نتائج البحث - "Subtilisins -- genetics"

1

Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks

المؤلفون: Albert Hofman, Megan L. Grove, Jennifer A. Brody, Adolfo Correa, Kim Lawson, Jose M. Ordovas, Yingchang Lu, André G. Uitterlinden, Riccardo E. Marioni, Nathan O. Stitziel, Oscar H. Franco, Yongmei Liu, Ingrid B. Borecki, Aron Y. Joon, Lindsay M. Reynolds, Ozren Polasek, Kelli K. Ryckman, Muredach P. Reilly, Johanna Jakobsdottir, Abbas Dehghan, L. Adrienne Cupples, Tamara B. Harris, Michael Griswold, Judy Wang, Christopher S. Carlson, Caroline Hayward, Leslie A. Lange, Stephen S. Rich, Kenneth Rice, Jacy R Crosby, Diego Ardissino, Charles Kooperberg, Gudny Eiriksdottir, Rachel H. Mackey, Ani Manichaikul, Martin Farrall, Jennifer E. Huffman, Albert V. Smith, Vilmundur Gudnason, Aniruddh P. Patel, Ruth J. F. Loos, Sumeet A. Khetarpal, Daniel J. Rader, Domenico Girelli, Eric Boerwinkle, Qunyuan Zhang, Valeska Redon, Anuj Goel, Cornelia M. van Duijn, Bruce M. Psaty, Ruth McPherson, Piera Angelica Merlini, Daniel Levy, Ian J. Deary, Christopher J. O'Donnell, Kurt Lohman, Josyf C. Mychaleckyj, Brian W. Davis, Mary F. Feitosa, Kent D. Taylor, James S. Pankow, Marju Orho-Melander, Alanna C. Morrison, Igor Rudan, Alexander P. Reiner, William E. Kraus, Ulrike Peters, Paul L. Auer, Paolo Zanoni, Svati H. Shah, Olle Melander, Jennifer G. Robinson, Joshua C. Bis, Erwin P. Bottinger, Mingyao Li, George Hindy, Omri Gottesman, Stefano Duga, Herman A. Taylor, Y.-D. Ida Chen, David S. Siscovick, Aaron Isaacs, Michael Y. Tsai, Sekar Kathiresan, James G. Wilson, Pamela J. Schreiner, Nicola Martinelli, Myriam Fornage, Serkalem Demissie, Lenore J. Launer, Hugh Watkins, Arend Voorman, Jerome I. Rotter, Jeanette M. Stafford, John M. Starr, Gina M. Peloso, Rosanna Asselta, Gail Davies, Rebecca D. Jackson

المساهمون: Epidemiology, Internal Medicine

المصدر: American Journal of Human Genetics, 94(2), 223-232. Cell Press
American Journal of Human Genetics, 94(2), 223-32. Cell Press

مصطلحات موضوعية: Male, Blood lipids, Coronary Disease, 030204 cardiovascular system & hematology, Inbred C57BL, Cohort Studies, chemistry.chemical_compound, Mice, 0302 clinical medicine, Gene Frequency, Genotype, Genetics(clinical), Subtilisins, European Continental Ancestry Group/genetics, Exome, Genetics (clinical), Genetics, 0303 health sciences, Cholesterol, HDL/blood, 1-Alkyl-2-acetylglycerophosphocholine Esterase/genetics, Middle Aged, 3. Good health, LDL/blood, Triglycerides/blood, Cholesterol, Phenotype, Cholesterol, LDL/blood, Genetic Code, HDL/blood, lipids (amino acids, peptides, and proteins), Female, Sequence Analysis, Microtubule-Associated Proteins, Adult, Sequence analysis, Black People, Biology, White People, Article, 03 medical and health sciences, Coronary Disease/blood, Animals, Humans, Allele frequency, Gene, Alleles, Genetic Association Studies, Triglycerides, 030304 developmental biology, Aged, PCSK9, Cholesterol, HDL, African Continental Ancestry Group/genetics, Genetic Variation, DNA, Cholesterol, LDL, Sequence Analysis, DNA, Microtubule-Associated Proteins/genetics, Subtilisins/genetics, Mice, Inbred C57BL, chemistry, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Linear Models

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58bcf3c1a5b72ab8d097dcaa1bd728d
https://doi.org/10.1016/j.ajhg.2014.01.009

View record from ScienceDirect

2

Computational Design of Protein-Based Inhibitors of Plasmodium vivax Subtilisin-Like 1 Protease

المؤلفون: Dung Le-Nguyen, Jean-Christophe Barale, Christophe Nguyen, Michael Nilges, Giacomo Bastianelli, Anthony Bouillon

المساهمون: Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Immunologie moléculaire des parasites, Sysdiag-Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic (SysDiag ), BIO-RAD-Centre National de la Recherche Scientifique (CNRS), This work was partly supported by MEST-CT-05-020311, a Marie Curie Early Stage Research Training Fellowship (EIMID) of the Framework Program 6 by the European Commission. AB is a fellow of the ‘‘Direction Generale pour l’Armement’’ from the French Ministry of Defense. This work was partly supported by the ‘‘Fond de ́die ́: combattre les maladies parasitaires’’ granted by Sanofi-Aventis and the French Ministry of Research and the Institut Carnot-Pasteur Maladies Infectieuses. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. SYSDIAG, CNRS UMR3145 CNRS-BioRad provided support in the form of salaries and operating costs for authors CN and DLN, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the ‘‘author contributions’’ section., Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)

المصدر: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩
PLoS ONE, Vol 9, Iss 10, p e109269 (2014)
PLoS ONE, 2014, 9 (10), ⟨10.1371/journal.pone.0109269⟩

مصطلحات موضوعية: Plasmodium, Protein Conformation, MESH: Sequence Homology, Amino Acid, medicine.medical_treatment, Plasmodium vivax, MESH: Subtilisins/genetics, Protozoan Proteins, lcsh:Medicine, Protein Synthesis, Bioinformatics, Crystallography, X-Ray, Biochemistry, MESH: Protozoan Proteins/chemistry, 0302 clinical medicine, Protein structure, MESH: Protein Conformation, Biochemical Simulations, Plasmodium Vivax, Subtilisins, Enzyme Inhibitors, lcsh:Science, Protein Synthesis Inhibitors, Protozoans, 0303 health sciences, Multidisciplinary, Malarial Parasites, Proteases, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Enzyme structure, 3. Good health, Enzymes, Molecular Docking Simulation, Plasmodium Falciparum, Protein Binding, Research Article, Trypsin inhibitor, MESH: Protozoan Proteins/genetics, Computational biology, Biology, MESH: Plasmodium vivax/chemistry, MESH: Subtilisins/chemistry, Protein Chemistry, Catalysis, 03 medical and health sciences, Chemical Biology, Parasite Groups, medicine, Malaria, Vivax, MESH: Molecular Docking Simulation, Humans, MESH: Protein Binding, Protease Inhibitors, Homology modeling, 030304 developmental biology, Protease, MESH: Humans, Sequence Homology, Amino Acid, lcsh:R, Subtilisin, Organisms, Biology and Life Sciences, Proteins, Computational Biology, MESH: Plasmodium vivax/metabolism, biology.organism_classification, MESH: Catalysis, MESH: Crystallography, X-Ray, Biochemical Activity, Parasitic Protozoans, Serine Protease Inhibitors, Docking (molecular), MESH: Malaria, Vivax/metabolism, Enzymology, lcsh:Q, Parasitology, Proteinase Inhibitors, Serine Proteases, Peptides, Apicomplexa, MESH: Malaria, Vivax/pathology, 030217 neurology & neurosurgery