, Chemistry, Organic Chemistry, Janus Kinase 3, Janus Kinase 1, Janus Kinase 2, Combinatorial chemistry, Molecular Docking Simulation, 030104 developmental biology, Covalent bond, Electrophile, Molecular Medicine
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المؤلفون: William J. Pitts, Robert J. Schmidt, Steven H. Spergel, Julie Carman, Hai-Yun Xiao, Carolyn A. Weigelt, Shuqun Lin, Alec Keon, John S. Sack, James Kempson, Rajeev S. Bhide, Michael A. Poss
المصدر: Bioorganicmedicinal chemistry letters. 27(21)
مصطلحات موضوعية: 0301 basic medicine, Niacinamide, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Pharmaceutical Science, Molecular Dynamics Simulation, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Structure-Activity Relationship, 0302 clinical medicine, Drug Discovery, Potency, Structure–activity relationship, Humans, Molecular Biology, Protein Kinase Inhibitors, Binding Sites, Chemistry, Cellular Assay, Organic Chemistry, Janus Kinase 3, IRAK4, Combinatorial chemistry, Small molecule, Protein Structure, Tertiary, 030104 developmental biology, Interleukin-1 Receptor-Associated Kinases, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, Structure based
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المؤلفون: Alaric J. Dyckman, David J. Shuster, James Kempson, Georgia Cornelius, Sandra Rex-Rabe, Tracy L. Taylor, Kim W. McIntyre, Anthony M. Marino, Percy H. Carter, Junqing Guo, Dana Banas, Celia D’Arienzo, Luisa Salter-Cid, Praveen Balimane, Suzanne J. Suchard, Jenny Xie, Kathleen M. Gillooly, Steven H. Spergel, Mary Ellen Cvijic, William J. Pitts, Scott H. Watterson, Murray McKinnon, Richard Liu, Joel C. Barrish, Charles M. Langevine, Ding Ren Shen, Melissa Yarde
المصدر: Bioorganicmedicinal chemistry letters. 26(10)
مصطلحات موضوعية: 0301 basic medicine, Male, Stereochemistry, Clinical Biochemistry, Dose dependence, Drug Evaluation, Preclinical, Pharmaceutical Science, Arthritis, Administration, Oral, Chemistry Techniques, Synthetic, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Pharmacokinetics, Sphingosine, Drug Discovery, medicine, Animals, Humans, Sphingosine-1-phosphate, Lymphocyte Count, Isoxazole, Molecular Biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Rodent model, Isoxazoles, medicine.disease, Arthritis, Experimental, In vitro, Receptors, Lysosphingolipid, 030104 developmental biology, Rats, Inbred Lew, Molecular Medicine, Lysophospholipids, Selectivity, 030217 neurology & neurosurgery
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المؤلفون: William J. Pitts, Alaric J. Dyckman, Scott H. Watterson, Robert V. Moquin, Kim W. McIntyre, Zheng Yang, Jagabandhu Das, Katy Van Kirk, James R. Burke, David B. Wang-Iverson, Hollie Booth-Lute, James Kempson, Laishun Chen, Charles M. Langevine, Joel C. Barrish, Guchen Yang, Xiaoxia Yang, John H. Dodd, David S. Nirschl, Murray McKinnon, Steven H. Spergel, Mark A. Pattoli, Michael Galella, Kurt R. Gregor, Junquing Guo
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:7006-7012
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Administration, Oral, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Acetamides, Drug Discovery, Animals, Humans, Inhibitory concentration 50, Structure–activity relationship, Potency, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Drug discovery, Organic Chemistry, Inflammatory Bowel Diseases, In vitro, I-kappa B Kinase, Rats, Enzyme Activation, chemistry, Molecular Medicine, Heterocyclic Compounds, 3-Ring, Acetamide, Tricyclic
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المؤلفون: Steven H. Spergel, William J. Pitts, Danielle R. Okoro
المصدر: The Journal of Organic Chemistry. 75:5316-5319
مصطلحات موضوعية: chemistry.chemical_classification, Aza Compounds, Indoles, Magnetic Resonance Spectroscopy, Ketone, Organic Chemistry, One-pot synthesis, chemistry.chemical_element, Ketones, Chemical synthesis, Catalysis, Mass Spectrometry, chemistry, One pot reaction, Organic chemistry, Palladium
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