المؤلفون: John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadroga, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch

المصدر: Journal of Lipid Research, Vol 60, Iss 3, Pp 717- (2019)

مصطلحات موضوعية: Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520326316; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/958579d899004c369825ee7df8364455

المؤلفون: John D. Douglass, Yin Xiu Zhou, Amy Wu, John A. Zadrogra, Angela M. Gajda, Atreju I. Lackey, Wensheng Lang, Kristen M. Chevalier, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Margery A. Connelly, Judith Storch

المصدر: Journal of Lipid Research, Vol 56, Iss 6, Pp 1153-1171 (2015)

مصطلحات موضوعية: monoacylglycerols, monoglycerides, monoacylglycerol lipase, Biochemistry, QD415-436

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0022227520317272; https://doaj.org/toc/0022-2275

URL الوصول: https://doaj.org/article/b971bbc51aba493cb64a321bc494f40f

المؤلفون: Michael R. Brandt, Pascal Bonaventure, Christine Dugovic, William G Bonnette, Lawrence Szewczuk, Ryan M Wyatt, Kristen M. Chevalier, Timothy W. Lovenberg, Brian Lord, Tatiana Koudriakova, Allison White, Ian Fraser, Peter J. Connolly, Kay Ahn, Michelle Wennerholm, Javier Suarez, Sujin Yun, Steven W. Sutton, Brahma Ghosh, Natalie Welty, Leslie Nguyen, Bin Zhu, Sui-Po Zhang, Gaochao Tian, Mark J. Macielag, Michael K. Ameriks, Christopher M. Flores

المصدر: Journal of Pharmacology and Experimental Therapeutics. 372:339-353

مصطلحات موضوعية: Male, 0301 basic medicine, Cannabinoid receptor, Pain, Sleep, REM, Pharmacology, Binding, Competitive, Piperazines, Substrate Specificity, Rats, Sprague-Dawley, Receptor, Cannabinoid, CB2, 03 medical and health sciences, 0302 clinical medicine, Receptor, Cannabinoid, CB1, In vivo, Escherichia coli, Animals, Humans, Enzyme Inhibitors, Receptor, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Brain, Long-term potentiation, Serine hydrolase, Endocannabinoid system, Monoacylglycerol Lipases, Mice, Inbred C57BL, Monoacylglycerol lipase, Kinetics, 030104 developmental biology, Leukocytes, Mononuclear, Molecular Medicine, 030217 neurology & neurosurgery, Endogenous agonist, HeLa Cells, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425d2e399b62ec058deb114196dce30
https://doi.org/10.1124/jpet.119.262139

المؤلفون: Peter J. Connolly, Bin Zhu, Sui-Po Zhang, Mark J. Macielag, Cynthia M. Milligan, Christopher M. Flores, Kristen M. Chevalier

المصدر: Bioorganicmedicinal chemistry letters. 30(12)

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Inhibitory postsynaptic potential, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Hydrolysis, Structure-Activity Relationship, Oral administration, Drug Discovery, Animals, Humans, Tissue Distribution, Enzyme Inhibitors, Thiazole, Molecular Biology, Diamide, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Endocannabinoid system, Enzyme assay, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 010404 medicinal & biomolecular chemistry, chemistry, biology.protein, Molecular Medicine, Arachidonic acid

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9426e86d5f273a83f9afc923d78a35c5
https://pubmed.ncbi.nlm.nih.gov/32334914

المؤلفون: Kristen M. Chevalier, Sui-Po Zhang, Shu-Chen Lin, Haiyan Bian, Michael R. Brandt, Mark J. Macielag, Li Liu, Cynthia M. Milligan, Christopher M. Flores, Peter J. Connolly, Yue-Mei Zhang, Bin Zhu, Mark McDonnell

المصدر: Bioorganicmedicinal chemistry letters. 30(14)

مصطلحات موضوعية: Models, Molecular, medicine.medical_treatment, Clinical Biochemistry, Azetidine, Pharmaceutical Science, Pharmacology, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Piperazines, chemistry.chemical_compound, Structure-Activity Relationship, Oral administration, Drug Discovery, medicine, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, Endocannabinoid system, Amides, Monoacylglycerol Lipases, 0104 chemical sciences, Monoacylglycerol lipase, 010404 medicinal & biomolecular chemistry, Piperazine, Enzyme, chemistry, Molecular Medicine, Azetidines, Arachidonic acid, Adjuvant

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3460671c2c7e0cc7a239a35e86f9ad63
https://pubmed.ncbi.nlm.nih.gov/32527545

المؤلفون: Kristen M. Chevalier, John D. Douglass, Judith Storch, Steven W. Sutton, Sui-Po Zhang, Christopher M. Flores, Yin Xiu Zhou, John A. Zadrogra, Angela M. Gajda, Margery A. Connelly, Atreju I. Lackey, Amy Wu, Wensheng Lang

المصدر: Journal of Lipid Research, Vol 56, Iss 6, Pp 1153-1171 (2015)

مصطلحات موضوعية: medicine.medical_specialty, Calorie, QD415-436, Biology, Diet, High-Fat, Weight Gain, Biochemistry, Energy homeostasis, Mice, chemistry.chemical_compound, Endocrinology, monoacylglycerol lipase, monoglycerides, Internal medicine, Glycerol, medicine, Animals, Homeostasis, Glucose homeostasis, Obesity, Mice, Knockout, Cell Biology, Metabolism, Dietary Fats, Lipids, Monoacylglycerol Lipases, Monoacylglycerol lipase, chemistry, monoacylglycerols, Erratum, medicine.symptom, Energy Metabolism, Weight gain, Endocannabinoids

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80002248063ffcf6910e9c2f508739d5
http://www.sciencedirect.com/science/article/pii/S0022227520317272

المؤلفون: Chaozhong Cai, Alexey B. Dyatkin, Paul R. Wade, Kavash Robert W, Sui-Po Zhang, Henry J. Breslin, Craig J. Diamond, Wei He, Tamara A. Miskowski, Pamela J. Hornby

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:4869-4872

مصطلحات موضوعية: Diarrhea, Agonist, Stereochemistry, medicine.drug_class, Clinical Biochemistry, Receptors, Opioid, mu, Pharmaceutical Science, Pharmacology, Biochemistry, Irritable Bowel Syndrome, Structure-Activity Relationship, Clinical Trials, Phase II as Topic, Opioid receptor, Receptors, Opioid, delta, Drug Discovery, medicine, Humans, Structure–activity relationship, Receptor, Molecular Biology, Irritable bowel syndrome, Molecular Structure, Chemistry, Organic Chemistry, Antagonist, medicine.disease, Opioid, Molecular Medicine, medicine.symptom, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c81ce41ee0795527efdfdb550ea3b0
https://doi.org/10.1016/j.bmcl.2012.05.042

المؤلفون: Matthew J. Todd, Marina I. Nelen, Celine Schalk-Hihi, Jose C. Clemente, James K. Kranz, Christopher M. Flores, Lawrence C. Kuo, Diane M. Maguire, Erica L Nulton, Sui-Po Zhang

المصدر: SLAS Discovery. 17:629-640

مصطلحات موضوعية: Cannabinoid receptor, High-throughput screening, Arachidonic Acids, Plasma protein binding, Biochemistry, Glycerides, Substrate Specificity, Analytical Chemistry, Inhibitory Concentration 50, Catalytic Domain, High-Throughput Screening Assays, medicine, Humans, Enzyme Inhibitors, Enzyme Assays, chemistry.chemical_classification, biology, Hydrolysis, Active site, Monoacylglycerol Lipases, Monoacylglycerol lipase, Kinetics, Enzyme, Solubility, chemistry, Mechanism of action, biology.protein, Molecular Medicine, medicine.symptom, Endocannabinoids, Protein Binding, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05db4e32fcae5283a2c28027f6dc8703
https://doi.org/10.1177/1087057112441012

المؤلفون: Ling Lin, Chaozhong Cai, Christopher M. Flores, Timothy P Coogan, Edmund K. LeGrand, Ellen E. Codd, Raymond W. Colburn, Angelique Leone, Charles Y. Wang, Mcdonnell Mark E, Scott L. Dax, Michael R. Brandt, Stewart Bryant, Bart DeCorte, James J. McNally, John R. Mabus, Sui-Po Zhang, John R. Carson, Michael Kemmerer, Dennis J. Stone, James M Lenhard, Michael K. McMillian, Kristen M. Chevalier, Judith Baker

المصدر: Toxicological Sciences. 117:493-504

مصطلحات موضوعية: Blood Glucose, Male, medicine.medical_specialty, Narcotic Antagonists, medicine.medical_treatment, Cyproheptadine, Cell Enlargement, Pharmacology, Osteochondrodysplasias, Toxicology, Rats, Sprague-Dawley, δ-opioid receptor, Mice, Dogs, Cell Line, Tumor, Insulin-Secreting Cells, Internal medicine, medicine, Animals, Insulin, Potency, Pancreas, chemistry.chemical_classification, Chemistry, High-Throughput Screening Assays, Rats, Diabetes Mellitus, Type 1, Endocrinology, Opioid, Hyperglycemia, Vacuoles, Toxicity, Female, Insulinoma, Serotonin Antagonists, Epiphyses, Hyperglycemic agent, medicine.drug, Tricyclic

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9776c107aa28aa0bdc15b9be77554703
https://doi.org/10.1093/toxsci/kfq200

المؤلفون: Susan K. Yagel, Ellen E. Codd, Sui-Po Zhang, Jack A. Kauffman

المصدر: SLAS Discovery. 11:672-677

مصطلحات موضوعية: Ziconotide, Voltage-dependent calcium channel, medicine.drug_class, Chemistry, Calcium channel, Ligand binding assay, Drug Evaluation, Preclinical, Brain, Calcium channel blocker, N-type calcium channel, Pharmacology, Calcium Channel Blockers, Ligand (biochemistry), Biochemistry, Rats, Analytical Chemistry, Calcium Channels, N-Type, Scintillation proximity assay, medicine, Animals, Scintillation Counting, Molecular Medicine, Biotechnology, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2c57b65e7d939461f0844fe01085b3
https://doi.org/10.1177/1087057106289210