المؤلفون: Morozko, EL, Smith-Geater, C, Monteys, AM, Pradhan, S, Lim, RG, Langfelder, P, Kachemov, M, Kulkarni, JA, Zaifman, J, Hill, A, Stocksdale, JT, Cullis, PR, Wu, J, Ochaba, J, Miramontes, R, Chakraborty, A, Hazral, TK, Laub, A, St-Cyrc, S, Orellanam, I, Kopan, L, Wang, KQ, Yeung, S, Leavitt, BR, Reidling, JC, Yang, XW, Steffan, JS, Davidson, BL, Sarkar, PS, Thompson, LM

المصدر: Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 32

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______325::09985a4ebf37235f513250eff78dfb8c
https://escholarship.org/uc/item/3qr022ts

المؤلفون: Nguyen TB, Miramontes R, Chillon-Marinas C, Maimon R, Vazquez-Sanchez S, Lau AL, McClure NR, England WE, Singha M, Stocksdale JT, Jang KH, Jung S, McKnight JI, Ho LN, Faull RLM, Steffan JS, Reidling JC, Jang C, Lee G, Cleveland DW, Lagier-Tourenne C, Spitale RC, Thompson LM

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Nov 02. Date of Electronic Publication: 2023 Nov 02.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Morozko EL; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Smith-Geater C; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Monteys AM; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Pradhan S; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555., Lim RG; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Langfelder P; Department of Human Genetics, David Geffen School of Medicine at University of California, Los Angeles, CA 90095., Kachemov M; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Kulkarni JA; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3., Zaifman J; Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1., Hill A; Incisive Genetics Inc., Vancouver, BC, Canada V6A 0H9., Stocksdale JT; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Cullis PR; Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3.; NanoMedicines Innovation Network, University of British Columbia, Vancouver, BC, Canada V6T 1Z3., Wu J; Department of Biological Chemistry, University of California, Irvine, CA 92697., Ochaba J; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697., Miramontes R; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Chakraborty A; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555., Hazra TK; Department of Internal Medicine, University of Texas Medical Branch, Galveston, TX 77555., Lau A; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., St-Cyr S; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104., Orellana I; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697., Kopan L; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Wang KQ; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697., Yeung S; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Leavitt BR; Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, BC, Canada V5Z 4H4., Reidling JC; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Yang XW; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA 90095., Steffan JS; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697., Davidson BL; Raymond G. Perelman Center for Cell and Molecular Therapeutics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104.; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104., Sarkar PS; Department of Neurology, University of Texas Medical Branch, Galveston, TX 77555.; Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555., Thompson LM; Department of Neurobiology and Behavior, University of California, Irvine, CA 92697; lmthomps@uci.edu.; Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92697.; Institute of Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697.; Department of Biological Chemistry, University of California, Irvine, CA 92697.; Sue and Bill Gross Stem Cell Institute, University of California, Irvine, CA 92697.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Jan 26; Vol. 118 (4).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: DNA Repair* , Protein Processing, Post-Translational*, DNA/*genetics , DNA Repair Enzymes/*genetics , Huntingtin Protein/*genetics , Huntington Disease/*genetics , Phosphotransferases (Alcohol Group Acceptor)/*genetics , Protein Inhibitors of Activated STAT/*genetics , Small Ubiquitin-Related Modifier Proteins/*genetics, Animals ; Cell Differentiation ; DNA/metabolism ; DNA Damage ; DNA Repair Enzymes/metabolism ; Disease Models, Animal ; Female ; Humans ; Huntingtin Protein/metabolism ; Huntington Disease/metabolism ; Huntington Disease/pathology ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurons/metabolism ; Neurons/pathology ; Phosphotransferases (Alcohol Group Acceptor)/metabolism ; Pluripotent Stem Cells/metabolism ; Pluripotent Stem Cells/pathology ; Primary Cell Culture ; Protein Inhibitors of Activated STAT/antagonists & inhibitors ; Protein Inhibitors of Activated STAT/metabolism ; RNA, Small Interfering/genetics ; RNA, Small Interfering/metabolism ; Small Ubiquitin-Related Modifier Proteins/antagonists & inhibitors ; Small Ubiquitin-Related Modifier Proteins/metabolism ; Sumoylation ; Transcription, Genetic

المؤلفون: Smith-Geater C; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697, USA., Hernandez SJ; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 96267, USA., Lim RG; Department of Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Adam M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Wu J; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92617, USA., Stocksdale JT; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 96267, USA., Wassie BT; LeadCrunch, San Diego, CA 92101, USA., Gold MP; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Wang KQ; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 96267, USA., Miramontes R; Department of Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Kopan L; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 96267, USA., Orellana I; Department of Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA., Joy S; Neural Stem Cell Institute, Rensselaer, NY 12144, USA., Kemp PJ; School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK., Allen ND; School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK., Fraenkel E; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Thompson LM; Department of Psychiatry and Human Behavior, University of California Irvine, Irvine, CA 92697, USA; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 96267, USA; Department of Memory Impairment and Neurological Disorders, University of California Irvine, Irvine, CA 92697, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biological Chemistry, University of California Irvine, Irvine, CA 92617, USA. Electronic address: lmthomps@uci.edu.

المصدر: Stem cell reports [Stem Cell Reports] 2020 Mar 10; Vol. 14 (3), pp. 406-419. Date of Electronic Publication: 2020 Feb 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE

مواضيع طبية MeSH: Wnt Signaling Pathway*, Huntington Disease/*pathology , Induced Pluripotent Stem Cells/*pathology , Neurons/*pathology, Adult ; Age of Onset ; Cell Cycle/genetics ; Cell Differentiation/genetics ; Cells, Cultured ; Epigenesis, Genetic ; Humans ; Huntington Disease/genetics ; Mitosis ; Neostriatum/pathology ; Neural Stem Cells/metabolism ; Transcription Factors/metabolism ; Transcriptome/genetics ; Up-Regulation/genetics

المؤلفون: Kedaigle AJ; Computational and Systems Biology Program., Reidling JC; Memory Impairment and Neurological Disorders Research Unit., Lim RG; Memory Impairment and Neurological Disorders Research Unit., Adam M; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Wu J; Memory Impairment and Neurological Disorders Research Unit., Wassie B; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Stocksdale JT; Memory Impairment and Neurological Disorders Research Unit., Casale MS; Memory Impairment and Neurological Disorders Research Unit., Fraenkel E; Computational and Systems Biology Program.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Thompson LM; Memory Impairment and Neurological Disorders Research Unit.; Departments of Psychiatry and Human Behavior and Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.

المصدر: Human molecular genetics [Hum Mol Genet] 2020 Jan 15; Vol. 29 (2), pp. 202-215.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Azepines/*pharmacology , Cerebral Cortex/*drug effects , Cerebral Cortex/*metabolism , Corpus Striatum/*drug effects , Corpus Striatum/*metabolism , Huntingtin Protein/*metabolism , Huntington Disease/*metabolism , Triazoles/*pharmacology, Acetylation ; Animals ; Behavior Rating Scale ; Behavioral Symptoms/drug therapy ; Cerebral Cortex/pathology ; Chromatin Immunoprecipitation Sequencing ; Corpus Striatum/pathology ; Disease Models, Animal ; Energy Metabolism/drug effects ; Epigenesis, Genetic/drug effects ; Gene Expression Regulation/drug effects ; Gene Expression Regulation/genetics ; Gene Ontology ; Histones/metabolism ; Huntingtin Protein/genetics ; Huntington Disease/drug therapy ; Huntington Disease/genetics ; Huntington Disease/pathology ; Male ; Mice ; Mice, Transgenic ; Motor Activity/drug effects ; Protein Biosynthesis/drug effects ; RNA-Seq ; Signal Transduction/drug effects ; Signal Transduction/genetics