المؤلفون: Bhattacharyya, M, Stratton, MM, Going, CC, McSpadden, ED, Huang, Y, Susa, AC, Elleman, A, Cao, YM, Pappireddi, N, Burkhardt, P, Gee, CL, Barros, T, Schulman, H, Williams, ER, Kuriyan, J

المصدر: Bhattacharyya, M; Stratton, MM; Going, CC; McSpadden, ED; Huang, Y; Susa, AC; et al.(2016). Molecular mechanism of activation-triggered subunit exchange in Ca2+/calmodulin-dependent protein kinase II. eLife, 5(MARCH2016). doi: 10.7554/eLife.13405. UC Berkeley: Retrieved from: http://www.escholarship.org/uc/item/23v355j7

مصطلحات موضوعية: enzymes and coenzymes (carbohydrates), musculoskeletal, neural, and ocular physiology, cardiovascular system, environment and public health

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______325::5266300e975d4936782388e489b66345
http://www.escholarship.org/uc/item/23v355j7

المؤلفون: Özden C; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts, USA., MacManus S; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA., Adafia R; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts, USA., Samkutty A; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA., Torres-Ocampo AP; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA.; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts, USA., Garman SC; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts, USA.

المصدر: Protein science : a publication of the Protein Society [Protein Sci] 2024 Apr; Vol. 33 (4), pp. e4960.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Internet ISSN: 1469-896X (Electronic) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

مواضيع طبية MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Calcium*, Male ; Humans ; Semen/metabolism

المؤلفون: Nguyen BV; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.; Chemistry-Biology Interface Training Program, University of Massachusetts, Amherst, MA 01003, USA.; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Özden C; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Dong K; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.; Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA., Torres-Ocampo AP; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.; Chemistry-Biology Interface Training Program, University of Massachusetts, Amherst, MA 01003, USA., Dziedzic N; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA.; Chemistry-Biology Interface Training Program, University of Massachusetts, Amherst, MA 01003, USA., Flaherty D; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Huang J; Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA., Sankura S; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Abromson NL; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Tomchick DR; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA.; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Chen J; Department of Chemistry, University of Massachusetts, Amherst, MA 01003, USA., Garman SC; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 27. Date of Electronic Publication: 2024 Mar 27.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Yang X, Ma X, Croucher DR, Nguyen EV, Clark KC, Hu C, Latham SL, Zhao T, Bayly-Jones C, Nguyen VCB, Shin SY, Nguyen LK, Cotton TR, Chüeh AC, Kam Sian TCCL, Stratton MM, Ellisdon AM, Daly RJ

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2024 Feb 15. Date of Electronic Publication: 2024 Feb 15.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Rigter PMF; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., de Konink C; ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Dunn MJ; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Proietti Onori M; ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Humberson JB; Pediatric Specialty Care, University of Virginia Health, Charlottesville, VA 22903, USA., Thomas M; Division of Genetics, Department of Pediatrics, University of Virginia Children's, Charlottesville, VA 22903, USA., Barnes C; Division of Genetics, Department of Pediatrics, University of Virginia Children's, Charlottesville, VA 22903, USA., Prada CE; Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA; Division of Genetics, Genomics, and Metabolism, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA; Fundacion Cardiovascular de Colombia, Bucaramanga, Colombia., Weaver KN; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Ryan TD; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA; Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA., Caluseriu O; Department of Medical Genetics, University of Alberta, Edmonton, AB T6G 2H7, Canada; Stollery Children's Hospital, Department of Medical Genetics, University of Alberta, Edmonton, AB T6G 2B7, Canada., Conway J; Stollery Children's Hospital, Department of Pediatrics, Division of Pediatric Cardiology, University of Alberta, Edmonton, AB T6G 2B7, Canada., Calamaro E; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Fong CT; Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA., Wuyts W; Department of Medical Genetics, University of Antwerp and University Hospital of Antwerp, 2650 Edegem, Belgium., Meuwissen M; Department of Medical Genetics, University of Antwerp and University Hospital of Antwerp, 2650 Edegem, Belgium., Hordijk E; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Jonkers CN; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Anderson L; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Yuseinova B; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Polonia S; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands., Beysen D; Department of Paediatric Neurology, University Hospital of Antwerp, 2650 Edegem, Belgium; Department of Translational Neurosciences, University of Antwerp, 2650 Edegem, Belgium., Stark Z; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia; Australian Genomics, Melbourne, VIC 3052, Australia., Savva E; Victorian Clinical Genetics Services, Murdoch Children's Research Institute, Melbourne, VIC 3052, Australia., Poulton C; Genetic Services of Western Australia, King Edward Memorial Hospital, Perth, WA 6008, Australia., McKenzie F; Genetic Services of Western Australia, King Edward Memorial Hospital, Perth, WA 6008, Australia; School of Paediatrics and Child Health, University of Western Australia, Perth, WA 6009, Australia., Bhoj E; Division of Human Genetics, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Bupp CP; Corewell Health & Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA., Bézieau S; Nantes Université, CHU Nantes, Service de Génétique Médicale, 44000 Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, 44000 Nantes, France., Mercier S; Nantes Université, CHU Nantes, Service de Génétique Médicale, 44000 Nantes, France; Nantes Université, CHU Nantes, CNRS, INSERM, l'institut du thorax, 44000 Nantes, France., Blevins A; GeneDx, Gaithersburg, MD 20877, USA., Wentzensen IM; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Xia F; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA., Rosenfeld JA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA; Baylor Genetics Laboratories, Houston, TX 77021, USA., Hsieh TC; Institute for Genomic Statistics and Bioinformatics, University of Bonn, 53127 Bonn, Germany., Krawitz PM; Institute for Genomic Statistics and Bioinformatics, University of Bonn, 53127 Bonn, Germany., Elbracht M; Institute for Human Genetics and Genomic Medicine, Medical Faculty, RWTH Aachen University, 52074 Aachen, Germany., Veenma DCM; ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; Sophia Children's Hospital, Erasmus Medical Center, Rotterdam 3015 CN, the Netherlands., Schulman H; Department of Neurobiology, Stanford University, School of Medicine, Stanford, CA 94305, USA; Panorama Research Institute, Sunnyvale, CA 94089, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Küry S; Corewell Health & Helen DeVos Children's Hospital, Grand Rapids, MI 49503, USA; Nantes Université, CHU Nantes, Service de Génétique Médicale, 44000 Nantes, France. Electronic address: sebastien.kury@chu-nantes.fr., van Woerden GM; Department of Clinical Genetics, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; ENCORE Expertise Centre for Neurodevelopmental Disorders, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands; Department of Neuroscience, Erasmus Medical Center, Rotterdam 3015 GD, the Netherlands. Electronic address: g.vanwoerden@erasmusmc.nl.

المصدر: American journal of human genetics [Am J Hum Genet] 2024 Feb 01; Vol. 111 (2), pp. 364-382. Date of Electronic Publication: 2024 Jan 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0370475 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1537-6605 (Electronic) Linking ISSN: 00029297 NLM ISO Abbreviation: Am J Hum Genet Subsets: MEDLINE

مواضيع طبية MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Cardiomyopathy, Dilated* , Intellectual Disability* , Neurodevelopmental Disorders*/genetics, Animals ; Humans ; Mice ; Heart

المؤلفون: Saha S; Department of Chemical Engineering, University of Massachusetts Amherst, MA 01003, USA. perrys@engin.umass.edu., Özden C; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA 01003, USA., Samkutty A; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA 01003, USA., Russi S; SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA., Cohen A; SLAC National Accelerator Laboratory, Menlo Park, CA 94025, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA 01003, USA., Perry SL; Department of Chemical Engineering, University of Massachusetts Amherst, MA 01003, USA. perrys@engin.umass.edu.

المصدر: Lab on a chip [Lab Chip] 2023 Apr 12; Vol. 23 (8), pp. 2075-2090. Date of Electronic Publication: 2023 Apr 12.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101128948 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-0189 (Electronic) Linking ISSN: 14730189 NLM ISO Abbreviation: Lab Chip Subsets: MEDLINE

مواضيع طبية MeSH: Polymers* , Proteins*/chemistry, Crystallography, X-Ray ; Crystallization ; Temperature ; Lab-On-A-Chip Devices

المؤلفون: Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA 01003.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Dec 06; Vol. 119 (49), pp. e2216529119. Date of Electronic Publication: 2022 Nov 30.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*

المؤلفون: Özden C; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA., Sloutsky R; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Mitsugi T; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Santos N; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Agnello E; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Gaubitz C; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Foster J; Molecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, MA 01003, USA., Lapinskas E; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Esposito EA; Malvern Panalytical, Northampton, MA 01060, USA., Saneyoshi T; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Kelch BA; Department of Biochemistry and Molecular Biotechnology, University of Massachusetts Chan Medical School, Worcester, MA 01605, USA., Garman SC; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA., Hayashi Y; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003, USA. Electronic address: mstratton@umass.edu.

المصدر: Cell reports [Cell Rep] 2022 Jul 12; Vol. 40 (2), pp. 111064.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism , Protein Processing, Post-Translational*, Calcium/metabolism ; Catalytic Domain ; Phosphorylation

المؤلفون: Sloutsky R; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA, USA.

المصدر: The European journal of neuroscience [Eur J Neurosci] 2021 Oct; Vol. 54 (8), pp. 6780-6794. Date of Electronic Publication: 2020 May 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: France NLM ID: 8918110 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-9568 (Electronic) Linking ISSN: 0953816X NLM ISO Abbreviation: Eur J Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Alternative Splicing* , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/genetics , Calcium-Calmodulin-Dependent Protein Kinase Type 2*/metabolism, Humans ; Long-Term Potentiation ; Phosphorylation

المؤلفون: Eriksen MS; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Nikolaienko O; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Hallin EI; Department of Biomedicine, University of Bergen, Norway., Grødem S; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Bustad HJ; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Flydal MI; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Merski I; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA, USA., Hosokawa T; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Lascu D; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Akerkar S; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Cuéllar J; Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Chambers JJ; Institute for Applied Life Sciences, University of Massachusetts Amherst, MA, USA., O'Connell R; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA, USA., Muruganandam G; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Brussels, Belgium.; Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Belgium., Loris R; VIB-VUB Center for Structural Biology, Vlaams Instituut voor Biotechnologie, Brussels, Belgium.; Structural Biology Brussels, Department of Bioengineering Sciences, Vrije Universiteit Brussel, Belgium., Touma C; Faculty of Biochemistry and Molecular Biology & Biocenter Oulu, University of Oulu, Finland., Kanhema T; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Hayashi Y; Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto, Japan., Stratton MM; Department of Biochemistry and Molecular Biology, University of Massachusetts Amherst, MA, USA., Valpuesta JM; Centro Nacional de Biotecnología (CNB-CSIC), Madrid, Spain., Kursula P; Department of Biomedicine, University of Bergen, Norway.; Faculty of Biochemistry and Molecular Biology & Biocenter Oulu, University of Oulu, Finland., Martinez A; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway., Bramham CR; Department of Biomedicine, University of Bergen, Norway.; KG Jebsen Centre for Neuropsychiatric Disorders, University of Bergen, Norway.

المصدر: The FEBS journal [FEBS J] 2021 May; Vol. 288 (9), pp. 2930-2955. Date of Electronic Publication: 2020 Nov 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

مواضيع طبية MeSH: Protein Conformation*, Amino Acid Motifs/*genetics , Cytoskeletal Proteins/*ultrastructure , Drosophila Proteins/*genetics , Nerve Tissue Proteins/*ultrastructure , Neurons/*metabolism, Animals ; Capsid Proteins/genetics ; Cryoelectron Microscopy ; Crystallography, X-Ray ; Cytoskeletal Proteins/genetics ; Drosophila Proteins/ultrastructure ; Humans ; Nerve Tissue Proteins/genetics ; Neuronal Plasticity/genetics ; Protein Domains/genetics ; RNA/genetics ; Sequence Homology, Amino Acid ; Signal Transduction/genetics ; Virion/genetics