-
1
المؤلفون: Emma K. Haley, Diane Mierz, Mark Panzenbeck, Steve Fogal, M. Lamine Mbow, Mederbek Matmusaev, Susan Lukas, Svenja Mayer-Wrangowski, Miller Craig Andrew, Jie Zheng, F. James King, Clemens Braun, Fergus R. Byrne, Joerg Ermann, Donna Terenzio, Li Li, Felix Jost, Jay S. Fine, Lori Patnaude, Naitee Ting, Alex P. Klimowicz, Jane Chime, Tom Simpson, Peng Hsiao, David Csordas
المصدر: American journal of physiology. Gastrointestinal and liver physiology. 321(5)
مصطلحات موضوعية: Oral dose, medicine.medical_specialty, Physiology, Colon, Biological Availability, Inflammation, Inflammatory bowel disease, Gastroenterology, Models, Biological, Monocytes, RIPK2, Feces, Crohn Disease, Intestinal inflammation, Receptor-Interacting Protein Serine-Threonine Kinase 2, Physiology (medical), Internal medicine, medicine, Animals, Humans, Microbiome, Protein Kinase Inhibitors, Cells, Cultured, Mice, Knockout, Mice, Inbred BALB C, Hepatology, business.industry, Kinase, medicine.disease, Lipocalins, Apex (geometry), DNA-Binding Proteins, Disease Models, Animal, Cytokines, Colitis, Ulcerative, medicine.symptom, Inflammation Mediators, business, T-Box Domain Proteins
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::249fa75449d8f623e54320bcf73b527e
https://pubmed.ncbi.nlm.nih.gov/34494462 -
2
المؤلفون: Donna Terenzio, Fergus R. Byrne, Susan Lukas, Emma K. Haley, Joerg Ermann, Jie Zheng, Felix Jost, Frank Li, Naitee Ting, Mark Panzenbeck, Frank J. King, David Csordas, Miller Craig Andrew, Svenja Mayer-Wrangowski, Jane Chime, Steve Fogal, Clemens Braun, Mederbek Matmusaev, Jay S. Fine, Diane Mierz, Alexander C. Klimowicz
المصدر: Gastroenterology. 160:S-326
مصطلحات موضوعية: RIPK2, Hepatology, business.industry, Intestinal inflammation, Immunology, Gastroenterology, medicine, medicine.disease, business, Inflammatory bowel disease
-
3
المؤلفون: Lori Patnaude, Anthony J. Slavin, Louise K. Modis, Melissa Hill-Drzewi, Josh Horan, Sokol A. Haxhinasto, Susan Lukas
المصدر: SLAS Discovery. 19:407-416
مصطلحات موضوعية: Down-Regulation, CHO Cells, Immune receptor, Pharmacology, Biology, Biochemistry, Cell Line, Analytical Chemistry, Mice, Cricetulus, Sphingosine, Drug Discovery, Cyclic AMP, Enzyme-linked receptor, Animals, Humans, 5-HT5A receptor, Receptor, Protease-activated receptor 2, Dose-Response Relationship, Drug, organic chemicals, Organophosphates, Rats, Receptors, Lysosphingolipid, Interleukin-21 receptor, Proteolysis, Molecular Medicine, Calcium, lipids (amino acids, peptides, and proteins), Estrogen-related receptor gamma, 5-HT1 receptor, Biotechnology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b583d75d74f31f9782fc6b7958455925
https://doi.org/10.1177/1087057113502234 -
4
المؤلفون: Bill G. Kapogiannis, John W. Sleasman, William A. Meyer, Salma S. Syed, Rula S. Balluz, Edmond K. Kabagambe, Sharon Nachman, Susan Lukas, Craig M. Wilson
المصدر: AIDS Research and Human Retroviruses. 29:493-500
مصطلحات موضوعية: Male, Very low-density lipoprotein, medicine.medical_specialty, Longitudinal study, Adolescent, Apolipoprotein B, Immunology, Vascular Cell Adhesion Molecule-1, HIV Infections, Disease, Cohort Studies, chemistry.chemical_compound, Virology, Internal medicine, Humans, Medicine, Longitudinal Studies, biology, Cell adhesion molecule, business.industry, Neopterin, Infectious Diseases, chemistry, Cardiovascular Diseases, Cohort, HIV-1, biology.protein, Female, lipids (amino acids, peptides, and proteins), Endothelium, Vascular, business, Biomarkers, Lipoprotein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e32f079fa293048256f43ba9d802f397
https://doi.org/10.1089/aid.2012.0086 -
5
المؤلفون: Walter Davidson, Scott Jakes, Susan Lukas, Gregory W. Peet, Christopher Pargellis, Roger J. Snow, Rachel R. Kroe, Lee Frego, Mark E. Labadia, Brian Werneburg, Christine A. Grygon
المصدر: Biochemistry. 43:11658-11671
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Molecular Sequence Data, Plasma protein binding, Calorimetry, Protein Serine-Threonine Kinases, Biochemistry, Substrate Specificity, Mitogen-Activated Protein Kinase 14, Mice, Adenosine Triphosphate, Protein structure, Animals, Protein Isoforms, Amino Acid Sequence, Enzyme Inhibitors, Phosphorylation, Binding site, Surface plasmon resonance, Cyclic AMP Response Element-Binding Protein, Cofactor binding, Binding Sites, Activating Transcription Factor 2, Molecular Structure, biology, Chemistry, Biphenyl Compounds, Intracellular Signaling Peptides and Proteins, Active site, Isothermal titration calorimetry, Surface Plasmon Resonance, Protein Structure, Tertiary, Docking (molecular), biology.protein, Mitogen-Activated Protein Kinases, Protein Binding, Transcription Factors
-
6
المؤلفون: Jessi Wildeson, Richard H. Ingraham, Rachel R. Kroe, Christopher Pargellis, Walter Davidson, Lee Frego, Susan Lukas, Mark E. Labadia, Brian Werneburg, Gregory W. Peet
المصدر: Biochemistry. 43:9950-9960
مصطلحات موضوعية: MAP Kinase Signaling System, p38 mitogen-activated protein kinases, Calorimetry, Protein Serine-Threonine Kinases, Biology, Biochemistry, Catalysis, Proinflammatory cytokine, Mitogen-Activated Protein Kinase 14, Mice, Structure-Activity Relationship, Animals, Humans, Phosphorylation, Surface plasmon resonance, Protein kinase A, Alternative splicing, Intracellular Signaling Peptides and Proteins, Isothermal titration calorimetry, Surface Plasmon Resonance, Peptide Fragments, Protein Structure, Tertiary, Cell biology, Isoenzymes, Alternative Splicing, Kinetics, Spectrometry, Fluorescence, Thermodynamics, Tumor necrosis factor alpha, Mitogen-Activated Protein Kinases, Ultracentrifugation, Fluorescein-5-isothiocyanate, Function (biology), Protein Binding
-
7Discovery of 2-Phenylamino-imidazo[4,5-h]isoquinolin-9-ones: A New Class of Inhibitors of Lck Kinase
المؤلفون: Maret Panzenbeck, Mario G. Cardozo, Robert M. Tolbert, Jeffrey D. Peterson, Susan Lukas, Stephen Jacober, Robert J. Eckner, Gregory W. Peet, Anthony S. Prokopowicz, Carl A. Busacca, Suresh R. Kapadia, Scott Jakes, Tina Morwick, Roger J. Snow, Rosemarie Sellati, Yong Dong, Matt Aaron Tschantz, Neil Moss
المصدر: Journal of Medicinal Chemistry. 45:3394-3405
مصطلحات موضوعية: Models, Molecular, CD3 Complex, Stereochemistry, T-Lymphocytes, High-throughput screening, Molecular Conformation, Crystallography, X-Ray, Chemical synthesis, Antibodies, Jurkat Cells, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Imide, Mice, Inbred BALB C, Binding Sites, biology, Kinase, Imidazoles, Isoquinolines, Adenosine, chemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Enzyme inhibitor, biology.protein, Interleukin-2, Molecular Medicine, Female, Pharmacophore, Signal transduction, medicine.drug
-
8
المؤلفون: Jean Rancourt, Kirrane Thomas M, Rajiv Sharma, Martin Poirier, John R. Proudfoot, Susan Lukas, Montse Llinas-Brunet, Usha R. Patel, Dominik Wernic, Alisa K. Kabcenell, Pierre L. Beaulieu, Neil Moss, Scott Jakes, Vida Gorys, Jean Gauthier, Mario G. Cardozo, Liang Tong, Eugene R. Hickey, Dale R. Cameron, Jean-Marie Ferland, Raj Betageri, Richard H. Ingraham, James Gillard, Ghiro Elise
المصدر: Journal of Medicinal Chemistry. 42:1757-1766
مصطلحات موضوعية: Models, Molecular, chemistry.chemical_classification, Dipeptide, Stereochemistry, Peptide, Dipeptides, Crystallography, X-Ray, Ligands, Ligand (biochemistry), SH2 domain, src Homology Domains, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Drug Discovery, Molecular Medicine, Moiety, Structure–activity relationship, Phosphorylation, Tyrosine kinase, Protein Binding
-
9
المؤلفون: Raj Betageri, John R. Proudfoot, Thomas C. Warren, Susan Lukas, Josephine Schembri-King, Liang Tong, Scott Jakes
المصدر: Journal of Biological Chemistry. 273:20238-20242
مصطلحات موضوعية: Models, Molecular, Phosphotyrosine binding, Protein Conformation, Phenylalanine, Molecular Conformation, Crystal structure, Crystallography, X-Ray, SH2 domain, Closed conformation, Biochemistry, src Homology Domains, Residue (chemistry), Side chain, Humans, Enzyme Inhibitors, Phosphotyrosine, Molecular Biology, Binding Sites, Molecular Structure, Chemistry, Cell Biology, Crystallography, Lymphocyte Specific Protein Tyrosine Kinase p56(lck), Protein Binding, Binding domain
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fc5b6112295c5916d495df6479ad36
https://doi.org/10.1074/jbc.273.32.20238 -
10
المؤلفون: Daniel J. Greenwood, Thomas C. Warren, Richard H. Ingraham, Mark E. Labadia, Scott Jakes, Susan Lukas, Josephine Schembri-King, Christine A. Grygon
المصدر: Archives of Biochemistry and Biophysics. 342:117-125
مصطلحات موضوعية: Binding Sites, ZAP-70 Protein-Tyrosine Kinase, Protein Conformation, Chemistry, Phosphopeptide, Protein subunit, Genetic Vectors, Molecular Sequence Data, T-cell receptor, Receptors, Antigen, T-Cell, Biophysics, Membrane Proteins, Cooperativity, Protein-Tyrosine Kinases, SH2 domain, Biochemistry, Protein structure, Amino Acid Sequence, Cloning, Molecular, Tyrosine, Molecular Biology, Tyrosine kinase