المؤلفون: Buffa V; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287, Darmstadt, Germany.; Present address Dr. Michael Bauder, InfectoPharm Arzneimittel und Consilium GmbH, Von-Humboldt-Str.1, 64646, Heppenheim, Germany., Meyners C; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287, Darmstadt, Germany.; Present address Dr. Michael Bauder, InfectoPharm Arzneimittel und Consilium GmbH, Von-Humboldt-Str.1, 64646, Heppenheim, Germany., Sugiarto WO; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287, Darmstadt, Germany.; Present address Dr. Michael Bauder, InfectoPharm Arzneimittel und Consilium GmbH, Von-Humboldt-Str.1, 64646, Heppenheim, Germany., Bauder M; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287, Darmstadt, Germany.; Present address Dr. Michael Bauder, InfectoPharm Arzneimittel und Consilium GmbH, Von-Humboldt-Str.1, 64646, Heppenheim, Germany., Gaali S; Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, 80804, Munich, Germany.; Present address Dr. Steffen Gaali, Roche Diagnostics GmbH, Nonnenwald 2, 82377, Penzberg., Hausch F; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287, Darmstadt, Germany.; Present address Dr. Michael Bauder, InfectoPharm Arzneimittel und Consilium GmbH, Von-Humboldt-Str.1, 64646, Heppenheim, Germany.; Center for Synthetic Biology, Technical University Darmstadt, Germany.

المصدر: ChemMedChem [ChemMedChem] 2024 Sep 02; Vol. 19 (17), pp. e202400264. Date of Electronic Publication: 2024 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Pyrazoles*/chemistry , Pyrazoles*/pharmacology , Pyrazoles*/chemical synthesis , Tacrolimus Binding Proteins*/antagonists & inhibitors , Tacrolimus Binding Proteins*/metabolism , Tacrolimus Binding Proteins*/chemistry, Structure-Activity Relationship ; Ligands ; Humans ; Molecular Structure ; Animals ; Dose-Response Relationship, Drug ; Models, Molecular

المؤلفون: Geiger TM; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Walz M; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Meyners C; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Kuehn A; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Dreizler JK; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Sugiarto WO; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Maciel EVS; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Zheng M; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Lermyte F; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany., Hausch F; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Peter-Grünberg-Straße 4, 64287, Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, 64283, Darmstadt, Germany.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Jan 15; Vol. 63 (3), pp. e202309706. Date of Electronic Publication: 2023 Dec 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Proteolysis Targeting Chimera* , Tacrolimus Binding Protein 1A*/metabolism, Tacrolimus Binding Proteins/chemistry ; Protein Domains ; Binding Sites ; Proteolysis ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Purder PL; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Meyners C; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Sugiarto WO; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Kolos J; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Löhr F; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany., Gebel J; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany., Nehls T; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Dötsch V; Institute of Biophysical Chemistry and Center for Biomolecular Magnetic Resonance, Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany., Lermyte F; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Hausch F; Department of Organic Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, 64287 Darmstadt, Germany.

المصدر: JACS Au [JACS Au] 2023 Aug 25; Vol. 3 (9), pp. 2478-2486. Date of Electronic Publication: 2023 Aug 25 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101775714 Publication Model: eCollection Cited Medium: Internet ISSN: 2691-3704 (Electronic) Linking ISSN: 26913704 NLM ISO Abbreviation: JACS Au

المؤلفون: Knaup FH; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany., Meyners C; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany., Sugiarto WO; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany., Wedel S; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany., Springer M; Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Walz C; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany., Geiger TM; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany., Schmidt M; Research Group Neurobiology of Stress Resilience, Max Planck Institute of Psychiatry, 80804 Munich, Germany., Sisignano M; Pharmazentrum Frankfurt/ZAFES, Institute of Clinical Pharmacology, University Hospital, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany.; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Theodor-Stern-Kai 7, 60596 Frankfurt am Main, Germany., Hausch F; Department of Chemistry and Biochemistry Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss Straße 4, 64287 Darmstadt, Germany.; Centre for Synthetic Biology, Technical University of Darmstadt, 64283 Darmstadt, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Apr 27; Vol. 66 (8), pp. 5965-5980. Date of Electronic Publication: 2023 Apr 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Tacrolimus Binding Proteins*/metabolism , Mammals*/metabolism, Mice ; Animals ; Molecular Conformation

المؤلفون: Bauder M; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Meyners C; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Purder PL; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Merz S; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Sugiarto WO; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Voll AM; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Heymann T; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany., Hausch F; Department Chemistry and Biochemistry, Clemens-Schöpf-Institute, Technical University Darmstadt, Alarich-Weiss-Straße 4, 64287 Darmstadt, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2021 Mar 25; Vol. 64 (6), pp. 3320-3349. Date of Electronic Publication: 2021 Mar 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Macrocyclic Compounds/*chemistry , Macrocyclic Compounds/*pharmacology , Tacrolimus Binding Proteins/*antagonists & inhibitors, Crystallography, X-Ray ; Drug Design ; Humans ; Models, Molecular ; Protein Conformation/drug effects ; Protein Domains/drug effects ; Tacrolimus Binding Proteins/chemistry ; Tacrolimus Binding Proteins/metabolism

المؤلفون: Jänsch N; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany., Sugiarto WO; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany., Muth M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany.; Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz-1, 76334, Eggenstein-Leopoldshafen, Germany., Kopranovic A; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany., Desczyk C; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany., Ballweg M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany., Kirschhöfer F; Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz-1, 76334, Eggenstein-Leopoldshafen, Germany., Brenner-Weiss G; Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz Platz-1, 76334, Eggenstein-Leopoldshafen, Germany., Meyer-Almes FJ; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstraße 7, 64295, Darmstadt, Germany.

المصدر: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2020 Oct 15; Vol. 26 (58), pp. 13249-13255. Date of Electronic Publication: 2020 Sep 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 9513783 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3765 (Electronic) Linking ISSN: 09476539 NLM ISO Abbreviation: Chemistry Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Wolff B; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany., Jänsch N; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany., Sugiarto WO; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany., Frühschulz S; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany., Lang M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany., Altintas R; Preclinical Program, Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), INF 280, D-69120 Heidelberg, Germany; German Cancer Research Consortium (DKTK), Germany; Medical Faculty of Heidelberg University, Germany., Oehme I; Preclinical Program, Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Germany; Clinical Cooperation Unit Pediatric Oncology, German Cancer Research Center (DKFZ), INF 280, D-69120 Heidelberg, Germany; German Cancer Research Consortium (DKTK), Germany., Meyer-Almes FJ; Department of Chemical Engineering and Biotechnology, University of Applied Sciences, Haardtring 100, 64295, Darmstadt, Germany. Electronic address: franz-josef.meyer-almes@h-da.de.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2019 Dec 15; Vol. 184, pp. 111756. Date of Electronic Publication: 2019 Oct 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylase Inhibitors/*pharmacology , Repressor Proteins/*antagonists & inhibitors , Thiazines/*pharmacology, Dose-Response Relationship, Drug ; Histone Deacetylase Inhibitors/chemical synthesis ; Histone Deacetylase Inhibitors/chemistry ; Histone Deacetylases/metabolism ; Humans ; Molecular Docking Simulation ; Molecular Structure ; Repressor Proteins/metabolism ; Structure-Activity Relationship ; Thiazines/chemical synthesis ; Thiazines/chemistry

المؤلفون: Schweipert M; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstr. 7, 64295 Darmstadt, Germany., Jänsch N; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstr. 7, 64295 Darmstadt, Germany., Sugiarto WO; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstr. 7, 64295 Darmstadt, Germany., Meyer-Almes FJ; Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Stephanstr. 7, 64295 Darmstadt, Germany.

المصدر: Biological chemistry [Biol Chem] 2019 May 27; Vol. 400 (6), pp. 733-743.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Walter De Gruyter Country of Publication: Germany NLM ID: 9700112 Publication Model: Print Cited Medium: Internet ISSN: 1437-4315 (Electronic) Linking ISSN: 14316730 NLM ISO Abbreviation: Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Histone Deacetylase Inhibitors/*pharmacology , Repressor Proteins/*antagonists & inhibitors, Catalytic Domain ; Histone Deacetylases/metabolism ; Humans ; Kinetics ; Ligands ; Repressor Proteins/metabolism