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المؤلفون: Curt A. Dvorak, Mandana Tootoonchi, Marcos E. Milla, Paul J. Krawczuk, Wendy Eccles, Xuejun Liu, Navin Rao, Jiejun Wu, John M. Keith, Steven P. Meduna, Jiao Song, Jonathan M. Blevitt, Jian Zhu, Alec D. Lebsack
المصدر: SLAS Discovery. 21:127-135
مصطلحات موضوعية: 0301 basic medicine, Leukotrienes, Polypharmacology, 5-Lipoxygenase-Activating Proteins, Biochemistry, Analytical Chemistry, Proinflammatory cytokine, Small Molecule Libraries, 03 medical and health sciences, chemistry.chemical_compound, Lipidomics, Humans, 5-lipoxygenase-activating protein, Glutathione Transferase, biology, Lipid signaling, Small molecule, 030104 developmental biology, chemistry, biology.protein, Eicosanoids, Molecular Medicine, lipids (amino acids, peptides, and proteins), Arachidonic acid, Ex vivo, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b562180eca681a6a602d925e4e31ab97
https://doi.org/10.1177/1087057115607815 -
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المؤلفون: Zhao Bao-Ping, Kevin Tays, Brad M. Savall, Hui Cai, Michael David Gaul, James P. Edwards, Patricia McGovern, Robin L. Thurmond, Steven P. Meduna
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:956-959
مصطلحات موضوعية: Pyrimidine, Pyridines, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Pyrrolidine, Receptors, G-Protein-Coupled, Pyridazine, chemistry.chemical_compound, chemistry, Diamine, Drug Discovery, Pyridine, Humans, Receptors, Histamine, Molecular Medicine, Amine gas treating, Histamine H4 receptor, Receptor, Molecular Biology, Receptors, Histamine H4
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المؤلفون: James P. Edwards, Laurent Gomez, Paul J. Dunford, Michael P. Curtis, Aaron M. Kearney, Savall Brad M, Steven P. Meduna, Jeffery M. Cowden, Frank Chavez, Robin L. Thurmond, Cheryl A. Grice
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6577-6581
مصطلحات موضوعية: chemistry.chemical_classification, Chemistry, Organic Chemistry, Clinical Biochemistry, Histamine Antagonists, Antagonist, Pharmaceutical Science, Metabolism, Pharmacology, Biochemistry, Receptors, G-Protein-Coupled, Mice, chemistry.chemical_compound, Water soluble, Drug Discovery, Animals, Receptors, Histamine, Molecular Medicine, Histamine H4 receptor, Benzofuran, Molecular Biology, Histamine, Receptors, Histamine H4, Tricyclic
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المؤلفون: Jianmei Wei, Lars Karlsson, Hui Cai, Steven P. Meduna, Yin Gu, Robin L. Thurmond, Barbara Pio, Siquan Sun, James P. Edwards, Wen Jiang
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:5525-5528
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Carboxylic Acids, Pharmaceutical Science, Thiophenes, Pyrazole, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Pyrazolopyridine, Animals, Humans, Structure–activity relationship, Potency, Protease Inhibitors, Molecular Biology, Benzofurans, Cathepsin S, Indole test, chemistry.chemical_classification, Aza Compounds, Molecular Structure, biology, Organic Chemistry, Cathepsins, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Pyrazoles, Molecular Medicine
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المؤلفون: Jianmei Wei, Patricia McGovern, James P. Edwards, Robin L. Thurmond, Jennifer Venable, Brad M. Savall, Michael D. Hack, Russell C. Smith, Steven P. Meduna
المصدر: Bioorganicmedicinal chemistry letters. 24(23)
مصطلحات موضوعية: Pyrimidine, Molecular Structure, Chemistry, Stereochemistry, Pyridines, Organic Chemistry, Clinical Biochemistry, Histamine Antagonists, Pharmaceutical Science, Histamine h, Ligands, Biochemistry, Orders of magnitude (mass), Receptors, G-Protein-Coupled, chemistry.chemical_compound, Pyrimidines, Drug Discovery, Pyridine, Molecular Medicine, Humans, Receptors, Histamine, Histamine H4 receptor, Molecular Biology, Histamine, Receptors, Histamine H4
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المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras
المصدر: Journal of Medicinal Chemistry. 48:6779-6782
مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life
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المؤلفون: Robert Smidt, Silvio Roggo, Julia Herrmann, Edward D. Robinson, Kathy G. Jahangiri, Teresa Aja, Kip Nalley, Thomas L. Deckwerth, Giorgio Rovelli, Kevin J. Tomaselli, Joe C. Wu, Bastian Hengerer, Steven P. Meduna, André Sauter, Jose-Luis Diaz, Joerg Kallen, Albert Schmitz, Donald S. Karanewsky, Brett R. Ullman, Steven D. Linton, Christoph Wiessner, Robert J. Ternansky, Peter R. Allegrini, Robert O. Sayers
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:2685-2691
مصطلحات موضوعية: Peptidomimetic, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Oxamyl, Apoptosis, Peptide, Biochemistry, Cell Line, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Molecular Biology, Caspase, chemistry.chemical_classification, Dipeptide, biology, Organic Chemistry, Neurodegenerative Diseases, Dipeptides, Caspase Inhibitors, In vitro, Stroke, Kinetics, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Carbamates
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المؤلفون: Edward D. Robinson, Silvio Roggo, Joe C. Wu, Robert J. Ternansky, Jose-Luis Diaz, Teresa Aja, Kevin J. Tomaselli, Steven P. Meduna, Vincent J. Kalish, Donald S. Karanewsky, Robert O. Sayers, Albert Schmitz, Brett R. Ullman, Julia Herrmann, Kip Nalley, Thomas L. Deckwerth
المصدر: Bioorganic & Medicinal Chemistry Letters. 13:3623-3626
مصطلحات موضوعية: chemistry.chemical_classification, Programmed cell death, biology, Chemistry, Organic Chemistry, Clinical Biochemistry, Leaving group, Pharmaceutical Science, Inflammation, Cysteine Proteinase Inhibitors, Caspase Inhibitors, Biochemistry, In vitro, Structure-Activity Relationship, Enzyme, Enzyme inhibitor, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, medicine.symptom, Molecular Biology, Caspase
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المؤلفون: Wenying Chai, Kenneth O. LaTessa, Steven P. Meduna, Thomas A. Engler
المصدر: The Journal of Organic Chemistry. 61:8598-8603
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Yield (chemistry), Organic Chemistry, Alkoxy group, Molecule, Regioselectivity, Lewis acids and bases, Benzoquinone, Medicinal chemistry
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المؤلفون: Thomas A. Engler, Steven P. Meduna, Wenying Chai, Kenneth O. Lynch
المصدر: Tetrahedron Letters. 36:2713-2716
مصطلحات موضوعية: 1,4-Benzoquinone, chemistry.chemical_compound, chemistry, Aryl, Organic Chemistry, Drug Discovery, Organic chemistry, chemistry.chemical_element, Biochemistry, Nitrogen, Cycloaddition
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