نتائج البحث - "Sulfones pharmacology"

1

Pharmaceutical-Grade Rigosertib Is a Microtubule-Destabilizing Agent

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Cell Biology, Celbiologie

المصدر: Molecular Cell
Molecular Cell, 79(1), 191. Cell Press
Molecular Cell, 79(1), 191-198.e3. Cell Press

مصطلحات موضوعية: Protein Conformation, Mutant, Cell, medicine.disease_cause, Crystallography, X-Ray, Microtubules, 0302 clinical medicine, Tubulin, Neoplasms, Sulfones, Cells, Cultured, Glycine/analogs & derivatives, Mutation, 0303 health sciences, Cultured, Crystallography, biology, Chemistry, rigosertib, Rigosertib, drug mechanism of action, 3. Good health, Cell biology, medicine.anatomical_structure, chemical genetics, Pharmaceutical Preparations, 030220 oncology & carcinogenesis, Pharmaceutical Preparations/chemistry, Drug Contamination, Antineoplastic Agents/pharmacology, Cells, Glycine, Antineoplastic Agents, Article, 03 medical and health sciences, CRISPRa, Tubulin/chemistry, Microtubule, medicine, Humans, Binding site, Molecular Biology, 030304 developmental biology, Cell Proliferation, drug target identification, CRISPRi, Cell Biology, In vitro, Neoplasms/drug therapy, Sulfones/pharmacology, Cancer cell, X-Ray, biology.protein, Microtubules/drug effects, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78e69dbc0caaaee2c44b7494dfd72fa4
https://pubmed.ncbi.nlm.nih.gov/32619469

2

Upregulated Na+/H+-exchange protects human colon cancer tissue against intracellular acidification

المؤلفون: Henrik Kold-Petersen, Ninna C. S. Voss, Casper Homilius, Ebbe Boedtkjer, Mikkel B. Henningsen

المصدر: Voss, N C S, Kold-Petersen, H H, Henningsen, M B, Homilius, C & Boedtkjer, E 2019, ' Upregulated Na + /H +-exchange protects human colon cancer tissue against intracellular acidification ', BioMed Research International, vol. 2019, 3702783 . https://doi.org/10.1155/2019/3702783
BioMed Research International
BioMed Research International, Vol 2019 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Colorectal cancer, PH, lcsh:Medicine, Guanidines, chemistry.chemical_compound, Fluorescence microscope, Ions/chemistry, Sulfones, Transcriptional Activation/genetics, Chemistry, Colonic Neoplasms/genetics, General Medicine, Hydrogen-Ion Concentration, Gene Expression Regulation, Neoplastic, Colonic Neoplasms, Female, Research Article, Transcriptional Activation, Sodium-Hydrogen Exchangers, Article Subject, Intracellular pH, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Downregulation and upregulation, medicine, Humans, Bicarbonates/metabolism, Guanidines/pharmacology, Ions, 030102 biochemistry & molecular biology, General Immunology and Microbiology, Cariporide, lcsh:R, Cancer, Metabolism, Carbon Dioxide, Acids/chemistry, medicine.disease, Molecular biology, GENE, digestive system diseases, Sulfones/pharmacology, Human colon cancer, Bicarbonates, 030104 developmental biology, Microscopy, Fluorescence, Gene Expression Regulation, Neoplastic/drug effects, Carbon Dioxide/metabolism, Acids, Sodium-Hydrogen Exchangers/genetics

وصف الملف: text/xhtml

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100bf714c00d6aa3a98379d7784224cf
https://pure.au.dk/portal/da/publications/upregulated-nahexchange-protects-human-colon-cancer-tissue-against-intracellular-acidification(08df03a6-f0bc-4f85-9e91-5d4daf27a06f).html

3

Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery

المؤلفون: Pihl, Liselotte, Nylander, Olof

المصدر: Acta Physiologica. 186(4):279-90

وصف الملف: print

URL الوصول: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-95369
http://www.ncbi.nlm.nih.gov/pubmed/16634783?dopt=Citation

View record at Wiley

4

The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor

المؤلفون: Ian C. Dunn, Robin Sellar, Robert P. Millar, Nerine T Joseph, Derek McBride, Kevin Morgan

المصدر: Joseph, N T, Morgan, K, Sellar, R, McBride, D, Millar, R P & Dunn, I C 2009, ' The chicken type III GnRH receptor homologue is predominantly expressed in the pituitary, and exhibits similar ligand selectivity to the type I receptor ', Journal of Endocrinology, vol. 202, no. 1, pp. 179-190 . https://doi.org/10.1677/JOE-08-0544
The Journal of Endocrinology

مصطلحات موضوعية: Male, Pituitary gland, Endocrinology, Diabetes and Metabolism, Flavonoids/pharmacology, Sequence Homology, Stimulation, Gonadotropin-releasing hormone, Ligands, Neutrophils/drug effects/immunology/metabolism, Lipopolysaccharides/ immunology/pharmacology, Transcriptional Activation/drug effects/ immunology, Substrate Specificity, Gonadotropin-Releasing Hormone, Phenanthrenes/pharmacology, Endocrinology, Chlorocebus aethiops, Protein Isoforms, Mitogen-Activated Protein Kinase 3/genetics/immunology, NF-kappa B/antagonists & inhibitors/genetics/immunology, Inositol phosphate, Receptor, Phylogeny, chemistry.chemical_classification, Peptides/pharmacology, Medicine(all), Chemokine CXCL2/biosynthesis/genetics/ immunology, Ligand (biochemistry), Up-Regulation, medicine.anatomical_structure, Hormone receptor, Pituitary Gland, COS Cells, Nitriles/pharmacology, Female, Protein Binding, medicine.medical_specialty, Flagellin/ immunology/pharmacology, Molecular Sequence Data, Signal Transduction/drug effects/genetics/ immunology, Biology, Transfection, MAP Kinase Kinase 1/antagonists & inhibitors, Leukocytes/drug effects/immunology/ metabolism, Internal medicine, medicine, Animals, Amino Acid Sequence, Butadienes/pharmacology, Antagonist, Interleukin-6/biosynthesis/genetics/ immunology, Molecular biology, Sulfones/pharmacology, chemistry, Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors, Regular papers, Chickens, Receptors, LHRH, Transcription Factor AP-1/antagonists & inhibitors/genetics/immunology

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94fbef37d2643a01cd1a2822308d1b00
https://hdl.handle.net/20.500.11820/c39d2fe3-6eae-459d-a60b-35e3ea13fe0a

5

Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells

المؤلفون: Park, KS, Poburko, D, Wollheim, CB, Demaurex, N

المصدر: British Journal of Pharmacology, Vol. 156, No 8 (2009) pp. 1296-1304

مصطلحات موضوعية: Sodium-Hydrogen Exchangers, Sarcoplasmic Reticulum Calcium-Transporting ATPases/metabolism, Transcription, Genetic, Diuretics/*toxicity, Apoptosis, Cell Cycle Proteins, Endoplasmic Reticulum, Guanidines, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Transcription, Genetic/drug effects, Amiloride, Endoplasmic Reticulum/*drug effects/metabolism, Protein Phosphatase 1, Transcription Factor CHOP/genetics, Endothelial Cells/*drug effects/metabolism/pathology, Humans, Sulfones, Thapsigargin/pharmacology, Enzyme Inhibitors, Diuretics, ddc:612, Guanidines/pharmacology, Cell Cycle Proteins/genetics, Enzyme Inhibitors/pharmacology, Dose-Response Relationship, Drug, Endothelial Cells, Calcium/*metabolism, Hydrogen-Ion Concentration, Sodium-Hydrogen Antiporter/antagonists & inhibitors/metabolism, Apoptosis/*drug effects, Research Papers, Antigens, Differentiation, Sulfones/pharmacology, Kinetics, Thapsigargin, Calcium, Amiloride/analogs & derivatives/*toxicity, Antigens, Differentiation/genetics, Transcription Factor CHOP, HeLa Cells

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::eda0cf26c0e45c533b0172dbe17fb0ad
https://archive-ouverte.unige.ch/unige:20019

View record at Wiley

6

Effects of phosphodiesterase-5 inhibitors on sperm parameters and fertilizing capacity

المؤلفون: Dimitriadis, F., Giannakis, D., Pardalidis, N., Zikopoulos, K., Paraskevaidis, E., Giotitsas, N., Kalaboki, V., Tsounapi, P., Baltogiannis, D., Georgiou, I., Saito, M., Watanabe, T., Miyagawa, I., Sofikitis, N.

مصطلحات موضوعية: Male, Phosphodiesterase 5 Inhibitors, Sperm Capacitation/drug effects, Cyclic AMP/physiology, Fertilization/*drug effects, Guanylate Cyclase/physiology, Phosphodiesterase Inhibitors/*pharmacology, Sperm Motility/*drug effects, Sulfones/pharmacology, Nitric Oxide/administration & dosage, Humans, Piperazines/pharmacology, Purines/pharmacology, Spermatozoa/*drug effects, Cyclic GMP/physiology, Second Messenger Systems/physiology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_____10561::05ec5c85c9f260ddb2bde26b9548be12
http://olympias.lib.uoi.gr/jspui/handle/123456789/22068

7

High-content classification of nucleocytoplasmic import or export inhibitors

المؤلفون: Hi Chul Kim, Sungyong Jung, Auguste Genovesio, Ulf Nehrbass, Brigitte David-Watine, Neil Emans, Nam Youl Kim, Yong-Jun Kwon

المساهمون: Institut Pasteur Korea - Institut Pasteur de Corée, Réseau International des Instituts Pasteur (RIIP), Biologie Cellulaire du Noyau (BCN), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Genovesio, Auguste, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS)

المصدر: Journal of Biomolecular Screening
Journal of Biomolecular Screening, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩
Journal of Biomolecular Screening, SAGE Publications, 2007, 12 (5), pp.621-627. ⟨10.1177/1087057107301319⟩

مصطلحات موضوعية: 0301 basic medicine, MESH: Signal Transduction, Cytoplasm, Time Factors, MESH: Cytoplasm/metabolism, [SDV]Life Sciences [q-bio], MESH: NF-kappa B/biosynthesis, Drug Evaluation, Preclinical, Anthraquinones, high-content screening, Kidney, 01 natural sciences, Biochemistry, MESH: Kidney/cytology, p38 Mitogen-Activated Protein Kinases, NF-κB, Analytical Chemistry, MESH: Dose-Response Relationship, Drug, MESH: Phorbol Esters/pharmacology, Phorbol Esters, MESH: Sulfones/pharmacology, Sulfones, Enzyme Inhibitors, Fluorescent Antibody Technique, Indirect, MESH: Inhibitory Concentration 50, nucleocytoplasmic transport, MESH: Cell Nucleus/drug effects, [SDV.BIBS] Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], MESH: Fatty Acids, Unsaturated/pharmacology, NF-kappa B, Protein kinase inhibitor, [SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM], Cell biology, MESH: Reproducibility of Results, [SDV] Life Sciences [q-bio], High-content screening, Fatty Acids, Unsaturated, Molecular Medicine, MESH: Drug Evaluation, Preclinical, I-kappa B Proteins, MESH: Flavonoids/pharmacology, Algorithms, Biotechnology, Signal Transduction, medicine.drug_class, In silico, Active Transport, Cell Nucleus, MESH: Algorithms, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Models, Biological, Sensitivity and Specificity, MESH: Nitriles/pharmacology, Cell Line, 03 medical and health sciences, Inhibitory Concentration 50, MESH: Computer Simulation, Nitriles, medicine, MESH: Fluorescent Antibody Technique, Indirect, Humans, Computer Simulation, Enhancer, Nuclear export signal, MESH: p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors, Transcription factor, MESH: I-kappa B Proteins/antagonists & inhibitors, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, automation, Cell Nucleus, Flavonoids, MESH: Humans, Dose-Response Relationship, Drug, MESH: Time Factors, MESH: Models, Biological, MESH: Anthraquinones/metabolism, Reproducibility of Results, MESH: Active Transport, Cell Nucleus/drug effects, MESH: Enzyme Inhibitors/pharmacology, MESH: Sensitivity and Specificity, 0104 chemical sciences, second messenger-activated kinases, MESH: Cell Line, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, image recognition, Nucleocytoplasmic Transport, MESH: HeLa Cells, Nuclear transport, HeLa Cells