-
1
المؤلفون: Michael Paul Burns, Rajesh Kumar, Loren M. Price, Dorff Peter H, Robert John Maguire, Jeffrey T. Kohrt, Melissa Wagenaar, Manjinder S. Lall, Chewah Lee, Steven Victor O'neil
المصدر: Organic Process Research & Development. 26:616-623
مصطلحات موضوعية: 010405 organic chemistry, Organic Chemistry, Flow chemistry, 010402 general chemistry, Ring (chemistry), 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, Transaminase, chemistry.chemical_compound, chemistry, Flow (mathematics), Biocatalysis, Amine gas treating, Azide, Physical and Theoretical Chemistry
-
2
المؤلفون: Christopher Ryan Butler, Timothy J. McCarthy, Ryosuke Arakawa, Deborah L. Smith, Klaas Schildknegt, Justin R. Piro, Lei Zhang, Kevin P. Maresca, Laura A. McAllister, Deane M. Nason, Zhisheng Jia, Sangram Nag, Akihiro Takano, Tarek A. Samad, Christer Halldin, Anabella Villalobos, Steven Victor O'neil, Patrick Trapa
المصدر: Journal of medicinal chemistry. 62(18)
مصطلحات موضوعية: Pharmacology, Ligands, 01 natural sciences, Madin Darby Canine Kidney Cells, Rats, Sprague-Dawley, 03 medical and health sciences, Dogs, In vivo, Drug Discovery, Radioligand, medicine, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, 0303 health sciences, Binding Sites, medicine.diagnostic_test, Chemistry, Brain, Serine hydrolase, Pet imaging, Ligand (biochemistry), Endocannabinoid system, Magnetic Resonance Imaging, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 010404 medicinal & biomolecular chemistry, Positron emission tomography, Drug Design, Positron-Emission Tomography, Solvents, Molecular Medicine, Carbamates, Endocannabinoids
-
3
المؤلفون: Daniel P. Walker, Antonia F. Stepan, Mark A. Moen, Gregg D. Cappon, Christopher Houle, Annie C Won, Joshua R. Dunetz, Michael John Bohanon, Lei Zhang, Marc B. Skaddan, Patrick Robert Verhoest, Susan E. Drozda, Xinjun Hou, Kenneth R. Zasadny, Julie Cianfrogna, Deborah L. Smith, Ann S. Wright, John T. Lazzaro, Steven Victor O'neil, Patrick Trapa, Emily Miller, Somraj Ghosh, Gabriela Barreiro, John M. Marcek, Margaret M. Zaleska, Jason Barricklow, Michelle Marie Claffey, Lois K. Chenard, Jessica Mancuso, Christopher L. Shaffer, Jessica Whritenour, Gayatri Balan, Brian P. Boscoe, Vinod D. Parikh, Karen J. Coffman, Laigao Chen, Isao Sakurada, Jamison B. Tuttle, Matthew R. Reese, Karki Kapil Kumar
المصدر: Journal of Medicinal Chemistry. 60:7764-7780
مصطلحات موضوعية: Male, 0301 basic medicine, Allosteric modulator, Pyridines, Receptor, Metabotropic Glutamate 5, Alkyne, Pharmacology, 030226 pharmacology & pharmacy, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Immune system, Allosteric Regulation, Drug Discovery, Animals, Humans, Structure–activity relationship, Receptor, chemistry.chemical_classification, Chemistry, Metabotropic glutamate receptor 5, HEK 293 cells, Rats, Molecular Docking Simulation, HEK293 Cells, 030104 developmental biology, Toxicity, Molecular Medicine, Female, Heterocyclic Compounds, 3-Ring
-
4
المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
-
5
المؤلفون: Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
المصدر: Journal of medicinal chemistry. 61(7)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Arachidonic Acids, Pharmacology, 01 natural sciences, Amidohydrolases, Glycerides, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Neuritis, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Neuroinflammation, Brain Chemistry, Trifluoromethyl, 010405 organic chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Leaving group, Serine hydrolase, Endocannabinoid system, Macaca mulatta, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, Carbamates, Biomarkers, Endocannabinoids
-
6
المؤلفون: Sarah J. Neal, M. Olsen, Sharon Rosenzweig-Lipson, S.K. Leonard, Zoë A. Hughes, Deborah L. Smith, Robert H. Ring, Stacey J. Sukoff Rizzo, T.H. Andree, John Dunlop, Susan M. Lotarski, C.M. Pulicicchio, Lee E. Schechter, Dane Springer, Shendi Lu, Jason M. Dwyer, Garth T. Whiteside, E. Kouranova, J.E. Harrison, Julie A. Brennan, Steven Victor O'neil, C.N. Bender
المصدر: Neuropharmacology. 66:202-214
مصطلحات موضوعية: Allosteric modulator, Pyridines, medicine.drug_class, Receptor, Metabotropic Glutamate 5, Drug Evaluation, Preclinical, Glutamic Acid, Pharmacology, Receptors, Metabotropic Glutamate, Anxiolytic, Depressive Disorder, Treatment-Resistant, Mice, Radioligand Assay, Cellular and Molecular Neuroscience, Allosteric Regulation, medicine, Animals, Humans, Analgesics, Behavior, Animal, Dose-Response Relationship, Drug, Metabotropic glutamate receptor 5, medicine.disease, Antidepressive Agents, Rats, Disease Models, Animal, HEK293 Cells, MTEP, Anti-Anxiety Agents, Metabotropic glutamate receptor, Benzamides, Metabotropic glutamate receptor 1, Antidepressant, Calcium, Psychology, Excitatory Amino Acid Antagonists, Treatment-resistant depression
-
7
المؤلفون: Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
المصدر: Journal of medicinal chemistry. 59(13)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, Allosteric modulator, Stereochemistry, medicine.drug_class, Carboxamide, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Muscarinic acetylcholine receptor, Drug Discovery, medicine, Structure–activity relationship, Animals, Picolinic Acids, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor, Muscarinic M1, Rats, Thiazoles, 030104 developmental biology, Pyran, Molecular Medicine, Cholinergic, Female, Pharmacophore, 030217 neurology & neurosurgery
-
8
المؤلفون: Veronica Reinhart, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren, Lei Zhang, Erik Alphie Lachapelle, Deane M. Nason, Michael Eric Green, Keith Dlugolenski, Anthony R. Harris, Jiangli Yan, Sarah Grimwood, Michelle R. Garnsey, Chewah Lee, Dennis P. Anderson, John T. Lazzaro, R. Scott Obach, Damien Webb, Lois K. Chenard, Jeremy R. Edgerton, Michael Aaron Brodney, Romelia Salomon-Ferrer, Gregory W. Kauffman, Steven Victor O'neil
المصدر: Bioorganicmedicinal chemistry letters. 26(2)
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Indoles, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Biochemistry, Molecular Docking Simulation, 03 medical and health sciences, chemistry.chemical_compound, Mice, Allosteric Regulation, Amide, Drug Discovery, Animals, Humans, Homology modeling, Molecular Biology, Chemistry, Hydrogen bond, Organic Chemistry, Receptor, Muscarinic M1, Hydrogen Bonding, Amides, 030104 developmental biology, Intramolecular force, Drug Design, Molecular Medicine, Pharmacophore
-
9
المؤلفون: Adam M. Gilbert, Jack A. Bikker, Steven Victor O'neil
المصدر: Expert Opinion on Therapeutic Patents. 21:1-12
مصطلحات موضوعية: Pharmacology, Metalloproteinase, Thrombospondin, biology, Chemistry, ADAMTS, General Medicine, Hydrogen-Ion Concentration, Symptomatic relief, Patents as Topic, Drug Delivery Systems, Biochemistry, Disease modification, Drug Design, Endopeptidases, Osteoarthritis, Drug Discovery, Disintegrin, biology.protein, Animals, Humans, Protease Inhibitors, Aggrecan, Aggrecanase