المؤلفون: Kayagaki N; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. kayagaki@gene.com., Stowe IB; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Alegre K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Deshpande I; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA.; Department of Structural Biology, Genentech, South San Francisco, CA, USA., Wu S; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Lin Z; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Kornfeld OS; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Lee BL; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Zhang J; Department of Translational Immunology, Genentech, South San Francisco, CA, USA., Liu J; Department of Translational Immunology, Genentech, South San Francisco, CA, USA., Suto E; Department of Translational Immunology, Genentech, South San Francisco, CA, USA., Lee WP; Department of Translational Immunology, Genentech, South San Francisco, CA, USA., Schneider K; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Lin W; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Seshasayee D; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Bhangale T; Department of Human Genetics, Genentech, South San Francisco, CA, USA., Chalouni C; Department of Pathology, Genentech, South San Francisco, CA, USA., Johnson MC; Department of Structural Biology, Genentech, South San Francisco, CA, USA., Joshi P; Department of Biomolecular Resources, Genentech, South San Francisco, CA, USA., Mossemann J; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada., Zhao S; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada., Ali D; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada., Goldenberg NM; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada., Sayed BA; Program in Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada.; Division of General Surgery, Hospital for Sick Children, Toronto, Ontario, Canada., Steinberg BE; Program in Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada.; Department of Anesthesia and Pain Medicine, Hospital for Sick Children, Toronto, Ontario, Canada., Newton K; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA., Webster JD; Department of Pathology, Genentech, South San Francisco, CA, USA., Kelly RL; Department of Antibody Engineering, Genentech, South San Francisco, CA, USA., Dixit VM; Department of Physiological Chemistry, Genentech, South San Francisco, CA, USA. dixit@gene.com.

المصدر: Nature [Nature] 2023 Jun; Vol. 618 (7967), pp. 1072-1077. Date of Electronic Publication: 2023 May 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal*/immunology , Cell Membrane*/pathology , Cell Membrane*/ultrastructure , Inflammation*/pathology , Liver*/pathology , Nerve Growth Factors*/antagonists & inhibitors , Nerve Growth Factors*/deficiency , Nerve Growth Factors*/immunology , Nerve Growth Factors*/ultrastructure , Reperfusion Injury*/pathology, Animals ; Mice ; Alanine Transaminase ; Alarmins ; Aspartate Aminotransferases ; Cell Adhesion Molecules, Neuronal/antagonists & inhibitors ; Cell Adhesion Molecules, Neuronal/deficiency ; Cell Adhesion Molecules, Neuronal/immunology ; Cell Adhesion Molecules, Neuronal/ultrastructure ; Cell Death ; Concanavalin A ; Galactosamine ; Hepatocytes/pathology ; Hepatocytes/ultrastructure ; Lactate Dehydrogenases ; Microscopy, Electron ; Neutrophil Infiltration

المؤلفون: Kayagaki N; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA. kayagaki@gene.com., Kornfeld OS; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA., Lee BL; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA., Stowe IB; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA., O'Rourke K; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA., Li Q; Department of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA., Sandoval W; Department of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA., Yan D; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Kang J; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Xu M; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Zhang J; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Lee WP; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., McKenzie BS; Department of Translational Immunology, Genentech Inc., South San Francisco, CA, USA., Ulas G; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA, USA., Payandeh J; Department of Structural Biology, Genentech Inc., South San Francisco, CA, USA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., South San Francisco, CA, USA., Modrusan Z; Department of Microchemistry, Proteomics and Lipidomics, Genentech Inc., South San Francisco, CA, USA., Reja R; Department of Bioinformatics, Genentech Inc., South San Francisco, CA, USA., Sagolla M; Department of Pathology, Genentech Inc., South San Francisco, CA, USA., Webster JD; Department of Pathology, Genentech Inc., South San Francisco, CA, USA., Cho V; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Andrews TD; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Morris LX; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Miosge LA; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Goodnow CC; Garvan Institute of Medical Research, Sydney, New South Wales, Australia.; Cellular Genomics Futures Institute, UNSW Sydney, Sydney, New South Wales, Australia., Bertram EM; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia.; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory, Australia., Dixit VM; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA, USA. dixit@gene.com.

المصدر: Nature [Nature] 2021 Mar; Vol. 591 (7848), pp. 131-136. Date of Electronic Publication: 2021 Jan 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Death*/genetics, Cell Adhesion Molecules, Neuronal/*metabolism , Cell Membrane/*metabolism , Nerve Growth Factors/*metabolism, Animals ; Apoptosis ; Cell Adhesion Molecules, Neuronal/chemistry ; Cell Adhesion Molecules, Neuronal/genetics ; Female ; Humans ; Macrophages ; Male ; Mice ; Mutation ; Necrosis ; Nerve Growth Factors/chemistry ; Nerve Growth Factors/genetics ; Protein Multimerization ; Pyroptosis/genetics

المؤلفون: Walle LV, Stowe IB, Šácha P, Lee BL, Demon D, Fossoul A, Van Hauwermeiren F, Saavedra PHV, Šimon P, Šubr V, Kostka L, Stivala CE, Pham VC, Staben ST, Yamazoe S, Konvalinka J, Kayagaki N, Lamkanfi M

المصدر: PLoS biology [PLoS Biol] 2019 Oct 16; Vol. 17 (10), pp. e3000529. Date of Electronic Publication: 2019 Oct 16 (Print Publication: 2019).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Vande Walle L; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Discovery Sciences, Janssen Research & Development, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Stowe IB; Department of Physiological Chemistry, Genentech, South San Francisco, California, United States of America., Šácha P; Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences, Prague, Czech Republic., Lee BL; Department of Physiological Chemistry, Genentech, South San Francisco, California, United States of America., Demon D; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Fossoul A; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Van Hauwermeiren F; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium., Saavedra PHV; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium., Šimon P; Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences, Prague, Czech Republic., Šubrt V; Institute of Macromolecular Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic., Kostka L; Institute of Macromolecular Chemistry, Academy of Science of the Czech Republic, Prague, Czech Republic., Stivala CE; Department of Discovery Chemistry, Genentech, South San Francisco, California, United States of America., Pham VC; Department of Discovery Chemistry, Genentech, South San Francisco, California, United States of America., Staben ST; Department of Discovery Chemistry, Genentech, South San Francisco, California, United States of America., Yamazoe S; Department of Discovery Chemistry, Genentech, South San Francisco, California, United States of America., Konvalinka J; Institute of Organic Chemistry and Biochemistry of The Czech Academy of Sciences, Prague, Czech Republic., Kayagaki N; Department of Physiological Chemistry, Genentech, South San Francisco, California, United States of America., Lamkanfi M; Inflammation Research Center, VIB, Ghent, Belgium.; Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium.

المصدر: PLoS biology [PLoS Biol] 2019 Sep 16; Vol. 17 (9), pp. e3000354. Date of Electronic Publication: 2019 Sep 16 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cryopyrin-Associated Periodic Syndromes/*genetics , Furans/*pharmacology , Inflammasomes/*antagonists & inhibitors , NLR Family, Pyrin Domain-Containing 3 Protein/*antagonists & inhibitors , Sulfonamides/*pharmacology, Animals ; Cytokines/antagonists & inhibitors ; Disease Models, Animal ; Drug Evaluation, Preclinical ; HEK293 Cells ; Heterocyclic Compounds, 4 or More Rings ; Humans ; Indenes ; Lipopolysaccharides ; Macrophages/drug effects ; Mice ; Mice, Inbred C57BL ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Protein Domains ; Sulfones

المؤلفون: Kayagaki N; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA. kayagaki@gene.com dixit@gene.com., Lee BL; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Stowe IB; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Kornfeld OS; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., O'Rourke K; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Mirrashidi KM; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Haley B; Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA., Watanabe C; Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA., Modrusan Z; Department of Molecular Biology, Genentech Inc., South San Francisco, CA 94080, USA., Kummerfeld S; Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA., Reja R; Department of Bioinformatics, Genentech Inc., South San Francisco, CA 94080, USA., Zhang Y; Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia., Cho V; Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia.; Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia., Andrews TD; Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia., Morris LX; Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia., Goodnow CC; Garvan Institute of Medical Research, Sydney, NSW 2010, Australia.; Faculty of Medicine, UNSW Sydney, Sydney, NSW 2052, Australia., Bertram EM; Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia.; Department of Immunology and Infectious Disease, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2600, Australia., Dixit VM; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA 94080, USA. kayagaki@gene.com dixit@gene.com.

المصدر: Science signaling [Sci Signal] 2019 May 21; Vol. 12 (582). Date of Electronic Publication: 2019 May 21.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Interferon Regulatory Factor-2/*genetics , Intracellular Signaling Peptides and Proteins/*genetics , Phosphate-Binding Proteins/*genetics , Pyroptosis/*genetics , Transcription, Genetic/*genetics, Animals ; Endothelial Cells/cytology ; Endothelial Cells/metabolism ; Inflammasomes/genetics ; Inflammasomes/metabolism ; Interferon Regulatory Factor-2/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Macrophages/cytology ; Macrophages/metabolism ; Mice, Inbred C57BL ; Mice, Knockout ; Phosphate-Binding Proteins/metabolism ; Signal Transduction/genetics ; Transcriptional Activation/genetics

المؤلفون: Lee BL; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA., Stowe IB; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA., Gupta A; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA., Kornfeld OS; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., South San Francisco, CA., Anderson K; Department of Molecular Biology, Genentech Inc., South San Francisco, CA., Warming S; Department of Molecular Biology, Genentech Inc., South San Francisco, CA., Zhang J; Department of Immunology, Genentech Inc., South San Francisco, CA., Lee WP; Department of Immunology, Genentech Inc., South San Francisco, CA., Kayagaki N; Department of Physiological Chemistry, Genentech Inc., South San Francisco, CA kayagaki.nobuhiko@gene.com.

المصدر: The Journal of experimental medicine [J Exp Med] 2018 Sep 03; Vol. 215 (9), pp. 2279-2288. Date of Electronic Publication: 2018 Aug 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 2985109R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-9538 (Electronic) Linking ISSN: 00221007 NLM ISO Abbreviation: J Exp Med Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis*, Apoptosis Regulatory Proteins/*immunology , Caspases/*immunology , Inflammasomes/*immunology , Macrophages/*immunology, Animals ; Apoptosis Regulatory Proteins/genetics ; Caspases/genetics ; Caspases, Initiator ; Gene Knock-In Techniques ; Gram-Negative Bacteria/immunology ; Gram-Negative Bacterial Infections/genetics ; Gram-Negative Bacterial Infections/immunology ; Gram-Negative Bacterial Infections/pathology ; Inflammasomes/genetics ; Intracellular Signaling Peptides and Proteins ; Lipopolysaccharides/immunology ; Macrophages/microbiology ; Macrophages/pathology ; Mice ; Mice, Knockout ; Phosphate-Binding Proteins

المؤلفون: Lee BL; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, USA., Mirrashidi KM; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, USA., Stowe IB; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, USA., Kummerfeld SK; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Watanabe C; Department of Bioinformatics, Genentech Inc., South San Francisco, California, USA., Haley B; Department of Molecular Biology, Genentech Inc., South San Francisco, California, USA., Cuellar TL; Department of Molecular Biology, Genentech Inc., South San Francisco, California, USA., Reichelt M; Department of Pathology, Genentech Inc., South San Francisco, California, USA., Kayagaki N; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California, USA. kayagaki.nobuhiko@gene.com.

المصدر: Scientific reports [Sci Rep] 2018 Feb 28; Vol. 8 (1), pp. 3788. Date of Electronic Publication: 2018 Feb 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis*, Apoptosis Regulatory Proteins/*metabolism , CARD Signaling Adaptor Proteins/*physiology , Calcium-Binding Proteins/*metabolism , Caspase 1/*physiology , Caspase 8/*physiology , Inflammasomes/*metabolism , Macrophages/*pathology, Animals ; Apoptosis Regulatory Proteins/antagonists & inhibitors ; Apoptosis Regulatory Proteins/genetics ; CRISPR-Cas Systems ; Calcium-Binding Proteins/antagonists & inhibitors ; Calcium-Binding Proteins/genetics ; Genome ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout

المؤلفون: Kayagaki N; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Stowe IB; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Lee BL; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA., O'Rourke K; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Anderson K; Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080, USA., Warming S; Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080, USA., Cuellar T; Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080, USA., Haley B; Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080, USA., Roose-Girma M; Department of Molecular Biology, Genentech Inc., South San Francisco, California 94080, USA., Phung QT; Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Liu PS; Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Lill JR; Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Li H; Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Wu J; Department of Protein Chemistry, Genentech Inc., South San Francisco, California 94080, USA., Kummerfeld S; Department of Bioinformatics, Genentech Inc., South San Francisco, California 94080, USA., Zhang J; Department of Immunology, Genentech Inc., South San Francisco, California 94080, USA., Lee WP; Department of Immunology, Genentech Inc., South San Francisco, California 94080, USA., Snipas SJ; Program in Cell Death Signaling Networks, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California 92037, USA., Salvesen GS; Program in Cell Death Signaling Networks, Sanford-Burnham-Prebys Medical Discovery Institute, La Jolla, California 92037, USA., Morris LX; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Fitzgerald L; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Zhang Y; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Bertram EM; The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia., Goodnow CC; Department of Immunology and Infectious Diseases, The John Curtin School of Medical Research, The Australian National University, Canberra, Australian Capital Territory 2601, Australia.; Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia.; St. Vincent's Clinical School, UNSW Australia, Darlinghurst, New South Wales 2010, Australia., Dixit VM; Department of Physiological Chemistry, Genentech Inc., South San Francisco, California 94080, USA.

المصدر: Nature [Nature] 2015 Oct 29; Vol. 526 (7575), pp. 666-71. Date of Electronic Publication: 2015 Sep 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Signal Transduction*/genetics, Apoptosis Regulatory Proteins/*metabolism , Caspases/*metabolism , Inflammasomes/*metabolism, Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/chemistry ; Apoptosis Regulatory Proteins/deficiency ; Apoptosis Regulatory Proteins/genetics ; Caspases, Initiator ; Cell Line ; Female ; Gram-Negative Bacteria/immunology ; Humans ; Inflammasomes/drug effects ; Interleukin-1beta/metabolism ; Intracellular Signaling Peptides and Proteins ; Lipopolysaccharides/pharmacology ; Macrophages, Peritoneal/drug effects ; Macrophages, Peritoneal/metabolism ; Male ; Mice ; Mutation/genetics ; Necrosis ; Neoplasm Proteins/genetics ; Neoplasm Proteins/metabolism ; Phosphate-Binding Proteins ; Protein Processing, Post-Translational/drug effects ; Sepsis/microbiology ; Survival Analysis

المؤلفون: Kayagaki N; Department of Physiological Chemistry, Genentech, South San Francisco, CA 94080, USA. kayagaki@gene.com, Wong MT, Stowe IB, Ramani SR, Gonzalez LC, Akashi-Takamura S, Miyake K, Zhang J, Lee WP, Muszyński A, Forsberg LS, Carlson RW, Dixit VM

المصدر: Science (New York, N.Y.) [Science] 2013 Sep 13; Vol. 341 (6151), pp. 1246-9. Date of Electronic Publication: 2013 Jul 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate*, Inflammasomes/*immunology , Lipid A/*immunology , Macrophages/*immunology , Toll-Like Receptor 4/*immunology, Animals ; Caspases/biosynthesis ; Caspases, Initiator ; Cholera Toxin/immunology ; Disease Models, Animal ; Escherichia coli/immunology ; Escherichia coli Infections/genetics ; Escherichia coli Infections/immunology ; Lipid A/genetics ; Mice ; Mice, Mutant Strains ; Mutation ; Salmonella Infections/immunology ; Salmonella typhimurium/immunology ; Sepsis/immunology

المؤلفون: Stowe IB; Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94158, USA., Mercado EL, Stowe TR, Bell EL, Oses-Prieto JA, Hernández H, Burlingame AL, McCormick F

المصدر: Genes & development [Genes Dev] 2012 Jul 01; Vol. 26 (13), pp. 1421-6.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 8711660 Publication Model: Print Cited Medium: Internet ISSN: 1549-5477 (Electronic) Linking ISSN: 08909369 NLM ISO Abbreviation: Genes Dev Subsets: MEDLINE

مواضيع طبية MeSH: Cafe-au-Lait Spots/*metabolism , Intracellular Signaling Peptides and Proteins/*metabolism , Membrane Proteins/*metabolism , Neurofibromatosis 1/*metabolism , Neurofibromin 1/*metabolism , Repressor Proteins/*metabolism, Adaptor Proteins, Signal Transducing ; Animals ; Cafe-au-Lait Spots/genetics ; Cells, Cultured ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; MAP Kinase Signaling System ; Membrane Proteins/genetics ; Mice ; Neurofibromatosis 1/genetics ; Neurofibromin 1/genetics ; Protein Binding ; Repressor Proteins/genetics

SCR Disease Name: Legius syndrome