-
1
المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
-
2
المؤلفون: Susan M. Lotarski, Sarah Grimwood, Michael Popiolek, Veronica Reinhart, Jeremy R. Edgerton, Jennifer E. Davoren, Stefanus J. Steyn, John F. Harms, David P. Nguyen
المصدر: Biochemistry. 55:7073-7085
مصطلحات موضوعية: 0301 basic medicine, chemistry.chemical_classification, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Muscarinic acetylcholine receptor M1, Pharmacology, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, chemistry, Muscarinic acetylcholine receptor, Muscarinic acetylcholine receptor M5, Muscarinic acetylcholine receptor M4, Inositol, Inositol phosphate, 030217 neurology & neurosurgery
-
3
المؤلفون: Melissa Kramer, Damon Young, Yael Mandelblat-Cerf, Susan M. Lotarski, Jonathan Garst-Orozco, Rouba Kozak, Eda Stark, Christopher Ryan Butler, Michael Popiolek
المصدر: ACS chemical neuroscience. 10(3)
مصطلحات موضوعية: Male, medicine.medical_specialty, Physiology, Cognitive Neuroscience, Population, Morris water navigation task, Hippocampal formation, Muscarinic Agonists, Biochemistry, Hippocampus, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, 0302 clinical medicine, Organ Culture Techniques, In vivo, Alzheimer Disease, Internal medicine, Muscarinic acetylcholine receptor, medicine, Animals, Rats, Long-Evans, education, Maze Learning, 030304 developmental biology, 0303 health sciences, education.field_of_study, Dose-Response Relationship, Drug, Receptor, Muscarinic M4, business.industry, Glutamate receptor, Cell Biology, General Medicine, Rats, Endocrinology, medicine.anatomical_structure, nervous system, Schaffer collateral, Systemic administration, Schizophrenia, business, 030217 neurology & neurosurgery
-
4
المصدر: Alzheimer's & Dementia. 13
مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Activator (genetics), Chemistry, Health Policy, Muscarinic acetylcholine receptor, Neurology (clinical), Geriatrics and Gerontology, Pharmacology, Receptor
-
5
المؤلفون: Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
المصدر: Journal of medicinal chemistry. 60(15)
مصطلحات موضوعية: Diarrhea, Male, Lactams, Vomiting, Scopolamine, Isoindoles, Structure-Activity Relationship, Dogs, Allosteric Regulation, Piperidines, Seizures, Thiadiazoles, Animals, Humans, Donepezil, Rats, Wistar, Oxazoles, Sulfonamides, Receptor, Muscarinic M1, Mice, Inbred C57BL, Amphetamine, Drug Design, Indans, Microsomes, Liver, Ataxia, Female
-
6
المؤلفون: Sean D. Donevan, Stacey Galvin, Heather S. Hain, Jason Peterson, Susan M. Lotarski, James Offord, Bryan Strenkowski
المصدر: Epilepsy Research. 108:833-842
مصطلحات موضوعية: Phenytoin, Mice, 129 Strain, Time Factors, medicine.drug_class, medicine.medical_treatment, Mutant, Analgesic, Mutation, Missense, Pregabalin, Mice, Transgenic, Pharmacology, Anxiolytic, Epilepsy, Species Specificity, Seizures, medicine, Animals, gamma-Aminobutyric Acid, Electroshock, Dose-Response Relationship, Drug, Voltage-dependent calcium channel, Chemistry, medicine.disease, Mice, Inbred C57BL, Disease Models, Animal, Anticonvulsant, Neurology, Anticonvulsants, Calcium Channels, Neurology (clinical), medicine.drug
-
7
المؤلفون: Michael, Popiolek, David P, Nguyen, Veronica, Reinhart, Jeremy R, Edgerton, John, Harms, Susan M, Lotarski, Stefanus J, Steyn, Jennifer E, Davoren, Sarah, Grimwood
المصدر: Biochemistry. 55(51)
مصطلحات موضوعية: Male, Dose-Response Relationship, Drug, Inositol Phosphates, Dopamine Agents, Receptor, Muscarinic M1, Brain, CHO Cells, Motor Activity, Muscarinic Agonists, Hippocampus, Corpus Striatum, Electrophysiological Phenomena, Rats, Sprague-Dawley, Amphetamine, Mice, Cricetulus, Cricetinae, Animals, Humans, Calcium
-
8
المؤلفون: Sarah J. Neal, M. Olsen, Sharon Rosenzweig-Lipson, S.K. Leonard, Zoë A. Hughes, Deborah L. Smith, Robert H. Ring, Stacey J. Sukoff Rizzo, T.H. Andree, John Dunlop, Susan M. Lotarski, C.M. Pulicicchio, Lee E. Schechter, Dane Springer, Shendi Lu, Jason M. Dwyer, Garth T. Whiteside, E. Kouranova, J.E. Harrison, Julie A. Brennan, Steven Victor O'neil, C.N. Bender
المصدر: Neuropharmacology. 66:202-214
مصطلحات موضوعية: Allosteric modulator, Pyridines, medicine.drug_class, Receptor, Metabotropic Glutamate 5, Drug Evaluation, Preclinical, Glutamic Acid, Pharmacology, Receptors, Metabotropic Glutamate, Anxiolytic, Depressive Disorder, Treatment-Resistant, Mice, Radioligand Assay, Cellular and Molecular Neuroscience, Allosteric Regulation, medicine, Animals, Humans, Analgesics, Behavior, Animal, Dose-Response Relationship, Drug, Metabotropic glutamate receptor 5, medicine.disease, Antidepressive Agents, Rats, Disease Models, Animal, HEK293 Cells, MTEP, Anti-Anxiety Agents, Metabotropic glutamate receptor, Benzamides, Metabotropic glutamate receptor 1, Antidepressant, Calcium, Psychology, Excitatory Amino Acid Antagonists, Treatment-resistant depression
-
9
المؤلفون: Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
المصدر: Journal of medicinal chemistry. 59(13)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, Allosteric modulator, Stereochemistry, medicine.drug_class, Carboxamide, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Muscarinic acetylcholine receptor, Drug Discovery, medicine, Structure–activity relationship, Animals, Picolinic Acids, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor, Muscarinic M1, Rats, Thiazoles, 030104 developmental biology, Pyran, Molecular Medicine, Cholinergic, Female, Pharmacophore, 030217 neurology & neurosurgery
-
10
المؤلفون: Veronica Reinhart, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren, Lei Zhang, Erik Alphie Lachapelle, Deane M. Nason, Michael Eric Green, Keith Dlugolenski, Anthony R. Harris, Jiangli Yan, Sarah Grimwood, Michelle R. Garnsey, Chewah Lee, Dennis P. Anderson, John T. Lazzaro, R. Scott Obach, Damien Webb, Lois K. Chenard, Jeremy R. Edgerton, Michael Aaron Brodney, Romelia Salomon-Ferrer, Gregory W. Kauffman, Steven Victor O'neil
المصدر: Bioorganicmedicinal chemistry letters. 26(2)
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Indoles, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Biochemistry, Molecular Docking Simulation, 03 medical and health sciences, chemistry.chemical_compound, Mice, Allosteric Regulation, Amide, Drug Discovery, Animals, Humans, Homology modeling, Molecular Biology, Chemistry, Hydrogen bond, Organic Chemistry, Receptor, Muscarinic M1, Hydrogen Bonding, Amides, 030104 developmental biology, Intramolecular force, Drug Design, Molecular Medicine, Pharmacophore