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1دورية أكاديمية
المؤلفون: Johan Gising, Saman Honarnejad, Maaike Bras, Gemma L. Baillie, Stuart P. McElroy, Philip S. Jones, Angus Morrison, Julia Beveridge, Mathias Hallberg, Mats Larhed
المصدر: International Journal of Molecular Sciences, Vol 25, Iss 7, p 4084 (2024)
مصطلحات موضوعية: insulin-regulated aminopeptidase (IRAP), ultra-high-throughput screening (uHTS), Biology (General), QH301-705.5, Chemistry, QD1-999
وصف الملف: electronic resource
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2دورية أكاديمية
المؤلفون: Euan Parnell, Stuart P. McElroy, Jolanta Wiejak, Gemma L. Baillie, Alison Porter, David R. Adams, Holger Rehmann, Brian O. Smith, Stephen J. Yarwood
المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2045-2322
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المؤلفون: Amy E. Monaghan, Alison Porter, Irene. Hunter, Angus Morrison, Stuart P. McElroy, Iain J. McEwan
المصدر: Assay and drug development technologies. 20(3)
مصطلحات موضوعية: Male, Transcriptional Activation, Receptors, Androgen, Cell Line, Tumor, Drug Discovery, Androgen Receptor Antagonists, Molecular Medicine, Humans, Prostatic Neoplasms, High-Throughput Screening Assays
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50958b2067a60ad6bdd9499704435337
https://pubmed.ncbi.nlm.nih.gov/35333596 -
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المؤلفون: Jürgen Brem, Tharindi Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J. M. Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula Kiuru, Shifali Shishodia, Daniel Krahn, Robert K. Leśniak, Juliane Schmidt, Karina Calvopiña, María-Carmen Turrientes, Madeline E. Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W. Langley, Ali F. Aboklaish, Anders Eneroth, Maria Backlund, Andrei G. Baran, Elisabet I. Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A. McDonough, Anna M. Rydzik, Thomas M. Leissing, Juan Carlos Jimenez-Castellanos, Matthew B. Avison, Solange Da Silva Pinto, Andrew D. Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari Yli-Kauhaluoma, Eric Bacque, Malcolm G. P. Page, Fredrik Björkling, Jonathan M. Tyrrell, James Spencer, Pauline A. Lang, Pawel Baranczewski, Rafael Cantón, Stuart P. McElroy, Philip S. Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R. Walsh, Christopher J. Schofield
المساهمون: Staff Services, Pharmaceutical Design and Discovery group, Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Jari Yli-Kauhaluoma / Principal Investigator, University Management
المصدر: Brem, J, Panduwawala, T, Hansen, J U, Hewitt, J, Liepins, E, Donets, P, Espina, L, Farley, A J M, Shubin, K, Campillos, G G, Kiuru, P, Shishodia, S, Krahn, D, Leśniak, R K, Schmidt Adrian, J, Calvopiña, K, Turrientes, M-C, Kavanagh, M E, Lubriks, D, Hinchliffe, P, Langley, G W, Aboklaish, A F, Eneroth, A, Backlund, M, Baran, A G, Nielsen, E I, Speake, M, Kuka, J, Robinson, J, Grinberga, S, Robinson, L, McDonough, M A, Rydzik, A M, Leissing, T M, Jimenez-Castellanos, J C, Avison, M B, Da Silva Pinto, S, Pannifer, A D, Martjuga, M, Widlake, E, Priede, M, Hopkins Navratilova, I, Gniadkowski, M, Belfrage, A K, Brandt, P, Yli-Kauhaluoma, J, Bacque, E, Page, M G P, Björkling, F, Tyrrell, J M, Spencer, J, Lang, P A, Baranczewski, P, Cantón, R, McElroy, S P, Jones, P S, Baquero, F, Suna, E, Morrison, A, Walsh, T R & Schofield, C J 2022, ' Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors ', Nature Chemistry, vol. 14, pp. 15-24 . https://doi.org/10.1038/s41557-021-00831-x
مصطلحات موضوعية: MECHANISM, Medicin och hälsovetenskap, General Chemical Engineering, Microbial Sensitivity Tests, beta-Lactams, Medical and Health Sciences, 03 medical and health sciences, Mice, Structure-Activity Relationship, AVIBACTAM, Gram-Negative Bacteria, polycyclic compounds, metallo-beta-lactamase, Animals, Humans, 030304 developmental biology, 0303 health sciences, 030306 microbiology, General Chemistry, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, 3. Good health, 317 Pharmacy, beta-Lactamase Inhibitors, ANTIBIOTICS, RESISTANCE, Protein Binding
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4fafe7a19ff7ed314c37086b73a558
https://research-information.bris.ac.uk/ws/files/323318874/IC_MBLinh_NatChem_accepted.pdf -
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المؤلفون: Irina G. Tikhonova, Graeme Milligan, Andrew B. Tobin, Stuart P. McElroy, Laura Jenkins, Zobaer Al Mahmud, Matt Barnes, Angus Morrison, K.A. Bennett, Sara Marsango, Sarah J. Mancini
المصدر: Jenkins, L, Marsango, S, Mancini, S, Mahmud, Z A, Morrison, A, McElroy, S P, Bennett, K A, Barnes, M, Tobin, A B, Tikhonova, I G & Milligan, G 2021, ' Discovery and Characterization of Novel Antagonists of the Proinflammatory Orphan Receptor GPR84 ', ACS Pharmacology & Translational Science . https://doi.org/10.1021/acsptsci.1c00151
مصطلحات موضوعية: Pharmacology, chemistry.chemical_classification, Orphan receptor, Antagonist, Small molecule, Amino acid, Proinflammatory cytokine, SDG 3 - Good Health and Well-being, chemistry, Biochemistry, Competitive antagonist, Pharmacology (medical), Homology modeling, Receptor
وصف الملف: application/pdf
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المؤلفون: Stuart P. McElroy, Lucas Philippe, Bernadette Connolly, Jonathan Pettitt, Berndt Müller, Michael Speake, Ammar Alturkistani, George C. Pandarakalam
المصدر: International Journal for Parasitology: Drugs and Drug Resistance, Vol 10, Iss, Pp 28-37 (2019)
International Journal for Parasitology: Drugs and Drug Resistanceمصطلحات موضوعية: RNA, Spliced Leader, 0301 basic medicine, Methyltransferase, Sinefungin, 030231 tropical medicine, Trans-splicing, Drug Evaluation, Preclinical, Drug resistance, Biology, SL1 trans-splicing, Article, Trans-Splicing, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, HTS assay, Gene expression, medicine, Animals, Pharmacology (medical), lcsh:RC109-216, Anthelmintic, Caenorhabditis elegans, Anthelminitics, Anthelmintics, Pharmacology, Genetics, Reporter gene, biology.organism_classification, High-Throughput Screening Assays, 3. Good health, 030104 developmental biology, Infectious Diseases, Nematode, Parasitology, medicine.drug
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المصدر: The Febs Journal
مصطلحات موضوعية: 0301 basic medicine, enzyme assay, Burkholderia pseudomallei, peptidoglycan, Biochemistry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, Bacterial Proteins, Binding site, Enzyme Inhibitors, Peptide Synthases, Molecular Biology, enzyme inhibition, Alanine, chemistry.chemical_classification, DNA ligase, Binding Sites, biology, Chemistry, Drug discovery, Cell Biology, Original Articles, biology.organism_classification, D-alanine—D-alanine ligase, Adenosine Monophosphate, 3. Good health, Anti-Bacterial Agents, Molecular Docking Simulation, antibacterial, 030104 developmental biology, Enzyme, Drug development, target validation, 030220 oncology & carcinogenesis, Original Article, Protein Binding
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المؤلفون: Lindsay Robinson, Angus Morrison, George C. Pandarakalam, Jonathan Gillespie, Julie M. Rainard, Veronique Hamon, Ian G. Ganley, Muralikrishnan Rajamanickam, Maria Zachari, Stuart P. McElroy
المصدر: Biochemical Journal
مصطلحات موضوعية: Cell Homeostasis & Autophagy, autophagy, High-throughput screening, Chemical biology, Bone Neoplasms, Protein Serine-Threonine Kinases, Biochemistry, high-throughput screening, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Drug Discovery, Chemical Biology, Tumor Cells, Cultured, Autophagy-Related Protein-1 Homolog, Humans, Phosphatidylinositol, Phosphorylation, Molecular Biology, Protein Kinase Inhibitors, Research Articles, 030304 developmental biology, Vacuolar protein sorting, 0303 health sciences, Osteosarcoma, Chemistry, Kinase, Autophagy, Intracellular Signaling Peptides and Proteins, Cell Biology, ULK1, Class III Phosphatidylinositol 3-Kinases, 3. Good health, High-Throughput Screening Assays, kinases, Drug development, 030220 oncology & carcinogenesis, Enzymology, Translational Science
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b1075c459e6d6698c70d1a00556951
https://pubmed.ncbi.nlm.nih.gov/32011652 -
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المؤلفون: Veronique Hamon, Helma van den Hurk, Philip H. Jones, Angus Morrison, Natalia A. Ignatenko, Gemma L. Baillie, Niels Smits, Nikolas Gunkel, Aubry K. Miller, Joanne Hewitt, Andrew Pannifer, Elena De Vita, Elizabeth M. Beck, Emily Russell, Stuart P. McElroy
المصدر: Chemmedchem
مصطلحات موضوعية: PATHOGENESIS, Chemistry, Medicinal, MELANOMA, 01 natural sciences, Biochemistry, 0305 Organic Chemistry, SERINE-PROTEASE NEUROSIN, Cytochrome P-450 Enzyme System, Cell Movement, Drug Discovery, Pharmacology & Pharmacy, General Pharmacology, Toxicology and Pharmaceutics, chemistry.chemical_classification, Full Paper, biology, Chemistry, Drug discovery, High-throughput screening, Stereoisomerism, Full Papers, SUBSTRATE-SPECIFICITY, ALZHEIMERS-DISEASE, Molecular Docking Simulation, Neuroprotective Agents, Molecular Medicine, Kallikreins, SPINAL-CORD, 1115 Pharmacology and Pharmaceutical Sciences, Life Sciences & Biomedicine, Half-Life, EXPRESSION, Medicinal & Biomolecular Chemistry, Inhibitory Concentration 50, Structure-Activity Relationship, TARGETS, Potency, Structure–activity relationship, Humans, Oxazolidinones, Pharmacology, Serine protease, Science & Technology, Binding Sites, 0304 Medicinal and Biomolecular Chemistry, 010405 organic chemistry, Organic Chemistry, Kallikrein, Protease inhibitors, HCT116 Cells, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Enzyme, Docking (molecular), biology.protein, Tissue Kallikreins, ACTIVATION PROFILES, Medicinal Chemistry
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028f6971b3491f16f6a912a55eb2fbe7
http://hdl.handle.net/10044/1/93822 -
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المؤلفون: John Robinson, Stuart P. McElroy, Philip S. Jones, Graeme Barker, Euan Parnell, Helma Rutjes, Lindsay Robinson, Angus Morrison, Elizabeth M. Beck, Andrew D. Pannifer, Martin Timmerman, Angela Cowley, Jolanta Wiejak, Veronique Hamon, Holger Rehmann, Urszula Luchowska-Stańska, Jonathan Gillespie, David Morgan, Stephen J. Yarwood, Alison Porter, Pravin Mahajan
المصدر: Cells
Volume 8
Issue 11مصطلحات موضوعية: Agonist, Models, Molecular, medicine.drug_class, guanine nucleotide exchange factor (GEF) activity, GTPase, Acetates, Ligands, Exocytosis, Article, Cell Line, chemistry.chemical_compound, medicine, Cyclic AMP, Guanine Nucleotide Exchange Factors, Humans, Benzofuran, Benzofurans, Rap1, Binding Sites, Molecular Structure, Microscale thermophoresis, Cell growth, EPAC, General Medicine, In vitro, High-Throughput Screening Assays, Molecular Docking Simulation, chemistry, Biochemistry, uHTS, agonists
وصف الملف: application/pdf
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