المؤلفون: Morin MD; Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Wang Y; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States., Jones BT; Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Su L; Department of Biophysics, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States., Surakattula MM; Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Berger M; Department of Genetics, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Huang H; Department of Genetics, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Beutler EK; Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States., Zhang H; Department of Biophysics, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States., Beutler B; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center , Dallas, Texas 75390, United States., Boger DL; Department of Chemistry and the Skaggs Institute of Chemical Biology, The Scripps Research Institute , 10550 North Torrey Pines Road, La Jolla, California 92037, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2016 May 26; Vol. 59 (10), pp. 4812-30. Date of Electronic Publication: 2016 Apr 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Aminobutyrates/*pharmacology , Benzamides/*pharmacology , Toll-Like Receptor 4/*agonists, Aminobutyrates/chemical synthesis ; Aminobutyrates/chemistry ; Animals ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Dose-Response Relationship, Drug ; Humans ; Mice ; Mice, Inbred C57BL ; Models, Molecular ; Molecular Structure ; Ovalbumin/immunology ; Structure-Activity Relationship

المؤلفون: Wang Y; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Su L; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Morin MD; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Jones BT; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Whitby LR; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Surakattula MM; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037;, Huang H; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037., Shi H; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Choi JH; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Wang KW; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Moresco EM; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Berger M; Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037., Zhan X; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390;, Zhang H; Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu., Boger DL; Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu., Beutler B; Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390; Bruce.Beutler@UTSouthwestern.edu boger@scripps.edu zhang@chop.swmed.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Feb 16; Vol. 113 (7), pp. E884-93. Date of Electronic Publication: 2016 Feb 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Lipopolysaccharides/*pharmacology , Lymphocyte Antigen 96/*agonists , Peptidomimetics/*pharmacology , Toll-Like Receptor 4/*agonists, Animals ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Mitogen-Activated Protein Kinases/metabolism ; NF-kappa B/metabolism ; Protein Serine-Threonine Kinases/metabolism ; Signal Transduction