نتائج البحث - "Stivala CE"

1

دورية أكاديمية

Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity.

المؤلفون: Cifone MT; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., He Y; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Basu R; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Wang N; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Davoodi S; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Spagnuolo LA; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Si Y; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Daryaee T; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Stivala CE; Discovery Chemistry, Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Walker SG; Department of Oral Biology and Pathology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States., Tonge PJ; Center for Advanced Study of Drug Action, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Chemistry, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.; Department of Radiology, Stony Brook University, John S. Toll Drive, Stony Brook, New York 11794-3400, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Dec 22; Vol. 65 (24), pp. 16510-16525. Date of Electronic Publication: 2022 Dec 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Escherichia coli*/metabolism , Acetyl-CoA Carboxylase*, Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/metabolism ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/metabolism ; Catalytic Domain

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2

دورية أكاديمية

Overcoming Preclinical Safety Obstacles to Discover ( S )- N -((1,2,3,5,6,7-Hexahydro- s -indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5 H -pyrazolo[5,1- b ][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor.

المؤلفون: McBride C; Jecure Therapeutics, San Diego, California 92121, United States., Trzoss L; Jecure Therapeutics, San Diego, California 92121, United States., Povero D; Jecure Therapeutics, San Diego, California 92121, United States., Lazic M; Jecure Therapeutics, San Diego, California 92121, United States., Ambrus-Aikelin G; Jecure Therapeutics, San Diego, California 92121, United States., Santini A; Jecure Therapeutics, San Diego, California 92121, United States., Pranadinata R; Jecure Therapeutics, San Diego, California 92121, United States., Bain G; Jecure Therapeutics, San Diego, California 92121, United States., Stansfield R; Jecure Therapeutics, San Diego, California 92121, United States., Stafford JA; Jecure Therapeutics, San Diego, California 92121, United States., Veal J; Jecure Therapeutics, San Diego, California 92121, United States., Takahashi R; Genentech Inc., South San Francisco, California 94080, United States., Ly J; Genentech Inc., South San Francisco, California 94080, United States., Chen S; Genentech Inc., South San Francisco, California 94080, United States., Liu L; Genentech Inc., South San Francisco, California 94080, United States., Nespi M; Genentech Inc., South San Francisco, California 94080, United States., Blake R; Genentech Inc., South San Francisco, California 94080, United States., Katewa A; Genentech Inc., South San Francisco, California 94080, United States., Kleinheinz T; Genentech Inc., South San Francisco, California 94080, United States., Sujatha-Bhaskar S; Genentech Inc., South San Francisco, California 94080, United States., Ramamoorthi N; Genentech Inc., South San Francisco, California 94080, United States., Sims J; Genentech Inc., South San Francisco, California 94080, United States., McKenzie B; Genentech Inc., South San Francisco, California 94080, United States., Chen M; Genentech Inc., South San Francisco, California 94080, United States., Ultsch M; Genentech Inc., South San Francisco, California 94080, United States., Johnson M; Genentech Inc., South San Francisco, California 94080, United States., Murray J; Genentech Inc., South San Francisco, California 94080, United States., Ciferri C; Genentech Inc., South San Francisco, California 94080, United States., Staben ST; Genentech Inc., South San Francisco, California 94080, United States., Townsend MJ; Genentech Inc., South San Francisco, California 94080, United States., Stivala CE; Genentech Inc., South San Francisco, California 94080, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Nov 10; Vol. 65 (21), pp. 14721-14739. Date of Electronic Publication: 2022 Oct 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: NLR Family, Pyrin Domain-Containing 3 Protein* , Oxazines*/pharmacology , Oxazines*/therapeutic use, Animals ; Humans ; Inflammasomes ; Sulfonamides/pharmacology ; Macaca fascicularis

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3

دورية أكاديمية

Chiral Amines via Enantioselective π-Allyliridium- C , O -Benzoate-Catalyzed Allylic Alkylation: Student Training via Industrial-Academic Collaboration.

المؤلفون: Stivala CE; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zbieg JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Liu P; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Krische MJ; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.

المصدر: Accounts of chemical research [Acc Chem Res] 2022 Aug 02; Vol. 55 (15), pp. 2138-2147. Date of Electronic Publication: 2022 Jul 13.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0157313 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4898 (Electronic) Linking ISSN: 00014842 NLM ISO Abbreviation: Acc Chem Res Subsets: MEDLINE

مواضيع طبية MeSH: Amines*/chemistry , Iridium*/chemistry, Alkylation ; Benzoates ; Catalysis ; Cesium ; Humans ; Kinetics ; Stereoisomerism ; Students

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4

دورية أكاديمية

Kinetic, ESI-CID-MS and Computational Studies of π-Allyliridium C,O -Benzoate-Catalyzed Allylic Amination: Understanding the Effect of Cesium Ion.

المؤلفون: Jung WO; University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA., Mai BK; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Yoo M; University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA., Shields SWJ; University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA., Zbieg JR; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA., Stivala CE; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, USA., Liu P; Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA., Krische MJ; University of Texas at Austin, Department of Chemistry, Austin, TX 78712, USA.

المصدر: ACS catalysis [ACS Catal] 2022 Mar 18; Vol. 12 (6), pp. 3660-3668. Date of Electronic Publication: 2022 Mar 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101562209 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2155-5435 (Print) NLM ISO Abbreviation: ACS Catal Subsets: PubMed not MEDLINE

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5

دورية أكاديمية

Regio- and Enantioselective Iridium-Catalyzed Amination of Alkyl-Substituted Allylic Acetates with Secondary Amines.

المؤلفون: Jung WO; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Yoo M; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Migliozzi MM; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zbieg JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Stivala CE; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Krische MJ; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.

المصدر: Organic letters [Org Lett] 2022 Jan 14; Vol. 24 (1), pp. 441-445. Date of Electronic Publication: 2021 Dec 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett

مواضيع طبية MeSH: Iridium*/chemistry , Amines*/chemistry , Allyl Compounds*/chemistry , Acetates*/chemistry, Catalysis ; Amination ; Stereoisomerism ; Molecular Structure

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6

دورية أكاديمية

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).

المؤلفون: Chan BK; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Seward E; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Lainchbury M; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Brewer TF; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., An L; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Blench T; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Cartwright MW; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Chan GKY; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Choo EF; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Drummond J; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Elliott RL; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Gancia E; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Gazzard L; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Hu B; Pharmaron Beijing Co, No. 6 Tai He Road, BDA, Beijing 100176, P.R. China., Jones GE; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Luo X; Pharmaron Beijing Co, No. 6 Tai He Road, BDA, Beijing 100176, P.R. China., Madin A; Charles River Laboratories, 8-9 Spire Green, Flex Meadow, Harlow, Essex CM19 5TR, United Kingdom., Malhotra S; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Moffat JG; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Pang J; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Salphati L; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Sneeringer CJ; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Stivala CE; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Wei B; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Wang W; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Wu P; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States., Heffron TP; Genentech Inc., 1 DNA Way, South San Francisco, California 94080, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Dec 08; Vol. 13 (1), pp. 84-91. Date of Electronic Publication: 2021 Dec 08 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

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7

دورية أكاديمية

Catalytic Asymmetric Synthesis of the Pentacyclic Core of (+)-Citrinadin A.

المؤلفون: Trost BM; Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States., Taft BR; Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States., Tracy JS; Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States., Stivala CE; Department of Chemistry, Stanford University, 333 Campus Drive, Stanford, California 94305, United States.

المصدر: Organic letters [Org Lett] 2021 Jul 02; Vol. 23 (13), pp. 4981-4985. Date of Electronic Publication: 2021 Jun 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 100890393 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1523-7052 (Electronic) Linking ISSN: 15237052 NLM ISO Abbreviation: Org Lett Subsets: PubMed not MEDLINE; MEDLINE

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8

دورية أكاديمية

Enantioselective Iridium-Catalyzed Allylation of Nitroalkanes: Entry to β-Stereogenic α-Quaternary Primary Amines.

المؤلفون: Jung WO; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Mai BK; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Spinello BJ; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Dubey ZJ; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Kim SW; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States., Stivala CE; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Zbieg JR; Discovery Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States., Liu P; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States., Krische MJ; Department of Chemistry, University of Texas at Austin, Austin, Texas 78712, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2021 Jun 30; Vol. 143 (25), pp. 9343-9349. Date of Electronic Publication: 2021 Jun 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Amines/*chemical synthesis , Nitro Compounds/*chemistry, Alkylation ; Catalysis ; Coordination Complexes/chemistry ; Density Functional Theory ; Iridium/chemistry ; Models, Chemical ; Stereoisomerism

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9

دورية أكاديمية

Lipid droplets can promote drug accumulation and activation.

المؤلفون: Dubey R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA., Stivala CE; Department of Chemistry, Stanford University, Stanford, CA, USA.; Genentech, South San Francisco, CA, USA., Nguyen HQ; Genentech, South San Francisco, CA, USA., Goo YH; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA., Paul A; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA., Carette JE; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Trost BM; Department of Chemistry, Stanford University, Stanford, CA, USA., Rohatgi R; Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA. rrohatgi@stanford.edu.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. rrohatgi@stanford.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2020 Feb; Vol. 16 (2), pp. 206-213. Date of Electronic Publication: 2020 Jan 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Evaluation, Preclinical/*methods , Lipid Droplets/*metabolism , Macrolides/*pharmacokinetics , Macrolides/*toxicity , Proteins/*metabolism, Cell Line, Tumor ; Cell Membrane/drug effects ; Cell Membrane/metabolism ; Haploidy ; Humans ; Inactivation, Metabolic ; Lipid Droplets/drug effects ; Macrolides/metabolism ; Proteins/genetics

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Correction: MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

المؤلفون: Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M

المصدر: PLoS biology [PLoS Biol] 2019 Oct 16; Vol. 17 (10), pp. e3000529. Date of Electronic Publication: 2019 Oct 16 (Print Publication: 2019).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: PubMed not MEDLINE; MEDLINE

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