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المؤلفون: Albert Hofman, Megan L. Grove, Jennifer A. Brody, Adolfo Correa, Kim Lawson, Jose M. Ordovas, Yingchang Lu, André G. Uitterlinden, Riccardo E. Marioni, Nathan O. Stitziel, Oscar H. Franco, Yongmei Liu, Ingrid B. Borecki, Aron Y. Joon, Lindsay M. Reynolds, Ozren Polasek, Kelli K. Ryckman, Muredach P. Reilly, Johanna Jakobsdottir, Abbas Dehghan, L. Adrienne Cupples, Tamara B. Harris, Michael Griswold, Judy Wang, Christopher S. Carlson, Caroline Hayward, Leslie A. Lange, Stephen S. Rich, Kenneth Rice, Jacy R Crosby, Diego Ardissino, Charles Kooperberg, Gudny Eiriksdottir, Rachel H. Mackey, Ani Manichaikul, Martin Farrall, Jennifer E. Huffman, Albert V. Smith, Vilmundur Gudnason, Aniruddh P. Patel, Ruth J. F. Loos, Sumeet A. Khetarpal, Daniel J. Rader, Domenico Girelli, Eric Boerwinkle, Qunyuan Zhang, Valeska Redon, Anuj Goel, Cornelia M. van Duijn, Bruce M. Psaty, Ruth McPherson, Piera Angelica Merlini, Daniel Levy, Ian J. Deary, Christopher J. O'Donnell, Kurt Lohman, Josyf C. Mychaleckyj, Brian W. Davis, Mary F. Feitosa, Kent D. Taylor, James S. Pankow, Marju Orho-Melander, Alanna C. Morrison, Igor Rudan, Alexander P. Reiner, William E. Kraus, Ulrike Peters, Paul L. Auer, Paolo Zanoni, Svati H. Shah, Olle Melander, Jennifer G. Robinson, Joshua C. Bis, Erwin P. Bottinger, Mingyao Li, George Hindy, Omri Gottesman, Stefano Duga, Herman A. Taylor, Y.-D. Ida Chen, David S. Siscovick, Aaron Isaacs, Michael Y. Tsai, Sekar Kathiresan, James G. Wilson, Pamela J. Schreiner, Nicola Martinelli, Myriam Fornage, Serkalem Demissie, Lenore J. Launer, Hugh Watkins, Arend Voorman, Jerome I. Rotter, Jeanette M. Stafford, John M. Starr, Gina M. Peloso, Rosanna Asselta, Gail Davies, Rebecca D. Jackson
المساهمون: Epidemiology, Internal Medicine
المصدر: American Journal of Human Genetics, 94(2), 223-232. Cell Press
American Journal of Human Genetics, 94(2), 223-32. Cell Pressمصطلحات موضوعية: Male, Blood lipids, Coronary Disease, 030204 cardiovascular system & hematology, Inbred C57BL, Cohort Studies, chemistry.chemical_compound, Mice, 0302 clinical medicine, Gene Frequency, Genotype, Genetics(clinical), Subtilisins, European Continental Ancestry Group/genetics, Exome, Genetics (clinical), Genetics, 0303 health sciences, Cholesterol, HDL/blood, 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics, Middle Aged, 3. Good health, LDL/blood, Triglycerides/blood, Cholesterol, Phenotype, Cholesterol, LDL/blood, Genetic Code, HDL/blood, lipids (amino acids, peptides, and proteins), Female, Sequence Analysis, Microtubule-Associated Proteins, Adult, Sequence analysis, Black People, Biology, White People, Article, 03 medical and health sciences, Coronary Disease/blood, Animals, Humans, Allele frequency, Gene, Alleles, Genetic Association Studies, Triglycerides, 030304 developmental biology, Aged, PCSK9, Cholesterol, HDL, African Continental Ancestry Group/genetics, Genetic Variation, DNA, Cholesterol, LDL, Sequence Analysis, DNA, Microtubule-Associated Proteins/genetics, Subtilisins/genetics, Mice, Inbred C57BL, chemistry, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Linear Models
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المؤلفون: Dung Le-Nguyen, Jean-Christophe Barale, Christophe Nguyen, Michael Nilges, Giacomo Bastianelli, Anthony Bouillon
المساهمون: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunologie moléculaire des parasites, Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), This work was partly supported by MEST-CT-05-020311, a Marie Curie Early Stage Research Training Fellowship (EIMID) of the Framework Program 6 by the European Commission. AB is a fellow of the ‘‘Direction Generale pour l’Armement’’ from the French Ministry of Defense. This work was partly supported by the ‘‘Fond de ́die ́: combattre les maladies parasitaires’’ granted by Sanofi-Aventis and the French Ministry of Research and the Institut Carnot-Pasteur Maladies Infectieuses. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SYSDIAG, CNRS UMR3145 CNRS-BioRad provided support in the form of salaries and operating costs for authors CN and DLN, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘‘author contributions’’ section., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩
PLoS ONE, Vol 9, Iss 10, p e109269 (2014)
PLoS ONE, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩مصطلحات موضوعية: Plasmodium, Protein Conformation, MESH: Sequence Homology, Amino Acid, medicine.medical_treatment, Plasmodium vivax, MESH: Subtilisins/genetics, Protozoan Proteins, lcsh:Medicine, Protein Synthesis, Bioinformatics, Crystallography, X-Ray, Biochemistry, MESH: Protozoan Proteins/chemistry, 0302 clinical medicine, Protein structure, MESH: Protein Conformation, Biochemical Simulations, Plasmodium Vivax, Subtilisins, Enzyme Inhibitors, lcsh:Science, Protein Synthesis Inhibitors, Protozoans, 0303 health sciences, Multidisciplinary, Malarial Parasites, Proteases, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Enzyme structure, 3. Good health, Enzymes, Molecular Docking Simulation, Plasmodium Falciparum, Protein Binding, Research Article, Trypsin inhibitor, MESH: Protozoan Proteins/genetics, Computational biology, Biology, MESH: Plasmodium vivax/chemistry, MESH: Subtilisins/chemistry, Protein Chemistry, Catalysis, 03 medical and health sciences, Chemical Biology, Parasite Groups, medicine, Malaria, Vivax, MESH: Molecular Docking Simulation, Humans, MESH: Protein Binding, Protease Inhibitors, Homology modeling, 030304 developmental biology, Protease, MESH: Humans, Sequence Homology, Amino Acid, lcsh:R, Subtilisin, Organisms, Biology and Life Sciences, Proteins, Computational Biology, MESH: Plasmodium vivax/metabolism, biology.organism_classification, MESH: Catalysis, MESH: Crystallography, X-Ray, Biochemical Activity, Parasitic Protozoans, Serine Protease Inhibitors, Docking (molecular), MESH: Malaria, Vivax/metabolism, Enzymology, lcsh:Q, Parasitology, Proteinase Inhibitors, Serine Proteases, Peptides, Apicomplexa, MESH: Malaria, Vivax/pathology, 030217 neurology & neurosurgery
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المؤلفون: Bratt, T, Cedervall, T, Akerström, B
المصدر: FEBS Letters. 354(1):57-61
مصطلحات موضوعية: Alpha-Globulins/chemistry, Animals, Base Sequence, CHO Cells, Cricetinae, Furin, Gene Expression, Glycoproteins/chemistry, Membrane Glycoproteins, Molecular Sequence Data, Molecular Weight, Protease Inhibitors/metabolism, Protein Precursors/genetics, Protein Processing, Post-Translational/physiology, Rats, Subtilisins/genetics, Transfection, Trypsin Inhibitor, Kunitz Soybean, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Immunologi inom det medicinska området, Medical and Health Sciences, Basic Medicine, Immunology in the medical area
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المؤلفون: Katharina Meyer, Philippe A. Halban, Jean-Claude Irminger
المصدر: Biochemical Journal, Vol. 320, No 1 (1996) pp. 11-15
مصطلحات موضوعية: endocrine system, medicine.medical_specialty, medicine.medical_treatment, Insulinoma/metabolism, urologic and male genital diseases, Cleavage (embryo), Biochemistry, Adenoviridae, law.invention, Proinsulin/ metabolism, Subtilisins/ genetics, In vivo, law, Internal medicine, Tumor Cells, Cultured, medicine, Aspartic Acid Endopeptidases, Animals, Subtilisins, Adenoviridae/ genetics, Molecular Biology, Proinsulin, ddc:616, Recombination, Genetic, Chemistry, Insulin, Rat Insulinoma, Cell Biology, Molecular biology, In vitro, Rats, Kinetics, Proprotein Convertase 2, Endocrinology, Cell culture, Aspartic Acid Endopeptidases/ genetics, Recombinant DNA, Insulinoma, Proprotein Convertases, Protein Processing, Post-Translational, hormones, hormone substitutes, and hormone antagonists, Research Article
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8aac058ae36817300881828870112fa
https://doi.org/10.1042/bj3200011 -
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المؤلفون: Trani, E, Giorgi, A, Canu, N, Amadoro, G, Rinaldi, A, Halban, P, Ferri, L, Possenti, R, Schinina, M, Levi, A
المصدر: Journal of Neurochemistry, Vol. 81, No 3 (2002) pp. 565-574
مصطلحات موضوعية: endoproteolytic processing, maldi-tof mass spectrometry, protein precursor, animal cell, Mice, Binding Sites/physiology, Sequence Analysis, Protein, Brain/cytology/metabolism, Aspartic Acid Endopeptidases, rat, Subtilisins, nerve growth-factor, prohormone convertase, rat brain, vgf peptides, Aspartic Acid Endopeptidases/genetics/ metabolism, Cells, Cultured, enzyme, neurotrophin, unclassified drug, VGF protein, animal tissue, article, brain, carboxy terminal sequence, central nervous system, controlled study, enzyme activity, gene, human, human cell, matrix assisted laser desorption ionization time of flight mass spectrometry, neurosecretory cell, nonhuman, peripheral nervous system, priority journal, protein isolation, site directed mutagenesis, Amino Acid Sequence, Animals, Aspartic Endopeptidases, Binding Sites, Brain, Brain Chemistry, Electrophoresis, Polyacrylamide Gel, Humans, Molecular Sequence Data, Molecular Weight, Neurons, Neuropeptides, Peptide Fragments, Pituitary Gland, Proprotein Convertase 1, Proprotein Convertase 2, Proprotein Convertases, Protein Precursors, Protein Processing, Post-Translational, Proteins, Rats, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Transfection, Animalia, Bovinae, ddc:616, Cultured, Protein Precursors/ metabolism, Proteins/ metabolism, Endoproteolytic processing, MALDI-ToF mass spectrometry, Prohormone convertase, Rat brain, VGF peptides, Sequence Analysis, Electrophoresis, Cells, Peptide Fragments/ chemistry/isolation & purification/metabolism, Settore BIO/09, Protein Processing, Post-Translational/physiology, Matrix-Assisted Laser Desorption-Ionization, Nerve Growth Factors, Protein Processing, Polyacrylamide Gel, Spectrometry, Protein, Subtilisins/genetics/ metabolism, Post-Translational, Pituitary Gland/cytology/metabolism, Mass, Neurons/cytology/metabolism
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6مورد إلكتروني
المصدر: Cytogenetics and cell genetics, 88 (1-2
مصطلحات الفهرس: Biologie moléculaire, Génétique, cytogénétique, Animals, Centromere -- genetics, Cyclin B -- genetics, Cyclin B1, Electron Transport Complex I, Genetic Predisposition to Disease -- genetics, Hybrid Cells, In Situ Hybridization, Fluorescence, Linkage (Genetics) -- genetics, Mammary Neoplasms, Animal -- genetics, Microsatellite Repeats -- genetics, NADH, NADPH Oxidoreductases -- chemistry, NADH, NADPH Oxidoreductases -- genetics, Physical Chromosome Mapping, Pituitary Neoplasms -- genetics, Polymerase Chain Reaction, Polymorphism, Genetic -- genetics, Proprotein Convertases, Quantitative Trait, Heritable, Rats, Saccharomyces cerevisiae Proteins, Subtilisins -- genetics, Tetrahydrofolate Dehydrogenase -- genetics, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL:
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/17917 http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL -
7مورد إلكتروني
المصدر: Cytogenetics and cell genetics, 88 (1-2
مصطلحات الفهرس: Biologie moléculaire, Génétique, cytogénétique, Animals, Centromere -- genetics, Cyclin B -- genetics, Cyclin B1, Electron Transport Complex I, Genetic Predisposition to Disease -- genetics, Hybrid Cells, In Situ Hybridization, Fluorescence, Linkage (Genetics) -- genetics, Mammary Neoplasms, Animal -- genetics, Microsatellite Repeats -- genetics, NADH, NADPH Oxidoreductases -- chemistry, NADH, NADPH Oxidoreductases -- genetics, Physical Chromosome Mapping, Pituitary Neoplasms -- genetics, Polymerase Chain Reaction, Polymorphism, Genetic -- genetics, Proprotein Convertases, Quantitative Trait, Heritable, Rats, Saccharomyces cerevisiae Proteins, Subtilisins -- genetics, Tetrahydrofolate Dehydrogenase -- genetics, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL:
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/17917 http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL -
8مورد إلكتروني
المصدر: Mammalian Genome, 10
مصطلحات الفهرس: Biologie moléculaire, Génétique, cytogénétique, Animals, Antigens, CD -- genetics, Chromosome Mapping, Cyclin B -- genetics, Cyclin B1, Cytokine Receptor gp130, In Situ Hybridization, Fluorescence, Linkage (Genetics), Membrane Glycoproteins -- genetics, Microsatellite Repeats, Proprotein Convertases, Rats, Saccharomyces cerevisiae Proteins, Subtilisins -- genetics, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL:
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/17935 http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL -
9مورد إلكتروني
المصدر: Mammalian Genome, 10
مصطلحات الفهرس: Biologie moléculaire, Génétique, cytogénétique, Animals, Antigens, CD -- genetics, Chromosome Mapping, Cyclin B -- genetics, Cyclin B1, Cytokine Receptor gp130, In Situ Hybridization, Fluorescence, Linkage (Genetics), Membrane Glycoproteins -- genetics, Microsatellite Repeats, Proprotein Convertases, Rats, Saccharomyces cerevisiae Proteins, Subtilisins -- genetics, info:eu-repo/semantics/article, info:ulb-repo/semantics/articlePeerReview, info:ulb-repo/semantics/openurl/article
URL:
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/17935 http://worldcat.org/search?q=on:EQY+http://difusion-oai.ulb.ac.be/oai/request+DCG_ENTIRE_REPOSITORY+CNTCOLL