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المؤلفون: Hua Gao, Christopher D. Hein, Steven W. Louie, Marian C. Bryan, Xiaoyang Xia, Bernd A. Bruenner, Elizabeth M. Doherty, Heather Eastwood
المصدر: ACS Combinatorial Science. 15:503-511
مصطلحات موضوعية: Library design, ATP Binding Cassette Transporter, Subfamily B, Cell Membrane Permeability, Swine, Process development, Molecular Dynamics Simulation, Cell Line, Small Molecule Libraries, Piperidines, Drug likeness, Microsomes, 4-aminopiperidine, Animals, Humans, Process engineering, Throughput (business), Molecular Structure, business.industry, Continuous flow, Chemistry, Drug discovery, General Chemistry, General Medicine, Modular design, Combinatorial chemistry, High-Throughput Screening Assays, Rats, Solubility, Drug Design, business, Algorithms
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2
المؤلفون: Samer Chmait, Adrie D. Jones, Amy Porter, Kristin L. Andrews, Xiaoning Zhao, Jennifer R. Allen, Shannon Rumfelt, Wenge Zhong, Essa Hu, James R. Falsey, Robert M. Rzasa, Steven W. Louie, James J. S. Treanor, Ning Chen
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:7371-7375
مصطلحات موضوعية: Models, Molecular, Phosphodiesterase Inhibitors, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, Drug Discovery, Humans, Potency, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, Molecular Biology, P-glycoprotein, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Phosphoric Diester Hydrolases, Drug discovery, Organic Chemistry, Phosphodiesterase, Enzyme, chemistry, biology.protein, Molecular Medicine, PDE10A, Efflux, Ethers
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المؤلفون: Patrick T. Ronaldson, Laurent Salphati, Björn Bauer, Steven W. Louie, Ayman El-Kattan, Hong Shen
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Drug, Clinical pharmacology, Organic anion transporter 1, biology, business.industry, media_common.quotation_subject, education, Transporter, Clinical correlation, 030226 pharmacology & pharmacy, Article, law.invention, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, law, biology.protein, Medicine, Distribution (pharmacology), Pharmacology (medical), business, media_common
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad66276e43202458f71cac7ab3d5927
https://europepmc.org/articles/PMC5466066/ -
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المؤلفون: Yuan Cheng, Matthew R. Kaller, Steven W. Louie, Martin Citron, Lewis D. Pennington, Daniel S. La, Matthew Weiss, Stephen J. Wood, Wenge Zhong, Michael Croghan, Toni Williamson, Scott Harried, James Brown, Kui Chen, Tisha San Miguel, Ronke Imbeah-Ampiah, Holger Monenschein, Qiufen Xue, Hongbing Huang, Patricia Lopez, Claire Rattan, Thomas Dineen, Daniel B. Horne, E. Allen Sickmier, Dean Hickman, Safura Babu-Khan, Charles Kreiman, Vivian S. W. Li, Paul H. Wen, Michael D. Bartberger, Russell Graceffa, Robert C. Wahl, Thomas T. Nguyen, Bryant Yang, Ted Judd, Joel Esmay, Vinod F. Patel, Stephen Hitchcock
المصدر: Journal of Medicinal Chemistry. 55:9009-9024
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Administration, Oral, Biological Availability, Stereoisomerism, Pharmacology, Crystallography, X-Ray, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, Oral administration, Drug Discovery, Ethylamines, Animals, Aspartic Acid Endopeptidases, Humans, Structure–activity relationship, ATP Binding Cassette Transporter, Subfamily B, Member 1, chemistry.chemical_classification, Amyloid beta-Peptides, Brain, Dioxolanes, Macaca mulatta, Peptide Fragments, Rats, Bioavailability, Protein Transport, Enzyme, chemistry, Biochemistry, Drug Design, Microsomes, Liver, Microsome, Molecular Medicine, Efflux, Amyloid Precursor Protein Secretases
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المؤلفون: Paul H. Wen, Robert C. Wahl, Michael Croghan, Ronke Imbeah-Ampiah, Paul Acton, Stephen J. Wood, Charles Kreiman, Vivian S. W. Li, Qiufen Xue, Lewis D. Pennington, Safura Babu-Khan, Daniel B. Horne, Thomas Dineen, Wenge Zhong, Scott Harried, Douglas A. Whittington, Dean Hickman, James Brown, Martin Citron, Matthew Weiss, Daniel S. La, Holger Monenschein, Bryant Yang, E. Allen Sickmier, Tisha San Miguel, Robert T. Dunn, Russell Graceffa, Patricia Lopez, Toni Williamson, Hongbing Huang, Yuan Cheng, Kui Chen, Matthew R. Kaller, Michael D. Bartberger, Steven W. Louie, Hugo M. Vargas, Stephen Hitchcock, Thomas T. Nguyen, Vinod F. Patel, Ted Judd, Joel Esmay
المصدر: Journal of Medicinal Chemistry. 55:9025-9044
مصطلحات موضوعية: Male, Models, Molecular, Protein Conformation, Swine, Administration, Oral, Peptide, In Vitro Techniques, Pharmacology, Crystallography, X-Ray, Inhibitory postsynaptic potential, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, Dogs, Pharmacokinetics, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Cytochrome P-450 CYP3A, Cytochrome P-450 Enzyme Inhibitors, Humans, Spiro Compounds, Dosing, chemistry.chemical_classification, Amyloid beta-Peptides, Cardiovascular safety, biology, Brain, Stereoisomerism, Blood Proteins, Peptide Fragments, Rats, Bioavailability, Thiazoles, Enzyme, Biochemistry, chemistry, Drug Design, Microsomes, Liver, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Protein Binding
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المؤلفون: Sarah Walter, Roger Pham, Savannah J Kerr, Joel D Esmay, Xiaochun Zhu, Michael E. Fitzsimmons, Raju Subramanian, Gary L Skiles, Marcus Soto, Steven W Louie, Sarah F Wilson, Katheryne Z Edson, Mylo Wagner
المصدر: Drug metabolism and disposition: the biological fate of chemicals. 44(8)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, medicine.drug_class, 030232 urology & nephrology, Pharmaceutical Science, Peptide, Pharmacology, Calcimimetic Agents, Kidney, Transfection, Risk Assessment, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Dogs, Pharmacokinetics, Cytochrome P-450 Enzyme System, Rats, Inbred BN, medicine, Animals, Humans, Drug Interactions, Tissue Distribution, Receptor, Biotransformation, Serum Albumin, chemistry.chemical_classification, Molecular Structure, Kidney metabolism, Membrane Transport Proteins, Metabolism, In vitro, Renal Elimination, 030104 developmental biology, Enzyme, HEK293 Cells, chemistry, Biochemistry, Liver, Administration, Intravenous, Female, Peptides, Receptors, Calcium-Sensing, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a3b78a29845db4808ed23d3bc60ec7
https://pubmed.ncbi.nlm.nih.gov/26895981 -
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المؤلفون: Timothy Powers, Stephen J. Wood, Ted Judd, Vivian S. W. Li, James Brown, E. Allen Sickmier, Klaus Michelsen, David J. St. Jean, Yi Luo, Dean Hickman, Yuan Cheng, Kui Chen, Stephen Hitchcock, Steven W. Louie, Patricia Lopez, Brad Jordan, Thomas Nixey, Robert T. Fremeau, Michael D. Bartberger, Paul H. Wen, Robert C. Wahl, Claire Rattan
المصدر: Journal of Medicinal Chemistry. 54:5836-5857
مصطلحات موضوعية: Male, Models, Molecular, Molecular model, Drug Evaluation, Preclinical, Crystallography, X-Ray, Cell Line, Rats, Sprague-Dawley, Structure-Activity Relationship, In vivo, Catalytic Domain, mental disorders, Drug Discovery, Amyloid precursor protein, Animals, Aspartic Acid Endopeptidases, Humans, Potency, Enzyme Inhibitors, Aminoquinolines, IC50, chemistry.chemical_classification, Amyloid beta-Peptides, Dose-Response Relationship, Drug, Molecular Structure, biology, Ligand, Brain, Combinatorial chemistry, Protein Structure, Tertiary, Rats, HEK293 Cells, Enzyme, Models, Chemical, Biochemistry, chemistry, Biocatalysis, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases
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8
المؤلفون: Jerome H. Hochman, Edward J. Carlini, Roy Eisenhandler, Bing Li, Qin Mei, Masayo Yamazaki, Brenda F. Leake, Steven W. Louie, Catherine Booth-Genthe, Thomas H. Rushmore, Richard B. Kim
المصدر: Journal of Pharmacological and Toxicological Methods. 54:78-89
مصطلحات موضوعية: ATP Binding Cassette Transporter, Subfamily B, Molecular Sequence Data, ATP-binding cassette transporter, Toxicology, Rats, Sprague-Dawley, Mice, Species Specificity, Cyclosporin a, Animals, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Amino Acid Sequence, Cloning, Molecular, P-glycoprotein, Pharmacology, biology, Transfection, Membrane transport, Molecular biology, In vitro, Rats, Protein Transport, Cell culture, Paracellular transport, biology.protein, LLC-PK1 Cells, ATP-Binding Cassette Transporters
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المؤلفون: Oleg Epstein, Stephen J. Wood, Dean Hickman, Paul H. Wen, Robert C. Wahl, Thomas Dineen, Robert T. Fremeau, Alan C. Cheng, Russell Graceffa, Y.-H. Kiang, Steven W. Louie, Hongbing Huang, Kui Chen, Vinod F. Patel, Douglas A. Whittington, Yi Luo, Daniel S. La
المصدر: Journal of medicinal chemistry. 55(21)
مصطلحات موضوعية: Drug, Models, Molecular, media_common.quotation_subject, Administration, Oral, Pharmacology, Crystallography, X-Ray, Cell Line, Single oral dose, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Alzheimer Disease, Drug Discovery, Animals, Aspartic Acid Endopeptidases, Humans, Cell potency, Oxazoles, media_common, Cathepsin, chemistry.chemical_classification, Amyloid beta-Peptides, Molecular Structure, Brain, Peptide Fragments, Bioavailability, Rats, Enzyme, chemistry, Xanthenes, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases, Penetrant (biochemical)
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المؤلفون: Yi Luo, Matthew Weiss, Stephen J. Wood, Tom Dineen, Kui Chen, Jodi Bradley, Hongbing Huang, Ted Judd, Patricia Lopez, Li Zhu, Yuan Cheng, Patricia Amarante, Dean Hickman, Bryant Yang, Paul Acton, Safura Babu-Khan, Steven W. Louie, Mathew Kaller, Joel Esmay, Jan Zhang, Russell Graceffa, Wenge Zhong, Daniel B. Horne, Toni Williamson, Paul H. Wen, Robert C. Wahl
المصدر: Alzheimer's & Dementia. 8
مصطلحات موضوعية: biology, Epidemiology, Chemistry, Health Policy, Pharmacology, Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Pharmacokinetics, Pharmacodynamics, Sprague dawley rats, biology.protein, Neurology (clinical), Geriatrics and Gerontology, Beta (finance), Amyloid precursor protein secretase
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