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1
المؤلفون: James W. Jetter, James M. Trzaskos, Ronald L. Magolda, Pitts William J, Shuaige Wang, Michael J. Orwat, Susan R. Sherk, Gregory C. Houghton, Maryanne B. Covington, Douglas G. Batt, Donald J. P. Pinto, Joseph J. Petraitis, Robert A. Copeland
المصدر: Bioorganic & Medicinal Chemistry Letters. 9:919-924
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Ring (chemistry), Biochemistry, Chemical synthesis, Sulfone, Structure-Activity Relationship, chemistry.chemical_compound, Terphenyl, Drug Discovery, Cyclooxygenase Inhibitors, heterocyclic compounds, Molecular Biology, Biphenyl, chemistry.chemical_classification, Cyclooxygenase 2 Inhibitors, Molecular Structure, biology, Organic Chemistry, Isoenzymes, Enzyme, chemistry, Cyclooxygenase 2, Prostaglandin-Endoperoxide Synthases, Enzyme inhibitor, biology.protein, Molecular Medicine, Cyclooxygenase
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2
المؤلفون: Bruce D. Jaffee, Ronald L. Magolda, Tracy L. Taylor, Douglas G. Batt, Susan R. Sherk, Joseph J. Petraitis, Randine L. Dowling, Robert A. Copeland, Elizabeth A. Jones
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:1745-1750
مصطلحات موضوعية: Bicyclic molecule, Stereochemistry, Biphenyl Compounds, Organic Chemistry, Clinical Biochemistry, Quinoline, Heteroatom, Substituent, Pharmaceutical Science, Mixed lymphocyte reaction, Biochemistry, Chemical synthesis, Carbon, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Drug Discovery, Lipophilicity, Dihydroorotate dehydrogenase, Molecular Medicine, Lymphocyte Culture Test, Mixed, Molecular Biology, Immunosuppressive Agents
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3
المؤلفون: Douglas G. Batt, Elizabeth A. Jones, Donald J. P. Pinto, Pitts William J, Joseph J. Petraitis, Susan R. Sherk, Michael J. Orwat, Robert A. Copeland, Bruce D. Jaffee, Ronald L. Magolda, Randine L. Dowling, Tracy L. Gardner, Irina Cipora Jacobson, James W. Jetter
المصدر: Bioorganic & Medicinal Chemistry Letters. 8:307-312
مصطلحات موضوعية: Oxidoreductases Acting on CH-CH Group Donors, Molecular model, Stereochemistry, Clinical Biochemistry, Heteroatom, Dihydroorotate Dehydrogenase, Pharmaceutical Science, Ring (chemistry), Biochemistry, Chemical synthesis, Structure-Activity Relationship, Heterocyclic Compounds, Drug Discovery, Humans, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, biology, Biphenyl Compounds, Organic Chemistry, Mixed lymphocyte reaction, Enzyme, chemistry, Enzyme inhibitor, Dihydroorotate dehydrogenase, biology.protein, Molecular Medicine, Lymphocyte Culture Test, Mixed, Oxidoreductases, Immunosuppressive Agents
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4
المؤلفون: Stephen W. Wright, Bruce Freimark, Jean M. Williams, M. A. Pratta, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, Joseph J. Petraitis, John V. Giannaras
المصدر: Bioorganic & Medicinal Chemistry. 4:851-858
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, Spectrophotometry, Infrared, medicine.medical_treatment, Clinical Biochemistry, Pharmaceutical Science, Matrix metalloproteinase, Organ culture, Biochemistry, Structure-Activity Relationship, Organ Culture Techniques, Reductive metabolism, Osteoarthritis, Drug Discovery, medicine, Nasal septum, Animals, Cartilage destruction, Enzyme Inhibitors, Molecular Biology, Chemistry, Hydrolysis, Cartilage, Organic Chemistry, Thiazoles, medicine.anatomical_structure, Cytokine, Microsome, Molecular Medicine, Cattle, Interleukin-1
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5
المؤلفون: Stephen W. Wright, Douglas Guy Batt, M. A. Pratta, Joseph J. Petraitis, Ronald L. Magolda, E. C. Arner, Susan R. Sherk, John V. Giannaras, Donald Joseph-Phillip Pinto, Orwat Michael James, Ronald L. Corbett, Bruce Freimark, Jean M. Williams, Susan V. Di Meo, Herman F. Stampfli
المصدر: Bioorganic & Medicinal Chemistry. 3:227-234
مصطلحات موضوعية: Pyridines, Indomethacin, Clinical Biochemistry, Pharmaceutical Science, Matrix metalloproteinase, Organ culture, Biochemistry, Structure-Activity Relationship, Naproxen, Organ Culture Techniques, Reductive metabolism, Microsomes, Drug Discovery, Nasal septum, medicine, Animals, Molecular Biology, Nasal Septum, Chemistry, Cartilage, Organic Chemistry, Metalloendopeptidases, Metabolism, Thiazoles, medicine.anatomical_structure, Microsome, Pyrazoles, Molecular Medicine, Cattle, Matrix Metalloproteinase 3, Proteoglycans, Oxidation-Reduction, Interleukin-1
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6
المؤلفون: Ronald L. Corbett, Susan R. Sherk, Ronald L. Magolda, Joseph J. Petraitis, Alicia M. Green, Lori L. Bostrom, Matthew M. Abelman, Rachel M. Kindt, Stephen W. Wright
المصدر: Bioorganic & Medicinal Chemistry Letters. 3:2875-2878
مصطلحات موضوعية: Chemistry, Cartilage, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Arthritis, Anatomy, Organ culture, medicine.disease, Biochemistry, In vitro, medicine.anatomical_structure, Drug Discovery, medicine, Biophysics, Molecular Medicine, Nasal cartilages, Molecular Biology
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7
المؤلفون: Alicia M. Green, Stephen W. Wright, Susan R. Sherk, Ronald L. Magolda, Donald Joseph-Phillip Pinto
المصدر: Bioorganic & Medicinal Chemistry Letters. 2:1079-1084
مصطلحات موضوعية: chemistry.chemical_classification, biology, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, chemistry.chemical_compound, Enzyme, Hydroxylamine, chemistry, Drug Discovery, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Organic chemistry, Arachidonic acid, Molecular Biology
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8
المؤلفون: Sarah Cox, Michael D. Boisclair, Charity L. Dean, Philip M. Czerniak, Pieter F. W. Stouten, David A. Nugiel, Steven P. Seitz, Chong-Hwan Chang, Catherine R. Burton, Marc R. Arnone, Lisa M. Sisk, Robert F. Kaltenbach, Barbara A. Harrison, Pamela A. Benfield, Robert H. Grafstrom, Jay A. Markwalder, Susan R. Sherk, Karen A. Rossi, Deborah Doleniak, Peter Worland, George L. Trainor
المصدر: Journal of medicinal chemistry. 47(24)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Transplantation, Heterologous, Antineoplastic Agents, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Cyclin-dependent kinase, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Structure–activity relationship, Animals, Humans, Cyclin D1, Binding site, Phosphorylation, Cells, Cultured, Binding Sites, biology, Molecular Structure, Cyclin-dependent kinase 4, Kinase, Chemistry, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinases, Transplantation, Pyrimidines, Enzyme inhibitor, biology.protein, Molecular Medicine, Pyrazoles, Drug Screening Assays, Antitumor