نتائج البحث - "Steven Victor O'neil"

1

Application of Flow and Biocatalytic Transaminase Technology for the Synthesis of a 1-Oxa-8-azaspiro[4.5]decan-3-amine

المؤلفون: Michael Paul Burns, Rajesh Kumar, Loren M. Price, Dorff Peter H, Robert John Maguire, Jeffrey T. Kohrt, Melissa Wagenaar, Manjinder S. Lall, Chewah Lee, Steven Victor O'neil

المصدر: Organic Process Research & Development. 26:616-623

مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, Flow chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Transaminase, chemistry.chemical_compound, chemistry, Flow (mathematics), Biocatalysis, Amine gas treating, Azide, Physical and Theoretical Chemistry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b9a430403bd70bda39d90ef4cfa1f7a2
https://doi.org/10.1021/acs.oprd.1c00075

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2

Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity

المؤلفون: Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa

المصدر: Journal of medicinal chemistry. 62(18)

مصطلحات موضوعية: Pharmacology, Ligands, 01 natural sciences, Madin Darby Canine Kidney Cells, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, In vivo, Drug Discovery, Radioligand, medicine, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Binding Sites, medicine.diagnostic_test, Chemistry, Brain, Serine hydrolase, Pet imaging, Ligand (biochemistry), Endocannabinoid system, Magnetic Resonance Imaging, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 010404 medicinal & biomolecular chemistry, Positron emission tomography, Drug Design, Positron-Emission Tomography, Solvents, Molecular Medicine, Carbamates, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf9e513dd3ea64b1d4e6e3ab52c34c1
https://pubmed.ncbi.nlm.nih.gov/31483137

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3

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates

المؤلفون: Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar

المصدر: Journal of Medicinal Chemistry. 60:7764-7780

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f7bf401a8f31cb0664e65627c9432b
https://doi.org/10.1021/acs.jmedchem.7b00604

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4

Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity

المصدر: Journal of Medicinal Chemistry. 60:6649-6663

مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e16d6e6b4f8608876f69c7501545a8c8
https://doi.org/10.1021/acs.jmedchem.7b00597

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5

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation

المصدر: Journal of medicinal chemistry. 61(7)

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Arachidonic Acids, Pharmacology, 01 natural sciences, Amidohydrolases, Glycerides, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Neuritis, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Neuroinflammation, Brain Chemistry, Trifluoromethyl, 010405 organic chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Leaving group, Serine hydrolase, Endocannabinoid system, Macaca mulatta, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, Carbamates, Biomarkers, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba4448563e7b467bb25a055a46ddd6
https://pubmed.ncbi.nlm.nih.gov/29498843

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6

Negative allosteric modulation of metabotropic glutamate receptor 5 results in broad spectrum activity relevant to treatment resistant depression

المصدر: Neuropharmacology. 66:202-214

مصطلحات موضوعية: Allosteric modulator, Pyridines, medicine.drug_class, Receptor, Metabotropic Glutamate 5, Drug Evaluation, Preclinical, Glutamic Acid, Pharmacology, Receptors, Metabotropic Glutamate, Anxiolytic, Depressive Disorder, Treatment-Resistant, Mice, Radioligand Assay, Cellular and Molecular Neuroscience, Allosteric Regulation, medicine, Animals, Humans, Analgesics, Behavior, Animal, Dose-Response Relationship, Drug, Metabotropic glutamate receptor 5, medicine.disease, Antidepressive Agents, Rats, Disease Models, Animal, HEK293 Cells, MTEP, Anti-Anxiety Agents, Metabotropic glutamate receptor, Benzamides, Metabotropic glutamate receptor 1, Antidepressant, Calcium, Psychology, Excitatory Amino Acid Antagonists, Treatment-resistant depression

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f27f357b121503721c2f3f01ac62415
https://doi.org/10.1016/j.neuropharm.2012.04.007

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7

Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects

المصدر: Journal of medicinal chemistry. 59(13)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2fc61159c2c41b46e640509efcd4086
https://pubmed.ncbi.nlm.nih.gov/27275946

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8

Design and optimization of selective azaindole amide M1 positive allosteric modulators

المصدر: Bioorganicmedicinal chemistry letters. 26(2)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3a645b21d1863c52f9d4f7a6024733
https://pubmed.ncbi.nlm.nih.gov/26631313

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9

Advances in the development of novel aggrecanase inhibitors

المؤلفون: Adam M. Gilbert, Jack A. Bikker, Steven Victor O'neil

المصدر: Expert Opinion on Therapeutic Patents. 21:1-12

مصطلحات موضوعية: Pharmacology, Metalloproteinase, Thrombospondin, biology, Chemistry, ADAMTS, General Medicine, Hydrogen-Ion Concentration, Symptomatic relief, Patents as Topic, Drug Delivery Systems, Biochemistry, Disease modification, Drug Design, Endopeptidases, Osteoarthritis, Drug Discovery, Disintegrin, biology.protein, Animals, Humans, Protease Inhibitors, Aggrecan, Aggrecanase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e2dddea1f4af80ab6ff43d8448898c
https://doi.org/10.1517/13543776.2011.539204

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