المؤلفون: Steinig AG; OSI Pharmaceuticals, LLC, A Wholly-Owned Subsidiary of Astellas US, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. arnosteinig@gmail.com, Li AH, Wang J, Chen X, Dong H, Ferraro C, Jin M, Kadalbajoo M, Kleinberg A, Stolz KM, Tavares-Greco PA, Wang T, Albertella MR, Peng Y, Crew L, Kahler J, Kan J, Schulz R, Cooke A, Bittner M, Turton RW, Franklin M, Gokhale P, Landfair D, Mantis C, Workman J, Wild R, Pachter J, Epstein D, Mulvihill MJ

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Aug 01; Vol. 23 (15), pp. 4381-7. Date of Electronic Publication: 2013 May 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*chemistry , Protein Kinase Inhibitors/*chemistry , Proto-Oncogene Proteins c-met/*antagonists & inhibitors , Pyridines/*chemistry , Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor ; Cell Survival/drug effects ; Female ; Half-Life ; Humans ; Hydrogen-Ion Concentration ; Mice ; Mice, Nude ; Mutation ; Neoplasms/drug therapy ; Phosphorylation/drug effects ; Protein Kinase Inhibitors/pharmacokinetics ; Protein Kinase Inhibitors/therapeutic use ; Proto-Oncogene Proteins c-met/genetics ; Proto-Oncogene Proteins c-met/metabolism ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptor Protein-Tyrosine Kinases/metabolism ; Structure-Activity Relationship ; Transplantation, Heterologous

المؤلفون: Jin M; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Gokhale PC; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Cooke A; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Foreman K; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Buck E; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., May EW; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Feng L; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Bittner MA; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Kadalbajoo M; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Landfair D; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Siu KW; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Stolz KM; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Werner DS; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Laufer RS; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Li AH; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Dong H; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Steinig AG; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Kleinberg A; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Yao Y; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Pachter JA; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735., Wild R; OSI Oncology, OSI Pharmaceuticals, Inc., 2860 Wilderness Place, Boulder, Colorado 80301., Mulvihill MJ; OSI Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, New York 11735.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2010 Aug 30; Vol. 1 (9), pp. 510-5. Date of Electronic Publication: 2010 Aug 30 (Print Publication: 2010).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Mulvihill MJ; (OSI) Oncology, OSI Pharmaceuticals, Inc., 41 Pinelawn Road, Melville, NY 11747, USA. mmulvihill@osip.com, Ji QS, Coate HR, Cooke A, Dong H, Feng L, Foreman K, Rosenfeld-Franklin M, Honda A, Mak G, Mulvihill KM, Nigro AI, O'Connor M, Pirrit C, Steinig AG, Siu K, Stolz KM, Sun Y, Tavares PA, Yao Y, Gibson NW

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Feb 01; Vol. 16 (3), pp. 1359-75. Date of Electronic Publication: 2007 Oct 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Imidazoles/*chemical synthesis , Imidazoles/*pharmacology , Protein Kinase Inhibitors/*chemical synthesis , Protein Kinase Inhibitors/*pharmacology , Pyrazines/*chemical synthesis , Pyrazines/*pharmacology , Quinolines/*chemistry , Receptor, IGF Type 1/*antagonists & inhibitors, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Blood Glucose/metabolism ; Cell Line ; Dogs ; Female ; Humans ; Imidazoles/chemistry ; Insulin/blood ; Ligands ; Mice ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Pyrazines/chemistry ; Rats ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Xenograft Model Antitumor Assays

المؤلفون: Mulvihill MJ; (OSI) Oncology, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mmulvihill@osip.com, Ji QS, Werner D, Beck P, Cesario C, Cooke A, Cox M, Crew A, Dong H, Feng L, Foreman KW, Mak G, Nigro A, O'Connor M, Saroglou L, Stolz KM, Sujka I, Volk B, Weng Q, Wilkes R

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Feb 15; Vol. 17 (4), pp. 1091-7. Date of Electronic Publication: 2006 Nov 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Imidazoles/*chemical synthesis , Imidazoles/*pharmacology , Pyrazines/*chemical synthesis , Pyrazines/*pharmacology , Receptor, IGF Type 1/*antagonists & inhibitors, Adenosine Triphosphate/metabolism ; Animals ; Area Under Curve ; Binding Sites ; Biological Availability ; Crystallography, X-Ray ; Databases, Protein ; Half-Life ; Indicators and Reagents ; Mice ; Models, Molecular ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Structure-Activity Relationship

المؤلفون: Li AH; Department of Cancer Chemistry, OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. ali@osip.com, Ahmed E, Chen X, Cox M, Crew AP, Dong HQ, Jin M, Ma L, Panicker B, Siu KW, Steinig AG, Stolz KM, Tavares PA, Volk B, Weng Q, Werner D, Mulvihill MJ

المصدر: Organic & biomolecular chemistry [Org Biomol Chem] 2007 Jan 07; Vol. 5 (1), pp. 61-4. Date of Electronic Publication: 2006 Nov 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1477-0520 (Print) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aldehydes/*chemistry , Benzaldehydes/*chemistry , Quinolines/*chemical synthesis, Iron/chemistry ; Ketones/chemistry ; Molecular Structure ; Oxidation-Reduction ; Quinolines/chemistry